• To reach the stated goal, there are two specific aims: 1) Analysis of the role of costimulatory adhesion pathways LFA-l/ICAM-1, VLA-4/VCAM-1 and CD2/LFA-3 + CD59, in post-thymus differentiation and maturation of human CD4+ T-cells under in vitro cell culture conditions. (grantome.com)
  • In particular focussed on regulation of cell surface expression of activation and differentiation antigens, and production of T-cell cytokines. (grantome.com)
  • The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation. (jci.org)
  • Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
  • Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
  • On the other hand, although bad self-reactive IgG+ memory B cells are generated, proliferation and subsequent differentiation are blocked in healthy animals. (osaka-u.ac.jp)
  • This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. (arigobio.cn)
  • The focus of this review is to highlight the role of statins in modulating the function and differentiation of various blood cells. (archivesofmedicalscience.com)
  • It is a member of the immunoglobulin superfamily and has been shown to interact with CD45 in signal transduction during lymphocyte proliferation and differentiation. (biolegend.com)
  • The main ligand of LFA-1 is ICAM-1, and the LFA-1/ICAM interaction stimulates signaling pathways that influence T cell differentiation. (immune-system-research.com)
  • Signal transduction down the Ras/MAPK pathway, including that critical to T cell activation, proliferation, and differentiation, has been generally considered to occur at the plasma membrane. (scielo.br)
  • In the skin, nAChRs regulate the activity of genes involved in the growth and division (proliferation), maturation (differentiation), and survival of cells. (medlineplus.gov)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)
  • Desk 2 Anti\cytotoxic T\lymphocyte antigen\4 (CTLA\4) monoclonal antibodies (mAbs) augment alloimmune response of individual T cells in secondary combined lymphocyte response (MLR) Anti\CTLA\4 mAbs were also added to main MLR of peripheral blood T lymphocytes against allogeneic monocyte\derived dendritic cells, acquired by tradition of purified peripheral blood monocytes with GM\CSF and IL\4 for 7 days. (technuc.com)
  • Among their other immunological properties, MSC inhibit lymphocyte proliferation and cytokine production, suppress dendritic cell function and alter DC cytokine production, and decrease IFN-g production by NK cells. (vin.com)
  • The antibody LT20 reacts with an extracellular epitope of CD20 (Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes. (exbio.cz)
  • CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). (exbio.cz)
  • The term co-receptor is prominent in literature regarding signal transduction, the process by which external stimuli regulate internal cellular functioning. (wikipedia.org)
  • Depending on the type of ligand a co-receptor binds, its location and function can vary. (wikipedia.org)
  • The cytotoxic T lymphocyte-associated antigen 4 (CTLA4) is a coinhibitory activation-induced surface receptor on T cells that functions as a major negative regulator of anti-self-immune responses. (snmjournals.org)
  • Cell surface CTLA4 has 100-1,000 times higher affinity for the costimulatory molecules expressed by antigen-presenting cells, thereby efficiently competing with the positive costimulatory receptor CD28 ( 1 ). (snmjournals.org)
  • Ly6C high MC exhibited activated neutrophil degranulation, lysosome, cytokine production/receptor interaction and myeloid cell activation pathways, and Ly6C low MC presented features of lymphocyte immunity pathways in both mice. (frontiersin.org)
  • We also dissected the biological relevance of perforin-dependent granule exocytosis and death receptor/ligand-mediated cytolytic mechanisms of lymphocytes. (vumc.org)
  • The use of CD20 as suicide gene was investigated in CMV specific T cells and in T cells genetically modified with an antigen specific T-cell receptor. (haematologica.org)
  • T-cell receptor (TCR) gene transfer is an attractive strategy for rapid in vitro generation of high numbers of antigen specific T cells. (haematologica.org)
  • Knockout of the PD-1 receptor in mice causes severe dilated cardiomyopathy characterized by high levels of immunoglobulin G autoantibodies that react specifically to cardiac troponin I. 12,13 In mouse models of lupus and other experimentally induced inflammatory states, inhibition of the PD-1 pathway has been recognized as an essential mediator of autoimmune myocarditis 14-16 and is similarly associated with high-titer autoantibodies against cardiac myosin. (acc.org)
  • Evidence has recently been obtained that two very different recombinatorial systems for lymphocyte antigen receptor diversification appeared at the beginning of vertebrate evolution approximately 500 million years ago. (scielo.br)
  • Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
  • It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. (exbio.cz)
  • Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)
  • Additionally, we measured DNA methylation levels using bisulfite amplicon sequencing in 345 mother-infant pairs for five candidate genes, including carbohydrate sulfotransferase 7 (CHST7), fibroblast growth factor 13 (FGF13), insulin receptor substrate 4 (IRS4), paired like homeobox 2Ap (PHOX2A), and plexin domain containing 1 (PLXDC1). (bvsalud.org)
  • Chimeric antigen receptor (CAR) T-cell therapy is effective in relapsed/refractory large B-cell lymphoma and results in a unique toxicity profile, namely cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome. (chemnews-japan.com)
  • A new tumor-rejection antigen recognized by cytotoxic T lymphocytes infiltrating into a lung adenocarcinoma. (nih.gov)
  • Occupancy of CTLA\4 (cytotoxic T\lymphocyte antigen\4 or CD152) negatively regulates the activation of mouse T lymphocytes, seeing that indicated with the destiny of CTLA\4\deficient mice, with the influence of anti\CTLA\4 monoclonal antibodies (mAbs) on mouse T\cell activation and by the influence of CTLA\4 blockade within the course of experimental tumoral, autoimmune, alloimmune or infectious disease with this animal. (technuc.com)
  • Number 5 Blocking anti\cytotoxic T\lymphocyte antigen\4 (CTLA\4) monoclonal antibodies (mAbs) increase cytokine production inside a polyclonal CD80\dependent T\cell activation assay. (technuc.com)
  • However, there is a paucity of data demonstrating that lymphocyte proliferation does occur in humans treated with CTLA4-blocking antibodies. (snmjournals.org)
  • The most consistent effects in peripheral blood cells after administering anti-CTLA4 antibodies have been limited to marginal increases in the surface expression of nonspecific activation markers predominantly on CD4+ T lymphocytes ( 16 - 18 ). (snmjournals.org)
  • The core function of this immune system is executed by B lymphocytes, which recognize foreign bodies and eliminate them by producing antibodies. (osaka-u.ac.jp)
  • B lymphocytes can produce an unlimited number of different antibodies against a diverse array of foreign bodies by utilizing random rearrangement of gene segments encoding antibodies (immunoglobulin genes). (osaka-u.ac.jp)
  • It is our biggest issue to clarify what sorts of mechanisms make B lymphocytes to differentiate and proliferate, to select cells that recognize foreign bodies (good cells) or our body itself (bad cells), to eliminate bad cells and maintain good cells and to differentiate good cells into plasma cells, thereby leading to production of only good antibodies. (osaka-u.ac.jp)
  • Humoral memory is characterized by recall immune responses, which are more rapid than the primary response, and by the production of higher serum titers of antigen-specific antibodies, mostly of the IgG isotype. (osaka-u.ac.jp)
  • Pembrolizumab and nivolumab are human monoclonal antibodies that block ligand binding to PD-1, leading to T cell activation. (acc.org)
  • 10 Newer anti-PD-1 antibodies, such as pidilizumab, as well as several anti-PD-L1 antibodies are currently under study. (acc.org)
  • However, immunization with recombinant gp120 does not elicit neutralizing antibodies against multiple HIV-1 isolates, and failed to demonstrate efficacy in recent clinical trials. (scielo.br)
  • Based on crystallographic studies of gp120 molecules from HIV-1 and SIV and on studies of antibody structures, a number of strategies are being pursued to induce broadly neutralizing anti-gp120 antibodies. (scielo.br)
  • Such chronic injury is usually mediated by anti-human leukocyte antigen antibodies. (medscape.com)
  • In a very interesting chapter, Z. PANCER and M. D. COOPER first consider the emergence of lymphocytes as a novel circulatory cell type in vertebrates and then discuss phylogenetic aspects of the superfamily of LRR - containing proteins and their role in immunity. (scielo.br)
  • Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
  • Importantly, HPMCs induced autologous CD3 + T-lymphocyte proliferation ( 3 H incorporation) after pulse with recall antigen. (bmj.com)
  • 3 Autologous lymphocytes genetically modified with the TCR for MART-1/Melan-A have been adoptively transferred to patients with advanced melanoma. (haematologica.org)
  • We have investigated human peritoneal mesothelial cells (HPMCs) for phagocytic activity, expression of surface Major Histocompatibility Complex (MHC) class II and accessory molecules involved in antigen presentation, and the ability to present recall antigens to T cells. (bmj.com)
  • It provides a dominant negative signaling to T cells on binding to the costimulatory molecules CD80 (B7.1) and CD86 (B7.2) expressed on the surface of antigen-presenting cells ( 1 ). (snmjournals.org)
  • Our data show a defect in the expression of the co-stimulatory molecules and an impairment of DC priming function, events that might contribute to T1DM pathogenesis. (torvergata.it)
  • For example, MSC are poor antigen presenting cells and do not express MHC class II or co-stimulatory molecules and only low levels of MHC class I molecules. (vin.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • As an evasion mechanism, many tumors are able to stimulate the expression of immune checkpoint molecules, resulting in an exhausted phenotype of T cells that cannot restrain tumor progression [ 1 ]. (oncotarget.com)
  • Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells. (nih.gov)
  • It plays an important role in immune response and shares many functions with IL-2, for example, it stimulates the proliferation of activated T cells (1, 2), NK cells (3) and B cells, and it induces immunoglobulin synthesis by B cells stimulated by anti-IgM or CD40 ligand (4). (biolegend.com)
  • IL-15 stimulates the proliferation of activated T cells, NK cells, and B cells, inducing immunoglobulin synthesis by B cells stimulated by anti-IgM or CD40 ligand. (biolegend.com)
  • 1 PD-1 binds to PD-L1 (programmed death ligand-1) and PD-L2 (programmed death ligand-2) on antigen-presenting cells to induce anergy in effector T cells. (acc.org)
  • Finally, and importantly, blockade of the connection of CTLA\4 with its ligands using Toceranib soluble anti\CTLA\4 mAbs, in undamaged form or as Fab fragments, Toceranib enhanced T\cell activation in several polyclonal or alloantigen\specific CD80\ or CD80/CD86\dependent assays, as measured by cytokine production, cellular proliferation or cytotoxic reactions. (technuc.com)
  • Number 6 Blocking the cytotoxic T\lymphocyte antigen\4 (CTLA\4)CCD80/CD86 connection enhances T\cell proliferation and cytotoxic reactions. (technuc.com)
  • Stimulation of BM CD20(+) B cells by CpG-containing oligodeoxynucleotide-enhanced expression of activation markers (CD86 and CD54) triggered IL-6 and TNF-alpha secretion and cell proliferation. (nih.gov)
  • Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
  • Reishi Mushroom Polysaccharides can kill tumor cells or promote their apoptosis by enhancing the functions of a variety of immune cells in the human body. (ganoherb.com)
  • 2) Analysis of early signal transduction pathways involved in the costimulatory function of the costimulatory adhesion pathways LFA-l/ICAM-1, VLA-4/VCAM-1, and CD2/LFA-3 + CD59. (grantome.com)
  • The key to optimal cellular functioning is maintained by possessing specific machinery that can carry out tasks efficiently and effectively. (wikipedia.org)
  • The Rho family of GTP-binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton-dependent morphological change. (embl-heidelberg.de)
  • Flow cytometry and/or cellular enzyme-linked immunosorbent assay showed constitutive expression of ICAM-1, LFA-3, and B7-1, but not B7-2 or MHC class II. (bmj.com)
  • The Shanker Laboratory explores lymphocyte crosstalk with an aim to understand molecular and cellular players driving immune effector responses. (vumc.org)
  • CMI) , cellular i. immune responses that are initiated by an antigen-presenting cell interacting with and mediated by T lymphocytes ( e.g., graft rejection, delayed-type hypersensitivity). (theodora.com)
  • Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
  • In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
  • Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
  • This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
  • Co-receptors have been identified as participants in cell signalling cascades, embryonic development, cell adhesion regulation, gradient formation, tissue proliferation and migration. (wikipedia.org)
  • The goal of this research proposal is to study in detail the recently established T-cell costimulatory roles of the adhesion pathways LFA-l/ICAM-1, VLA-4/VCAM-1 and CD2/LFA-3 + CD59. (grantome.com)
  • It inhibits binding of intercellular adhesion molecule-1 (ICAM-1) to LFA-1 and has been effective in reducing ocular surface inflammation. (aao.org)
  • Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)
  • A clear example of the critical role of CTLA4 on tolerance is the striking phenotype of CTLA4 knock-out mice, which develop rapid T-cell proliferation and autoimmune infiltration of multiple organs shortly after birth ( 6 , 7 ). (snmjournals.org)
  • HS may also arise as the result of persistent antigen stimulation due to autoimmune disease or malignancy. (scirp.org)
  • Data from animal models suggest that modulation of the PD-1 pathway can lead to immune-mediated CV toxicity, primarily in the form of autoimmune myocarditis. (acc.org)
  • In accordance with preclinical data, autoimmune myocarditis has been reported with both anti-CTLA4 and anti-PD-1 therapies. (acc.org)
  • In autoimmune or inflammatory diseases, there is increased expression of LFA-1 and/or its counterligand, ICAM-1. (immune-system-research.com)
  • Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. (embl-heidelberg.de)
  • Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. (arigobio.cn)
  • This correlates to humans where tumor-infiltrating lymphocytes from post-surgery relapse-free breast cancer patients show signatures of NK cell activation (J Transl Med 11:145). (vumc.org)
  • In contrast to CTLA-4, signaling through the PD-1 pathway occurs primarily during the late phase of T cell activation. (acc.org)
  • Accumulating data indicate that BM of RA patients participates in the pathogenesis of this disease as a site of proinflammatory cytokines overproduction and lymphocytes activation. (nih.gov)
  • Thus, our data indicate that TLR9 may participate in direct activation and proliferation of B cells in BM, and therefore could play a role in the pathogenesis of RA. (nih.gov)
  • The field of Lymphocyte Surface Antigens and Activation Mechanisms is examined in two chapters. (scielo.br)
  • Piperlongumine inhibited inflammatory mediators and adherence of lymphocyte function-associated antigen 1 to MH-S cells following TDM activation. (chemnews-japan.com)
  • In the GC, the combined processes of somatic hypermutation and selection based on the affinity of the BCR for the antigen, are responsible for the generation of high-affinity antibody variants which ultimately differentiate into long-lived plasma cells or long-lived memory B cells. (osaka-u.ac.jp)
  • 17 Similarly, in a phase I trial, 1 patient of a total of 207 patients treated with anti-PD-L1 antibody was diagnosed with myocarditis. (acc.org)
  • The antibody response to HIV-1 in vivo is direct against several viral proteins. (scielo.br)
  • in most applications the substance in question serves as antigen, both in antibody production and in measurement of antibody by the test substance. (theodora.com)
  • 1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
  • IL-12 has a role in inducing T helper-1 lymphocyte and IFN-g secretion from T helper-1 and natural killer cells 4 , 8 Improving the function of macrophage phagocytic activity with immunomodulatory substances is one of the efforts to prevent DM patients from being easily infected with TB 9 . (scialert.net)
  • Visual impairment is common, affecting between 2.8% and 10% of patients, 1 - 3 and may result directly from damage to uveal tract structures, or may occur due to secondary effects on neighboring tissues: for example, accelerated cataract formation, glaucoma, and macular edema. (dovepress.com)
  • Donor T cells may also induce GvHD due to recognition of allo-antigens on non-malignant tissues of the patient. (haematologica.org)
  • Regenerative medicine refers to the process of using living function tissues to repair or replace organs that are functionally damaged. (vin.com)
  • However, clear evidence for functional NK cell subsets exists in humans and the presence of NK cells in the thymus and immature NK cells in the liver suggests specific functions for NK cells in the tissues. (scielo.br)
  • In the present study, we examine the specific impacts of MSCs on mitochondrial morphology and function in host tissues. (frontiersin.org)
  • Proliferation was assessed on day 7 by [H-3]-thymidine incorporation assay. (torvergata.it)
  • In addition, it can block the proliferation of human T cells in mixed lymphocyte reaction (MLR) assay. (immune-system-research.com)
  • 4 ]. A relationship between activated or lymphocytes and enzyme-linked immuno- memory-effector lymphocyte populations sorbent assay (ELISA) for CD117. (who.int)
  • We identified novel immunostimulatory effects of bortezomib on lymphocyte effector functions (Oncotarget 8:8604). (vumc.org)
  • Preclinical models predict that blockade of the coinhibitory molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA4) on lymphocytes results in the release of a cell cycle inhibitory checkpoint, allowing lymphocyte proliferation, tumor targeting, and regression. (snmjournals.org)
  • 1 Signaling through CTLA-4 counteracts CD28-mediated costimulation and induces an inhibitory program that stops T cell proliferation. (acc.org)
  • Co-receptors localized in endothelial cells function to enhance cell proliferation and cell migration. (wikipedia.org)
  • Reishi Mushroom Triterpenes can inhibit tumor angiogenesis by inhibiting the proliferation of vascular endothelial cells. (ganoherb.com)
  • We investigated whether alterations in phenotype and function of DC may contribute to the pathogenesis of Type 1 diabetes (T1DM). (torvergata.it)
  • Chimienti F, Hogg RC, Plantard L, Lehmann C, Brakch N, Fischer J, Huber M, Bertrand D, Hohl D. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. (medlineplus.gov)
  • The unique characteristic of this study will be the utilization of affinity purified natural ligands, namely ICAM-1, VCAM-1, LFA-3 and CD59, to study the contribution of the various pathways in isolation. (grantome.com)
  • While T\cell proliferation in principal civilizations had not been changed in the current presence of soluble anti\CTLA\4 mAb regularly, responses had been significantly improved in supplementary MLR in comparison to isotype\control mAbs (Desk 2). (technuc.com)
  • Despite occasional cases of expansion of melanoma-specific T cells ( 14 , 15 ), the bulk of the data suggest that there is no detectable expansion of tumor antigen-specific lymphocytes, in particular when focusing on CD8+ T-cell responses. (snmjournals.org)
  • It has been reported that IL-27 performs an anti-inflammatory function by acting on conventional CD4 + T cells to induce IL-10-producing cells that are implicated in controlling inflammatory responses [ 3 ]. (hindawi.com)
  • The prevailing view is that antigen-specific B cells are maintained as a pool of memory B cells after clonal expansion during the primary immune responses. (osaka-u.ac.jp)
  • In the GC reaction, de novo generated antigen-specific memory B cells are thought to acquire intrinsically different traits from their naive predecessors, accounting for more rapid and heightened secondary responses. (osaka-u.ac.jp)
  • Anti-HIV-1 T cell responses are evaded by continuous mutation of the virus. (scielo.br)
  • The current presence of soluble anti\CTLA\4 mAbs elevated T\cell proliferation weighed against isotype\control mAbs particularly, specifically at times 4C5 Toceranib of lifestyle. (technuc.com)
  • Furthermore, improved T\cell proliferation was also observed in the current presence of anti\CTLA\4 Fab fragments. (technuc.com)
  • In these ethnicities, anti\CTLA\4 mAb again improved the T\cell proliferative response over a range of stimulatorCresponder ratios from 1 : 4 to 1 1 : 40 (Fig. 6a). (technuc.com)
  • Molecular imaging with the PET probe 18 F-FLT allows mapping and noninvasive imaging of cell proliferation in secondary lymphoid organs after CTLA4 blockade in patients with metastatic melanoma. (snmjournals.org)
  • Ly6C low MC manifested activated T-cell signaling pathways and potentially can adapt the function of lymphocytes. (frontiersin.org)
  • Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
  • IL-27 binds to IL-27ra and gp-130 complex, which is expressed on multiple cell types, including T lymphocytes [ 2 ]. (hindawi.com)
  • Meanwhile IL-27 exerts proinflammatory effects by promoting Th1, CD8, natural killer (NK), T follicular helper (Tfh), and B cell proliferation/functions and by inhibiting Treg and Th2 cell generation in parasites infection [ 4 ]. (hindawi.com)
  • In response to a cancer-germline self-antigen P1A, akin to human MAGE-like antigens, our pioneering studies using TCR-P1A transgenic mice (J Immunol 172:5069) established normal thymic development of CD8 T cells and discovered a paradigm of CD8 T cell help for innate NK effector function in solid tumor microenvironments. (vumc.org)
  • 20 nM) into mice does not induce cell death in lymphoid or myeloid cells, nor does it affect antigen presentation or proliferation of antigen-specific CD4 or CD8 T cells (Cancer Res 75:5260). (vumc.org)
  • Interleukin-15 (IL-15) was discovered in supernatant from simian kidney epithelial cell line CV-1/EBNA, as a soluble factor capable of supporting proliferation of the IL-2-dependent cell line, CTLL-2 (1). (biolegend.com)
  • such recognition maintains cell survival and intermittent proliferation (9). (biolegend.com)
  • Potential effects of forced CD20 expression on T-cell function were investigated by comparing CD20- and mock-transduced cytomegalovirus (CMV) specific T cells for cytolysis, cytokine release and proliferation. (haematologica.org)
  • No effect of CD20 on T-cell function was observed. (haematologica.org)
  • Herpes simplex virus thymidine kinase (HSV-tk) is a well-established suicide gene that has been successfully used to control GvHD following donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation. (haematologica.org)
  • 4 In addition, TCRs for minor histocompatibility antigens, including HA-1 and HA-2, have been transferred to donor-derived virus-specific T cells to treat patients with hematologic malignancies after allogeneic stem cell transplantation. (haematologica.org)
  • Although human CD20 has previously been described as functional selection marker and suicide gene after retroviral transfer to T lymphocytes, 9 , 10 the specificities of these T cells were unknown, and therefore a potential effect of CD20 on antigen-specific T-cell functions could not be investigated. (haematologica.org)
  • To date, development of these agents has focused on two major targets: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and the programmed cell death protein-1 (PD-1) pathway. (acc.org)
  • Biopsies have demonstrated a measurable repopulation of goblet cells and a decrease in both conjunctival epithelial cell turnover and the number of lymphocytes. (aao.org)
  • In vitro, BMS-587101 effectively inhibits LFA-1 mediated T-cell proliferation in human HUVEC cells. (immune-system-research.com)
  • Here, we investigated the functionality of TLR9 and its role in the modulation of RA BM B-cell functions. (nih.gov)
  • Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
  • Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)
  • CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. (exbio.cz)
  • Hultin LE, Hausner MA, Hultin PM, Giorgi JV: CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes. (exbio.cz)
  • 2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • HS is often described in binary terms as "primary," indicating Mendelian inheritance of gene mutations resulting in cytotoxic lymphocyte dys- function, or "secondary" indicating an acquired reactive disorder. (scirp.org)
  • IL1 beta: The protein encoded by this gene is a member of the interleukin 1 cytokine family. (arigobio.cn)
  • This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. (arigobio.cn)
  • IL6: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. (arigobio.cn)
  • The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. (arigobio.cn)
  • We investigated the use of human CD20 as suicide gene in T-lymphocytes. (haematologica.org)
  • Human CD20 has been proposed as non-immunogenic protein with a dual function as selection marker and suicide gene. (haematologica.org)
  • The SLURP1 gene provides instructions for making a protein called secreted Ly6/uPAR-related protein-1 (SLURP-1). (medlineplus.gov)
  • The SLURP1 gene mutations involved in this condition lead to production of an altered SLURP-1 protein that is unstable and quickly broken down, if any protein is produced at all. (medlineplus.gov)
  • Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. (medlineplus.gov)
  • Two sets of primers were used for DNA amplification targeting the specific sequence of a 529 bp repeat element and another set of primers was utilised for the surface antigen protein-1 gene. (chemnews-japan.com)
  • Researchers speculate that without SLURP-1, the activity of genes controlled by nAChR signaling is altered, leading to overgrowth of skin cells or survival of cells that normally would have died. (medlineplus.gov)
  • This plant is expected to have the potential as an immunomodulator in patients with diabetes mellitus (DM), which can prevent tuberculosis infection by increasing the phagocytic function of macrophage cells and interleukin-12 (IL-12) levels. (scialert.net)
  • HHcy in Cbs -/- mice reinforced inflammatory features in Ly6C high MC by upregulating inflammatory TFs ( Ets1 and Tbx21 ) and strengthened lymphocytes functional adaptation in Ly6C low MC by increased expression of CD3, DR3, ICOS, and Fos . (frontiersin.org)
  • HHcy reinforced inflammatory feature in Ly6C high MC and strengthened lymphocytes functional adaptation in Ly6C low MC. (frontiersin.org)
  • MC can be classified into inflammatory or anti-inflammatory subsets ( 1 ). (frontiersin.org)
  • Murine Ly6C high and Ly6C middle MC subsets perform pro-inflammatory functions, which are considered the counterpart of human CD14 ++ CD16 + intermediate MC or CD14 + CD40 + inflammatory MC ( 4 , 5 ). (frontiersin.org)
  • As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)
  • [ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)
  • Leukocyte function-associated antigen-1 ( LFA-1 ), also known as CD11a/CD18 and αLβ2, is a member of the β2-integrin family found on lymphocytes and other leukocytes. (immune-system-research.com)
  • As a result, affected individuals have little or no SLURP-1 protein. (medlineplus.gov)
  • The members of the CD family of co-receptors have a wide range of function. (wikipedia.org)
  • Like other Ly6/uPAR-related proteins, SLURP-1 folds into a particular shape and is thought to attach (bind) to other proteins called receptors to carry out signaling within cells. (medlineplus.gov)
  • Laboratory studies show that SLURP-1 can bind to nicotinic acetylcholine receptors (nAChRs). (medlineplus.gov)
  • Through its interaction with these receptors, SLURP-1 may be involved in skin growth and development. (medlineplus.gov)
  • 1 Thus, MSC are very non-immunogenic and can be transferred to fully allogeneic recipients and still mediate their immunologic effects. (vin.com)
  • Human peritoneal mesothelial cells equipped with phagocytic and antigen-presenting machinery are anticipated to have an integral role in intraperitoneal immune surveillance. (bmj.com)
  • Normal human lymphocytes from lymph node. (exbio.cz)
  • Biological effects of SLURP-1 on human keratinocytes. (medlineplus.gov)
  • The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-related diabetes (CFRD), type 2 diabetes (T2D), gestational diabetes, islet autoantibody positivity (AAb+), and without diabetes. (nature.com)
  • A workplace investigation of lymphocytic bronchiolitis characterized by proliferation of mucosa-associated lymphoid tissue (MALT). (cdc.gov)
  • Understanding the roles of Asthma is a worldwide problem, the prevalence of miRNAs in asthma pathogenesis may also aid to asthma ranged from 1% to 18% of the population in explore new therapeutic targets. (cdc.gov)
  • Meanwhile, the number of T helper 1 (Th1) and T helper 17 (Th17) cells was decreased. (hindawi.com)
  • Macrophage-derived apolipoprotein (apo) E and multimers of a synthetic apo E-peptide display monokine-like functions by inhibiting mitogen- or antigen-driven lymphocyte proliferation. (jci.org)
  • This study demonstrated how the target lymphocyte itself can modulate macrophage apo E production. (jci.org)
  • Ly6C high MC expressed higher levels of macrophage (MΦ) markers, whereas, Ly6C low MC highly expressed lymphocyte markers in both mice. (frontiersin.org)
  • have extended the conclusion that STIM1 functions as a critical regulator for inducing calcium influx to primary mast cells, by analyzing STIM1knock-out mice. (osaka-u.ac.jp)
  • The immunomodulatory potential in vivo on BALB/c mice model DM was carried out by oral induction of TB antigen with extract dose, control positive, negative and normal groups. (scialert.net)
  • 2-5 The majority of these studies provide evidence that systemic administration of bone marrow-derived or adipose-tissue derived MSC can help preserve renal function in the face of acute insults and can also help reduce tubular injury and fibrosis. (vin.com)
  • As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
  • CA Cancer J Clin 72(1):7-33, 2022. (msdmanuals.com)
  • 7 Moreover, PD-1 blockade may be particularly beneficial when combined with anti-CTLA4 therapy in specific patient populations. (acc.org)
  • Lifitegrast, 5%, preservative-free topical solution, a lymphocyte function-associated antigen 1 (LFA-1) antagonist administered twice daily, was approved by the FDA in 2016 for treatment of dry eye. (aao.org)
  • BMS-587101 is a potent and orally active LFA-1 antagonist. (immune-system-research.com)
  • In general, BMS-587101 is a potent and orally active LFA-1 antagonist, with efficacy in in vivo models of inflammation. (immune-system-research.com)
  • The chemical composition of the ethanol extract of the fruit of E. rubroloba has the potential as an immunomodulator in TB antigen-induced DM in vivo . (scialert.net)
  • They are generated by immunizing an animal with an antigen to elicit an immune response. (cellsignal.cn)
  • Patients with prior VTE did not have progression https://joplink.net/antigens/ or evidence of new VTE. (chemnews-japan.com)