• biomarkers
  • The combinatorial use of biomarkers derived from biological fluids, such as cerebrospinal fluid (CSF), with advanced molecular imaging and neuropsychological testing may eventually achieve the diagnostic sensitivity and specificity necessary to identify people in the earliest stages of the disease when drug modification is most likely possible. (springer.com)
  • In this regard, positive amyloid or tau tracer retention on positron emission tomography imaging, low CSF concentrations of the amyloid-β 1-42 peptide, high CSF concentrations in total tau and phospho-tau, mesial temporal lobe atrophy on magnetic resonance imaging, and temporoparietal/precuneus hypometabolism or hypoperfusion on 18F-fluorodeoxyglucose positron emission tomography have all emerged as biomarkers for the progression to AD. (springer.com)
  • Moreover, biomarkers for AD progression may also have clinical utility for tracking the efficacy of potential disease-modifying therapies. (springer.com)
  • Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life. (fredhutch.org)
  • Indeed, epidemiological studies found that inflammation biomarkers may help to predict the development and progression of these illnesses. (scireslit.com)
  • Exosomes can potentially be used for prognosis, for therapy, and as biomarkers for health and disease. (wikipedia.org)
  • biomarker
  • Indeed, advances in biomarker discovery and a greater appreciation of tubulointerstitial histopathology and the role of tubular hypoxia in the pathogenesis of chronic kidney disease have given us pause to reconsider the current "glomerulocentric" paradigm and focus attention on the proximal tubule that by virtue of the high energy requirements and reliance on aerobic metabolism render it particularly susceptible to the derangements of the diabetic state. (diabetesjournals.org)
  • Of course, an ideal biomarker should be more than a surrogate marker, and should provide us with new information about how the brain functions in disease. (pubmedcentralcanada.ca)
  • chronic
  • His academic interests are in clinical renal pathology and research of mechanisms of kidney injury repair and progression of chronic kidney disease. (yale.edu)
  • In addition, histological studies of chronic renal diseases confirmed that renal function correlates better with tubular and interstitial changes than with glomerular changes ( 2 , 19 , 20 ). (diabetesjournals.org)
  • NYHA) Grade II or greater congestive heart failure (see Appendix C), unstable symptomatic arrhythmia requiring medication (subjects with chronic atrial arrhythmia, i. e. atrial fibrillation or paroxysmal supraventricular tachycardia are eligible), or peripheral vascular disease (Grade II or greater). (knowcancer.com)
  • Primary sclerosing cholangitis is a serious chronic inflammatory disease of the bile duct, which is believed to be autoimmune in origin. (wikipedia.org)
  • These include: The distinction between CRS type 2 and CRS type 4 is based on the assumption that, also in advanced and chronic disease, two different pathophysiological mechanisms can be distinguished, whereas both CKD and HF often develop due to a common pathophysiological background, most notably hypertension and diabetes mellitus. (wikipedia.org)
  • patients
  • These findings are, however, juxtaposed with the more recent knowledge that some patients with advanced disease display neither substantial glomerular pathology nor proteinuria and that kidney function declines well before traditional indicators of kidney disease such as microalbuminuria or creatinine-based estimated glomerular filtration rate (eGFR) decline ( 2 ). (diabetesjournals.org)
  • The disease control rate will be calculated as the total number of patients in each group with best overall response of CR, PR or Stable Disease (SD) divided by the total number of randomized patients in the group and will be compared similarly as Objective Response Rate (ORR. (clinicaltrials.gov)
  • Patients may receive up to a maximum total of 8 cycles (16 doses), but patients with a partial response or stable disease at that time, or patients who had achieved an objective response but relapsed after discontinuing treatment, may continue to be treated based on physician discretion. (careacross.com)
  • These studies have spurred a growing interest in understanding the troubles of SC in neurodegenerative diseases, as well as the development of psycho-therapeutic approaches that may be able to improve the management of behavioural symptoms of patients and their quality of life. (scireslit.com)
  • Conference Awards, which fund meetings that bring together researchers, patients, and caregivers to address a specific topic of inquiry relating to Parkinson's disease research. (wikipedia.org)
  • Abnormalities of diastolic function, ranging from asymptomatic heart disease to overt heart failure, are common in hypertensive patients. (wikipedia.org)
  • Biogen, Inc. (previously known as Biogen Idec) is an American multinational biotechnology company based in Cambridge, Massachusetts, specializing in the discovery, development, and delivery of therapies for the treatment of neurodegenerative, hematologic, and autoimmune diseases to patients worldwide. (wikipedia.org)
  • disorders
  • There has been an increasing interest in the role of inflammation as a common mechanism of disease in a several medical disorders including cardiovascular and neurodegenerative diseases, diabetes and cancer [1- (scireslit.com)
  • Changes in the ratio of kynurenine versus tryptophan are reported for many diseases like e.g. arthritis, HIV/AIDS, neuropsychiatric disorders, cancer and inflammations. (wikipedia.org)
  • Analogous terms such as "drug-induced" or "toxic" liver disease are also used to refer to disorders caused by various drugs. (wikipedia.org)
  • Harry Ostrer is a medical geneticist who investigates the genetic basis of common and rare disorders and, in the diagnostic laboratory, translates the findings of genetic discoveries into tests that can be used to identify people's risks for having a disease prior to its occurrence or for predicting its outcome once it has occurred. (wikipedia.org)
  • In a 2001 article in Nature Reviews Genetics, he noted the curious over-representation of lysosomal storage diseases, disorders of DNA repair, clotting disorders, and metabolic disorders, suggesting a possible commonality for selection of heterozygotes for each of these classes of disorders. (wikipedia.org)
  • duration
  • The Duration of Disease Control is defined as the time from randomization to the date of the first documented disease progression (taking as reference for progressive disease the smallest measurements recorded on study) or death, whichever occurs first. (clinicaltrials.gov)
  • However, these studies are not easy to compare given the different target populations (early or advanced disease, medication effects), testing paradigms used (gap or overlap of stimuli, 'reflexive' or 'voluntary' task) and parameters of the saccade measured (velocity, amplitude, duration, errors). (pubmedcentralcanada.ca)
  • pathway
  • Scientists are investigating the role of dysregulation of this pathway in aging and neurodegenerative diseases. (wikipedia.org)
  • Role of mitogen signaling in cell cycle progression The ERK pathway plays an important role of integrating external signals from the presence of mitogens such as epidermal growth factor (EGF) into signaling events promoting cell growth and proliferation in many mammalian cell types. (wikipedia.org)
  • renal
  • While clearly of great importance, changes in the glomerulus are not the major determinant of renal prognosis in diabetes and may not be the primary event in the development of diabetic kidney disease either. (diabetesjournals.org)
  • It is an independent predisposing factor for heart failure, coronary artery disease, stroke, renal disease, and peripheral arterial disease. (wikipedia.org)
  • diabetes
  • From a pathogenetic perspective, as illustrated in Fig. 1 and as elaborated on further in this review, tubular hypoxia as a consequence of increased energy demands and reduced perfusion combine with nonhypoxia-related forces to drive the development of tubular atrophy and interstitial fibrosis in a vicious cycle that promotes disease progression in diabetes. (diabetesjournals.org)
  • Unlike most other genetic models of type 2 diabetes, diabetes in GK rats is polygenic in origin and in this respect they are a good surrogate for the human disease. (pubmedcentralcanada.ca)
  • antioxidants
  • People with this syndrome show naturally elevated levels of bilirubin in the blood and also higher concentrations of antioxidants, which can protect against disease. (medicalsearch.com.au)
  • Analysis of blood revealed that those study participants with Gilbert Syndrome had less free radical damage and consistently showed higher levels of antioxidants in their blood,' said Dr Bulmer. (medicalsearch.com.au)
  • The study was designed to investigate the natural history and risk factors of age-related macular degeneration (AMD) and cataracts, and evaluate the effects of high doses of antioxidants and zinc on the progression of the two conditions in those with AMD The study followed 3640 individuals for an average of 6.3 years between 1992 and 2001. (wikipedia.org)
  • time
  • Additionally, PDF's director of research programs identifies lack of trial participants as one of the chief obstacles to advancing Parkinson's disease clinical research (along with time and cost), with the PAIR program serving as PDF's main initiative to address this challenge. (wikipedia.org)
  • In HIV research, this method was shown to enhance the specific humoral immune response and at the same time avoid an excess activation of the cellular immune response which could otherwise even thrive disease progression. (wikipedia.org)
  • cancer
  • The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off. (fredhutch.org)
  • The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. (fredhutch.org)
  • H4K20me3 is observed to be concentrated in heterochromatin and reductions in this trimethylation are observed in cancer progression. (wikipedia.org)
  • They have also studied the role of copy number alterations in cancer progression to metastasis. (wikipedia.org)
  • viral
  • Since it has already failed in human clinical trials previously, it is unlikely MK-608 itself will be developed as an antiviral medication, but the continuing lack of treatment options for these emerging viral diseases means that much research continues using MK-608 and related antiviral drugs. (wikipedia.org)
  • PMID 27234417 doi:10.1093/infdis/jiw226 Zmurko J, Marques RE, Schols D, Verbeken E, Kaptein SJ, Neyts J. The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model. (wikipedia.org)
  • treatment
  • For example, the U.S. Food and Drug Administration (FDA) conducts public meetings to better understand the patient perspective for diseases like PD and assess research and treatment gaps. (wikipedia.org)
  • This index was also designed to screen large populations to determine treatment needs and formulate preventive strategies, not to describe the prevalence and severity of periodontal diseases. (wikipedia.org)
  • therapies
  • Successful patient engagement improves not only an individual's health outcomes, but also that of the Parkinson's disease community as a whole through improved care and accelerated therapies. (wikipedia.org)
  • liver
  • There are more than a hundred different kinds of liver disease. (wikipedia.org)
  • Hereditary diseases that cause damage to the liver include hemochromatosis, involving accumulation of iron in the body, and Wilson's disease. (wikipedia.org)
  • Liver damage is also a clinical feature of alpha 1-antitrypsin deficiency and glycogen storage disease type II. (wikipedia.org)
  • One general mechanism, increased DNA damage, is shared by some of the major causes of liver disease. (wikipedia.org)
  • Epigenetic alterations and mutations affect the cellular machinery that may cause the cell to replicate at a higher rate and/or result in the cell avoiding apoptosis, and thus contribute to liver disease. (wikipedia.org)
  • response
  • An example of this program is a recent award granted to a student researcher who was part of a team at Georgetown University who found how α-synuclein, a protein that accumulates in Parkinson's disease, activates the brain's immune response. (wikipedia.org)
  • lesion
  • The clinical spectrum is very broad, ranging from an isolated, asymptomatic monostotic lesion discovered incidentally, to severe disabling disease involving practically the entire skeleton and leading to loss of vision, hearing, and/or mobility. (wikipedia.org)
  • consequence
  • Hypertension-related cognitive impairment and dementia may be a consequence of a single infarct due to occlusion of a "strategic" larger vessel or multiple lacunar infarcts due to occlusive small vessel disease resulting in subcortical white matter ischemia. (wikipedia.org)
  • effects
  • If progression occurred during therapy, patient must have recovered from any side effects before starting GCP therapy. (mdanderson.org)
  • These Fc-dependent effects seem to play an important role in disease control as shown by the non-human primate (NHP) experiment. (wikipedia.org)
  • Epidemiology of periodontal disease is the study of patterns, causes, and effects of periodontal diseases. (wikipedia.org)
  • bone
  • Disease can affect one bone (monostotic) or multiple (polyostotic), and may occur in isolation or in combination with cafe-au-lait skin macules and hyperfunctioning endocrinopathies, termed McCune-Albright syndrome. (wikipedia.org)
  • clinical research
  • The goal of this clinical research study is to learn if clofarabine when given in combination with cytarabine can help to control myelodysplastic syndrome (MDS) after the disease could not be controlled with standard therapy. (mdanderson.org)
  • The goal of the program to add a patient perspective to the field of Parkinson's disease clinical research, and ultimately improve outcomes by focusing on issues that researchers may overlook. (wikipedia.org)
  • Specifically, the advocates in the program serve as patient representatives on boards that review Parkinson's clinical research trials, shape clinical research trials by providing sponsors and investigators with input on how the trials are designed and implemented, educate the community on the importance of clinical research and encourage participation, and serve as spokespeople for the Parkinson's disease community in local and national media. (wikipedia.org)
  • In addition to clinical research, PAIR advocates may participate in scientific meetings and conference focused on a specific aspect of Parkinson's disease, in order to provide a patient perspective. (wikipedia.org)
  • severity
  • The long-term goal of the Boeckh Research Program is to prevent infectious disease in immunocompromised hosts and reduce the severity of infections that do occur. (fredhutch.org)
  • A full-mouth examination remains the best method of accurately assessing the prevalence and severity of periodontal disease in a population. (wikipedia.org)
  • participants
  • Published in the leading journal Free Radical Biology and Medicine , the scientific report details how Dr Bulmer and his team conducted a study with 44 participants, half of whom had Gilbert Syndrome. (medicalsearch.com.au)
  • role
  • The role of self-consciousness (SC) in behavioural troubles of brain diseases is an emerging neuroscience topic, supported by evidence from studies in the last decade of years. (scireslit.com)
  • thus
  • The incidence of PD ranges from 8 to 18 per 100,000 person-years [ 1 ], and thus identifying effective drugs that can slow the progression of PD is critical. (springer.com)
  • The less frequent the disease, the more difficult it becomes for a partial recording system to detect it and thus may lead to greater underestimation of the disease prevalence. (wikipedia.org)
  • development
  • The supplements had no significant effect on the development or progression of cataracts. (wikipedia.org)
  • PDF's specific funding strategies include: Fellowship and Career Development Grants encourage scientists to pursue research focused on Parkinson's Disease, which they may not have done without support from PDF. (wikipedia.org)
  • research
  • PAIR representatives also help advance research by advocating on behalf of the Parkinson's disease community at the federal level. (wikipedia.org)
  • Since its founding in 1957, PDF has funded more than $115 million worth of scientific research in Parkinson's disease. (wikipedia.org)
  • The Stanley Fahn Junior Faculty Award, through which PDF aims to ensure that young scientists who begin to pursue Parkinson's disease research stay in the field and avoid the funding "valley of death" that can occur during the transition from mentored to independent research. (wikipedia.org)
  • A third recipient, from the University of Washington, is studying genetic risk factors for Parkinson's in Latino populations and will expand upon genetics research that has already provided many important clues about the disease. (wikipedia.org)
  • International Research Grants, which provide researchers with creative ideas funding for their Parkinson's disease studies. (wikipedia.org)
  • mutations
  • Fibrous dysplasia is a mosaic disease resulting from post-zygotic activating mutations of the GNAS locus at 20q13.2-q13.3, which codes for the α subunit of the Gs G-coupled protein receptor. (wikipedia.org)