Progression k562 cells. Medical search. Frequent questions

Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed. (researchsquare.com)
Therefore, besides the regulation of immune cells, NFAT2 also exerts modulatory effect of proliferation, invasion, metastasis and malignancy in breast cancer, lung cancer, melanoma and leukemia [13-15]. (researchsquare.com)
In this study, we constructed NFAT2 overexpressed cells (HepG2/NFAT2) based on HepG2 and investigated the effect of NFAT2 overexpression on HepG2 cells' viability, apoptosis, proliferation, invasion and migration. (researchsquare.com)
Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
To evaluate the leukemogenic role of RUNX1-MT in ASXL1 -mutated cells, we co-expressed RUNX1 -MT (R135T) and ASXL1 -MT (R693X) in different cell lines and performed immunoblot, co-immunoprecipitation, gene expression microarray, quantitative RT-PCR, cell proliferation, differentiation, and clonogenic assays for in vitro functional analyses. (biomedcentral.com)
The expression of RUNX1 mutant in ASXL1 -mutated myeloid cells augmented proliferation, blocked differentiation, and increased self-renewal activity. (biomedcentral.com)
Cancer cells can be defined by their constant and uncontrolled proliferation. (biomedcentral.com)
The effects of heterozygous deletion of Mrad1 on proliferation and apoptosis of keratinocytes is different from those resulted from Mrad9 heterozygous deletion (from our previous study), suggesting that Mrad1 also functions independent of Mrad9 besides its role in the Mrad9-Mrad1-Mhus1 complex in mouse cells. (biomedcentral.com)
It is likely that increased Rad9 expression is needed for proliferation of tumor cells by mechanisms such as getting beyond (tolerating) oncogene-induced replicative stress and enhancing DNA repair capability. (biomedcentral.com)
The pathogenesis of anaemia in cancer is multifactorial and includes classical features of the inflammatory anaemia of chronic disease, such as iron restriction within the reticuloendothelial system, an impaired biological activity of erythropoetin and a diminished proliferation of erythroid progenitor cells, all of which are the reflection of a cancer driven activated immune system ( 2 ). (iiarjournals.org)
Bosutinib is a potent inhibitor of CML cell proliferation in vitro and has demonstrated promising activity in CML patients resistant or intolerant to IM as well as in newly diagnosed patients with chronic phase CML (CML-CP). (mdm2-receptor.com)
Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhanced by co-signals such as IL-4 and LPS. (thermofisher.com)
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. (thermofisher.com)
miR-29b suppressed cellular proliferation and promoted apoptosis of pulmonary artery smooth muscle cells, possibly through the inhibition of Mcl-1 and CCND2. (cusabio.cn)
data indicate that linc00598 plays an important role in cell cycle regulation and proliferation through its ability to regulate the transcription of CCND2. (cusabio.cn)
The surface immune molecule CD274 plays a critical role in the proliferation of leukemia-initiating cells, LICs. (cusabio.cn)
MiR-497 significantly suppressed cell proliferation by arresting the cell cycle through the CCND2 protein. (cusabio.cn)
Kelly and SH-SY5Y neuroblastoma cells also exhibited a reduced proliferation rate after exposure to carvacrol (Kocal and Pakdemirli, 2020). (dieselok.md)
The inhibition of cell proliferation and apoptosis on MDA-MB231 and MCF-7 cell lines occurred via the mitochondrial pathway and induction of oxidative damage to DNA through Bax/Bcl-2 modulation, decreased levels of procaspase-8, -9, -3, increased levels of cleaved caspase-3 and ROS, and also cell cycle arrest at S-phase (Jamali et al. (dieselok.md)

Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
The NFAT2 overexpression suppressed the cell viability, invasion and migration capabilities, and promoted apoptosis of HepG2 cells. (researchsquare.com)
Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
Activation of caspases in response to treatment method with Inhibitors,Modulators,Libraries extracts To achieve insights to the potential mechanisms of apoptosis concerned, caspase 3 seven exercise at the same time as pro tein expression of caspase eight and 9 have been measured for that six most potent extracts in HeLa cells just after sixteen h of remedy. (screeninglibraries.com)
The apoptosis was improved when TNF- knockout cells were cultured with imatinib. (ppbhg.org)
Keratinocytes isolated from Mrad1 +/- mice had significantly more spontaneous DNA double strand breaks, proliferated slower and had slightly enhanced spontaneous apoptosis than Mrad1 +/+ control cells. (biomedcentral.com)
We showed that β-catenin could suppress sorafenib-induced apoptosis and cell growth inhibition in HCC cell lines. (biomedcentral.com)
Erythropoetin (Epo) is a 30.4 kDa glycoprotein that regulates erythropoesis by stimulating growth, preventing apoptosis and inducing differentiation of red blood cell precursors. (iiarjournals.org)
The cell apoptosis was detected using flow cytometry. (lookformedical.com)

Thus miR-628 is likely to be involved in the development and progression of gastric cancer. (wikipedia.org)
Angiogenesis, the growth of new blood vessels, is critical for the development and progression of cancerous tumors. (acgtfoundation.org)

The effects of WR-1065 (2-((aminopropyl)amino)ethanethiol) on cell cycle progression, topoisomerase (topo) IIα activity, and topo IIα phosphorylation in Chinese hamster ovary (CHO) cells have been investigated. (ucy.ac.cy)
Eukaryotic cells have developed exquisite mechanisms that monitor and coordinate cell cycle progression with repair of DNA damage to maintain genome integrity. (biomedcentral.com)

The expanded NK cells were significantly more potent than unstimulated or IL-2-stimulated NK cells against acute myeloid leukemia cells in vitro . (aacrjournals.org)

We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
Inhibition of lipogenesis leads to cell death both in vitro and in vivo and does not induce cell death of normal splenocytes. (biomedcentral.com)
Using in vitro cell lines derived in from conditional MYC, RAS, and BCR-ABL transgenic murine models and oncogene-driven human cell lines, we determined gene regulation, metabolic profiles, and sensitivity to inhibition of lipogenesis in lymphoid malignancies. (biomedcentral.com)
We identify specific cell death responses to TOFA in vitro and in vivo and demonstrate delayed engraftment and progression in vivo in transplanted lymphoma cell lines. (biomedcentral.com)
Tumor cells were cultured in vitro with the proteasome inhibitor bortezomib, which stabilizes SLiPs and DRiPs, shunting proteins into the autophagy pathway [ 12 ]. (biomedcentral.com)
Treatment with VIP or PACAP prior to in vitro LC Ag presentation to CD4+ T cells enhanced IL-17A, IL-6, and IL-4 production, decreased interferon (IFN)-γ and interleukin (IL)-22 release, and increased RORγt and Gata3 mRNA expression while decreasing T-bet expression. (syksignaling.com)
Intradermal administration of VIP or PACAP prior to application of a contact sensitizer at the injection site, followed by harvesting of draining lymph node CD4+ T cells EPZ015666 in vitro and stimulation with anti-CD3/anti-CD28 mAbs, enhanced IL-17A and IL-4 production but reduced production of IL-22 and IFN-γ. (syksignaling.com)

We have recently demonstrated that vaccination with irradiated murine allogeneic ovarian cancer cells secreting heat shock protein 70 (Hsp70) were capable of generating potent tumor antigen-specific immune responses and strong anti-tumor effects against ovarian cancers (Chang et al. (acgtfoundation.org)

NFAT2, as an important transcriptional promoter, regulates expression of TNF-α, myc proto-oncogene protein (c-myc), cyclooxygenase-2 (COX-2), Fas ligand (FasL) and also generates crosstalks with ERK/MAPK pathway and AKT/GSK3b signaling, which achieves its control of the cell fate [7-12]. (researchsquare.com)
The CD274/JNK/Cyclin D2 pathway promotes the cell cycle entry of LIC. (cusabio.cn)

In recent studies, this linker modified analog of goniothalamin was shown to be cytotoxic against PC-3 (prostate cancer) and MCF-7 (human breast cancer) cell lines with half maximal inhibitory concentration values of 0.13 Î¼M and 2.6 Î¼M, respectively. (lookformedical.com)
CONCLUSIONS These results suggest that activation of VEGFR-1 by VEGF-A within the carcinoma, and activation of lymphatic endothelial cell VEGFR-3 by VEGF-D within the adjacent benign stroma may be important see more signaling mechanisms involved in the progression and subsequent metastatic spread of prostate cancer. (cdk-receptor.com)
doi:10.7287/peerj.9626v0.1/reviews/1, Soković, M., Glamoclija, J., and Ciric, A. Thymol also caused a decrease in cell viability of prostate cancer (PC-3 cell line), and provoked cytotoxic effects (Pathania et al. (dieselok.md)

miR-638 levels are significantly downregulated in gastric cancer cell lines, along with deregulation of 23 other miRNAs. (wikipedia.org)
Notch signaling and transcription factors STAT3 (signal transducer and activator of transcription 3) and Twist regulate tumor development and are critical regulators of gastric cancer progression. (tmu.edu.tw)
Herein, the relationship among Notch, STAT3 and Twist pathways in the control of gastric cancer progression was studied. (tmu.edu.tw)
Gastric cancer progression of SC-M1 cells was promoted by N1IC through STAT3 phosphorylation and Twist expression including colony formation, migration and invasion. (tmu.edu.tw)
STAT3 regulated gastric cancer progression of SC-M1 cells via Twist. (tmu.edu.tw)
N1IC also elevated the progression of other gastric cancer cells such as AGS and KATO III cells through STAT3 and Twist. (tmu.edu.tw)

Compare clinical response, in terms of 1-year progression-free survival and rate of molecular complete remission, in patients with Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) in chronic phase who have achieved a complete cytogenetic remission to single-agent tyrosine kinase inhibitor treated with interferon alfa and sargramostim (GM-CSF) vs tyrosine kinase inhibitor and GM-K562 cell vaccine. (knowcancer.com)
1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
Having examined the nature of the signals required by the T cells for their own survival and sustained functionality, Dr. Sadelain designed improved antigen receptors that provide both activating and co-stimulatory signals to the tumor-targeted T cell. (acgtfoundation.org)
Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival. (uu.se)

Nuclear factor of activated T cells 2 (NFAT2, also known as NFATc and NFATc1) is an important member of NFAT family which plays a vital role in T cell activation and differentiation [4]. (researchsquare.com)
Mechanistically, the cell differentiation mediated by JOA may be originated from the inhibition of BCR-ABL/c-MYC signaling in CML cells expressing wild-type BCR-ABL and BCR-ABL-T315I. (jcancer.org)
JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. (thermofisher.com)

We found that Twist and phosphorylated STAT3 levels were promoted by the activated Notch1 receptor in human stomach adenocarcinoma SC-M1, embryonic kidney HEK293 and erythroleukemia K562 cells. (tmu.edu.tw)

In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)

Co-expression of two mutant genes increased myeloid stem cells in animal model, suggesting that cooperation of RUNX1 and ASXL1 mutations played a critical role in leukemia transformation. (biomedcentral.com)
Mice transduced with both ASXL1 and RUNX1 mutations enhanced inhibitor of DNA binding 1 (ID1) expression in the spleen, liver, and bone marrow cells. (biomedcentral.com)
NSCLC without driver mutations is one of the most heavily mutated of human cancers [ 8 ], thus it is likely that NSCLC cells harbor neoantigens to which the host would not be tolerant, and against which the immune system could mount a strong, destructive immune response. (biomedcentral.com)

We determined the capacity of the leukemia cell line K562 modified to express a membrane-bound form of interleukin (IL)-15 and 41BB ligand (K562-mb15-41BBL) to generate human NK cells with enhanced cytotoxicity. (aacrjournals.org)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

SP27 exhibited effective PLK4 degradation, more potent inhibition of cell growth, and more efficient precision-therapeutic effect in the TRIM37-amplified MCF-7 cell line than conventional inhibitor CZS-035. (bvsalud.org)
Recent studies demonstrate that PLK4 has emerged as a therapeutic target for the treatment of multiple cancers owing to its indispensable role in cell division. (bvsalud.org)
This clinical translational proposal aimed to assess the therapeutic potential of genetically targeted T cells in the treatment of leukemia and lymphoma. (acgtfoundation.org)
Importantly, he found that T cell stimulation with the cytokine lnterleukln-15, but not the widely used lnterteukin-2, is critical for sustaining the therapeutic activity of infused CO19-spedflc T cells. (acgtfoundation.org)
Valencia J, Gul-Uludağ, H, Mahdipoor P. Jiang, X, Uludağ H. Investigating siRNA delivery to chronic myeloid leukemia K562 cells with lipophilic polymers for therapeutic BCR-ABL down-regulation. (udea.edu.co)
Furthermore, cKap satisfies the therapeutic criteria of being able to trigger ADCC MMusing human peripheral blood-derived effector cells. (slideserve.com)

Dr. Sadelain demonstrated that human peripheral blood T cells could be effectively redirected to recognize the CO19 antigen and eradicate established, systemic human B cell tumors borne by immunodeficient mice, This was the first publication showing that genetically modified human T cells can induce durable remissions in an in vivo setting. (acgtfoundation.org)
Expression of neoantigens alone is insufficient without cross-presentation by antigen presenting cells in the appropriate cytokine milieu. (biomedcentral.com)
However, with the exception of idiotype, few antigen targets have been identified that would facilitate specific immunotherapy of MM. We have previously described a murine monoclonal antibody that recognizes a conformation-dependent epitope on free human kappa light chains and a cell surface antigen, KMA, expressed on kappa MM (MM) plasma cells 1,2. (slideserve.com)
In T cells, productive antigen stimulation triggers the activation of MAPK including extracellular signal-regulated kinase, p38 and JNK.33 The JNK is activated through the dual phosphorylation of its Thr and Tyr residues by mitogen-activated kinase kinase Pembrolizumab 4 (MKK4) and MKK7. (syksignaling.com)

Arm II: Patients receive GM-K562 cell vaccine intradermally once every 3 weeks for a minimum of 6 months. (knowcancer.com)
Based on the encouraging preclinical data, we propose to generate a clinical grade tumor cell-based vaccine engineered to secrete high levels of Hsp70. (acgtfoundation.org)
Autologous vaccine generated from tumor cells harvested from pleural effusions was administered to patients with advanced NSCLC with the objectives of assessing safety and immune response. (biomedcentral.com)
All patients came off study after 4 or fewer vaccine treatments due to progression of disease. (biomedcentral.com)
DRibble vaccine given with GM-CSF appeared safe and capable of inducing an immune response against tumor cells in this small, pilot study. (biomedcentral.com)
This study was designed to test a novel immunotherapy strategy using a vaccine enriched for short-lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from autologous tumor cells. (biomedcentral.com)

However, the molecular pathogenesis of the progression of CMML to sAML remains unclear. (biomedcentral.com)

Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
Importantly, cell death was not significantly observed in non-malignant cells in vivo . (biomedcentral.com)
In addition, co-existing factors such as vitamin deficiency, renal insufficiency, tumour infiltration into the bone marrow and local cytokine production by malignant cells within this compartment further contribute to cancer-related anaemia. (iiarjournals.org)

In this study, we aimed to explore the effect of NFAT2 expression on cell fate of HepG2 cell and its potential mechanisms. (researchsquare.com)
First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)

We therefore adapted the K562-mb15-41BBL stimulation method to large-scale clinical-grade conditions, generating large numbers of highly cytotoxic NK cells. (aacrjournals.org)
The results that we report here provide rationale and practical platform for clinical testing of expanded and activated NK cells for cell therapy of cancer. (aacrjournals.org)
The engineered T cells eradicate large tumors in pre-clinical experiments. (acgtfoundation.org)
Background: Adverse outcomes in breast cancer patients treated with recombinant human erythropoietin (rhEpo) have been linked to the expression of Epo-receptors (EpoR) in cancer cells, although limited data on the clinical significance of these observations are available. (iiarjournals.org)
However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)

Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)
Nonetheless, 2009 data has shown for that to start with time that the subcellular localization selleck chemicals of Kaiso while in the cytoplasm of the cell is straight connected using the bad prognosis of patients with lung cancer, and close to 85 to 95% of lung cancers are non small cell. (screeninglibraries.com)
The protocol will test whether the T cells that are designed to withstand the toxic effects of the tumor are able to mediate tumor regression in patients with advanced ovarian cancer that has failed to regress after chemotherapy. (acgtfoundation.org)
Three of four patients had tumor cells available for testing. (biomedcentral.com)
Although the majority of patients will not respond to checkpoint inhibition, results of these and other studies have led to FDA approval for checkpoint inhibitors for the treatment of advanced NSCLC, both in the first line setting, and after progression on platinum-based chemotherapy. (biomedcentral.com)
The incidence of anaemia increases with the progression of the disease and the age of patients. (iiarjournals.org)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)

In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
In addition to mutated proteins, NSCLC can over-express a number of non-mutated proteins that can induce both humoral and cytotoxic T cell responses [ 10 ], and also have the potential to serve as tumor rejection antigens [ 11 ]. (biomedcentral.com)
We further confirmed that Nek2 could induce sorafenib resistance in HCC cell lines, and that β-catenin was the key element involved in this process. (biomedcentral.com)
Interestingly, amyloid-beta (A beta) soluble oligomers were able to induce upregulation of VDAC1 in a human neuroblastoma cell line, further supporting a correlation between A beta levels and VDAC1 expression. (cdk-receptor.com)

The N1IC-promoted tumor growth and lung metastasis of SC-M1 cells in mice were suppressed by the STAT3 inhibitor JSI-124 and Twist knockdown. (tmu.edu.tw)
We examined the consequences of CTCF depletion in immortalised human and mouse cells using shRNA knockdown and CRISPR/Cas9 genome editing and examined the growth and development of heterozygous Ctcf ( Ctcf +/- ) mice. (preprints.org)
These mice are devoid of endogenous natural killer and T-cell activity and were used to determine whether adoptively transferred expanded natural killer cells could inhibit myeloma growth and myeloma-associated bone destruction. (haematologica.org)
Knockdown of Rad9 in prostate tumor cells correlates with reduction of tumorigenicity in nude mice [ 16 ]. (biomedcentral.com)

Overexpression of Notch1 receptor intracellular domain (N1IC) enhanced the interaction between nuclear STAT3 and Twist promoter in cells. (tmu.edu.tw)
Here we design a high-throughput reporter assay called enhancer × promoter self-transcribing active regulatory region sequencing (ExP STARR-seq) and applied it to examine the combinatorial compatibilities of 1,000 enhancer and 1,000 promoter sequences in human K562 cells. (nature.com)

Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
Using cell lines derived from conditional MYC, RAS, and BCR-ABL transgenic murine models, we demonstrate shared responses to inhibition of lipogenesis by the acetyl-coA carboxylase inhibitor 5-(tetradecloxy)-2-furic acid (TOFA), and other lipogenesis inhibitors. (biomedcentral.com)
Here we show that the murine antibody, mKap, binds specifically to a range of kappa-type multiple myeloma (MM) cell lines and mediates in vivo anti-tumor activity in a SCID mouse human myeloma xenograft model. (slideserve.com)

While CTCF is essential for embryonic development, little is known of its absolute requirement in somatic cells and the consequences of CTCF haploinsufficiency. (preprints.org)
Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development. (uu.se)

miR-638 has additionally been found to be upregulated in the K562 leukaemic cell line. (wikipedia.org)
These information are steady with all the results found in the K562 cell line in which expression of the Kaiso is predominantly cytoplasmic. (screeninglibraries.com)
The values of LD50 (lethal dose 50%) calculated from experiments are different for each cell line . (lookformedical.com)

Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

As a master regulator in cells, RNA-binding protein (RBP) plays critical roles in organismal development, metabolism and various diseases. (bvsalud.org)
Tumor necrosis element (TNF-), a pleiotropic cytokine exerting both inhibitory and stimulatory effects on diverse cellular processes, is a key regulator of immunological reactions.9 It has been reported that CML stem/progenitor cells (CML-SPCs) create TNF- at higher levels inside a kinase-independent style. (ppbhg.org)
cyclin D2 acts as regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. (cusabio.cn)

Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
Expanded natural killer cells killed both allogeneic and autologous primary myeloma cells avidly via a perforin-mediated mechanism in which the activating receptor NKG2D, natural cytotoxicity receptors, and DNAX-accessory molecule-1 played a central role. (haematologica.org)

18,21 Early in 2010, a team of Taiwanese researchers discovered that GLA regulates the inflammatory "master molecule" nuclear factor-kappaB or NF-kB, preventing it from switching on genes for inflammatory cytokines in cell nuclei. (lifeextension.com)
Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
The introduction of genes that code for tumor-specific receptors into T lymphocytes, which are cells of the immune system that mediate tumor elimination, was a novel approach to cancer therapy. (acgtfoundation.org)
la hipermetilación del DNA está implicada en la regulación transcripcional de genes supresores de tumoresen diferentes tipos de neoplasias hematológicas incluyendo la leucemia mieloide crónica (LMC). (udea.edu.co)
Se realizó una revisiónsistemática siguiendo las indicaciones propuestas en la guía PRISMA (Preferred Reporting Items for Systematic reviewsand Meta-Analyses) con el objetivo de identificar los principales genes hipermetilados en pacientes con LMC en las tresfases clínicas de la enfermedad de acuerdo con lo publicado en la literatura científica entre 2003-2013. (udea.edu.co)
en los análisis de hipermetilación en pacientes con LMC se evaluaron 39 genes clasificados como supresoresde tumores, reguladores del ciclo circadiano, codificantes para factores de transcripción/receptores, involucrados enreparación del DNA, vías de señalización y metabolismo de nucleótidos, entre otros. (udea.edu.co)
Además, se obtuvo un valor de p = 0,000 en las comparaciones múltiples de la proporción de hipermetilación según la fase clínica de la enfermedad,estableciendo una posible relación entre la progresión de la enfermedad y el porcentaje de metilación de genes enpacientes con LMC. (udea.edu.co)
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. (cusabio.cn)

The process by which a chemical or physical signal is transmitted through a cell as a series of molecular events is called signal transduction. (screeninglibraries.com)
Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate. (uu.se)
CD38 participates in cell adhesion, signal transduction and calcium signaling. (thermofisher.com)

GLA plays an important role in modulating inflammation throughout the body, especially when incorporated into the membranes of immune system cells. (lifeextension.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
It is hoped that the host immune status can be accurately predicted and gradually advance γδ T cell precise individualized medicine. (explorationpub.com)

The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)

CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. (thermofisher.com)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)

At the cellular level, it presented excellent antiproliferative activity against breast cancer cells. (bvsalud.org)
Infusions of natural killer (NK) cells are an emerging tool for cancer immunotherapy. (aacrjournals.org)
Natural killer (NK) cells can kill cancer cells in the absence of prior stimulation and hold considerable potential for cell-based therapies targeting human malignancies ( 1 - 4 ). (aacrjournals.org)
Many ORs are expressed by tumor cells and tissues, suggesting that they may be associated with cancer progression or may be cancer biomarkers. (bmbreports.org)
To achieve this, cancer cells must reprogram their metabolic pathways to accumulate intermediates as sources for these building blocks. (biomedcentral.com)
The physical structure of these solid tumors presents a formidable challenge to drug delivery vehicles that need to penetrate and reach all cancer cells in order to be optimally effective. (acgtfoundation.org)
Immunotherapy using gene-transduced tumor cells has emerged as a potentially plausible approach for the control of advanced stage ovarian cancer. (acgtfoundation.org)
The secretion of Hsp70 from the ovarian cancer cells will allow the Hsp70-associated antigenic peptide to be concentrated and targeted to dendritic cells (DCs) with subsequent DC activation. (acgtfoundation.org)
GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer. (uu.se)
Non-small cell lung cancer (NSCLC) is the leading cancer killer worldwide [ 1 ]. (biomedcentral.com)
Unrepaired DNA lesions can lead to cell death, gene mutation and cancer. (biomedcentral.com)
In addition, several cancer cells were found to express EpoR on their surface whose function is a matter of discussion ( 16 - 18 ). (iiarjournals.org)
Interestingly, the half maximal inhibitory concentration (IC50) of BLMs in different cancer cell lines varies from nM to μM ranges. (lookformedical.com)
Our results indicate that miR-4317 can reduce Non-small cell lung cancer (NSCLC) cell growth and metastasis by targeting FGF9 and CCND2. (cusabio.cn)
Cell cycle involvement in cancer treatment with carvacrol and thymol. (dieselok.md)
2002). The Mechanism of Carvacrol-Evoked [Ca2+]i Rises and Non-ca2+-triggered Cell Death in OC2 Human Oral Cancer Cells. (dieselok.md)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)

We have access to several high grade serous carcinoma cell lines, that express several known tumor antigens, such as CA-125 and mesothelin. (acgtfoundation.org)

Moreover, compound B43 effectively inhibited leukemia cells in 29 tested cell lines, especially chronic myeloid leukemia (CML) cell lines K562 and KU-812. (bvsalud.org)

To this end we used deep sequencing (GRO-seq and PRO-seq) and analyzed nascent mtDNA-encoded RNA transcripts in diverse human cell lines and metazoan organisms. (biorxiv.org)
This pausing site correlated with the presence of a bacterial pausing sequence motif, yet the transcription pausing index varied quantitatively among the cell lines. (biorxiv.org)
Kaiso and prognosis As expected for a transcriptional aspect, the Kaiso Inhibitors,Modulators,Libraries protein is often discovered while in the nucleus of quite a few tumor or non tumor derived mammalian cell lines. (screeninglibraries.com)
In a panel of human cell lines, we demonstrate sensitivity to TOFA treatment as a metabolic liability due to the general convergence on de novo lipogenesis in lymphoid malignancies driven by MYC, RAS, or BCR-ABL. (biomedcentral.com)
By screening β-catenin-interacting proteins, we found that Nek2 could bind β-catenin in sorafenib-treated HCC cell lines. (biomedcentral.com)

In epithelial cells, VEGF-A and VEGFR-1 expression was higher in tumor tissue compared to benign tissue. (cdk-receptor.com)

Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)

In preliminary studies, we have developed genetically engineered T cells as a complementary immunotherapy to augment traditional treatment strategies. (acgtfoundation.org)

PI3k belongs to a family of lipid kinases, involved in extracellular signals transduction and cell growth promotion (Wullschleger et al. (dieselok.md)

Molecular Monito-ring of BCR-ABL Transcripts after Allogeneic Stem Cell Transplantation for Chronic Myeloid Leukemia. (udea.edu.co)

Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. (thermofisher.com)

Comparisons of the gene expression profiles of the expanded NK cells and their unstimulated or IL-2-stimulated counterparts showed marked differences. (aacrjournals.org)
Raw and processed data for ExP STARR-seq, motif ExP STARR-seq, HS-STARR-seq and K562 PRO-seq can be found at the NCBI's Gene Expression Omnibus under accession number GSE184426 . (nature.com)
Moreover, the RUNX1 mutant protein was more stable than WT and increased HIF1-α and its target ID1 gene expression in ASXL1 mutant cells. (biomedcentral.com)

The development of clinically applicable methods to produce large numbers of fully functional NK cells is a critical step to maximize the potential of this approach. (aacrjournals.org)
DNA replication allowing time for DNA repair.30,31 p21Cip1 interaction with PCNA results in the inhibition of PCNA and thereby causes G1 and G2 block in T cells.14,32 There was some association of p21Cip1 with PCNA in stimulated control Th1 cells, but the functional significance of this low-level interaction was not determined. (syksignaling.com)
At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)

In CML progression to accelerated phase and blastic phase appears to be due mainly to genomic instability, which predisposes to the de velopment of other molecular abnormalities. (screeninglibraries.com)
2Department of Cell and Molecular Biology, University of Technology Sydney, Broadway, NSW, 2007, Australia JJN3 MMk cells (IgAk) were incubated with mKap or cKap alone or in the presence of competing free kappa light chains (kBJP). (slideserve.com)
Los cromatogramas fueron elaborados en: Instituto de InvestigaciÃ³n en BioquÃ-mica y BiologÃ-a Molecular de la UNALM, 2014. (dieselok.md)

For example, in multiple myeloma, the inhibition of canonical Wnt signaling suppresses tumor growth and sensitizes cells to anti-tumor drugs [ 14 ]. (biomedcentral.com)

23 PPARs are intracellular receptors that modulate cell metabolism and responses to inflammation. (lifeextension.com)
Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells. (uu.se)

Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
The current study firstly suggested that NFAT2 suppressed the aggression and malignancy of HepG2 cells through inducing the expression of Egr2. (researchsquare.com)
Around the contrary, in K562 cells, on Kaiso knock down we observed a signifi cant reduce within the Wnt11 expression. (screeninglibraries.com)
Re-expression of glucuronyl C5-epimerase in the mutant MEF cells increases heparan sulfate epimerization but has no influence on the Golgi localization and enzymatic activity of 2-O-sulfotransferase. (uu.se)
Its expression is reported on a subpopulation of thymocytes, mature T cells, and NK cells. (thermofisher.com)
Both CCND1- and CCND2-expressing MM cells arrested in S/G2/M, and did not differ in other cell-cycle proteins or sensitivity to IR.Differential expression of D-cyclin does not appear to affect cell-cycle response to IR, and is unlikely to underlie differential sensitivity to DNA damage. (cusabio.cn)

The testosterone secretion from TM3 cells was measured using the enzyme-linked immunosorbent assay. (lookformedical.com)

Here, we established an efficient HyperTRIBE (Targets of RNA-binding proteins Identified By Editing) in yeast, by fusing an RBP to the hyper-active catalytic domain of human RNA editing enzyme ADAR2 and expressing the fusion protein in yeast cells. (bvsalud.org)
1 probable explanation is the fact that Kaiso, like other proteins or variables that normally reside during the cytoplasm, need a post translational modification, to get targeted and translocated towards the cell nucleus. (screeninglibraries.com)
It is believed that this complex is important for the function of these three proteins in DNA repair as well as activation of cell cycle checkpoints. (biomedcentral.com)

Anatomy17

Organisms9

Diseases57

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Psychiatry and Psychology1

Phenomena and Processes55

Disciplines and Occupations1

Information Science4

Health Care19

Proliferation22

Apoptosis10

Development and progression2

Cycle progression2

Acute myeloid1

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Prostate cancer3

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