• We aimed to investigate the prognostic value of tumor-infiltrating lymphocytes (TILs) in a uniform cohort of patients with completely resected stage IIIA(N2) NSCLC. (oncotarget.com)
  • Treatment resistance could be due to the tumour microenvironment, a desmoplastic stroma consisting of cancer-associated fibroblasts and tumour-infiltrating lymphocytes (TILs). (hal.science)
  • The aim of the study was to evaluate the prognostic value of TILs and cancer-associated fibroblasts (CAFs) in pancreatic cancer of the body and tail. (hal.science)
  • TILs can often be found in the tumor stroma and within the tumor itself. (wikipedia.org)
  • Their functions can dynamically change throughout tumor progression and in response to anticancer therapy TILs are implicated in killing tumor cells. (wikipedia.org)
  • TILs can be found between the tumor cells, as TILs in the stroma surrounding the tumor cells do not count. (wikipedia.org)
  • TILs are often found floating around the tumor without actual penetration or action on the tumor cells. (wikipedia.org)
  • TILs can not only recognize over-expressed self/melanocyte differentiation antigens, such as Melan-A/MART-1 (melanoma-specific), gp100, tyrosinase, and survivin, but TILs can also recognize other unknown antigens specific to the tumor and individual patient. (wikipedia.org)
  • In Adoptive T cell transfer therapy, TILs are expanded ex vivo from surgically resected tumors that have been cut into small fragments or from single cell suspensions isolated from the tumor fragments. (wikipedia.org)
  • The process can also involve a preliminary chemotherapy regimen to deplete endogenous lymphocytes in order to provide the adoptively transferred TILs with enough access to surround the tumor sites. (wikipedia.org)
  • Lympho-depletion is thought to eliminate the negative effects of other lymphocytes that may compete for growth factors and decrease anti-tumor effects of the TILs, depleting regulatory or inhibitory lymphocyte populations. (wikipedia.org)
  • The spurt of knowledge available for the TILs has completely changed the concept of using simple cells infiltrating from the tumors as a novel and efficient treatment regimen. (researchandmarkets.com)
  • Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
  • ImmunoPulse™ IL-12, which employs intratumoral electroporation to enhance delivery of DNA-based interleukin-12 (IL-12), is designed to enhance tumor immunogenicity, leading to increased tumor infiltrating lymphocytes (TILs) and pro-inflammatory cytokines. (prnewswire.com)
  • Previous studies have demonstrated that breast cancer patients whose tumors are associated with markers of inflammation, such as the presence of TILs, have better clinical outcomes. (prnewswire.com)
  • 6 There is increasing evidence that tumors need TILs for anti-PD-1/PD-L1 therapies to be most effective. (prnewswire.com)
  • In addition, a deeper characterization of immune infiltrates, including the presence of a high number of cytotoxic (CD8 + ) TILs or a high CD8 + /FOXP3 + ratio, is able to define TNBC patients with a better prognosis following neoadjuvant chemotherapy [ 6 ]. (biomedcentral.com)
  • Tumor-infiltrating lymphocytes [TILs] have been shown to be prognostic of outcome in triple-negative breast cancer and to a smaller extent in hormone receptor-positive [breast cancer]. (onclive.com)
  • So there's a heightened awareness around the prognostic and predictive impact of TILs, but we're not doing it formally. (onclive.com)
  • Tumor-infiltrating lymphocytes (TILs) have shown remarkable clinical responses in some patients with advanced solid tumors . (bvsalud.org)
  • This study aims to investigate the characteristics and function of CD3+CD4-CD8- TILs (double-negative TIL, DN-TILs) derived from solid tumor . (bvsalud.org)
  • The cytotoxicity of DN-TILs was determined against established tumor cell lines in vitro or through in vivo adoptive transfer into xenograft models. (bvsalud.org)
  • DN-TILs significantly reduced tumor volume in xenograft models with superior tumor -homing ability and low off-target toxicity . (bvsalud.org)
  • Immunosuppressive mechanisms within the tumor microenvironment have been associated with the failure of TILs [ 5 ]. (biomedcentral.com)
  • Tumor infiltrating lymphocytes (TILs) are a significant component of the tumor microenvironment [ 1 ]. (bmj.com)
  • The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. (tilsinbreastcancer.org)
  • Tumour infiltrating lymphocytes (TILs) in breast cancer during pregnancy. (tilsinbreastcancer.org)
  • Tumor-infiltrating lymphocytes (TILs) have emerged as prognostic in triple-negative breast cancer (TNBC). (ox.ac.uk)
  • Conclusion In patients with resected left-sided pancreatic cancer, a tumour microenvironment characterized by a high CD4/CD3 lymphocyte ratio along with a low αSMA/vimentin ratio is correlated with poorer survival. (hal.science)
  • Such methods allow for systematic TIL enumeration and characterization of the tumor microenvironment in diverse cancer types and across thousands of tumors, an approach largely led by Ash Alizadeh, Ajit Johnson among others. (wikipedia.org)
  • Her research is focused on breast cancer and gynecologic oncology, with a specific interest in prediction of treatment response and the tumor immune microenvironment. (case.edu)
  • Immunologic checkpoints" expressed on cells in the tumor microenvironment or on the surface of tumor cells (TCs) can promote immune escape by inducing apoptosis in immune effector cells. (biomedcentral.com)
  • Many recent studies have reported that the response to immunotherapy primarily depends on the expression of PD-L1 in the tumor microenvironment. (biomedcentral.com)
  • This microenvironment comprises a variety of non-cancerous cells, such as immune cells (e.g. macrophages, lymphocytes, natural killer cells), fibroblasts, adipocytes and endothelial cells, together with extracellular matrix components and soluble factors, which influence cancer progression and are predictive of clinical outcome. (ua.pt)
  • This review addresses current knowledge on this metabolic crosstalk within the breast tumour microenvironment (TME). (ua.pt)
  • Implication of tumor microenvironment in the resistance to chemotherapy in breast cancer patients. (tilsinbreastcancer.org)
  • Their abundance varies with tumor type and stage and in some cases relates to disease prognosis. (wikipedia.org)
  • An active immune environment within the tumor often indicates a better prognosis as can be determined by the Immunological constant of rejection. (wikipedia.org)
  • Prognosis is affected by the characteristics of primary and metastatic tumors. (cancer.gov)
  • Not only are there epidemiological differences in BC, there are also differences in tumor biology that affect the prognosis and response to treatment. (spandidos-publications.com)
  • At ASCO [American Society of Clinical Oncology Annual Meeting], there was an abstract on looking at a pooled analysis of the presence of tumor-infiltrating lymphocytes associated with prognosis. (onclive.com)
  • Univariate and multivariate Cox regression analyses were performed to ascertain the independent factors impacting the prognosis of EOEC patients, while a prognostic nomogram was established. (preprints.org)
  • Although immune checkpoint inhibitors have opened a new mode of treatment for solid tumors, their efficacy in nasopharyngeal carcinoma (NPC) needs to be further investigated. (jcancer.org)
  • Immunotherapy has recently emerged as a novel approach in treating solid tumors. (biomedcentral.com)
  • Tumor immune infiltration can also be determined using gene expression methods like Microarray or RNA Sequencing through deconvolution methods such as CIBERSORT. (wikipedia.org)
  • Detection of gene expression specific for different kind of immune cell populations can then be used to determine the degree of lymphocyte infiltration as has been shown in breast cancer. (wikipedia.org)
  • Lymphocyte infiltration in human CRC is associated with favourable outcome, both in terms of overall survival and recurrence-free survival [ 3 ]. (biomedcentral.com)
  • It is characterized by Epstein-Barr virus (EBV) infection and heavy lymphocyte infiltration [ 2 ]. (jcancer.org)
  • This improved efficacy was associated with higher tumor T-cell infiltration and overexpression of PD-1/PD-L1. (unav.edu)
  • Lymphocyte infiltration in breast cancer: a key prognostic factor that should not be ignored. (tilsinbreastcancer.org)
  • SYNE1 Mutation Is Associated with Increased Tumor Mutation Burden and Immune Cell Infiltration in Ovarian Cancer. (cdc.gov)
  • Autologous TIL therapy for metastatic melanoma has broad T cell recognition of both defined and undefined tumor antigens against all human leukocyte antigen (HLA) restrictions. (wikipedia.org)
  • However, they have a limited effect on patients with locally advanced or distantly metastatic disease, and approximately 30% of high-risk patients still experience tumor recurrence, with distant metastasis as the primary failure pattern [ 4 ]. (jcancer.org)
  • Abstract: Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TIL) mediates objective responses in 30% to 50% of patients with metastatic melanoma according to multiple, small phase 2 trials. (tau.ac.il)
  • Current work included metastatic breast cancer patients (n = 48), who were treated with trastuzumab and had pre-treatment tumour samples available. (oulu.fi)
  • The results suggest important prognostic and predictive role of tumour infiltrating lymphocytes in center of the tumours in metastatic HER2+ breast cancer. (oulu.fi)
  • Two of them are relate to rather similar trials of adjuvant therapy, and one is really a bit of an evolution when we talk about tumor-infiltrating lymphocyte (TIL) therapy for metastatic disease. (medscape.com)
  • Numerous studies support that sentinel lymph node status is the most important independent prognostic factor with respect to disease progression and melanoma-specific survival. (medscape.com)
  • Studies presented at the 2016 San Antonio Breast Cancer Symposium added to growing evidence that tumor-infiltrating lymphocytes are important prognostic factors in breast cancer. (ascopost.com)
  • The presence of lymphocytes in tumors is often associated with better clinical outcomes (after surgery or immunotherapy). (wikipedia.org)
  • Now-a-days, the market of immunotherapy is more attributed towards developing Tumor-Infiltrating Lymphocytes for causing complete remission of the tumor cells from the cancer patients. (researchandmarkets.com)
  • As per "Global Tumor Infiltrating Lymphocytes Immunotherapy Market Opportunity & Clinical Trials Insight 2025" report findings, it is estimated that the innovative research and development sector has excited the oncology researchers for driving the overall oncology pharmaceutical industry. (researchandmarkets.com)
  • As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
  • Inhibitors of the PD-1/PD-L1 immune checkpoint are one of the hot topics in tumor immunotherapy. (jcancer.org)
  • Tumor-infiltrating lymphocytes (TIL) play an essential role in mediating the response to immunotherapy and affect clinical outcomes in many cancer subtypes. (biomedcentral.com)
  • Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)
  • Wang, X. (2014) Neutrophil to Lymphocyte Ratio in Relation to Risk of All-Cause Mortality and Cardiovascular Events among Patients Undergoing Angiography or Cardiac Revascularization: A Meta-Analysis of Observational Studies. (scirp.org)
  • Xue, P. (2014) Neutrophil-to-Lymphocyte Ratio for Predicting Palliative Chemotherapy Outcomes in Advanced Pancreatic Cancer Patients. (scirp.org)
  • Retrospective data of 481 systemically untreated, N0, young TNBC patients showed that increasing stromal tumour infiltrating lymphocytes (TIL) have a prognostic value for improved outcome [1]. (medicom-publishers.com)
  • The expression of PD-L2 exhibited different spatial patterns among NPC tumor and stromal tissues. (jcancer.org)
  • A total of 90.8% of the cases showed membranous PD-L2 expression in tumors, and 80.8% showed membranous PD-L2 expression in stromal tissue. (jcancer.org)
  • High stromal expression of PD-L2 predicted favorable overall and disease-free survival of NPC patients and was negatively correlated with tumor size, recurrence or metastasis and clinical stage. (jcancer.org)
  • Multivariate analysis indicated that stromal PD-L2 was an independent and favorable prognostic factor. (jcancer.org)
  • All 8 EBV-GCLSs occurred in male patients and invaded deep submucosa (SM2) without lymph node metastasis (LNM), four (50%) of which had synchronous non-gastric malignant tumors (3 gastric gastrointestinal stromal tumors and 1 primary clear cell renal cell carcinoma), and four (50%) arose in the proximal stomach. (biomedcentral.com)
  • A growing body of research supports stromal tumour-infiltrating lymphocyte (TIL) density in breast cancer to be a robust prognostic and predicive biomarker. (lu.se)
  • The endothelial adhesion molecule, vascular adhesion protein-1 (VAP-1, AOC3 ) promotes lymphocyte recruitment to tumours, although the contribution that VAP-1 makes to lymphocyte recruitment in human colorectal cancer (CRC) is unknown. (biomedcentral.com)
  • Secondary CNS melanoma most often results from hematogenous spread from a known or unknown primary tumor. (medscape.com)
  • DNA extraction from formalin-fixed paraffin-embedded (FFPE) primary skin nodular melanoma tissue was performed after selection of tumor-rich slides using the GeneAll ® ExgeneTM DNA Extraction Kit (GeneAll Biotechnology, Seoul, Korea) according to the protocol provided by the producer. (researchsquare.com)
  • Melanoma is a malignant tumor of melanocytes, which are the cells that make the pigment melanin and are derived from the neural crest. (cancer.gov)
  • Uveal melanomas differ significantly from cutaneous melanoma in incidence, prognostic factors, molecular characteristics, and treatment. (cancer.gov)
  • There is increasing evidence that breast cancer patients with tumors characterized by a 'pro-inflammatory phenotype,' including those with TNBC, have better responses to chemotherapy and experience longer disease-free and overall survival rates," said Mai H. Le , MD, Chief Medical Officer at OncoSec. (prnewswire.com)
  • High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
  • This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
  • This study aimed to establish a prognostic nomogram for predicting overall survival (OS) and cancer-specific survival (CSS) of patients with early-onset endometrial cancer (EOEC). (preprints.org)
  • In contrast, high tumor abundance of PD-L2 correlated with poor disease-free survival, but had no obvious correlation with clinicopathological parameters. (jcancer.org)
  • High number of CD3 and CD8 positive T-cells was associated with significant survival benefit in the center of the tumour (CT) (p = 0.007, p = 0.001) but not in the invasive margin. (oulu.fi)
  • With the exception of the low-TIL group, for every potential subgroup with prognostic value, there was clear superiority for both relapse-free and distant metastasis-free survival for the pembrolizumab arm vs placebo arm. (medscape.com)
  • Treatment arm, tumor depth, and mitotic rate were all significant independent factors for relapse-free survival. (medscape.com)
  • Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)
  • In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
  • Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
  • Unraveling the prognostic significance and molecular characteristics of tumor-infiltrating B lymphocytes in clear cell renal cell carcinoma through a comprehensive bioinformatics analysis. (cdc.gov)
  • Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)
  • Subsequent studies assessed histopathological parameters of treatment response and recurrence risk in ovarian cancers and borderline tumors. (case.edu)
  • CD3 in the center of the tumor and CD8 in the invasive margins (IM) were significantly higher in ER/PR negative Her2/neu positive tumors compared to triple negative breast cancers. (bmj.com)
  • Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2/neu oncogene. (tilsinbreastcancer.org)
  • The prognostic landscape of genes and infiltrating immune cells across human cancers. (tilsinbreastcancer.org)
  • Endoscopic submucosal dissection (ESD) enables en bloc curative resection of early gastric cancers (EGCs) with a negligible risk of lymph node metastasis (LNM). (e-ce.org)
  • Recent advances in endoscopic resection techniques, such as endoscopic submucosal dissection (ESD), allow for en bloc curative resection of early gastric cancers (EGCs) with a minimal risk of lymph node metastasis (LNM), regardless of tumor size or presence of submucosal fibrosis. (e-ce.org)
  • In conclusion, this study shows a prognostic value for TIL in young TNBC patients. (medicom-publishers.com)
  • We anticipate that ImmunoPulse™ IL-12 will drive a tumor-specific inflammatory response in TNBC patients. (prnewswire.com)
  • Lower CD3, CD8 and FOXP3 percentages were noticed in TNBC tumors. (bmj.com)
  • 89 metastases, 33 deaths) and 170 deaths (35%) occurred during a median of 16.2 and 21.2 years follow-up, respectively, and 110 (23%) patients developed a second primary tumour. (medicom-publishers.com)
  • Tumor reduction of 50% or more was observed in about half of patients. (wikipedia.org)
  • Some patients experienced complete responses with no detectable tumor remaining years after treatment. (wikipedia.org)
  • The therapy is completely dependent on the tumor biopsy extracted from the patients rather than circulating T cells in the blood. (researchandmarkets.com)
  • Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. (researchgate.net)
  • Wang, J. (2014) The Clinical Significance of Tumor-Infiltrating Neutrophils and Neutrophil-to-CD8+ Lymphocyte Ratio in Patients with Resectable Esophageal Squamous Cell Carcinoma. (scirp.org)
  • PD-L1 IHC positivity and abundance of tumor infiltrating lymphocytes were of positive prognostic value in univariable regression analyses in patients treated with (neo)adjuvant chemotherapy, where it was strongest for 22C3 CPS ≥ 10 and distant relapse-free interval (HR = 0.18, p = 0.019). (lu.se)
  • Baseline levels of tumour infiltrating lymphocytes (TIL) in pre-treatment biopsies from patients with HER2-positive breast cancer are significantly associated with pathological complete response (pCR) rates following neoadjuvant chemotherapy plus anti-HER2 agents (trastuzumab, lapatinib or their combination). (esmo.org)
  • This study aimed to evaluate the role of PD-L2 as a prognostic factor for NPC patients as well as its role in immune regulation. (jcancer.org)
  • Tumor Infiltrating Lymphocytes - The Next Step in Assessing Outcome and Response to Treatment in Patients with Breast Cancer. (tilsinbreastcancer.org)
  • The stratified analysis suggested the molecular subtype and tumor stage significantly influenced the prognostic value of FoxP3(+) Tregs in certain types of cancer. (nih.gov)
  • In conclusion, our meta-analysis suggests that the prognostic role of FoxP3(+) Tregs was highly influenced by tumor site, and was also correlated with the molecular subtype and tumor stage. (nih.gov)
  • The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter? (tilsinbreastcancer.org)
  • The prognostic value of FoxP3(+) regulatory T cells (Tregs) in cancer remains controversial. (nih.gov)
  • We did a meta-analysis to assess the prognostic effect of FoxP3(+) Treg across different types of cancer and to investigate factors associated with variations in this effect. (nih.gov)
  • Furthermore, we found no significant reduction in CD8 + T cells, whereas the ratio of CD8 + T:Foxp3 cells and CD8 + T:PD-L1 cells was suppressed in tumor tissues and elevated in adjacent normal tissues. (biomedcentral.com)
  • An unsupervised hierarchical analysis also identified correlations between CD8 + T and Foxp3 + tumor-infiltrating lymphocyte (TIL) densities and average PD-L1 levels. (biomedcentral.com)
  • In addition to its ability to promote recruitment to the gut via its expression on mucosal vessels, VAP-1 has also been implicated in the recruitment of lymphocytes to several human tumours including head and neck cancer and hepatocellular carcinoma where VAP-1 expressed on tumour endothelium was shown to support lymphocyte binding [ 7 , 8 ]. (biomedcentral.com)
  • The tumours were immunostained for T-cell (CD3, CD8), natural killer (NK)-cell (CD56) and macrophage (CD68) markers and quantitative analysis of the immune cells was carried out using a computer-assisted image analysis in different tumour locations. (oulu.fi)
  • PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes. (tilsinbreastcancer.org)
  • The status of lymph node involvement is a major component of the tumor, node, metastasis (TNM) staging system. (researchgate.net)
  • BC is a highly heterogeneous disease that has been classified according to a variety of characteristics, such as histology, anatomical features (Tumor-Node-Metastasis staging system) ( 4 ), tumor grade and molecular traits. (spandidos-publications.com)
  • Defining lymphocyte-predominant breast cancer by the proportion of lymphocyte-rich stroma and its significance in routine histopathological diagnosis. (tilsinbreastcancer.org)
  • Even nowadays, application of the BRAF V600 mutation for diagnostic and prognostic purposes is still under investigation. (researchsquare.com)
  • A promising approach is measuring the presence of biomarkers to detect tumors at various stages and determine their specific characteristics, thus allowing for more personalized treatment. (spandidos-publications.com)
  • Subsequent studies assessed the intratumoral heterogeneity of miRNA and protein expression in breast and ovarian cancer and its implications for assessment of prognostic and predictive biomarkers. (case.edu)
  • However, PD-L1 status was not independently prognostic when adjusting for abundance of tumor infiltrating lymphocytes in multivariable analyses. (lu.se)
  • Hence, pre-existing germline variants provide a profound constraint on the evolution of tumor founding clones and subclones and therefore have a contingent effect on the genetic makeup of tumor and presumably patient outcomes. (nature.com)
  • But a large, pooled analysis of randomized adjuvant trials was conducted that showed that tumor-infiltrating lymphocytes had an important impact on outcomes. (onclive.com)
  • Host and tumor tissues undergo extensive immune interactions, and the ability of the tumor to evade immune recognition often determines clinical outcomes. (biomedcentral.com)
  • With clinical consideration that BRAF inhibitors are indicated for all BRAF V600 mutation-positive tumors, regardless of percentage, the detection of BRAF mutations must be done with more sensitive testing methods. (researchsquare.com)
  • The SP142 assay was better at identifying 22C3 positive tumors than the 22C3 assay was at detecting SP142 positive tumors. (lu.se)
  • 0.001), but the prognostic effect varied greatly according to tumor site. (nih.gov)
  • A positive correlation between CD3 and CD8 expression (rs=0.614, n=24, P 0.001) and CD3 and CD45RO expression (rs=0.621, n=24, P 0.001) were noted in the center of the tumor (CT).CD3 median percentage in CT was higher in grade 2 and grade 3 breast carcinoma compared to grade 1 (P 0.023). (bmj.com)
  • In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
  • If you look at overall tumor regression in the swimmer's plot, at those who had tumor shrinkage vs those who didn't, it was 67% for TIL vs 35% for ipilimumab. (medscape.com)
  • Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
  • Integrative analysis of lysine acetylation-related genes and identification of a novel prognostic model for oral squamous cell carcinoma. (cdc.gov)
  • I am an author for 25 book chapters in breast disease including the WHO blue book and Fletcher Diagnostic Histopathology of Tumors new editions and I am acting as a reviewer to 20 indexed and high profile international journals and editor to three journals. (nottingham.ac.uk)
  • More recently, Dr. Avril started to investigate the CXCR3-chemokine system, its association with tumor infiltrating lymphocytes and prognostic value in breast and ovarian cancer. (case.edu)
  • During tumorigenesis, breast tumour cells undergo metabolic reprogramming, which generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and fatty acid biosynthesis. (ua.pt)
  • In breast cancer the prognostic and predictive value of TIL is under active investigation [ 2 ]. (bmj.com)
  • Diagnostic and therapeutic implications of tumor-infiltrating lymphocytes in breast cancer. (tilsinbreastcancer.org)
  • Tumor-infiltrating lymphocytes in breast cancer: A new predictor for responses to therapy. (tilsinbreastcancer.org)
  • Lymphocytes prognostic in breast cancer. (tilsinbreastcancer.org)
  • Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer. (tilsinbreastcancer.org)
  • Background: Malignant pleural mesothelioma is a lethal disease and hence the strong need for identifying new prognostic factors. (scirp.org)
  • Specific risk factors such as celiac trunk (TC) stenosis and high calcification score of the aorta have been identified, but no data are available on their relative prognostic values. (uni-frankfurt.de)
  • While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
  • In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
  • This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen. (thno.org)
  • These findings suggest that the response to anti-PD-1 hinges on pre-existing anti-tumor immune response and that anti-PD-1 acts to free the CD8 T cells from inhibition to exert their anti-tumor activities [ 3 ]. (biomedcentral.com)
  • Although immune checkpoint blockade (ICB) reinvigorates anti-tumor immune responses by disrupting co-inhibitory T-cell signaling, relapse frequently occurs after ICB treatment and acquired resistance often emergence after initial response [ 4 ]. (thno.org)
  • T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)
  • Until now, the biological behavior and prognostic significance of PAC are unclear due to the rare incidence of PAC. (e-ce.org)
  • Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
  • Both MDSC (myeloid-derived suppressor cells) and regulatory T cells are recruited to CRC where they inhibit the anti-tumour immune response, thereby promoting tumour progression. (biomedcentral.com)
  • The primary objective of the study is to evaluate the potential of ImmunoPulse™ IL-12 to promote a pro-inflammatory molecular and histological signature in tumor samples obtained from study participants. (prnewswire.com)
  • In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
  • A single normal cell randomly acquires a series of mutations that allows it to proliferate and to be transformed into a cancer cell (i.e., founding clone), which initiates tumor progression and recurrence. (nature.com)
  • We have previously shown that tumor founding clone mutations are able to predict tumor recurrence. (nature.com)
  • These tumors differ in their histologic and, possibly, biologic characteristics. (medscape.com)
  • Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
  • They are detectable in tissues and blood, including plasma and/or serum, are stable and often tumor specific. (spandidos-publications.com)
  • Lymphocytes are recruited to tissues from blood via binding to vessels in the target tissue mediated by interactions between specific receptors on the lymphocyte surface and ligands on the endothelium. (biomedcentral.com)
  • We found that PD-L1 was expressed in gastric ulcer and in tumor cells (TCs), as well as in tumor-infiltrating immune cells (TIICs), but not in normal gastric mucosa or other gastric intraepithelial neoplastic tissues. (biomedcentral.com)
  • Three main groups were identified based on the results of CD8 + T:PD-L1 ratios in gastric tumor tissues. (biomedcentral.com)
  • This retrospective study aimed to compare and evaluate calcification score versus stenosis quantification with regards to prognostic impact on anastomotic leakage. (uni-frankfurt.de)
  • [ 1 ] The primary tumor may occur at any location on the skin or, less commonly, on the mucus membranes or other locations. (medscape.com)
  • The sentinel lymph node concept is that a primary or sentinel lymph node (or nodes) exists through which tumor cells from a primary tumor in a particular location first must travel to spread to a particular regional lymph node basin. (medscape.com)
  • A tracer substance injected into the dermis at the primary tumor site provides a roadmap leading to the sentinel lymph node(s). (medscape.com)
  • Anal squamous-cell carcinoma (ASCC) and rectal adenocarcinoma are typically indistinguishable on MRI, and a biopsy prior to imaging is necessary to accurately stage the tumor and determine the treatment approach. (bvsalud.org)
  • Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
  • Tumor cells are released into the circulation, arrest in end arteries, penetrate the blood-brain barrier, enter the CNS, and establish growth in the new tissue. (medscape.com)
  • double-negative tumor-infiltrating lymphocytes expanded from solid tumor tissue suppress the proliferation of tumor cells in an MHC-independent way. (bvsalud.org)
  • However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
  • Neutrophil lymphocyte (N/L) ratio was assessed before second line chemotherapy. (scirp.org)
  • Conclusion: N/L ratio is a potential prognostic marker for advanced MPM treated with second line chemotherapy. (scirp.org)
  • GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
  • Tumor size and lymph node status are all variables, but we don't know that they influence treatment. (onclive.com)
  • Programmed cell death-1 (PD-1) is mainly expressed on activated T cells and acts as an immune activation reaction of tumors after the combination of inhibitory receptor and ligand (PD-L1). (jcancer.org)
  • Metastases reach the central nervous system (CNS) via hematogenous spread of tumor cells. (medscape.com)
  • Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. (unav.edu)