Progression lung diseases interstitial. Medical search. Frequent questions

Systemic sclerosis (SSc) is a heterogeneous autoimmune disease, characterised by vascular damage, inflammation and fibrosis of skin and various visceral organs. (bmj.com)
Patients who had systemic sclerosis with an onset of the first non-Raynaud's symptom within the past 7 years and a high-resolution computed tomographic scan that showed fibrosis affecting at least 10% of the lungs were randomly assigned, in a 1:1 ratio, to receive 150 mg of nintedanib, administered orally twice daily, or placebo. (nih.gov)
Asbestosis is a type of interstitial pulmonary fibrosis. (wikipedia.org)
Subjects in the two INPULSIS trials had a clinical diagnosis of idiopathic pulmonary fibrosis (IPF) while subjects in the INBUILD trial had a progressive fibrosing ILD other than IPF and met protocol-defined criteria for ILD progression despite management. (ersjournals.com)
Idiopathic pulmonary fibrosis (IPF) is, by definition, a progressive fibrosing interstitial lung disease (ILD) [ 1 ]. (ersjournals.com)
In addition to IPF, there are a number of other ILDs that may develop a progressive fibrosing phenotype characterised by declining lung function, an increasing extent of fibrosis on high-resolution computed tomography (HRCT), worsening symptoms and quality of life, and early mortality [ 2 - 5 ]. (ersjournals.com)
We evaluated whether lysyl oxidase-like 2 (LOXL2), which promotes cross-linking of collagen in pathological stroma, was detectable in serum from idiopathic pulmonary fibrosis (IPF) patients, and assessed its relationship with IPF disease progression. (ersjournals.com)
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease of the lungs involving airway epithelial cell damage, fibroblast activation and proliferation, and excessive deposition of collagen and other extracellular matrix (ECM) components [ 1 ]. (ersjournals.com)
LOXL2 has also been localised to the active disease interface in liver fibrosis [ 9 ], and is considered a "core" driver in fibrosis [ 10 ]. (ersjournals.com)
In the early stages of lung injury, the degree of inflammation of interstitial and alveolar spaces is associated with subsequent fibrosis. (medscape.com)
Following the initial insult, further activation of fibroblasts and myofibroblasts leads to lung fibrosis and scarring. (medscape.com)
Overall, the improvements in biomarkers seen in the Phase 2 liver fibrosis trial reinforce our belief that these data may serve as a potential bridge to other anti-fibrotic indications such as PSC, providing additional evidence that CM-101 could be a valuable therapy for this potentially fatal disease that lacks effective treatment options. (stockhouse.com)
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a non-neoplastic disorder resulting from damage to the lung parenchyma by varying patterns of inflammation and fibrosis. (bmj.com)
To compare survival of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) versus idiopathic pulmonary fibrosis (IPF) and patients with systemic sclerosis-associated ILD (SSc-ILD) versus other CTD-ILD followed at our center. (jrheum.org)
Interstitial lung disease (ILD) represents a heterogeneous group of diseases that involves inflammation and interstitial fibrosis of the lung parenchyma. (jrheum.org)
The most common types of ILD include idiopathic pulmonary fibrosis (IPF) and connective tissue disease (CTD)-associated ILD (CTD-ILD). (jrheum.org)
Disease-modifying treatment aims at inhibiting tissue fibrosis and vascular and immune system alterations, which are the three crucial components of disease pathogenesis. (medscape.com)
Supporting the FVC results, high-resolution computed tomography showed less progression of lung fibrosis with tocilizumab than with placebo. (medscape.com)
For example, trials of rituximab have yielded promising results, with improvement of skin fibrosis and prevention of worsening lung fibrosis. (medscape.com)
The relevance of these findings is demonstrated within the context of TGFB1 signaling and idiopathic pulmonary fibrosis, suggesting therapies against this lethal disease. (nature.com)
Immune-mediated diseases are associated with substantial activation of tissue-resident fibroblasts resulting in fibrosis and organ damage ( 1 ). (snmjournals.org)
Activated fibroblasts that are located in the lining and sublining of the synovium contribute to pannus formation and bone destruction in rheumatoid arthritis, whereas fibroblasts in the lung tissue react to stimulation by an excessive release of extracellular matrix, resulting in progressive tissue fibrosis. (snmjournals.org)
In contrast to rheumatoid arthritis, which is characterized by a strong inflammatory component, in SSC interstitial lung disease the activation of fibroblasts leads to excessive fibrosis of the lungs. (snmjournals.org)
Idiopathic pulmonary fibrosis (IPF) represents probably the most aggressive form of ILD and systemic sclerosis is a multiorgan fibrotic disease frequently associated with ILD. (ersjournals.com)
The lung is susceptible to various forms of short- and long-term injuries, both airborne and blood-borne, that may result in fibrosis. (ersjournals.com)
Some forms of fibrosis, such as acute lung injury or cryptogenic organising pneumonia, are at least partially reversible, whereas others, in particular idiopathic pulmonary fibrosis (IPF), are progressive and fatal. (ersjournals.com)
In systemic sclerosis (SSc) patients, the change in the trend of scleroderma-related deaths over the past 30 years demonstrates that lung involvement (both pulmonary hypertension and pulmonary fibrosis) is among the primary causes of mortality [ 6 ]. (ersjournals.com)
In SSc, pulmonary disease can exist as a heterogeneous combination of pulmonary fibrosis and pulmonary arterial hypertension (PAH), but the pathogenic mechanisms that induce different pulmonary responses are poorly understood. (ersjournals.com)
This schematic view of the morpho-functional unit of the lung (alveolus) depicts the main differences in cellular composition in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) compared with normal physiological cellular components. (ersjournals.com)
that that immune events in the lung could be monitored in the peripheral blood in many forms of human pulmonary fibrosis. (yale.edu)
For example, using the 18-glycolsyl hydrolase protein Chi3L1 as a prototype, we were able to show that a single gene product can simultaneously suppress or promote injury and fibrosis depending on its temporospatial expression in the disease process. (yale.edu)
Importantly, these mediators can be detected in the tissue of patients with various forms of pulmonary fibrosis, cementing the association with human disease. (yale.edu)
Rationale Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease. (bmj.com)
Specifically, there were some recommendations by an expert panel, that we no longer use antacid therapy or proton pump inhibitors that target slowing the progression of pulmonary fibrosis. (medscape.com)
Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. (lu.se)
In this study we show Ogg1-targeting siRNA mitigates bleomycin-induced pulmonary fibrosis in male mice, highlighting OGG1 as a tractable target in lung fibrosis. (lu.se)
In addition, TH5487 decreases levels of pro-inflammatory mediators, inflammatory cell infiltration, and lung remodeling in a murine model of bleomycin-induced pulmonary fibrosis conducted in male C57BL6/J mice. (lu.se)
DPLD may be idiopathic, a classic illustration of which is idiopathic interstitial fibrosis (IPF), which is discussed in another article (see Pulmonary Fibrosis, Idiopathic ). (medscape.com)
It is thought to begin with acute injury to the pulmonary parenchyma, leading to chronic interstitial inflammation, then to fibroblast activation and proliferation, and finally progressing to the common endpoint of pulmonary fibrosis and tissue destruction. (medscape.com)
one underwent a lung biopsy that revealed silicotic nodules and fibrosis. (cdc.gov)
Microscopic examination revealed widespread interstitial inflammation and fibrosis, and mineralogic analysis revealed extremely high silica particle content. (cdc.gov)

ILD associated with CTDs (CTD-ILD) may display a variety of histologic subtypes, including usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), organizing pneumonia (OP), diffuse alveolar damage, lymphoid interstitial pneumonia (LIP), bronchiectasis, constrictive bronchiolitis, follicular bronchiolitis, and alveolar hemorrhage. (medscape.com)
In this setting, IPF is defined as a chronic progressive fibrotic ILD, with unknown aetiology and a pattern of usual interstitial pneumonia (UIP), which is represented by heterogeneous lesions at different stages of evolution with foci of proliferative fibroblasts. (ersjournals.com)
Blood monocytes have been linked to all-cause mortality, and neutrophils to progression to IPF in patients with the indeterminate for usual interstitial pneumonia CT pattern. (bmj.com)

Objectives To identify the predictive clinical characteristics and establish a prediction model for the progression of mild interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). (bmj.com)
Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis and a leading cause of systemic sclerosis-related death. (nih.gov)
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by articular and extra-articular manifestations affecting approximately 1-2% of the general population [ 1 ]. (hindawi.com)
Similarly, interstitial lung diseases (ILDs) are a heterogeneous group of lung disorders-characterized by parenchymal lung injury as a consequence of systemic autoimmunity-classified on the basis of their radiologic as well as histopathologic features. (medscape.com)
CTD associated with ILD include systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis and dermatomyositis (PM/DM), Sjögren's syndrome, and mixed connective tissue disease (MCTD) 4 . (jrheum.org)
To date, the US Food and Drug Administration (FDA) has approved nintedanib and as well as tocilizumab for refractory, progressive intersitial lung disease due to systemic sclerosis. (medscape.com)
In patients with systemic sclerosis-related interstitial lung disease, a clinically meaningful decline of 10% or more in lung function was seen in 24.5% of placebo recipients, compared with 8.6% of tocilizumab recipients. (medscape.com)
Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. (scirp.org)
Clinical assessments of disease activity in immune-mediated rheumatologic disorders such as rheumatoid arthritis or systemic sclerosis (SSC)-associated interstitial lung disease usually include physical examinations and evaluation of functional parameters, as well as the patient's self-reporting of disease activity and quality of life ( 5 ). (snmjournals.org)
Primary Sjogren syndrome (pSS) is a systemic autoimmune disease characterised by lymphocytic infiltration of exocrine glands and by a number of systemic manifestations, including those regarding the lung. (ersjournals.com)
SS can occur as a primary disease (primary SS (pSS)) or be associated with another autoimmune disease, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), dermatomyositis, or systemic sclerosis (SSc) [ 1 ]. (ersjournals.com)
Sometimes, the disease course can be also complicated by systemic manifestations that can represent the first signs of the disease, also preceding SS by many years [ 11 ]. (ersjournals.com)
In children, localized scleroderma is three times more common than the systemic form of the disease. (mountsinai.org)
People with scleroderma may develop either a localized or a systemic (body-wide) form of the disease. (mountsinai.org)
Its progression is very slow, and it rarely, if ever, spreads throughout the body (becomes systemic) or causes serious complications. (mountsinai.org)
Our study aims to evaluate the efficacy of systemic chemotherapy and assess risk of acute exacerbation (AE)-IP with cytotoxic drugs for extensive disease (ED)-SCLC patients with IP. (biomedcentral.com)
Granulomatosis with polyangiitis, formerly known as Wegener granulomatosis , is a disease that typically consists of a triad of airway necrotizing granulomas, systemic vasculitis, and focal glomerulonephritis. (medscape.com)
Some forms of DPLD are related to occupational, environmental, drug, and/or radiation exposure, as well as systemic illness such as collagen-vascular disease (see Collagen-Vascular Disease Associated With Interstitial Lung Disease ). (medscape.com)
Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is an uncommon non-immunoglobulin E (IgE), T-helper cell type 1 (Th1)-mediated inflam- matory pulmonary disease with systemic symptoms resulting from repeated inhalation and subsequent sensitization to a large variety of aerosolized antigenic organic dust particles. (cdc.gov)

We used data from the INBUILD and INPULSIS trials to investigate the natural history of progressive fibrosing interstitial lung diseases (ILDs). (ersjournals.com)
These findings indicate that patients with fibrosing ILDs other than IPF, who are progressing despite management, have a subsequent clinical course similar to patients with untreated IPF, with a high risk of further ILD progression and early mortality. (ersjournals.com)
The interstitial lung diseases (ILDs) are a diverse group of chronic lung conditions characterised by dyspnoea on exertion and poor health related quality of life. (bmj.com)
ILDs cause this interstitial space to become inflamed or scarred making it more difficult for oxygen to get into the bloodstream. (stanford.edu)
These three groups of ILDs have slightly different presentations, and different findings on the CT scans, lung tissue biopsy (if done), and bloodwork results. (stanford.edu)
The interstitial lung diseases (ILDs) are a group of diffuse parenchymal lung disorders that are classified according to specific clinical, radiological and histopathological features. (ersjournals.com)
Frequently, however, ILDs can also be associated with a specific environmental exposure or an underlying connective tissue disease. (ersjournals.com)
The term idiopathic interstitial pneumonia encompasses a wide range of different ILDs with unique clinical, radiological and pathological features. (ersjournals.com)
However, a recent trial showed the efficacy of the antifibrotic drug nintedanib in slowing progression of various ILDs, including those in pSS patients. (ersjournals.com)

[ 9 ] To address this, the European Respiratory Society and American Thoracic Society released a joint consensus statement in 2015 proposing the term "interstitial pneumonia with autoimmune features" (IPAF) be used for "idiopathic interstitial pneumonia" (IIP) with clinical features that suggest an underlying autoimmune process. (medscape.com)
1 2 Respiratory manifestations are common and include airways, pleural and interstitial disorders. (bmj.com)
The 6 min walk distance (6MWD), incremental exercise test, modified Medical Research Council (MRC) dyspnoea score and Chronic Respiratory Disease Questionnaire (CRDQ) were performed at baseline, following intervention and at 6 months. (bmj.com)
Current guidelines for exercise prescription in chronic lung disease are based on evidence from studies of patients with COPD 7 where respiratory mechanics and peripheral muscle dysfunction are major limitations to exercise capacity. (bmj.com)
It is one of the main children respiratory infectious diseases, i.e., mycoplasma pneumonia (MP). (hindawi.com)
panel B demonstrates the progression to acute respiratory disease syndrome (ARDS) on day 8. (cdc.gov)
Responders to the World Trade Center attack were exposed to toxic dust, which has been linked to increased incidence of respiratory and cardiovascular disease, but the relationship between the amount of exposure and the extent and progression of disease is not well understood. (cdc.gov)
The proposed research uses automated image analysis software to identify and measure specific respiratory and cardiovascular diseases: emphysema, pleural thickening, interstitial lung disease, and coronary artery calcifications. (cdc.gov)
Lung fibrotic disorders are characterised by accumulation of fibroblasts, myofibroblasts and extracellular matrix (ECM), leading to chronic respiratory failure. (ersjournals.com)
Archivos de Bronconeumologia is a scientific journal that preferentially publishes prospective original research articles whose content is based upon results dealing with several aspects of respiratory diseases such as epidemiology, pathophysiology, clinics, surgery, and basic investigation. (archbronconeumol.org)
1 Respiratory symptoms are one of the most common post-COVID-19 manifestations that need to be assessed during follow-up, mainly in patients who had pulmonary involvement in the acute phase of the disease. (archbronconeumol.org)
In contrast, airway disease usually has little effect on respiratory function and is rarely the cause of death in these patients. (ersjournals.com)
1976) found increased mortality from malignant respiratory disease among workers with at least 5 years of exposure. (cdc.gov)
Conclusions Increased engineering control s and respiratory protection can lead to decreased Inresp, InP and biomarkers of interstitial lung disease among workers in 2 years. (cdc.gov)
An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias. (msdmanuals.com)
Other major histopathologic forms of idiopathic interstitial pneumonias include the following: desquamative interstitial pneumonia (DIP), respiratory bronchiolitis interstitial lung disease (RBILD), acute interstitial pneumonitis (AIP), also known as Hamman-Rich syndrome, nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP) (see Bronchiolitis Obliterans Organizing Pneumonia ), and lymphocytic interstitial pneumonia (LIP) (see Lymphocytic Interstitial Pneumonia ). (medscape.com)
Introduction: A cluster of pneumonia cases of unknown origin was first reported in Wuhan China then the causa- tive pathogen was identified and named severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) and the associated disease was named coronavirus disease 2019 (COVID-19). (who.int)
COVID-19 with evidence of worsening of respiratory navirus 2 (SARS-CoV2) and the associated disease status and for patients with moderate to severe features was named coronavirus disease 2019 (COVID-19). (who.int)
National surveillance screening in the United Kingdom from 1992 to 2001 estimated 50 cases of hypersensitivity pneumonitis annually, rep- resenting 1.8% of all cases of work-related respiratory disease seen by chest physi- cians. (cdc.gov)
0.7% of all work-related respiratory disease. (cdc.gov)
Introduction: A cluster of pneumonia cases of unknown origin was first reported in Wuhan China then the causative pathogen was identified and named severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) and the associated disease was named coronavirus disease 2019 (COVID-19). (bvsalud.org)

In recent years, the number of studies on rheumatoid arthritis-related interstitial lung disease (RA-ILD) has been increasing, which has led to many publications on this topic. (hindawi.com)
The retrieval steps and strategies were as follows: Title = rheumatoid arthritis AND Title = (interstitial lung disease OR interstitial pneumonia) AND Language = English AND Document type = (review OR article) AND Time span =1980 to 2021. (hindawi.com)
Background Anti-tumour necrosis factor (anti-TNF) therapy has been associated with reports of rapid severe progression of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). (bmj.com)
Patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) had slower rates of decline in lung function over 1 year when treated with nintedanib (Ofev), an intracellular inhibitor of tyrosine kinases, according to a post-hoc analysis from a larger trial known as INBUILD. (medpagetoday.com)
An impressive example of the use of FAPI PET/CT for the detection and quantification of disease in rheumatoid arthritis was given by Luo et al. (snmjournals.org)
MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression. (cdc.gov)

If you undergo a lung biopsy, the pathologist can confirm a diagnsosi of Hypersensitivity Pneumonitis by findings in the lung tissue. (stanford.edu)
Product labeling includes a boxed warning for QTc prolongation and Torsades de Pointes, and warnings for interstitial lung disease/pneumonitis, cardiac toxicity, and diarrhea. (fda.gov)
Ocular toxicity is the most prevalent safety event, and ILD [interstitial lung disease]/pneumonitis was reported, including grade 3 or worse, in 2.4% of patients. (medpagetoday.com)
The underlying histopathology of IPF is usual interstitial pneumonitis (UIP). (medscape.com)
The earliest forms of hypersensitivity pneumonitis were related to farming and, each year, new antigens causing occupational disease are described. (cdc.gov)
Hypersensitivity pneumonitis was originally described in 1713 as an occupational lung disease in grain workers and later, in 1932, in farmers inhaling moldy hay contam- inated with thermophilic actinomyces, hence the term farmer's lung.1 With this recog- nition, modernization of farming methods has resulted in the reduction in farmer's lung prevalence estimated at 0.5% to 3% of exposed farmers in studies spanning from 1980 to 2003. (cdc.gov)
Farmer's lung is the prototype occupational hypersensitivity pneumonitis. (cdc.gov)
9 Agricul- tural exposures were the most common occupation for hypersensitivity pneumonitis in the Czech Republic, with 69% of cases of farmer's lung (cattleman and dairyman), followed by malt workers and chemical workers. (cdc.gov)

and the National Heart and Lung Institute, Imperial College London, and the National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London (T.M.M. (nih.gov)
Furthermore, referral to centers with expertise in pulmonary hypertension on lung transplantation may be required, depending on the individual clinical context. (medscape.com)
Baseline serum LOXL2 (sLOXL2) levels were compared with baseline clinical and physiological surrogates of disease severity, and the association with IPF disease progression was assessed using a classification and regression tree (CART) method. (ersjournals.com)
[ 7 , 8 ] It has been suggested that some patients with ILD and autoimmune features who do not meet clinical criteria for CTDs may have a lung-predominant form of a CTD. (medscape.com)
TEL AVIV, Israel , Aug. 14, 2023 /PRNewswire/ -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB), (Chemomab), a clinical stage biotechnology company developing innovative therapeutics to treat rare fibro-inflammatory diseases with high unmet need, today announced financial and operating results for the second quarter ended June 30, 2023 , and provided a corporate update. (stockhouse.com)
Since the clinical course, response to treatment, and prognosis are highly variable among patients with myositis-associated ILD ( 3 , 5 ), the treatment regimen is decided based mainly on the progression speed and severity of ILD. (frontiersin.org)
The follow up dose for adult patients with GPA and MPA who have achieved disease control with induction treatment, in combination with glucocorticoids is two 500 mg intravenous infusions separated by two weeks, followed by a 500 mg intravenous infusion every 6 months thereafter based on clinical evaluation ( 2.6 ). (drugs.com)
Direct measurement of disease activity is not established in clinical practice. (snmjournals.org)
Furthermore, SUV max correlated with clinical and laboratory disease activity and radiographic progression of joint damage. (snmjournals.org)
Interstitial lung disease (ILD) encompasses a large and diverse group of pathological conditions that share similar clinical, radiological and pathological manifestations, despite potentially having quite different aetiologies and comorbidities. (ersjournals.com)
Among 62 workers participating in both 2012 and 2014, 18 (29%) had new or worsening chest symptoms and 2 (3%) had functional decline in lung function or radiographic progression, but average KL-6 and SP-D concentrations decreased, and no cases of clinical indium lung disease were recognised. (cdc.gov)
of unknown etiology that share similar clinical and radiologic features and are distinguished primarily by the histopathologic patterns on lung biopsy. (msdmanuals.com)
General reference Idiopathic interstitial pneumonias (IIPs) are interstitial lung diseases of unknown etiology that share similar clinical and radiologic features and are distinguished primarily by the histopathologic. (msdmanuals.com)
Generally, SCLC patients with interstitial pneumonia (IP) has been excluded in previous clinical studies, and efficacy of cytotoxic chemotherapy for ED-SCLC patients with IP is unclear. (biomedcentral.com)
Methods We performed a retrospective analysis of an IPF cohort (n=128) who had their first clinical visit at the Oxford Interstitial Lung Disease Service between 2013 and 2017. (bmj.com)
Early Tacrolimus Concentrations After Lung Transplant Are Predicted by Combined Clinical and Genetic Factors and Associated With Acute Kidney Injury. (cdc.gov)

People who live near mines can also be exposed to airborne asbestos fibers Asbestosis is the scarring of lung tissue (beginning around terminal bronchioles and alveolar ducts and extending into the alveolar walls) resulting from the inhalation of asbestos fibers. (wikipedia.org)
Due to the asbestos fibers' natural resistance to digestion, some macrophages are killed and others release inflammatory chemical signals, attracting further lung macrophages and fibrolastic cells that synthesize fibrous scar tissue, which eventually becomes diffuse and can progress in heavily exposed individuals. (wikipedia.org)
In patients with suspected connective tissue disease (CTD)-associated interstitial lung disease (ILD) (CTD-ILD), referral to a center with expertise in management of CTD-ILD is recommended. (medscape.com)
As mentioned previously, immunosuppression is the cornerstone of the medical management of connective tissue disease (CTD)-associated interstitial lung disease (ILD) (CTD-ILD). (medscape.com)
LOXL2 protein expression is observed in the fibroblastic foci and collagenous regions of diseased IPF lung tissue, with relatively minor expression in healthy lung tissue [ 9 ]. (ersjournals.com)
Although the distinct cause of interstitial lung disease (ILD) in connective disease tissue (CTD) is not known, the underlying pathogenesis is thought to be secondary to varying degrees inflammation, alveolar injury, dysregulated tissue repair, and fibroproliferation. (medscape.com)
Interstitial Lung Disease refers to a large group of lung disorders that cause inflammation or scarring in the lung tissue. (stanford.edu)
The interstitium refers to the tissue area in and around the wall of the airsacs (alveoli) of the lung area where oxygen moves from the alveoli into the capillary network (small blood vessels) that covers the lung like a thin sheet of blood. (stanford.edu)
The changes in the lung tissue can also cause a dry, hacky cough for some patients. (stanford.edu)
2021). Besides these well-known pathogenetic mechanisms related to inflammaging, other processes are involved in age-related and inflammatory-related diseases including enzyme dysfunctions, cell death, impaired tissue renewal and tissue degeneration (Li, 2013). (researchgate.net)
Patients could be taking stable doses of medications for RA or connective tissue disease at baseline, except azathioprine, cyclosporine, mycophenolate mofetil (Cellcept), tacrolimus, rituximab (Rituxan), cyclophosphamide, or oral glucocorticoids in dosages above 20 mg/day. (medpagetoday.com)
Despite the overall low incidence of fibrotic diseases, fibrotic tissue responses across different diseases have been estimated to account for up to 45% of deaths in high-income countries, causing socioeconomic costs of tens of billions of U.S. dollars per year ( 2 ). (snmjournals.org)
Progression of disease is defined as tissue destruction between 2 patient examinations, meaning that disease activity is measured only indirectly by progression of existing tissue damage. (snmjournals.org)
Ten years later 2,668 participants had full lung CT scans evaluated by a radiologist for presence of scar tissue or other abnormalities. (trustedhealthproducts.com)
The vitamin D-deficient participants had a larger volume of bright spots in the lung suggestive of damaged lung tissue, compared with those with adequate vitamin D levels. (trustedhealthproducts.com)
OGG1 and SMAD7 interact to induce fibroblast proliferation and differentiation and display roles in fibrotic murine and IPF patient lung tissue. (lu.se)
Side effects caused by different drugs affecting the lung tissue are observed increasingly in different patient populations, however incidence and prevalence are poorly understood. (lu.se)
Lund University is one of the 21 sites within the consortium named TRISTAN (Translational Imaging in Drug Safety Assessment), that perform preclinical models and apply imaging techniques such as MRI, CT and PET to assess lesions in the lung tissue caused by drug administration. (lu.se)

These modifications of ECM composition and organisation alter the biomechanical properties of the lung parenchyma and increase local tension, which is critical in IPF disease pathogenesis [ 5 ]. (ersjournals.com)

Patients received mobocertinib 160 mg orally daily until disease progression or intolerable toxicity. (fda.gov)
The recommended mobocertinib dose is 160 mg orally once daily until disease progression or unacceptable toxicity. (fda.gov)
Patients received mirvetuximab soravtansine at 6 mg/kg (based on adjusted ideal body weight) as an intravenous infusion every 3 weeks until disease progression or unacceptable toxicity. (ascopost.com)
The recommended mirvetuximab soravtansine dose is 6 mg/kg adjusted ideal body weight administered once every 3 weeks (21-day cycle) as an intravenous infusion until disease progression or unacceptable toxicity. (ascopost.com)
For patients with advanced non-small cell lung cancer, current standard of care second-line docetaxel is associated with limited benefit and substantial toxicity. (businesswire.com)
Mechanisms are not fully elucidated and several hundreds of various types of drugs are able to cause the type of toxicity and injury, called Drug-induced interstitial lung disease (DIILD). (lu.se)

We ultimately found that because fibrocytes were rare and difficult to detect in the blood, removal or repolarizing of macrophages is a more viable therapeutic strategy for fibrotic lung disease. (yale.edu)
Silicosis is a potentially fatal and typically chronic fibrotic lung disease caused by occupational exposure to respirable crystalline silica dust (1). (cdc.gov)

Previous studies explored baseline predictors for lung progression and mortality in SSc-ILD. (bmj.com)
To stratify patients with polymyositis/dermatomyositis-associated interstitial lung disease (ILD) who were initially treated with an intensive regimen consisting of high-dose corticosteroids, a calcineurin inhibitor, and intravenous cyclophosphamide (triple-combo therapy) into subgroups based on mortality outcomes by a cluster analysis using a large-scale multicenter retrospective cohort of Japanese patients with myositis-associated ILD (JAMI). (frontiersin.org)
Initial predictors for mortality previously reported in patients with myositis-associated ILD were used as variables and included age, sex, disease duration, classification of myositis, requirement of supplemental oxygen, anti-aminoacyl tRNA synthetase (ARS) antibody, anti-melanoma differentiation-associated gene 5 (MDA5) antibody, and serum levels of C-reactive protein (CRP) and Krebs von den Lungen-6 (KL-6). (frontiersin.org)
In particular, interstitial lung disease (ILD) is one of the major manifestations associated with poor mortality in patients with polymyositis (PM)/dermatomyositis (DM) ( 2 ). (frontiersin.org)
Several articles have reported that ILAs are associated with increased mortality, and they can show radiologic progression. (koreamed.org)
The section is organized into three different types of studies: human cancer mortality studies ( Section 3.1.1 ), studies of lung-retained fibers in humans ( Section 3.1.2 ), and laboratory animal studies ( Section 3.1.3 ). (cdc.gov)
Objective To determine association between blood monocytes, neutrophils and lymphocytes levels (and their derived indexes), with lung function decline and mortality in IPF. (bmj.com)
Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality. (cdc.gov)

Diffuse cutaneous subset, presence of antitopoisomerase-I antibodies, decreased baseline forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO) were reported to be significantly associated with lung progression in patients with SSc, while positive anticentromere antibody (ACA) was protective. (bmj.com)
Other less common side effects include cholestatic jaundice , colitis and a diffuse interstitial lung disease. (sas-centre.org)
Pre-existing IP was diagnosed when the diffuse ground-glass opacity, peripheral reticular opacity, consolidation without segmental distribution, and a honeycomb pattern were detected in bilateral lung fields on pretreatment CT findings. (biomedcentral.com)
Diffuse parenchymal lung diseases (DPLDs) comprise a heterogenous group of disorders. (medscape.com)
As a group, diffuse interstitial diseases of the lung are uncommon. (medscape.com)

Treatment with SYD985 significantly improved progression-free survival in comparison with standard physician's choice treatment in patients with HER2-positive metastatic breast cancer with two prior regimens or T-DM1 (trastuzumab emtansine, Kadcyla) in the metastatic setting," she said in conclusion. (medpagetoday.com)

Overview of Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked. (msdmanuals.com)

Eligible patients also had reticular abnormalities with traction bronchiectasis of at least 10% on high-resolution CT, FVC of at least 45% predicted, and diffusing capacity of the lungs for carbon monoxide of 30% to 80% predicted, and met criteria for progression of ILD within the 2 years prior to screening despite management considered appropriate. (medpagetoday.com)
Interstitial lung abnormalities (ILAs) are radiologic abnormalities found incidentally on chest CT that are potentially related to interstitial lung diseases. (koreamed.org)
She is applying these methods to develop an automated model of classifying and scoring abnormalities in patterns of interstitial lung disease, such as fibrotic reticular and honeycomb patterns, and ground glass opacity abnormalities. (uclahealth.org)
The data from the full lung scans revealed those with deficient or intermediate vitamin D levels were also 50 to 60 percent more likely to have abnormalities on their full lung scans suggestive of early signs of interstitial lung disease, compared with those with optimal vitamin D levels. (trustedhealthproducts.com)
Lung abnormalities in marfan syndrome: a pathogenetic model of early-onset emphysema? (ers-education.org)

Idiopathic interstitial pneumonia should be suspected in any patient with unexplained interstitial lung disease. (msdmanuals.com)

The comparison is done on the incidence of bronchial and pulmonary interstitial lesions, the degree of lymph node enlargement, the volume and depth of pleural effusion, and the location and morphology of the pulmonary lesions in the chest CT images of children patients from the two groups. (hindawi.com)
The more obvious manifestations were that the flaky shadows appeared in the lungs, the pleural effusion became thicker, and the transverse diameters of enlarged lymph nodes were bigger. (hindawi.com)

This inflammatory reaction can be described as chronic rather than acute, with a slow ongoing progression of the immune system attempting to eliminate the foreign fibers. (wikipedia.org)
SSc, a chronic disease with multisystemic involvement, is characterized by widespread collagen deposition. (medscape.com)
Although exercise training effectively improves exercise capacity and health related quality of life in patients with chronic obstructive pulmonary disease (COPD), 4 its role in patients with ILD is unclear. (bmj.com)
Editorial on the Research Topic Inflammation and aging in chronic and degenerative diseases: Current and future therapeutic strategies Inflammation and aging represent the most common risk factors for several chronic and degenerative disorders (Furman et al. (researchgate.net)
2021). Of note, inflammation and aging are both pathophysiological processes that have been associated with an increased risk of different chronic-degenerative diseases, including tumors, neurological and cardiovascular disorders (Gupta et al. (researchgate.net)
On these bases, the aim of the Research Topic entitled "Inflammation and Aging in Chronic and Degenerative Diseases: Current and Future Therapeutic Strategies" was to collect the latest update on the molecular and cellular determinants responsible for inflammatory processes during aging as well as the role of aging in the onset of chronic-degenerative diseases. (researchgate.net)
This drug has also been used for a number of other conditions with a possible auto immune basis, such as psoriatic arthritis, juvenile chronic polyarthritis (Stills disease) and pemphigus. (sas-centre.org)
Moreover, the goal of this recommendation is merely bone health, not optimal health and chronic disease prevention. (mindbodyhealth.com)
My training as a physician scientist motivates me to seek new treatments for chronic lung diseases. (yale.edu)

The examination of surgical lung specimens and an integrated clinico-radiological evaluation allow the start of a complex differential diagnosis and prediction of survival, through the identification of different interstitial patterns [ 2 ]. (ersjournals.com)
BUSINESS WIRE )--Positive results from the pivotal TROPION-Lung01 Phase III trial showed that datopotamab deruxtecan (Dato-DXd) demonstrated a statistically significant improvement for the primary endpoint of progression-free survival (PFS) compared to docetaxel, the current standard of care, in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) treated with at least one prior line of therapy. (businesswire.com)
The improvement in progression-free survival observed with datopotamab deruxtecan, particularly in patients with non-squamous tumors, and the improved tolerability of this antibody drug conjugate compared to docetaxel, represent a meaningful advance for patients with lung cancer. (businesswire.com)
In cancer studies, Kim's work involves identifying a predictive classifier and surrogate outcomes to a therapeutic response, including progression-free survival and overall survival, via MRI images. (uclahealth.org)
Median progression-free survival (PFS) improved from 4.9 months with investigator's choice of chemotherapy to 7.0 months with trastuzumab duocarmazine (SYD985). (medpagetoday.com)
BICR-assessed CNS objective response rate (CNS-ORR), CNS disease control rate (CNS-DCR), CNS duration of response (CNS-DoR), CNS progression-free survival (CNS-PFS), and CNS depth of response (CNS-DepOR) were evaluated. (bvsalud.org)
FCGR3A and FCGR2A Genotypes Differentially Impact Allograft Rejection and Patients' Survival After Lung Transplant. (cdc.gov)

On September 15, 2021, the Food and Drug Administration granted accelerated approval to mobocertinib (Exkivity, Takeda Pharmaceuticals, Inc.) for adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or after platinum-based chemotherapy. (fda.gov)

Computed tomography-based machine learning for donor lung screening before transplantation. (nih.gov)
Specifically, Kim is studying approaches to classify abnormal patterns in interstitial lung diseases in computed tomography (CT) images, as well as removing noise in CT imaging. (uclahealth.org)

Complications may include lung cancer, mesothelioma, and pulmonary heart disease. (wikipedia.org)

After 48 weeks, decline in lung function from baseline, as defined by changes in predicted forced vital capacity (FVC), had occurred 50.5% of patients in the tocilizumab arm, versus 70.3% of those in the placebo arm ( P = 0.015). (medscape.com)

Just like the inhaled exposures, it is important for your physician to obtain a detailed medication history during your ILD evaluation, especially as it relates to timing of the medication with changes in your lung symptoms. (stanford.edu)
We assessed symptoms, lung function, serum biomarkers of interstitial lung disease (Krebs von den Lungen (KL)-6 and surfactant protein (SP)-D) and chest high-resolution CT at both time points and evaluated workers who participated in both 2012 and 2014 for changes in health outcomes (new, worsened or improved). (cdc.gov)
Treatment involves a combination approach to treat the immune response, improve circulation, and stop the progression of skin symptoms. (mountsinai.org)
Granulomatous diseases cause a great range of symptoms not only in the head and neck but also throughout the body. (medscape.com)

The coronavirus disease-19 (COVID-19) pandemic continues to determine a significant impact on the health system globally, not only related to the acute phase, but also to the long-term manifestations. (archbronconeumol.org)
A quality control worker in a feed factory developed acute disease after taking samples of cattle feed treated with phytase, a fungal-derived enzyme used to treat cattle feed to strengthen bone. (cdc.gov)

Patients with CTD who develop drug-induced ILD may also manifest a variety of histologic patterns in lung biopsy specimens. (medscape.com)

16 In addition, ILD is a heterogeneous group of diseases. (bmj.com)

Lung transplantation may be an option for those with end-stage lung disease. (medscape.com)
CT-based Machine Learning for Donor Lung Screening Prior to Transplantation. (nih.gov)
Epidemiology and persistence of rhinovirus in pediatric lung transplantation. (cdc.gov)
Transplant infectious disease : an official journal of the Transplantation Society 2020 7 22 (6): e13422. (cdc.gov)

These therapies were subsequently allowed after 6 months in patients whose lung or autoimmune disease deteriorated. (medpagetoday.com)
Scleroderma is an uncommon, complex, autoimmune disease. (mountsinai.org)

Pulmonary involvement in pSS includes interstitial lung disease (ILD) and airway disease, together with lymphoproliferative disorders. (ersjournals.com)
In disseminated disease, 78-100% sensitivity is reported, whereas in upper airway disease, 60-70% sensitivity is reported. (medscape.com)

Although similar histologically, granulomatous diseases of the head and the neck require a thorough approach because of the wide variety of disease processes. (medscape.com)
Pathologically, all DPLDs manifest histologically with disease largely within the interstitial compartment of the lung. (medscape.com)

When such fibers reach the alveoli (air sacs) in the lung, where oxygen is transferred into the blood, the foreign bodies (asbestos fibers) cause the activation of the lungs' local immune system and provoke an inflammatory reaction dominated by lung macrophages that respond to chemotactic factors activated by the fibers. (wikipedia.org)
As a group, the studies reinforce our extensive data highlighting the central role of CCL24 in the pathophysiology of fibro-inflammatory diseases and confirm that our CCL24-neutralizing antibody, CM-101, has potential therapeutic utility in these conditions. (stockhouse.com)
Some of the medications that can cause an inflammatory reaction in the lung include amiodarone, methotrexate, some chemotherapy agents used to treat cancers, and nitrofurantoin (sulfa drugs). (stanford.edu)
Idiopathic inflammatory myopathies often affect extramuscular organs such as the skin, joints, lungs, heart and gastrointestinal tract ( 1 ). (frontiersin.org)
2013). Therefore, it is evident how a better knowledge of inflammaging and novel therapeutic strategies aimed at reducing inflammation during aging are mandatory to effectively manage age- and inflammatory-related diseases. (researchgate.net)
Although SSc-associated ILD (SSc-ILD) is associated more frequently with a nonspecific interstitial pneumonia pattern, which is characterised by homogeneous lesions with predominant inflammatory infiltrates, some aspects of IPF and SSc-ILD suggest that these diseases could share some common features [ 7 ]. (ersjournals.com)
We knew that the activated vitamin D hormone has anti-inflammatory properties and helps regulate the immune system, which goes awry in ILD," says Erin Michos, M.D., M.H.S. , associate professor of medicine at the Johns Hopkins University School of Medicine and associate director of preventive cardiology at the Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease. (trustedhealthproducts.com)

Among patients with measurable disease at baseline (about 85% of the population), the overall response rate was 28-29% in each group, but the average reduction in the target lesion was 70.2% with SYD985 versus 58.2% with standard therapy. (medpagetoday.com)
Disease severity and timing of imaging appear to impact the rates of normal baseline imaging. (who.int)

The imaging examination can be adopted to quickly observe the morphology and scope of the pulmonary lesions and know the effect of disease treatment and subsequent changes in the disease in order to provide a basis for treatment. (hindawi.com)

Efficacy was evaluated in 114 patients whose disease had progressed on or after platinum-based chemotherapy. (fda.gov)
Non-progressing (including stable disease), low-grade, CD20-positive, B-cell NHL as a single agent after first-line cyclophosphamide, vincristine, and prednisone (CVP) chemotherapy. (drugs.com)
EXKIVITY is a kinase inhibitor indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or after platinum-based chemotherapy. (nih.gov)
For patients with no or minor CNS disease, Krop recommended third-line trastuzumab deruxtecan, fourth-line tucatinib combined with trastuzumab/capecitabine (Xeloda), and fifth-line trastuzumab/chemotherapy or, if approved, margetuximab/chemotherapy for patients with low affinity FcR genotype. (onclive.com)
In patients with significant CNS disease, optimal third-, fourth-, and fifth-line treatments would be tucatinib/trastuzumab plus chemotherapy, trastuzumab deruxtecan, and trastuzumab/chemotherapy or margetuximab/chemotherapy for patients with low affinity FcR genotype. (onclive.com)
The TROPION-Lung01 results demonstrate for the first time that an antibody drug conjugate can delay disease progression or death for longer than conventional chemotherapy in patients with advanced non-small cell lung cancer. (businesswire.com)
An antibody-drug conjugate (ADC) targeting HER2 significantly slowed progression of previously treated metastatic breast cancer versus chemotherapy, a multinational randomized trial showed. (medpagetoday.com)
Small cell lung cancer (SCLC) is characterized by a high propensity for metastases and a poor prognosis irrespective of high sensitivity for initial chemotherapy. (biomedcentral.com)
Although interstitial pneumonia (IP) is one of risk factors for lung cancer, efficacy of cytotoxic chemotherapy for patients with SCLC with IP remains unclear. (biomedcentral.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)

A scleroderma lung study that compared oral cyclophosphamide and placebo showed 1 year of cyclophosphamide was associated with a significant but modest improvement in dyspnea and lung function. (medscape.com)
A recent double-blind placebo-controlled study showed that patients with SSc-ILD treated with 1 year of oral cyclophosphamide experienced a statistically significant improvement in lung function, dyspnea, and health-related quality of life compared with those treated with placebo 15 , 16 . (jrheum.org)

It provides assessment of the potential etiology, extent, and distribution of disease and is more likely to detect underlying or coexisting disease (eg, occult mediastinal adenopathy, cancer, emphysema). (merckmanuals.com)

Johns Hopkins researchers have found that lower than normal blood levels of vitamin D are linked to increased risk of early signs of interstitial lung disease - a relatively rare group of disorders characterized by lung scarring and inflammation that may lead to progressive, disabling and irreversible lung damage. (trustedhealthproducts.com)

Accurate imaging diagnosis can help clinicians to treat the disease in time and use drugs rationally, so as to avoid delay in the conditions of patients. (hindawi.com)
We develop and implement magnetic resonance imaging (MRI) methods for evaluation and diagnosis of musculoskeletal disease. (lu.se)

Studies of the natural history of HIV infection have documented a wide spectrum of disease manifestations, ranging from asymptomatic infection to life-threatening conditions characterized by severe immunodeficiency, serious opportunistic infections, and cancers (4-13). (cdc.gov)

J Heart Lung Transplant. (nih.gov)

Anatomy27

Organisms9

Diseases85

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment59

Psychiatry and Psychology1

Phenomena and Processes36

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Named Groups2

Health Care21

Fibrosis41

Usual interstit3

Systemic19

ILDs9

Respiratory21

Rheumatoid arthritis6

Pneumonitis8

Clinical16

Tissue18

Parenchyma1

Toxicity6

Fibrotic lung disease2

Mortality8

Diffuse5

Improved progression-free sur1

Alveolar1

Abnormalities5

Idiopathic interstitial1

Pleural2

Chronic9

Survival7

20211

Computed tomography2

Pulmonary heart d1

Decline in lung function1

Symptoms4

Acute2

Biopsy1

Heterogeneous group of diseases1

Transplantation4

Autoimmune disease2

Airway disease2

Histologically2

Inflammatory7

Baseline2

Lesions1

Chemotherapy11

Cyclophosphamide2

Etiology1

Disorders-characterized1

Diagnosis2

Manifestations1

Heart Lung Trans1