RegulatesAutophagyPhosphorylationInduce apoptosisExtracellularMutationsRegulationKinasesEmbryonicDifferentiationDisease progressionPathwaysPancreaticOxidative stressCellularMechanismRegulateTumorsTransductionMechanismsTurnoverNucleic AcidsEndoplasmic reticulumMitochondriaArrestInflammationCaspaseInteractionsCytoplasmProcessesEncodesDevelopment and progressionInvasionOverexpressionSurvivalExpressionMolecularInhibitionActivationMorphologicalLigandSuppressNuclearInhibitorCancerMembraneLymphomaOnsetCatalyticCellsTranscription factorChromosomeCyclinChromatinMediatesScaffoldOccursDefects
Regulates8
- Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression. (nih.gov)
- MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability. (nih.gov)
- 2. We recently identified a novel PDX1 stress inducible complex (es) positioned over CARE sites and involving ATF4 and ATF5 that regulates expression of stress and apoptosis genes to govern β cell survival. (upenn.edu)
- Our current efforts on this project are directed at (1) determining the mechanisms whereby Pdx1 and Oc1 cooperate to establish a chromatin landscape permissive for endocrine differentiation and proliferation, (2) Defining the roles of the Pdx1 and Oc1 IDPRs in protein-protein interaction and endocrine differentiation, and (3) Defining the molecular mechanisms by which the Pdx1 C-terminal domain regulates protein stability and function during pancreas organogenesis and endocrine differentiation. (upenn.edu)
- CyclinE is a cell cycle regulatory protein which regulates the G1-S phase transition during cell proliferation. (biomedcentral.com)
- Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. (nih.gov)
- It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. (nih.gov)
- CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis. (nih.gov)
Autophagy5
- These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)
- In animals, morphological distinctions have since been used to distinguish different types of cell deaths, including apoptosis, necrosis and autophagy. (essaywriter.org)
- Primarily, the aim of anti-cell death in animals is to describe the processes of autophagy and apoptosis, while necrosis is the mechanism for defining the uncontrollable or chaotic mode of death. (essaywriter.org)
- Majority of the literature and experiments in the field of programmed cell death in plants draw heavily on comparative analysis retrieved from paradigms of animal systems such as apoptosis, necrosis and autophagy. (essaywriter.org)
- RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
Phosphorylation4
- Each stage of the cell cycle is profiled by distinct protein complexes and phosphorylation events. (janechin.net)
- Compound 51 inhibited the proliferation of 13 out of 15 cancer cell lines with IC50 values between 0.27 and 6.9 μM, which correlated with the complete suppression of retinoblastoma phosphorylation and the onset of apoptosis. (rcsb.org)
- Low PDCD4 level was associated with reduced proliferation but not apoptosis or phosphorylation of endothelial nitric oxide synthase caused by pulsatile shear stress to help maintain the homeostasis of endothelial cells. (plos.org)
- A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. (lookformedical.com)
Induce apoptosis2
- Stable monoubiquitinated form of wild type p53, accumulates in the cytoplasm and interacts with BAK or BAX proteins in mitochondria to induce apoptosis Thus Kevetrin activates both transcription dependent and transcription independent pathways to promote apoptosis. (shu.edu)
- Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. (nih.gov)
Extracellular7
- Selective compounds have been developed that target either the extracellular ligand-binding region of the EGFR (including a number of monoclonal antibodies [MAbs], immunotoxins, and ligand-binding cytotoxic agents) or the intracellular tyrosine kinase region (including various small-molecule inhibitors). (medscape.com)
- sfRON lacks almost all of the extracellular domain and is incapable of ligand binding. (spandidos-publications.com)
- AQP4 operates in complex with the potassium channel Kir4.1, and their cell surface expression is mediated through the dystrophin-associated protein complex (DAPC) and the extracellular matrix. (dcu.ie)
- Moreover, a number of extracellular proteins can bind to their receptors and activate signaling pathways that promote the proliferation of cancer cells. (biomedcentral.com)
- Integration of intracellular metabolic states with extracellular signals leads to proliferation, differentiation, apoptosis, or quiescence. (janechin.net)
- These factors couple extracellular signals to intracellular processes to determine cell cycle progression. (janechin.net)
- In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
Mutations9
- Through her work with two genera of retroviruses, Quackenbush determined mutations to Gammaretrovirus (feline leukemia virus) makes them less lethal, and Epsilretrovirus (walleye dermal sarcoma virus) contains sequences that encode for cyclin proteins, leading to the proliferation of normal cells and eventually giving a means for cancer cells to become abundant Her most notable work focuses on feline leukemia virus. (wikipedia.org)
- As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
- Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
- The basic unit of the p53 protein consists of three major functional domains such as an N-terminal transactivation domain (TAD), a core DNA-binding domain (DBD)-the main target for mutations, and a C-terminal regulatory domain (CTD) ( Figure 1 A) [ 2 ] . (encyclopedia.pub)
- Moreover, the models also predict that mutations of RAS, ARF and P21 in the context of HMGB1 signaling can influence the cancer cell's fate - apoptosis or survival - through the crosstalk of different pathways. (biomedcentral.com)
- In this paper, we ask the following questions: How do these proteins and their mutations change the cell's fate - apoptosis or survival - when HMGB1 signal transduction is activated? (biomedcentral.com)
- These mutations are typically seen in the DNA binding domain, which affects transcriptional activity and its overall cellular activities. (shu.edu)
- Familial AD (FAD) cases are caused by autosomal dominant mutations in the genes for amyloid precursor protein (APP) and the presenilins (PS1 and PS2) ( Sisodia and St George-Hyslop, 2002 ). (jneurosci.org)
Regulation10
- Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
- Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)
- Also, a KCNN4 and S100A14-centered protein interaction subnetwork was built from the STRING database, and the shortest regulation path between them, called the KCNN4-UBA52-KLF4-S100A14 axis, was identified. (oncotarget.com)
- These interacting partners play important roles in various biological processes such as transcriptional regulation, vesicular transport and apoptosis as well as in signaling pathways such as MAPK, mTOR signaling and NOD-like receptor signaling 22 , 23 . (nature.com)
- The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1. (thermofisher.com)
- If some important proteins are mutated or there are defects in the signaling mechanisms, normal cell growth regulation will break down, possibly leading to the occurrence of cancer in the future. (biomedcentral.com)
- Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. (nih.gov)
- Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
- Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
- Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. (springer.com)
Kinases5
- Her lab is trying to determine the mode by which transcription, apoptosis, and transduction are controlled by viral regulatory proteins such as kinases. (wikipedia.org)
- The retroviral cyclin of walleye dermal sarcoma virus binds cylin-dependent kinases 3 and 8. (wikipedia.org)
- HMGB1 can activate a series of signaling components, including mitogen-activated protein kinases (MAPKs) and AKT, which play an important role in tumor growth and inflammation, through binding to different surface receptors, such as RAGE and TLR2/4. (biomedcentral.com)
- Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (rcsb.org)
- Using affinity purification-mass spectrometry and global phosphoproteomic and protein abundance analyses using three IAV strains (pH1N1, H3N2, H5N1) in three human cell types (A549, NHBE, THP-1), we map 332 IAV-human protein-protein interactions and identify 13 IAV-modulated kinases. (cdc.gov)
Embryonic3
- Comparative biochemical studies of rapamycin and wortmannin on transforming growth factor-beta 1 (TGF-beta1)-mediated G(1)-S cell cycle progression in C3H-10T1/2 embryonic fibroblasts. (janechin.net)
- Expression of these proteins is spatially and temporally regulated during embryonic development. (nih.gov)
- Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)
Differentiation5
- The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
- 3. We hypothesize that PDX1-Onecut1 (OC1) interactions, in part mediated by their intrinsically disordered protein regions (IDPRs), regulate Pdx1 stability, cell cycle progression, and pancreatic endocrine differentiation during development. (upenn.edu)
- Indeed, this process is controlled by the same oncoproteins and tumor suppressors that normally control cell cycle progression, cell differentiation, and cell proliferation. (oncotarget.com)
- This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. (nih.gov)
- For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. (nih.gov)
Disease progression2
- I have recently shown that synovial tissue poly-T-cells can predict RA-patient stratification, correlate with disease progression in RA and PsA and importantly, are present at the joints of at risk-individuals prior to development of clinical-inflammation. (dcu.ie)
- Assessment of serum IL-10 levels in HCV patients may provide a possible predictive marker for disease progression. (who.int)
Pathways7
- Reduced number and function of insulin-secreting beta cells underlies the progression of all forms of diabetes, underscoring the translational relevance of deciphering molecular pathways regulating the formation, growth, and function of beta cells. (upenn.edu)
- Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
- What pathways are this gene/protein implicaed in? (cancerindex.org)
- Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
- The cell cycle is strictly regulated and controlled by a complex network of signaling pathways [ 1 ], comprised of hundreds of proteins. (biomedcentral.com)
- The HMGB1 signal transduction can influence the cell's fate by two important processes - apoptosis and cell proliferation - which are regulated respectively by the proteins p53 and CyclinE, acting in two different signaling pathways. (biomedcentral.com)
- Which signaling pathways are fundamental for describing HMGB1 signal transduction, and what mechanisms are responsible to explain recent results linking overexpression of HMGB1 with decrease of apoptosis (and increased cancer cell survival)? (biomedcentral.com)
Pancreatic2
- 1. The Stoffers laboratory recently identified the polyC binding protein (PCBP) family of RBPs as important players in the post-transcriptional regulatory landscape of pancreatic beta cells. (upenn.edu)
- Recent studies have found that overexpression of the High-mobility group box-1 (HMGB1) protein, in conjunction with its receptors for advanced glycation end products (RAGEs) and toll-like receptors (TLRs), is associated with proliferation of various cancer types, including that of the breast and pancreatic. (biomedcentral.com)
Oxidative stress1
- GLT) and that depletion of JUND in β cells reduces oxidative stress and apoptosis caused by GLT. (upenn.edu)
Cellular5
- The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. (nih.gov)
- The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
- Human HTT codes for a large protein of 3144 amino acids, which is ubiquitously expressed in various tissues and is present in several sub-cellular locations. (nature.com)
- Taken together, these data indicate that the reduction of JHDM1B leads to a more aggressive cellular phenotype in mammary gland cells, by virtue of its negative regulatory activity on ribosome biogenesis. (oncotarget.com)
- Factors mandating cellular consequence include cell surface-receptors, cytoplasmic proteins, and nuclear proteins. (janechin.net)
Mechanism6
- Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
- Verification for this suggested mechanism was included with the breakthrough that overexpression of hPOT1 supplied level of resistance to these substances (58 59 61 Additionally hPOT1 appearance is altered in lots of tumors and tumor cell lines (65-67) and it is particularly upregulated in healing and radiation-resistant cell lines (68 69 recommending a job for hPOT1 in tumor progression. (academicediting.org)
- Mechanism of action studies showed that Kevetrin strongly induced apoptosis by activation of Caspase 3 and cleavage of PARP. (shu.edu)
- 2019 ). However, the reported lncRNAs in HPH are all focused on the cytoplasm of PASMCs, and the specific lncRNAs located in the nucleus, especially in PAECs involved in HPH progression and their related regulatory mechanism, remain largely unknown. (biomedcentral.com)
- Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
- For example, excessive inhibition by which tissue remodeling takes place during normal of apoptosis is an underlying mechanism of cancer, while growth and development and the physiologic mechanism an inappropriate increase is seen in some neurodegenera- by which labile cell populations such as gastrointestinal tive diseases and other conditions. (cdc.gov)
Regulate3
- As microRNAs regulate gene expression post-transcriptionally, the changed EV content in disease may cause changes in BBB-related proteins, affecting barrier strength. (dcu.ie)
- Our simulations show that, if HMGB1 is overexpressed, then the oncoproteins CyclinD/E, which regulate cell proliferation, are overexpressed, while tumor suppressor proteins that regulate cell apoptosis (programmed cell death), such as p53, are repressed. (biomedcentral.com)
- However, whether m6A modified transcripts of lncRNAs can regulate pyroptosis in HPH progression remains unexplored. (biomedcentral.com)
Tumors5
- Among immune cells, Foxp3 + regulatory T cells (Treg cells) are potent inhibitors of cancer immunity, and their presence within solid tumors is generally associated with a poor prognosis. (mdpi.com)
- During the progression of NSCLC, E2F1 overexpression could produce more aggressive tumors with a high proliferation rate and chemoresistance. (aacrjournals.org)
- The alterations of ribosome biogenesis and protein synthesis play a direct role in the development of tumors. (oncotarget.com)
- An obvious requirement for the stringent control of cell cycle progression is the prevention of deregulated proliferation - loss of control may result in tumors and cancers. (janechin.net)
- Although PDCD4 in general suppresses the development and progression of tumors, its specific biological functions differ by cell type [8] . (plos.org)
Transduction1
- Mathematical modeling of signal transduction networks has previously been used to map out thermodynamical using rate equations is increasingly attracting attention as a properties of protein-folding models (6,7). (lu.se)
Mechanisms4
- Protein and gene expression of apoptotic signaling pathway-related proteins such as caspase-3, cytochrome c, and PARP were determined to provide evidence for the mechanisms of action of Tan IIA in the treatment of psoriasis. (hindawi.com)
- Therefore, a better understanding of the molecular mechanisms underlying HCC growth and progression is necessary to develop more effective treatment strategies for HCC. (techscience.com)
- However, the underlying mechanisms by whichEIF5B promotes HCC progression are poorly understood. (techscience.com)
- Understanding the genetic mechanisms underlying the progression is critical, because it would provide a clue for early detection and chemoprevention strategies. (biomedcentral.com)
Turnover3
- 7]. Clonal Personal computers in MM make use of the ubiquitin-proteasome program to modify their higher rate of proteins turnover weighed against normal cells. (antiviralbiologic.com)
- Gain of function and loss of function experiments showed that PDCD4 induced turnover (proliferation and apoptosis) of HUVECs. (plos.org)
- PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
Nucleic Acids1
- Antibodies recognize specific configurations (epitopes, or antigenic determinants) on the surfaces of antigens (eg, proteins, polysaccharides, nucleic acids). (msdmanuals.com)
Endoplasmic reticulum2
- 7]. Inhibition of the ubiquitin-proteasome program leads to build up of ubiquitinated protein creating endoplasmic reticulum tension resulting in apoptosis and cell loss of life? (antiviralbiologic.com)
- They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)
Mitochondria1
- There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)
Arrest2
- Alteration of human being Container1 (hPOT1) function can result in G-strand overhang reduction chromosomal-end fusions chromosomal rearrangements and fast cell routine arrest ultimately resulting in senescence and apoptosis (7 9 11 Furthermore to offering a protective cover for the ssDNA overhang Container1 can be an important regulatory protein permitting controlled usage of the 3′ result in purchase to facilitate full chromosome replication (14-17). (academicediting.org)
- The protein p53 is one of the most important tumor suppressor proteins: its activation can lead to cell cycle arrest, DNA repair, or apoptosis. (biomedcentral.com)
Inflammation3
- Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
- These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
- Elevated C-reactive protein levels are a nonspecific indicator of infection or inflammation. (msdmanuals.com)
Caspase2
- Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. (hindawi.com)
- Analyzing the protein expression patterns of Fas, FADD, caspase 8, CDC25B, fascin, CK14, CK4, annexin I, laminin-5γ2 and SPARC would be valuable to develop rational strategies for early detection of lesions at risk in advance as well as for prevention and treatment of ESCC. (biomedcentral.com)
Interactions2
- The p53 protein, to exert its function, binds in a sequence-specific manner to the DNA-binding sites by forming a tetramer, via four self-assembling p53 molecules, which are stabilized by protein-protein and base-stacking interactions [ 3 ] . (encyclopedia.pub)
- The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. (nih.gov)
Cytoplasm1
Processes1
- The large number of genes and the diversity of processes involved in the progression of neurological diseases in general, and HD in specific, emphasizes the need for comprehensive approaches in additional to studies of individual genes 14 . (nature.com)
Encodes4
- This gene encodes a protein phosphatase 1 binding protein. (nih.gov)
- This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. (nih.gov)
- The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
- Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
Development and progression1
- The major risk factors associated with HCC development and progression include chronic hepatitis B or C virus infections, high alcohol consumption, and activation of oncogenes [ 2 ]. (techscience.com)
Invasion3
- RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)
- It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
- A multistage process has been proposed for the evolution of esophageal squamous cell carcinoma (ESCC), in which normal squamous epithelia undergo a series of histological and genetic progression towards noninvasive precursor lesions, i.e., dysplasia (DYS) and carcinoma in situ (CIS), then towards invasive cancer, and, finally towards deep invasion and metastasis to lymph nodes and other organs. (biomedcentral.com)
Overexpression1
- Due to caveats connected with RNAi/shRNA knockdown and overexpression tests the exact function from the DNA-binding activity of hPOT1 in telomere maintenance is not described (9 11 70 71 When the G-quadruplex marketing ligands work by displacing hPOT1 immediate inhibition of hPOT1 activity may end up being a far more effective technique to impede telomere security and provide essential understanding into hPOT1 function. (academicediting.org)
Survival3
- In the glioma cells, EIF5B promotes cell survival by enhancing the translation of several IRES-containing mRNAs including those encoding anti-apoptotic proteins such as XIAP and Bcl-xL [ 4 ]. (techscience.com)
- These data suggest that EIF5B functions as an oncogene that promotes cancer cell growth, survival, and progression. (techscience.com)
- CHICAGO and RARITAN, NJ, June 4, 2017 - Janssen Research & Development, LLC today announced new data from updated analyses of the pivotal Phase 3 CASTOR and POLLUX clinical studies, demonstrating that DARZALEX ® (daratumumab) in combination with bortezomib and dexamethasone, or lenalidomide and dexamethasone, improved progression-free survival (PFS) and the overall response rate (ORR) for previously-treated patients with multiple myeloma, regardless of cytogenetic risk. (jnj.com)
Expression13
- While, for PTEN protein expression, we used immunohistochemistry. (cancerindex.org)
- Results: We found that LOH and methylation of the PTEN promoter were significantly associated with loss of PTEN protein expression, while, PTEN mutation was a rare event. (cancerindex.org)
- Recent studies have indicated that altered RON expression contributes significantly to cancer progression and malignancy. (spandidos-publications.com)
- This revealed increased expression of B-cell lymphoma 2 associated X and reduced expression of B-cell lymphoma 2, indicating apoptosis induction by piperine. (ijpsonline.com)
- Finally, Western blotting assay predicted constant expression of phosphatidylinositol 3-kinase and protein kinase B and reduced expression of phosphorylated phosphatidylinositol 3-kinase. (ijpsonline.com)
- In order to identify genes that may modify disease onset and progression, genome-wide association and gene expression studies have been performed 12 , 13 . (nature.com)
- In this study, we are interested in investigating the expression of a variety of functional classes of proteins in ESCC and its precursor lesions and characterizing the correlation of these proteins with ESCC malignant progression. (biomedcentral.com)
- The method of tissue microarray (TMA), which could confirm the results of cDNA microarray on protein level, has been popularly used for gene expression profiling in many types of cancer including ESCC, but rarely in the consecutive stages of carcinogenesis, especially in the precursor lesions. (biomedcentral.com)
- The elevated expression of p53 leads to greater stability, which also induces the regulatory protein Mdm2. (shu.edu)
- Stabilized wild type p53 induced apoptosis by inducing the expression of PUMA. (shu.edu)
- In addition, Kevetrin increased expression of p53 target genes such as p21 (Waf1), an inhibitor of cell cycle progression. (shu.edu)
- Immunohistochemistry was done to investigate the protein expression of E2F1, TS, and Survivin. (aacrjournals.org)
- The groups used very different isolation methods (i.e., expression cloning, protein purification, genomics), yet all identified the same enzyme and concurred that it possessed all the known characteristics of β-secretase ( Fig. 1 ) ( Cole and Vassar, 2008 ). (jneurosci.org)
Molecular1
Inhibition2
- Studies have shown that endothelial cells (ECs) are the direct targets of hypoxia and are involved in the pathogenesis process of HPH leading to cell hyperproliferation, inhibition of apoptosis and plexiform intima injuries (Ranchoux et al. (biomedcentral.com)
- 10]. This irreversible binding capability makes carfilzomibs proteasome inhibition even more suffered than bortezomib? (antiviralbiologic.com)
Activation3
- Pentapeptide insertion mutagenesis of the Hoxa1 protein: mapping of transcription activation and DNA-binding regulatory domains. (nih.gov)
- Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
- for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)
Morphological1
- Phase contrast microscopy evidenced some specific morphological modifications indicating apoptosis allied cytotoxicity of piperine like apoptotic bodies, condensed nucleus and membrane blabbing. (ijpsonline.com)
Ligand2
- CteC adopts a special 'D-E' catalytic motif for catalysis and binds NAD+ in a half-ligand binding mode. (bvsalud.org)
- The only ligand recognized to bind MST1R (RON) is Macrophage Stimulating 1 (MST1), also known as Macrophage Stimulating Protein (MSP) or Hepatocyte Growth Factor-Like Protein (HGFL). (frontiersin.org)
Suppress1
- 3] The HALT-C trial was a multicenter, randomized controlled study that evaluated whether long-term interferon would suppress HCV, prevent progression to cirrhosis, prevent liver cancer, and reduce the need for liver transplantation. (medscape.com)
Nuclear1
- Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold. (nih.gov)
Inhibitor2
- Targeting this pathway with a small molecule inhibitor, LCRF-0004, resulted in decreased proliferation with a concomitant increase in apoptosis. (frontiersin.org)
- An orally administered, irreversible inhibitor of Bruton's tyrosine kinase (BTK), ibrutinib, is effective at arresting the progression of MCL [ 1 ] as is a highly selective BCL2 inhibitor, venetoclax (ABT-199, Venclexta™) [ 2 ]. (bmj.com)
Cancer7
- This research investigated the role of retroviral cyclin (RV-cyclin) in sarcoma progression in walleyes as a comparable study to human cancer. (wikipedia.org)
- Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)
- There is a growing body of scientific evidence that suggests the potential implication of periodontitis in the causation and progression of various systemic disease and conditions, such as diabetes, cardiovascular disease, pulmonary disease, adverse pregnancy outcomes and cancer. (intechopen.com)
- Western blotting assay was implemented to check the levels of phosphatidylinositol 3-kinase and protein kinase B. Results revealed that piperine induced dose reliant cytotoxicity in MCF-7 human breast cancer cells. (ijpsonline.com)
- Flow cytometric analysis evidenced that piperine arrested the cell cycle at growth 2/mitosis phase, hence suppressed the breast cancer progression. (ijpsonline.com)
- Patients who are radioresistant respond poorly to RT and may experience cancer progression. (nature.com)
- Ribosome biogenesis, the process of ribosome production, is frequently up-regulated in cancer in order to respond to the increased demand of protein synthesis in highly proliferating cells. (oncotarget.com)
Membrane4
- Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
- Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
- Dietary fatty acids and membrane protein function. (springer.com)
- The β-secretase cuts APP first to generate the N terminus of Aβ, thus producing a membrane bound C-terminal fragment called C99. (jneurosci.org)
Lymphoma1
- 1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
Onset1
- Currently, identification of new targets, drugs and therapeutic strategies is at a crucial juncture, which can ultimately contribute to a delayed onset or ameliorate progression of HD. (nature.com)
Catalytic1
- Carfilzomib, a tetrapeptide epoxyketone, can be a second-generation intravenous PI that irreversibly binds the chymotrypsin-like catalytic site from the 20S proteasome primary particle and inhibits its activity? (antiviralbiologic.com)
Cells5
- Acridine orange/ethidium bromine staining assay revealed that piperine induced apoptosis in MCF-7 cells which was further investigated by Western blotting. (ijpsonline.com)
- overhang can be tightly and particularly bound from the shelterin element Container1 which safeguards against unacceptable ssDNA control (7 9 Deletion of S. pombe Container1 (SpPot1) leads to nearly complete lack of telomeric DNA and cell viability with a little inhabitants of cells making it through via chromosome circularization (10). (academicediting.org)
- En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
- Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
- Extensive lymphocyte severe infections is a massive loss of lymphocytes, den- apoptosis has also occurred in humans and animals infect- dritic cells, gastrointestial epithelial cells, and other cell ed with several exotic agents, including Bacillus anthracis , types through apoptosis, or programmed cell death. (cdc.gov)
Transcription factor1
- Conserved transcription factor-binding sites within promoter regions of human RON genes were then searched. (spandidos-publications.com)
Chromosome1
- These substances have been suggested to improve chromosome end availability by inducing MLN4924 manufacture G-quadruplex development on the telomere ends hence restricting gain access to of telomerase to its substrate (29 47 This course of compounds demonstrated quite effective in tumor cell lines producing a amazingly rapid lack of telomeric DNA and apoptosis in mere several cell cycles whilst having no influence on regular cell lines (52-57). (academicediting.org)
Cyclin1
- It was determined that he RV-cyclin bound to cyclin-dependent kinase 8 (CDK8) and increased its activity. (wikipedia.org)
Chromatin1
- The relationship between FENDRR and dynamin-related protein 1 (DRP1) was explored using bioinformatics analysis, Chromatin Isolation by RNA Purification (CHIRP), Electrophoretic mobility shift assay (EMSA) and Methylation-Specific PCR (MSP) assays. (biomedcentral.com)
Mediates2
- A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. (nih.gov)
- EIF5B (Eukaryotic Translation Initiation Factor 5B) is a conserved eukaryotic translation factor that mediates association of the 40S and 60S ribosomal subunits during eukaryotic translation initiation, and modulates the cell cycle progression by regulating the translation of upstream open reading frames (uORF)-containing mRNAs such as p27 and p21 [ 3 ]. (techscience.com)
Scaffold2
- Binding of CAPN3 to titin, a huge myofibrillar proteins that acts as a scaffold for sarcomeric. (exposed-skin-care.net)
- Whole exome sequencing of patients who experienced severe influenza reveals several genes, including scaffold protein AHNAK, with predicted loss-of-function variants that are also identified in our proteomic analyses. (cdc.gov)
Occurs1
- Acute phase reactants are plasma proteins whose levels dramatically increase (called positive acute phase reactants) or, in some cases, decrease (called negative acute phase reactants) in response to the elevated circulating levels of interleukin (IL)-1 and IL-6 that occur when infection or tissue damage occurs. (msdmanuals.com)
Defects1
- acquired defects in the control of apoptosis may lead to a Apoptosis, or programmed cell death, is the method variety of disease states. (cdc.gov)