• cytoplasmic
  • The C-terminus also interacts with several cytoplasmic proteins of the junctional plaque and interacts with signaling molecules responsible for cell survival. (wikipedia.org)
  • Furthermore, studies in which mice were deprived of occludin expression showed morphological stability in several epithelial tissues but also found chronic inflammation and hyperplasia in the gastric epithelium, calcification in the brain, testicular atrophy, loss of cytoplasmic granules in straited duct cells of salivary gland, and thinning of the compact bone. (wikipedia.org)
  • molecules
  • BLT2 is a Cell surface receptor that functions by recognizing, binding, and mediating responses to a particular set of messenger molecules or ligands. (wikipedia.org)
  • lymphocytes
  • Specific high-affinity receptors for 1,25dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. (springer.com)
  • induces
  • When dietary calcium absorption is inadequate to satisfy the body's requirement, then 1, 25(OH) 2 D mobilizes stem cells and induces them to become mature osteoclasts, which in turn mobilize calcium stores from bone to maintain serum calcium in a physiologically acceptable range (1-3) . (springer.com)
  • LPS stimulation induces a series of interactions with several accessory proteins which form the TLR4 complex on the cell surface. (wikipedia.org)
  • extracellular domain
  • The nine domains are as follows: N-terminus domain (66 aa) transmembrane domain 1 (23 aa) extracellular loop 1 (46 aa) transmembrane domain 2 (25 aa) intracellular loop (10 aa) transmembrane domain 3 (25 aa) extracellular domain 2 (48 aa) transmembrane domain 4 (22 aa) C-terminus domain (257 aa) The C-terminus domain has been shown experimentally to be required for correct assembly of tight junction barrier function. (wikipedia.org)
  • line
  • Kuribayashi T, Tanaka H, Abe E, Suda T. Functional defect of variant clones of a human myeloid leukemia cell line (HL-60) resistant to 1a,25-dihydoxyvitamin D3. (springer.com)
  • cyclin
  • Hepatocellular carcinoma miR-26a has been found to induce cell cycle arrest at the G1 phase in human hepatocellular carcinoma cells, in part through direct downregulation of cyclin D2 and cyclin E2. (wikipedia.org)
  • miR-26a again suppresses tumorigenesis in nasopharyngeal cells in vivo, with suppressed expression of c-myc, cyclins D3 and E2, and cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
  • colon
  • Ulcerative colitis is a chronic inflammatory disease of the colon and people who have the disease have an increased colon cancer risk ( 2 ). (aacrjournals.org)
  • The decrease is caused by expression of a few mutant forms of ENPP7, which lack exon 4, resulting in total inactivation of the enzyme, as found in human colon and liver cancer cells. (wikipedia.org)
  • stem
  • Recently, miR-200 silencing was also reported in cancer stem cells, implying that miR-200 deregulation is a key event in multiple levels of tumor biology. (wikipedia.org)
  • miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. (wikipedia.org)
  • activation
  • One prominent cell-activating pathway involves BLT2 receptor activation of NOX2 or NOX1 with the subsequent production of reactive oxygen species which in turn activate the transcription inducing function of NF-κB. (wikipedia.org)
  • tumor
  • Overexpression of miR-26a in glioma primarily results from amplification at the miR-26a-2 locus, a genomic event strongly associated with monoallelic PTEN loss.miR-26a-mediated PTEN repression in a murine glioma model both enhances de novo tumor formation and precludes loss of heterozygosity and the PTEN locus. (wikipedia.org)
  • signals
  • These messenger ligands are any one of a range of structurally different arachidonic acid metabolites made and released by nearby cells to act as paracrine signals for coordinating responses between cells or autocrine signals for modulating their parent cells' responses. (wikipedia.org)
  • The C-terminus of occludin is important in receiving and transmitting cell survival signals. (wikipedia.org)
  • intestinal
  • D without a subscript represents either D 2 or D 3 ] that is responsible for maintaining serum calcium levels in the normal range by increasing the efficiency of intestinal calcium absorption. (springer.com)
  • survival
  • 1 a,25- Dihydroxyvitamin D3 and la-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells. (springer.com)
  • phosphorylation
  • Based on pRb's direct ability to regulate the cell cycle through phosphorylation status, and that pRb phosphorylation is altered following exposure to free radicals and other inflammatory species ( 7 - 10 ), we hypothesized that pRb phosphorylation status and its pathway are dysregulated in ulcerative colitis in vivo . (aacrjournals.org)
  • abundant
  • Sphingomyelin is a lipid constituent of cell membrane, and a dietary component being particularly abundant in milk, cheese, egg, and meat. (wikipedia.org)
  • family
  • The miR-26 family is composed of miR-26a-1, miR-26a-2 and miR-26b located in chromosomes 3, 12 and 2, respectively. (wikipedia.org)
  • lines
  • Nasopharyngeal carcinoma miR-26a is commonly downregulated in nasopharyngeal carcinoma samples and cell lines. (wikipedia.org)
  • miR-26a is found to be downregulated in primary human Burkitt lymphoma and MYC-driven lymphoma cell lines. (wikipedia.org)
  • found
  • It cooperates with LY96 (also referred as MD-2) and CD14 to mediate in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. (wikipedia.org)
  • different
  • The mature miRNA of miR-26a-1 and miR-26a-2 possesses the same sequence, with the exception of 2 different nucleotides in mature miR-26b. (wikipedia.org)
  • activity
  • Camel milk fermented byLc.K782 had the highest antioxidant activity by 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulphonic acid). (greenmedinfo.com)