• metabolism
  • Relative to the results, research have showed also that cisapride is normally mainly metabolized to norcisapride (Meuldermans data usually do not reveal any relevant connection by cisapride within the rate of metabolism of other medicines. (technumber.com)
  • In previous pharmacokinetic research, cisapride was proven to raise the absorption price of concomitantly provided H2-antagonists (cimetidine (Kirch research that was performed through diagnostic inhibitors, relationship research and heterologous manifestation systems, the rate of metabolism of cisapride was proven to mainly involve CYP3A4, nevertheless, CYP2A6 could be implicated in the forming of norcisapride (Desk 2). (technumber.com)
  • The info on the result of itraconazole within the rate of metabolism BMS-354825 of cisapride had been verified by Shulman (1996). (technumber.com)
  • liver
  • Strategies Components 14C-Cisapride was labelled in the amide group at Janssen Pharmaceutica, Beerse, Belgium (Amount 1) (Janssen fat burning capacity of cisapride in individual liver organ microsomes. (technumber.com)
  • itself
  • However, it's possible that cisapride itself may impact the pharmacokinetics of co-administered providers through its pharmacological influence on accelerated gastric-emptying or improved absorption in the tiny intestine. (technumber.com)
  • drug
  • The U.S. Food and Drug Administration (FDA) issued a warning letter to doctors, and cisapride was voluntarily removed from the U.S. market on July 14, 2000. (wikipedia.org)
  • research
  • The medication is normally well tolerated (McCallum outcomes described within this research demonstrate that cisapride is normally metabolized principally oxidative fat burning capacity by CYP3A4 (Desk 1, Desk 2, Amount 6). (technumber.com)