Checkpoint Kinase 2Protein-Serine-Threonine KinasesProtein KinasesCell Cycle ProteinsDNA DamageDisease ProgressionAtaxia Telangiectasia Mutated ProteinsCell CycleG2 PhaseGenes, cdcMitosisM Phase Cell Cycle CheckpointsPhosphorylationS PhaseCell Cycle CheckpointsProtein Kinase InhibitorsPhosphatidylinositol 3-KinasesMutationcdc25 PhosphatasesDNA ReplicationHydroxyureaMAP Kinase Signaling SystemCDC2 Protein KinaseSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsSpindle ApparatusCell Line, TumorNuclear ProteinsSchizosaccharomyces pombe ProteinsG2 Phase Cell Cycle CheckpointsTumor Suppressor ProteinsSchizosaccharomycesSignal TransductionIntracellular Signaling Peptides and ProteinsS Phase Cell Cycle CheckpointsDNA RepairKinetochoresTumor Suppressor Protein p53Saccharomyces cerevisiaeApoptosisRNA, Small InterferingCalcium-Calmodulin-Dependent Protein KinasesHeLa CellsCyclin-Dependent KinasesProtein-Tyrosine KinasesProtein BindingModels, BiologicalBlotting, Westernsrc-Family KinasesEnzyme ActivationMolecular Sequence DataG1 PhaseCell DivisionRadiation, IonizingNocodazoleCell LineRNA InterferenceNeoplasmsAntineoplastic AgentsCell SurvivalCdc20 ProteinsAurora Kinasesp38 Mitogen-Activated Protein KinasesCell ProliferationProtein Kinase CGenomic InstabilityBreast NeoplasmsAmino Acid SequenceMethyl MethanesulfonateDNA Breaks, Double-StrandedTransfectionHistonesCyclin BUltraviolet RaysMitogen-Activated Protein Kinase 1RNA, MessengerCyclic AMP-Dependent Protein KinasesFungal ProteinsChromosome SegregationEarly Detection of CancerProstatic NeoplasmsGene Expression Regulation, NeoplasticProtein Structure, TertiaryTumor Cells, CulturedDNA, FungalTime FactorsMitogen-Activated Protein Kinase KinasesBase SequenceCell NucleusColonic NeoplasmsJNK Mitogen-Activated Protein KinasesDown-RegulationMitogen-Activated Protein Kinase 3p21-Activated KinasesProto-Oncogene ProteinsEnzyme InhibitorsGamma RaysLung NeoplasmsHCT116 CellsImmunoblotting