Glucagon-like peptide 1 (1-37) (human, rat) is a pancreatic hormone synthesized by post-translational processing of proglucagon. (tocris.com)
formed by tissue-specific, post-translational processing of proglucagon by intestinal L-cells. (drugfuture.com)
Peptides1
Tissue-specific posttranslational processing of proglucagon by the prohormone convertase produced the different proglucagon derived peptides (PGDPs) in both pancreas and intestine. (eaglebio.com)
Intestinal L-cells2
A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. (nih.gov)
Primary cleavage product of proglucagon in intestinal L cells. (severnbiotech.com)
Gene6
Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene. (wikidoc.org)
Finally, GLP-2 did not alter other markers of intestinal or pancreatic gene expression, including levels of mRNA transcripts for ornithine decarboxylase, multidrug resistance gene, amylase, proglucagon, proinsulin, and prosomatostatin. (nih.gov)
Congenital hypomorphism for this gene causes a rare autosomal disorder that impairs the processing of specific proproteins to their more bioactive derivatives, affecting, for example, the processing of POMC, proinsulin and proglucagon. (columbia.edu)
Dalvi PS , Erbiceanu FD, Irwin DM, Belsham DD (2012) Direct Regulation of the Proglucagon Gene by Insulin, Leptin and cAMP in Embryonic versus Adult Hypothalamic Neurons. (pharmapdf.com)
The proglucagon gene is expressed in both pancreatic A cell and intestinal L cell. (eaglebio.com)
GLP-1 is a neuropeptide and an incretin derived from the transcription product of the proglucagon gene. (viho.es)
Proinsulin1
The pancreatic processing enzymes, PC1 and PC2, convert proinsulin to insulin and convert proglucagon to glucagon and glucagon-like peptide 1 (GLP-1). (jci.org)
Precursor3
Proglucagon is a precursor of glucagon, and several other components. (wikipedia.org)
GLP-1 is a peptide hormone from the intestinal mucosa, which is produced from its precursor, proglucagon by post transnational processing. (biovendor.com)
The well conserved peptide is generated by tissue-specific posttranslational processing of the proglucagon precursor, yielding the amidated GLP-1(7-36)amide or the non-amidated GLP-1(7-37) (1). (sysy.com)
Posttranslational1
Glucagon-like peptide-1 ( GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from the tissue-specific posttranslational processing of the proglucagon peptide. (eusaintlaurent.de)
Hormones1
Here, we use CRISPR-Cas9 editing to remove glucagon codons 2-29 in immunocompromised NSG mice, preserving the production of other proglucagon-derived hormones. (nature.com)
Mice1
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice. (progen.com)
Peptide9
[ 14 ] GLP-1 is an insulinotropic peptide generated by cleavage of proglucagon. (medscape.com)
Proglucagon peptide secretion profiles in type 2 diabetes before and after bariatric surgery: 1-year prospective study. (nih.gov)
Glucagon like peptide-1 (GLP-1) is a GI hormone produced in endocrine cells in the distal small intestine by alternative processing of the proglucagon gene product. (pancreapedia.org)
Glucagon is a 29 amino acid containing peptide hormone processed from proglucagon. (bachem.com)
Preproglucagon first has its signal peptide removed by signal peptidase , forming the 160- amino acid protein proglucagon. (mdwiki.org)
Glucagon-like peptide (GLP)-1 is really a proglucagon-derived peptide secreted by gut endocrine cells (L cells) in response to food ingestion (1). (conferencedequebec.org)
Preproglucagon has a short tail called a leader or signal peptide which is cleaved off to form proglucagon, and proglucagon is then further cleaved to form glucagon . (osmosis.org)
Pancreatic5
9. Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor. (nih.gov)
16. Pancreatic and intestinal processing of proglucagon in man. (nih.gov)
GLP-1) is derived from the transcription product of the proglucagon gene.It is a potent antihyperglycemic hormone, inducing glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion.GLP-1 appears to restore the glucose sensitivity of pancreatic β-cells.GLP-1 is also known to inhibit pancreatic β-cell apoptosis and stimulate the proliferation and differentiation of insulin-secreting β-cells. (medillsb.com)
The human proglucagon amino acid sequence contains 160 amino acids with pancreatic glucagon made up of residues 33-61 and GLP-1 derived from residues 72-108 after further processing ( Figure 1 ). (pancreapedia.org)
19. Proglucagon processing in islet and intestinal cell lines. (nih.gov)
GLP-1 and GLP-2 were identified in the distal small intestinal mucosa as the product of post-translational processing by prohormone convertase 1/3 (PC1/3) of the proglucagon gene product (8) which in the Islets is processed by PC2 to yield glucagon (71, 82, 92). (pancreapedia.org)
GLP-1 is a polypeptide that is mainly produced by intestinal L cells and is encoded by the proglucagon gene. (medicilon.com)
Pancreas1
Diagram of the differential processing of the proglucagon gene product in α-cells of the pancreas and L-cells in the gut. (pancreapedia.org)
Glicentin1
In gut endocrine cells, proglucagon is processed to glicentin, oxyntomodulin, GLP-1 and GLP-2, all of which have biological activity (25, 51). (pancreapedia.org)
Islet1
Ablation of Gs or Gq signaling in α-cells caused reduced circulating glucagon, most likely due to decreased proglucagon gene expression and islet glucagon content. (nih.gov)
Holst1
For further details on proglucagon processing see the review by Holst (51). (pancreapedia.org)
Preproglucagon2
Proglucagon is a protein that is cleaved from preproglucagon. (wikipedia.org)
Proglucagon is the 158-amino acid segment of preproglucagon without the N-terminal signal sequence. (nih.gov)
Gene expression1
17. Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigen gene. (nih.gov)
This polypeptide, known as pre-proglucagon, is responsible for the production of glucagon and other hormones, and GLP1 is a member of the hormone family known as incretins. (todaytechhelp.com)
Proteins1
Post-translational processing of proglucagon results in several different proteins. (mercodia.com)
Transcription1
Genetic variation in transcription factor 7-like 2 (TCF7L2), a regulator of proglucagon processing, is reproducibly associated with type 2 diabetes. (nih.gov)
Cells2
Interestingly GLP-1 and various other proglucagon gene items are expressed in flavor cells also. (opioid-receptors.com)
We thank Drs Daniel Drucker and Fiona Gribble for the GLUTag cells, and Dr. Jacques Philippe for the proglucagon luciferase reporter. (elsevierpure.com)
CENTRAL NERVOU1
GLP-1 is also produced in the central nervous system where proglucagon is processed similar to the gut (14). (pancreapedia.org)
Type1
Roux-en-Y Gastric Bypass Increases Glycemic Variability and Time in Hypoglycemia in Patients With Obesity and Prediabetes or Type 2 Diabetes: A Prospective Cohort Study. (nih.gov)