Centers for DiseasDialysisAcute kidneyOutcomesBiomarkersAutosomalStagesDiabetesMortalityInterventionsNephrologyIncreased riskGlomerularBiomarkerDeclining kidney functionRenal functionFibrosisCardiovascular DiseasesComplicationsESKDDeclineBiopsiesRisk of kidney diseasePopulationsPrevalenceLesionsIncidenceTubularParikhTransplantsClinicalSeverity of the diseaseAdultsRapid kidneySusceptibilityUricEpidemiologicInfectionSystemicDecreasesGlomerulosclerosisTubulointerstitialSlowFunctionIncident
Centers for Diseas5
- According to the United States Centers for Disease Control and Prevention, an estimated 37 million people are living with CKD in the U.S., making it the 8th leading cause of death in the country. (medicalxpress.com)
- 1. Centers for Disease Control and Prevention: Chronic Kidney Disease Surveillance System website. (nephsap.org)
- Centers for Disease Control and Prevention. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Adults on dialysis treatment for end-stage kidney disease were 100 times more likely to have a Staphylococcus aureus (staph) bloodstream infection than adults not on dialysis during 2017-2020, according to a new Vital Signs report released today by the Centers for Disease Control and Prevention (CDC). (cdc.gov)
Dialysis10
- Many individuals with chronic kidney disease (CKD) are undiagnosed or unaware of the disease and at risk of not receiving services to manage their condition and of "crashing" into dialysis. (ajmc.com)
- Past studies report higher health care costs among patients with delayed nephrology care and suboptimal dialysis initiation, but they are limited because they focused on patients undergoing dialysis and did not evaluate costs associated with unrecognized disease for patients "upstream," or patients with late-stage CKD. (ajmc.com)
- Our findings indicate that costs associated with undiagnosed CKD extend to patients not yet requiring dialysis and highlight potential savings from earlier disease detection and management. (ajmc.com)
- 1 The majority of individuals with CKD are unaware they have the disease, 1 and half or more of adults at increased risk of CKD go untested or undiagnosed, 2,3 putting them at risk of receiving inappropriate care, not receiving services and treatments intended to help delay or slow CKD progression, and having little or no nephrologist care prior to dialysis (or "crashing" into dialysis). (ajmc.com)
- These patients may require urgent dialysis and kidney transplantation. (medscape.com)
- Our study is the first to confirm that long-term treatment with allopurinol slows the progression of chronic kidney disease and prevents the entry on dialysis. (ajkdblog.org)
- If left unchecked, this disease can progress to end-stage kidney failure, which is fatal unless the patient is able to get regular dialysis or a kidney transplant, and chronic kidney disease also increases the risk of other serious chronic conditions such as cardiovascular disease. (todayspractitioner.com)
- Preventing infections among patients receiving dialysis requires a broad and equitable approach to the prevention and care of kidney disease for people from all racial, ethnic, and socioeconomic groups. (cdc.gov)
- Blood Pressure in Chronic Kidney Disease for patients not preparation and measurement protocols adhered to by receiving dialysis represents an update to the KDIGO patients and clinicians. (bvsalud.org)
- The strength of kidney disease (CKD) not receiving dialysis, the exception recommendations is based on the "Grading of being children and kidney transplant recipients. (bvsalud.org)
Acute kidney4
- In a new study looking at the long-term effects of hospitalized patients who have acute kidney injury (AKI), a sudden but temporary loss of kidney function, Johns Hopkins Medicine researchers found that higher levels of certain biomarkers in urine and blood can predict a patient's risk of developing chronic kidney disease (CKD). (medicalxpress.com)
- Yumeng Wen et al, Longitudinal biomarkers and kidney disease progression after acute kidney injury, JCI Insight (2023). (medicalxpress.com)
- In acute kidney injury (AKI), the serum creatinine level can take several hours or days to reach a new steady state and does not reflect the true decrease in GFR. (medscape.com)
- She noted that adverse kidney outcomes after COVID-19 disease often follow acute kidney injury (AKI). (renalandurologynews.com)
Outcomes9
- Kidney transplant outcomes vary depending on factors such as donor type (living or deceased) and blood relation. (doctorworld.net)
- There is literature to support using allopurinol to reduce CV and kidney outcomes in CKD patients. (ajkdblog.org)
- Studies on the association of serum uromodulin and outcomes of chronic kidney disease (CKD) are lacking. (biomedcentral.com)
- We measured serum uromodulin concentrations by ELISA in 2652 CKD patients from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) and investigated the association of serum uromodulin with outcomes of CKD patients, including end-stage kidney disease (ESKD) receiving kidney replacement therapy, cardiovascular events and mortality by Cox proportional hazards regression model. (biomedcentral.com)
- Hence, in the current study, we measured the serum uromodulin levels and investigated the association of serum uromodulin with kidney function and outcomes of CKD in a large, multicenter prospective cohort study of CKD patients, the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). (biomedcentral.com)
- Results from the cohort, case-control and cross-sectional studies pointed out a positive association between obesity, diabetes and risks for renal disease outcomes. (researchsquare.com)
- Find out how an integrated approach produces better outcomes for renal disease - a common, complex and costly condition. (optum.com)
- Given their role in the body's response to inflammation, elevations in sTNFR1 and sTNFR2 in the setting of COVID-19 may serve as markers of disease severity, with prolonged inflammation leading to worse kidney outcomes," Dr Parikh and colleagues wrote. (renalandurologynews.com)
- According to the recommendations of the Pediatric Work Group of Kidney Disease Outcomes Quality Initiative (KDOQI) for chronic kidney disease (CKD), all children with evidence of CKD should be referred to a pediatric nephrologist for consultation and comanagement. (medscape.com)
Biomarkers12
- In a cohort of 656 hospitalized patients with AKI, researchers measured seven urine and two plasma biomarkers of kidney injury, inflammation and tubular health at multiple timepoints over the course of a year after diagnosis. (medicalxpress.com)
- The goal was to determine the associations of longitudinal changes in these biomarkers with progression of kidney disease after AKI. (medicalxpress.com)
- Finally, Paré's team assessed whether the biomarkers identified by reverse Mendelian randomization predicted the eventual development of chronic kidney disease in the ORIGIN participants, who had normal kidney function at the study's start. (todayspractitioner.com)
- Importantly … reverse [Mendelian randomization] could be a novel method used to identify sensitive and early diagnostic biomarkers for a variety of other diseases. (todayspractitioner.com)
- A Mendelian Randomization-Based Approach to Identify Early and Sensitive Diagnostic Biomarkers of Disease, Clinical Chemistry. (todayspractitioner.com)
- Evaluate new developments related to clinical risk factors and emerging biomarkers for identification and treatment of cardiovascular disease in CKD. (nephsap.org)
- [ 1 ] Clinically, biomarkers can be used to screen for, diagnose, or monitor the activity of diseases as well as guide molecularly targeted therapy or assess therapeutic response. (medscape.com)
- Biomarkers of kidney function can be used to estimate the severity and nature of kidney injury. (medscape.com)
- Conventional biomarkers for kidney function include serum creatinine (SCr), urine output (changes in which may precede biochemical changes), and urine microscopy. (medscape.com)
- Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
- Other research identified plasma biomarkers that may predict major adverse kidney events (MAKE) in patients hospitalized with COVID-19. (renalandurologynews.com)
- In another study, published in the American Journal of Kidney Diseases , Chirag R. Parikh, MD, PhD, of Johns Hopkins University School of Medicine in Baltimore, Maryland, and colleagues investigated the ability of 26 plasma biomarkers of injury, inflammation, and repair to predict COVID-19-associated major adverse kidney events (MAKE). (renalandurologynews.com)
Autosomal4
- Autosomal dominant polycystic kidney disease (ADPKD) is a rare, hereditary disorder that is characterized by the silent, progressive growth of multiple bilateral renal cysts. (medscape.com)
- Cite this: Slowing Progression of Autosomal Dominant Polycystic Kidney Disease - Medscape - Feb 25, 2022. (medscape.com)
- Genetic variants of the gene that encodes collagen type IV (COL4) protein have been associated with several familial kidney diseases, including thin basement membrane nephropathy (TBMN), autosomal dominant Alport syndrome (ADAS), and focal segmental glomerulosclerosis (FSGS). (alportsyndromenews.com)
- Renal disease progression in autosomal dominant polycystic kidney disease. (rug.nl)
Stages7
- Unrecognized disease progression is associated with higher health care costs both for patients with end-stage kidney disease and late-stage (stages G4-G5) chronic kidney disease. (ajmc.com)
- We compared costs for patients with unrecognized progression to late-stage (stages G4 and G5) CKD and end-stage kidney disease (ESKD) with costs for individuals with prior CKD recognition. (ajmc.com)
- In stages 1 and 2, early detection and a suitable treatment plan, along with dietary adjustments, can enable individuals to live with the disease and manage its symptoms effectively. (doctorworld.net)
- Three different kidney disease types caused by similar genetic alterations may actually represent different stages of disease progression, according to the authors of a study published in Cytogenetic and Genome Research . (alportsyndromenews.com)
- However, the tests currently used to gauge the severity of kidney damage in diabetics do not reliably detect chronic kidney disease in its initial stages. (todayspractitioner.com)
- Patients with CKD stages G3b and G4 were twice as likely to experience rapid kidney function decline during the pandemic compared with patients with CKD stage G3a. (renalandurologynews.com)
- Conclusion Treatment with high daily doses of cholecalciferol in patients with CKD Stages 3-4 halts the progression of SHPT and does not cause hypercalcaemia or other side effects. (medscape.com)
Diabetes14
- CKD stemming from diabetes or glomerular disease progresses more rapidly than that caused by hypertension or tubular interstitial disease. (doctorworld.net)
- Researchers have developed a new test that could diagnose early chronic kidney disease in patients with type 2 diabetes. (todayspractitioner.com)
- With diabetes becoming a global epidemic, it is more important than ever for healthcare providers to detect chronic kidney disease early so that patients can undergo timely interventions that slow the progression of this condition. (todayspractitioner.com)
- The relationship between heart failure and risk of CKD progression was consistent in subgroups defined by age, race, gender, baseline eGFR, and diabetes. (johnshopkins.edu)
- To estimate the incidence and direct cost of care for chronic kidney disease (CKD) in patients with type 2 diabetes. (populationmedicine.eu)
- The progression from diabetes mellitus to chronic kidney disease generates an escalation of costs that affects the health system. (populationmedicine.eu)
- Obesity and diabetes are the main causes of chronic kidney disease (CKD) and end stage renal disease (ESRD). (researchsquare.com)
- Regulation of Weight and diabetes are highly recommended in obese and diabetic patients to prevent the subsequent renal disease. (researchsquare.com)
- NCDs, namely cardiovascular diseases, cancer, diabetes and chronic respiratory diseases, are largely preventable by addressing the four common modifiable risk factors - tobacco use, harmful use of alcohol, unhealthy diet and physical inactivity. (who.int)
- CVDs), cancer, diabetes and chronic respiratory diseases (CRDs), are the leading causes of morbidity and mortality worldwide. (who.int)
- Diabetes mellitus (DM) is a widespread disorder that effects patients from different age groups and sexes, and is a complex disease that involves both genetic and environmental factors. (who.int)
- Depression can also increase progression of diabetes due to low medication compliance (9). (who.int)
- Lack of access to preventive care for conditions like diabetes and high blood pressure, which increase the risk of developing end-stage kidney disease. (cdc.gov)
- Failure to prevent the progression of many of the diseases that lead to the need for medical products of human origin, such as trachoma causing corneal blindness and diabetes resulting in kidney failure, means that the growth in demand for these products continues to outpace the increase in their availability. (who.int)
Mortality4
- Because kidney disease often coincides with multiple other chronic conditions, the contribution of kidney disease to mortality is likely underestimated. (nephsap.org)
- The most common cause of mortality worldwide is cerebrovascular disease (CVD), which includes coronary heart disease (CHD), congestive heart failure, CVD and stroke, peripheral artery diseases, carotid artery diseases, and aortoiliac disease. (medscape.com)
- Additionally, it is a predictor of morbidity and mortality in patients who do not have evidence of significant renal disease. (medscape.com)
- Role of haptoglobin 2-2 genotype on disease progression and mortality among South Indian chronic kidney disease patients. (cdc.gov)
Interventions4
- This shows that individuals with high levels of TFF3 have a significantly greater risk of developing chronic kidney disease and indicates that diabetic patients with elevated TFF3 results could potentially benefit the most from early chronic kidney disease interventions. (todayspractitioner.com)
- Package of Essential Noncommunicable Disease Interventions for primary health care (PHC) in low- resource settings is a prioritized set of cost-effective interventions for integration of essential NCDs in PHC. (who.int)
- In adults with chronic kidney disease, interventions to slow the progression of kidney disease that have been proven to be effective include strict blood pressure control and angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor-blocker (ARB) therapy, lipid lowering therapy, and correction of anemia. (medscape.com)
- The burden of the pressure targets, lifestyle interventions, antihypertensive recommendations on patients and resources, public medications, and specific management in kidney policy implications, and limitations of the evidence are transplant recipients and children. (bvsalud.org)
Nephrology2
- Dr Anjay Rastogi, clinical chief of nephrology at University of California, Los Angeles reports on strategies to slow the progression of ADPKD, including lifestyle modifications, management of complications, and disease-specific therapy. (medscape.com)
- About 20% of hospitalized patients develop AKI and have a three- to eight-fold increased risk of developing chronic kidney disease later on in life," says Chirag Parikh, director of the Division of Nephrology at the Johns Hopkins University School of Medicine and the study's corresponding author. (medicalxpress.com)
Increased risk1
- Whether these risk factors reflect an increased risk for tuberculous infection or an increased risk for disease progression is not clear, however. (cdc.gov)
Glomerular6
- Chronic kidney disease (CKD) follows a five-stage progression, each stage marked by a decline in glomerular filtration rate (GFR). (doctorworld.net)
- Casual blood specimens were obtained at each examination to determine white blood cell count, serum blood urea nitrogen, glomerular filtration rate, and cystatin C. The glomerular filtration rate from serum creatinine was estimated using the Modification of Diet in Renal Disease (Study) prediction equation. (medscape.com)
- Mild chronic kidney disease was defined as a glomerular filtration rate of more than 45 mL/min/1.73 m 2 to 60 mL/min/1.73 m 2 or less. (medscape.com)
- Serum creatinine is reflective of glomerular filtration rate (GFR) under steady-state conditions but has less utility in the context of decreasing kidney function. (medscape.com)
- The primary outcome was a composite of either end-stage renal disease or a 50% decline in estimated glomerular filtration rate (eGFR) from baseline. (johnshopkins.edu)
- Rapid kidney function decline, defined as a 40% or greater annual decline in estimated glomerular filtration rate (eGFR), occurred in 2.5% of the COVID-19 group compared with 1.5% of the uninfected group, Clarissa Jonas Diamantidis, MD, MHS, of Duke University School of Medicine in Durham, North Carolina, and colleagues reported in Kidney Medicine . (renalandurologynews.com)
Biomarker3
- Through these analyses, the researchers found that when kidney function decreases, TFF3 is the one biomarker that is directly affected, i.e. its levels increase in response. (todayspractitioner.com)
- A biomarker (biologic marker) is a measurable indicator of a specific biological state, particularly one relevant to the risk for, presence of, or stage of a disease. (medscape.com)
- Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. (mdpi.com)
Declining kidney function1
- To develop this test, Paré's team first analyzed data from more than 130,000 participants in various chronic kidney disease studies to identify genetic variants that are linked with declining kidney function. (todayspractitioner.com)
Renal function1
- Since most ingested K is excreted through the kidneys, decreased renal function is a major factor in increased serum levels, and target values for its intake according to the degree of renal dysfunction have been established. (mdpi.com)
Fibrosis1
- In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)
Cardiovascular Diseases1
- [ 5 , 7 ] Although the underlying mechanisms are complex, the chronic inflammatory state and microbial burden in people with periodontal disease may predispose them to cardiovascular diseases in ways proposed for other infections. (medscape.com)
Complications2
- AKI is most commonly seen in hospitalized patients whose kidneys are affected by medical and surgical stress and complications, potentially resulting in a longer recovery process and prolonged harm to the kidneys. (medicalxpress.com)
- DM may cause several complications if not controlled properly, including cardiac disease, stroke, retinopathy that may progress to blindness, kidney failure, and limb amputations resulting from progression of diabetic foot problems. (who.int)
ESKD3
- Total costs were higher both for unrecognized patients with ESKD and unrecognized patients with late-stage disease. (ajmc.com)
- More than 37 million US adults have chronic kidney disease (CKD), and approximately 800,000 live with end-stage kidney disease (ESKD). (ajmc.com)
- Using a large, deidentified commercial and Medicare claims database, we calculated health care costs for patients with unrecognized progression to late-stage CKD or ESKD immediately before and after late-stage diagnosis and compared them with costs for individuals with late-stage CKD or ESKD who had prior CKD recognition. (ajmc.com)
Decline8
- Conclusions: Self-reported heart failure was an independent risk factor for the development of the endpoint of ESRD or 50% decline in GFR in a cohort of patients with chronic kidney disease. (johnshopkins.edu)
- Factors associated with increased odds of rapid kidney function decline during the pandemic included Asian race, higher Charlson comorbidity index, advancing CKD stage, prepandemic rapid kidney function decline, and COVID-19 infection. (renalandurologynews.com)
- Rapid kidney function decline often follows COVID-19 infection, including in patients with moderate to severe chronic kidney disease (CKD), a new study finds. (renalandurologynews.com)
- The COVID-19 group had significant 1.6-fold increased odds of rapid kidney function decline. (renalandurologynews.com)
- Noninfection-related experiences of the pandemic may have indirectly contributed to rapid kidney function decline, the investigators suggested. (renalandurologynews.com)
- Rapid progressors prior to the pandemic had 3-fold increased odds of rapid kidney function decline during the pandemic. (renalandurologynews.com)
- Dr Diamantidis' team further found that Asian patients had 4.2-fold increased odds of rapid kidney function decline during the pandemic compared with White patients. (renalandurologynews.com)
- Only a drop in TB progression rates could likely account for this decline because, as for much of Europe, the early postwar period was a time of scarcity and housing shortages, which rules out decreases in crowding and transmission as plausible explanations. (cdc.gov)
Biopsies1
- The extent of tubulointerstitial damage observed in kidney biopsies directly impacts the speed of kidney failure progression. (doctorworld.net)
Risk of kidney disease3
- Parikh says these findings suggest that sustained tissue injury and inflammation, as well as slower restoration of tubular health, are associated with higher risk of kidney disease progression. (medicalxpress.com)
- Numerous epidemiologic studies have shown an association between hyperuricemia and the risk of kidney disease. (ajkdblog.org)
- Visiting physicians for CKD treatment during the first 6 months after screening may be associated with a lower risk of kidney disease progression. (nih.gov)
Populations3
- Future research should be directed toward better elucidating the biological role of TFF3 and trefoil family proteins in the kidneys and further evaluating the clinical utility of TFF3 as an early diagnostic tool for chronic kidney disease in broader populations. (todayspractitioner.com)
- This "young women, older men" pattern is found in most populations in which TB is endemic and appears to be caused by age- and sex-specific differences in risk of disease progression, because these differences are not found in TB infection prevalence ( 7 ). (cdc.gov)
- The demand for medical products of human origin is growing with the emergence of new therapeutic applications, improved access to health care in some regions, and changing demographics of potential donor and recipient populations, such as ageing and increased burdens of chronic diseases. (who.int)
Prevalence1
- The prevalence and 15-year cumulative incidence and progression of AMD were similar in men and women and increased with age. (medscape.com)
Lesions1
- Neonates with low birth weight (less than 2500g), premature birth, or exposure to nephrotoxic drugs during maternal pregnancy may exhibit heightened susceptibility to kidney lesions. (doctorworld.net)
Incidence3
- AKI incidence in the hospital continues to rise, so we set out to understand how and why AKI progresses to CKD, and if monitoring these patients over time can give us clues to kidney disease progression. (medicalxpress.com)
- February 27, 2009 - Serum cystatin C level and chronic kidney disease may have a link to incidence of age-related macular degeneration (AMD) that is independent of smoking and other risk factors, according to a population-based cohort study reported in the February issue of the Archives of Ophthalmology . (medscape.com)
- The goal of this study was to examine the associations of the serum cystatin C level and chronic kidney disease with the incidence and progression of AMD during 15 years of follow-up in 4926 participants of the Beaver Dam Eye Study. (medscape.com)
Tubular1
- Uromodulin is specifically synthesized and secreted by kidney tubular epithelial cells. (biomedcentral.com)
Parikh1
- and accurate dosing of all medications with reduced kidney function ," says Parikh. (medicalxpress.com)
Transplants1
- For blood-related kidney transplants, the 5-year survival rate is 95-98%, 10-year survival is 75-85%, and 20-year survival is 50%, on average. (doctorworld.net)
Clinical5
- Despite the shared genetic cause, these three diseases differ in clinical diagnosis, treatment, and prognosis. (alportsyndromenews.com)
- Based on the clinical similarities of TBMN and ADAS, the researchers believe that "TBMN and ADAS may be different phases of collagen type IV kidney disease. (alportsyndromenews.com)
- This novel method, published in AACC's Clinical Chemistry journal, could improve quality of life for diabetic patients by potentially catching chronic kidney disease in time to stop its progression to full-blown kidney failure. (todayspractitioner.com)
- Every physician caring for patients with chronic kidney failure must determine the various factors or clinical states that may have aggravated or exacerbated the degree of kidney failure. (medscape.com)
- In diabetic and hypertensive patients, microalbuminuria is a predictor of future development of clinical renal disease. (medscape.com)
Severity of the disease2
- Consequently, the treatment approaches for CKD are tailored to the severity of the disease. (doctorworld.net)
- The host response to this infection is an important factor in determining the extent and severity of the disease. (medscape.com)
Adults1
- Separate research by Ashish Verma, MBBS, of Evans Biomedical Research Center in Boston, Massachusetts, published in Kidney Medicine , documents greater proportions of kidney-disease related deaths overall among Asian (and Black) adults compared with White adults in the United States. (renalandurologynews.com)
Rapid kidney1
- Men are more prone to rapid kidney disease development than women. (doctorworld.net)
Susceptibility1
- Low socioeconomic status is a risk factor for both lead exposure and diseases that increase susceptibility. (cdc.gov)
Uric8
- New data over the last decade have forced us to relook at the possibility of a causal relationship between high uric acid levels and chronic kidney disease (CKD). (ajkdblog.org)
- A steady stream of epidemiologic data has shown that elevated serum uric acid level is an independent risk factor for incident kidney disease in the general population (see here as well). (ajkdblog.org)
- Could this be compelling evidence for uric acid lowering therapy to be considered a standard intervention for slowing CKD progression? (ajkdblog.org)
- Currently, there are some small published studies showing that lowering uric acid prevents progression of CKD. (ajkdblog.org)
- This is a difficult question to answer, since epidemiologic studies show associations with different cutoffs of uric acid and renal disease progression. (ajkdblog.org)
- Does uric acid-lowering treatment slow the progression of chronic kidney disease? (revistanefrologia.com)
- However, the effect of uric acid-lowering therapies on delaying CKD progression is still uncertain. (revistanefrologia.com)
- Subgroup analyses showed that the difference in follow-up time and CKD population type in the studies may explain the controversy about the role of uric acid-lowering therapies in CKD progression. (revistanefrologia.com)
Epidemiologic1
- Although this finding is not universal, we think there is sufficient epidemiologic data to try to establish a causal relationship between hyperuricemia and progression of kidney disease. (ajkdblog.org)
Infection5
- For three-quarters of patients with CKD, kidney function worsened during the pandemic regardless of infection. (renalandurologynews.com)
- Infection with HIV is the strongest known risk factor for disease progression to TB. (cdc.gov)
- In the absence of HIV infection, disease develops in 5% to 15% of infected persons. (cdc.gov)
- We hypothesize that, in addition to HIV, another sexually transmitted infection (STI) also increases such disease progression. (cdc.gov)
- Membranous nephropathy is rare in children and, when it occurs, is usually due to hepatitis B virus infection, SLE, or autoimmune thyroid disease. (msdmanuals.com)
Systemic4
- Research on the relationship between oral health and systemic diseases gained rapid acceleration after the death of President Theodore Roosevelt in 1919 from odontogenic sepsis. (medscape.com)
- When a local or systemic disease process or concomitant use of medications alters this overall pattern, atypical organisms begin to predominate and some normal organisms with a benign nature may become pathogenic. (medscape.com)
- Increasing evidence indicates that oral microbiota participate in various systemic diseases. (medscape.com)
- Flowchart showing the possible mechanisms linking oral/dental infections to systemic diseases. (medscape.com)
Decreases1
- In individuals without kidney disease, the GFR typically decreases by an average of 1 ml/min/1.73 m^2 per year after the age of 30. (doctorworld.net)
Glomerulosclerosis1
Tubulointerstitial1
- these cannot fully reflect the tubulointerstitial function or the heterogeneity of CKD progression. (biomedcentral.com)
Slow2
- These remedies at best only slow, but not completely halt, CKD progression, and they are often ineffective and possess adverse side effects. (frontiersin.org)
- Efforts to prevent and/or slow progression of CKD are essential. (cdc.gov)
Function7
- However, when CKD reaches stage 5 (end-stage CKD), kidney function becomes severely impaired, necessitating renal replacement therapy to sustain life. (doctorworld.net)
- More than 35% of diabetic patients aged 20 years or older have chronic kidney disease, a condition in which the patient gradually loses kidney function. (todayspractitioner.com)
- Serum creatinine may not become elevated before substantial kidney function has been lost due to renal reserve. (medscape.com)
- Serum creatinine measurement is not reliably indicative of underlying pathophysiology (ie, it does not allow differentiation of hemodynamically mediated changes in kidney function, such as prerenal azotemia from intrinsic renal failure or obstructive uropathy from structural kidney damage). (medscape.com)
- Once these factors are corrected or reversed, the severity of kidney failure may improve, and kidney function may return to stable basal level of function. (medscape.com)
- Genome-wide association analysis of cystatin-C kidney function in continental Africa. (cdc.gov)
- Kidney function, albuminuria, and their modification by genetic factors and risk of incident dementia in UK Biobank. (cdc.gov)
Incident1
- We demonstrated TFF3 concentration is a significant independent predictor of incident chronic kidney disease in a dysglycemic population," said Paré. (todayspractitioner.com)