For these patients, cellular immunotherapy could help achieve deep leukemic clearance, although chimeric antigen receptor (CAR) T-cell strategies against T-cell cancers have been difficult. (ajmc.com)
Chimeric antigen receptor-modified T (CAR T) cells exhibit very effective function in elimination of relapsed/refractory B-cell lymphoid malignancies, we investigated their use in a patient with relapsed MCL. (bmj.com)
The efficacy of cellular or humoral immunotherapy has been demonstrated with the success of chimeric antigen receptor T-cell therapy and the bispecific engager blinatumomab in treating advanced disease. (haematologica.org)
CD568
To explore correlations between CD7, CD34, CD56 and HLA-DR expressions and its prognosis among patients with acute myeloid leukemia. (biomedres.info)
CD7, CD34, CD56 and HLA-DR expressions of bone marrow among patients were detected. (biomedres.info)
Complete remission rate of CD7, CD34, CD56 and HLA-DR antigen expression positive among patients with Acute Myeloid Leukemia (AML) is low, mean survival is short and prognosis is poor. (biomedres.info)
There are reports showing that CD7, CD34, CD56 and HLA-DR expressions have a certain correlations with prognosis of patients with leukemia [ 7 - 9 ]. (biomedres.info)
Therefore, this study selects 225 patients with Acute Myeloid Leukemia (AML) in our hospital from Jan 2013 to Dec 2016 as study objects to explore CD7, CD34, CD56 and HLA-DR expression antigen and its relations with clinical effects and prognosis. (biomedres.info)
MNKPL is characterized by extramedullary involvement, immature lymphoblastoid morphology without myeloperoxidase (MPO) reactivity, the CD7 + /CD33 + /CD34 + /CD56 + /HLA−DR + phenotype. (confex.com)
The blasts in MDS may show anomalous expression of CD56 and CD7. (medscape.com)
Immunohistochemical examination demonstrated that these accumulated lymphocytes mainly comprised small- to medium-sized T cells expressing CD3, CD4, CD5, CD7, and CD103, but lacking CD8, CD56, and Epstein-Barr virus-encoded small RNAs. (springeropen.com)
CD341
Furthermore, it was developed using the basic platform of the CD34 + CD38 - markers, but applying more advanced antigens such as CD45 dim and CD133. (researchsquare.com)
Intracellular4
About 30% to 40% of PTCL, NOS, express markers of cytotoxic T-cells such as T-cell intracellular antigen-1 (TIA-1). (webpathology.com)
Flow cytometric detection of intracellular antigens has become a standard method in establishing proper leukemic cell lineage affiliation. (ijpmonline.org)
Regarding the detection of intracellular antigens, standardization of the procedure remains, however, a real challenge. (ijpmonline.org)
Detection of intracellular antigens by flow cytometry (FCM) requires effective fixation and permeabilization of the cell membrane. (ijpmonline.org)
Flow cytometry1
The initial disease data and MRD review data in the form of 159 flow cytometry standard 3.0 files from 36 CD7-positive AML patients in whom MRD was detected more than once were exported. (oncotarget.com)
The maturing myeloid cells in MDS may show immunophenotypic abnormalities by flow cytometric immunophenotyping, as follows: a decrease in side light scatter properties (due to hypogranulosis), increased intensity of CD33 expression, persistence of CD33 to later myeloid stages, decreased CD10 expression, abnormal patterns of CD11b versus CD16 expression or CD13 versus CD16 expression, deviations in myeloid antigen intensity, dyssynchronous expression of 2 myeloid antigens, and aberrant nonmyeloid antigen expression. (medscape.com)
CD451
B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
Clinical2
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
Tumor-infiltrating lymphocytes are related to positive clinical prognoses in numerous cancer types. (cancer-genetics.org)
Blasts2
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis. (wikipedia.org)
Despite reinduction therapy and 2 blocks of high-intensity chemotherapy, he had refractory disease that manifested as persistent cytopenia with more than 80% blasts in bone marrow, all of which were expressing CD7. (ajmc.com)
Curative1
Mycosis Fungoides and Sézary syndrome are two forms of cutaneous T cell lymphoma associated to a poor prognosis at advanced stages due to a lack of curative treatments. (hipi-lab-saint-louis.fr)
Leukemia1
Immunophenotypes of leukemia can identify cells which cannot be identified by morphology, and it can promote diagnosis for leukemia and play a certain prognosis judgment [ 5 , 6 ]. (biomedres.info)
CCA patients with a higher proportion of neutrophils and T-regulatory cells (Tregs) and lower proportion of CD8 + T cells in the tumor tissues are associated with poor prognosis [ 5 ]. (aging-us.com)
however, drug agents targeting HER2 in breast cancer have significantly positively altered the otherwise poor-prognosis natural history of HER2-positive breast cancer. (iiab.me)
Patients3
Because 10% of Sézary patients display malignant T cells that do not express KIR3DL2, we pursue our search for specific tumor antigens. (hipi-lab-saint-louis.fr)
The antigen is named after one of the patients - a Mrs Gerbich. (wikidoc.org)
Current data indicates that anti-tumor T cell-mediated immunity correlates with a better prognosis in cancer patients. (encyclopedia.pub)
Tumor1
Our main goal is to identify new tumor antigens specifically expressed at the tumor cell surface and to validate their potential use as new therapeutic targets through the development of antibody-based immune-therapies. (hipi-lab-saint-louis.fr)
Diagnosis1
Drug misuse and community pharmacists 199 if in trace quantities in the body that may affect the solubility of the potential uses and current diagnosis and treatment is primarily chosen with the native, unprocessed ti antigens are generated in empty cavity is mostly related to patient packaging, and the associated risks. (stonecottagegardens.com)
Expression3
Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS). (wikipedia.org)
Interest because expression is regulated by cd7 ab1 has the predominant symptoms and experience guilt if they continue to progress as far as european regulations on how it should protect the host is identical with those of genramicin. (stonecottagegardens.com)
3 Changes in the regulation of the different variant expression patterns in a variety of tissue types has been associated with differing prognosis. (roche.com)
Chemotherapy1
MCL can be both indolent or aggressive, in either case it responds poorly to chemotherapy and consequently the aggressive form has a dismal prognosis assessed by incorporating Ki-67 proliferation index and Mantle Cell International Prognostic Index scores. (bmj.com)
Detection1
Although malignant cells were identified as a clonal expansion of CD4+ T cell with memory phenotype, their phenotypic detection relies on the loss of pan-T cell antigens such as CD26 or/and CD7. (hipi-lab-saint-louis.fr)
Biology1
Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of malignancies of different biology and prognosis. (medscape.com)
Cells3
The team transduced healthy volunteer donor T cells using a lentivirus to express a CAR with specificity for CD7, which is expressed in T-cell ALL. (ajmc.com)
Since CD7 is overexpressed on recently activated T cells and under expressed on anti-viral T cells, it is a good target to kill disease-causing activated T cells while sparing 'normal' antiviral T cells. (labiotech.eu)
Combination of analysis of fluorescence labeling and light scatter properties of cells allows rapid and better determination of target cell antigens. (ijpmonline.org)
Immune1
The protein has no known natural ligand [4] and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikidoc.org)
Protein2
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene. (wikipedia.org)
Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV)", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Anti-CD44 (SP37) is a rabbit monoclonal antibody produced against a conserved region of the CD44 protein. (roche.com)
Positive1
The patient was seropositive for HTLV-1 by Western blot and positive for hepatitis B surface antigen. (cdc.gov)
Cell3
The investigators then used base editing to inactivate 3 genes encoding CD52 and CD7 receptors and the b chain of the ab T-cell receptor to evade lymphodepleting serotherapy, CAR7 T-cell fratricide, and graft-versus-host disease, respectively. (ajmc.com)
Background The aggressive form of Mantle cell non-hodgkin B cell lymphoma (MCL) has a dismal prognosis. (bmj.com)
The anti-CD3 one provides immunosuppression independent of the RTA-induced cell killing through its action on the CD3 complex, which plays a central role in the antigen recognition process. (labiotech.eu)
Shown1
Cluster of differentiation CD7 has been shown to interact with PIK3R1. (wikipedia.org)
Response1
The antigen was discovered in 1960 when three women who lacked the antigen made anti-Gea in response to pregnancy. (wikidoc.org)