• Estrogen receptors (ERs) are a group of proteins found inside cells. (wikipedia.org)
  • The concept of selective estrogen receptor modulators is based on the ability to promote ER interactions with different proteins such as transcriptional coactivator or corepressors. (wikipedia.org)
  • Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding. (embl.de)
  • The tetratricopeptide repeat (TPR) is a degenerate 34 amino acid sequence identified in a wide variety of proteins, present in tandem arrays of 3-16 motifs, which form scaffolds to mediate protein-protein interactions and often the assembly of multiprotein complexes. (embl.de)
  • The spatial arrangement of alpha-helices in the PP5-TPR domain is similar to those within 14-3-3 proteins. (embl.de)
  • The recently discovered TPR gene family encodes a diverse group of proteins that function in mitosis, transcription, splicing, protein import and neurogenesis. (embl.de)
  • Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. (embl-heidelberg.de)
  • Lipid-derived (soluble) hormones can enter the cell by diffusing across the plasma membrane and binding to DNA to regulate gene transcription and to change the cell's activities by inducing production of proteins that affect, in general, the long-term structure and function of the cell. (openstax.org)
  • Functional groups contained in this DE gene list include metabolic proteins (including opposing patterns ofCA3andCA4), mitochondrial proteins (CKMT1A), oxidative status (SEPP1,HIG2A) and cholesterol homeostasis (APOA1,INSIG1). (1library.net)
  • Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
  • Life is based on carbon compounds including carbohydrates, lipids, proteins and nucleic acids. (ivy-way.com)
  • The identification of an inactivating missense mutation in NANOS3 suggests a mechanism for POI involving increased primordial germ cells (PGCs) apoptosis during embryonic cell migration and highlights the importance of NANOS proteins in human ovarian biology. (hindawi.com)
  • They are receptors that are activated by the hormone estrogen (17β-estradiol). (wikipedia.org)
  • Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors estrone, and raloxifene bind preferentially to the alpha receptor estriol, and genistein to the beta receptor Subtype selective estrogen receptor modulators preferentially bind to either the α- or the β-subtype of the receptor. (wikipedia.org)
  • In the luteal-follicle phase transition period the serum levels of progesterone and estrogen (primarily estradiol) decrease and no longer suppress the release of FSH, consequently FSH peaks at about day three (day one is the first day of menstrual flow). (explained.today)
  • Estradiol concentrations at FTAI impacted oviductal gene expression and has been reported to play an important role in establishing the timing of uterine receptivity. (animal-reproduction.org)
  • Cows with greater estradiol concentrations at the time of GnRH-induced ovulation also had a larger dominant follicle size and greater circulating progesterone concentrations on day 7. (animal-reproduction.org)
  • Therefore, it is impossible to accurately determine the individual benefit of greater estradiol concentrations prior to ovulation and greater progesterone concentrations following ovulation to pregnancy establishment, as these two measurements are confounded. (animal-reproduction.org)
  • Bó GA, Cedeño A. Expression of estrus as a relevant factor in fixed-time embryo transfer programs using estradiol/progesterone-based protocols in cattle. (animal-reproduction.org)
  • We have previously shown that the human pS2 gene, which codes for a secreted peptide of 60 amino acids, is expressed in a number of human carcinomas, including carcinomas of the breast, the pancreas , and the large bowel. (xenbase.org)
  • There are three basic types of hormones: lipid-derived, amino acid-derived, and peptide. (openstax.org)
  • 11) Why is it that steroid hormones use receptors inside of target cells, whereas protein, peptide, and amino acid hormones do not? (easynotecards.com)
  • B) Amino acids and peptide hormones do not have a 3 dimensional structure that can bind to internal receptors. (easynotecards.com)
  • The farnesoid X receptor (FXR) regulates the homeostasis of bile acids, lipids and glucose. (nature.com)
  • Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. (frontiersin.org)
  • A) Steroids can cross the cell membrane because they are lipids and the membrane is lipid. (easynotecards.com)
  • Two classes of ER exist: nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs) (GPER (GPR30), ER-X, and Gq-mER), which are mostly G protein-coupled receptors. (wikipedia.org)
  • In vitro , it stimulates the synthesis of specific milk protein mRNA by binding to membrane receptors. (e-cep.org)
  • Hormones can affect cells directly through intracellular hormone receptors or indirectly through plasma membrane hormone receptors. (openstax.org)
  • Lipid insoluble hormones bind to receptors on the plasma membrane surface and trigger a signaling pathway to change the cell's activities by inducing production of various cell products that affect the cell in the short-term. (openstax.org)
  • E) block the production of a cell membrane. (easynotecards.com)
  • 17) Membrane receptors are used by which of the following types of hormones? (easynotecards.com)
  • Know normal platelet count, increased bleeding time, increased PTT *Captopril is a teratogen *MOA of Amphotericin B  Punches holes in ergosterol of the fungal cell membrane *Tons of biostats. (pdfcoffee.com)
  • The mouse pS2 gene is highly expressed in the stomach mucosa cells, whereas no pS2 gene expression could be detected in the mouse mammary gland, even during postnatal development processes dependent on growth factors or hormones. (xenbase.org)
  • Glucocorticoids are steroid hormones secreted from the zona fasciculata of the adrenal cortex, and play numerous important roles in the maintenance of internal homeostasis by influencing activities of virtually all organs and tissues, such as the brain, liver, skeletal muscles and the immune-related organs and cells [1]. (brainimmune.com)
  • Hormones affect only cells that are their targets (that have receptors for that specific hormone). (lionden.com)
  • A hormone will not have an effect on target cells of other hormones. (lionden.com)
  • Amino acid-derived hormones are relatively small molecules and include the adrenal hormones epinephrine and norepinephrine. (openstax.org)
  • Hormones cause cellular changes by binding to receptors on target cells. (openstax.org)
  • D) The target cells affected by steroid hormones have all of their receptors in the cell cytoplasm. (easynotecards.com)
  • It produces 2 hormones: vasopressin, which causes blood pressure to rise and regulates the amount of water in the body's cells, and oxytocin, which causes the uterus to contract during childbirth and lactation to begin. (medscape.com)
  • The endocrine system consists of endocrine glands that produce and secrete hormones into the blood stream to reach and act on target cells of specific organs. (medscape.com)
  • These hormones regulate the body's growth, and are involved in cell to cell communication, control metabolic activity, sleep-wake homeostasis, and altered regulation or dysregulation of adaptive response in various physiologic and pathophysiologic states. (medscape.com)
  • Once activated by estrogen, the ER is able to translocate into the nucleus and bind to DNA to regulate the activity of different genes (i.e. it is a DNA-binding transcription factor). (wikipedia.org)
  • Further, the GR gene expresses a splicing variant GRbeta, which does not bind glucocorticoids but functions as a dominant negative isoform for GRalpha. (brainimmune.com)
  • Because endogenous chemicals bind and activate FXR, it is important to examine which xenobiotic compounds would disrupt normal receptor function. (nature.com)
  • D) bind to receptors within the cell. (easynotecards.com)
  • The mitochondria can bind a certain amount of calcium during stress, but accumulating calcium can reach a point at which it inactivates the mitochondria, forcing cells to increase their inefficient glycolytic energy production, producing an excess of lactic acid. (raypeat.com)
  • C1 domains are compact alpha/beta structural units of about 50 amino acids which tightly bind two zinc ions. (embl-heidelberg.de)
  • As hormone receptors for sex steroids (steroid hormone receptors), ERs, androgen receptors (ARs), and progesterone receptors (PRs) are important in sexual maturation and gestation. (wikipedia.org)
  • In males , FSH induces Sertoli cells to secrete androgen-binding protein s (ABPs), regulated by inhibin 's negative feedback mechanism on the anterior pituitary . (explained.today)
  • Structure-activity relationships of FXR-active compounds revealed by this screening were then compared against the androgen receptor, estrogen receptor α, peroxisome proliferator-activated receptors δ and γ and the vitamin D receptor. (nature.com)
  • FSH stimulates the maturation of sperm cells in testes and is inhibited by the hormone inhibin, while LH stimulates the production of the androgen testosterone. (openstax.org)
  • Stage II lactogenesis, which occurs in the postpartum period, initiates with a decrease in plasma progesterone level, increase in blood flow and oxygen and glucose uptakes, and a sharp increase in citrate concentration, a reliable marker of lactogenesis stage II. (e-cep.org)
  • Prolactin also enhances the uptake of some amino acids and glucose as well as the production of milk sugar and milk fats [ 7 - 9 ]. (e-cep.org)
  • Insulin is produced by the pancreas in response to rising blood glucose levels and allows cells to utilize blood glucose and store excess glucose for later use. (openstax.org)
  • D) inactivate glucose so it cannot be used by a cell. (easynotecards.com)
  • Every single cell in your body can utilize glucose as a source of rapid energy. (medium.com)
  • Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)
  • In early (small) antral follicles, FSH is the major survival factor that rescues the small antral follicles (2-5 mm in diameter for humans) from apoptosis (programmed death of the somatic cells of the follicle and oocyte). (explained.today)
  • As a consequence of treatments, the most frequent mechanism of cell death is apoptosis, followed by autophagy. (frontiersin.org)
  • Sphingolipids are remarkably diverse and have crucial roles in maintaining barrier function and fluidity, as well as regulating the cell cycle, cell motility, differentiation, adhesion, and apoptosis ( 1 ). (frontiersin.org)
  • Lizama C, *Lagos CF, *Lagos-Cabre R, Cantuarias L, Rivera F, Huenchunir P, Perez-Acle T, Carrion F, Moreno RD. Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes. (cienciavida.org)
  • The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. (hindawi.com)
  • The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. (embl.de)
  • The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding. (embl-heidelberg.de)
  • Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly involved in altered cancer cell metabolism, resulting in cancer aggressiveness and resistance. (bvsalud.org)
  • Because the progesterone receptor can localise to avian mitochondria, our data continue to point to muscle mitochondrial metabolism as an important component of the phenotypic expression of variation in broiler FE. (1library.net)
  • Metabolism is the web of all the enzyme-catalysed reactions in a cell or organism. (ivy-way.com)
  • Amino sugar and nucleotide sugar metabolism 43 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)
  • The present case-control study aimed to investigate the main effect of polymorphisms in genes involved in xenobiotic metabolism and estrogen biosynthesis, CYP1A1, CYP1B1, COMT and CYP17, CYP19 and the BRCA1 founder mutation in relation to BC risk and to explore possible interactions between the gene polymorphisms and serum POP levels on BC risk in Greenlandic Inuit women. (biomedcentral.com)
  • Polymorphisms including single nucleotide polymorphisms (SNPs) in genes involved in xenobiotic metabolism and in genes involved in oestrogen biosynthesis and metabolism might affect circulating estrogen levels and modulate the individual susceptibility to environmental carcinogens in relation to developing BC [ 5 ]. (biomedcentral.com)
  • These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)
  • Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene and is present on chromosome 11 in humans. (thermofisher.com)
  • It is one of the two subunits of NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells) that heterodimerizes with the other subunits p50 or p52. (thermofisher.com)
  • Strong pS2 gene expression was also observed in the normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of the gastrointestinal tract . (xenbase.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. (medindex.am)
  • 3) ________ are chemical messengers that are released by cells and transported in the bloodstream to alter the activities of specific cells in other tissues. (easynotecards.com)
  • Specialized tissues can develop by cell differentiation in multicellular organisms. (ivy-way.com)
  • Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. (embl-heidelberg.de)
  • In humans, the two forms of the estrogen receptor are encoded by different genes, ESR1 and ESR2 on the sixth and fourteenth chromosome (6q25.1 and 14q23.2), respectively. (wikipedia.org)
  • Although it is present in approximately 0.15-0.3% of males, most of the genetic defects associated with MRX, which may involve more than ten different genes, remain unknown. (embl-heidelberg.de)
  • Primary bile acid biosynthesis 13 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)
  • We found that the acidic domain of MZF-1 and the heparin-binding domain of Elk-1 facilitate the heterodimeric interaction between the two genes before the complex formation binds to the PKCα promoter. (oncotarget.com)
  • There are two different forms of the estrogen receptor, usually referred to as α and β, each encoded by a separate gene (ESR1 and ESR2, respectively). (wikipedia.org)
  • In addition, the different estrogen receptor combinations may respond differently to various ligands, which may translate into tissue selective agonistic and antagonistic effects. (wikipedia.org)
  • Estrogens augment the stimulation of ovarian aromatase activity by follicle-stimulating hormone in cultured rat granulosa cells. (animal-reproduction.org)
  • FSH stimulates egg maturation in ovaries, while LH stimulates the production of estrogens and progesterone. (openstax.org)
  • The parafollicular cells of the thyroid produce calcitonin, which reduces blood Ca 2+ levels. (openstax.org)
  • In cancer treatment this phenomenon can be exploited to selectively kill tumour cells that have specific genetic mutations. (hrb.ie)
  • Here we report the characterization of a new gene on the long arm of the X-chromosome (position Xq12) and the identification in unrelated individuals of different mutations that are predicted to cause a loss of function. (embl-heidelberg.de)
  • Rare mutations have been described in genes involved in ovarian development and/or function such as FSHR (MIM 136435), LHCGR (MIM 152790), BMP15 (MIM 300247), POF1B (MIM 300603), NOBOX (MIM 610934), INHA (MIM 147380), GDF9 (MIM 601918), NR5A1 (MIM 184757), and FIGLA (MIM 608697) and in meiotic genes [ 9 - 23 ]. (hindawi.com)
  • Nevertheless, mutations in these genes account for a minority of cases of ovarian dysfunction, indicating that additional factors remain to be identified. (hindawi.com)
  • Strong association between c-myb and oestrogen-receptor expression in human breast cancer. (xenbase.org)
  • Expression of the oestrogen regulated pNR-2 mRNA in human breast cancer: relation to oestrogen receptor mRNA levels and response to tamoxifen therapy. (xenbase.org)
  • An essential fatty acid belonging to the omega-3 fatty acids group. (medindex.am)
  • Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols). (medindex.am)
  • Ceramide contains a fatty acid residue. (frontiersin.org)
  • Fatty acids can be saturated, monounsaturated or polyunsaturated. (ivy-way.com)
  • Unsaturated fatty acids can be cis or trans isomers. (ivy-way.com)
  • Triglycerides are formed by condensation from three fatty acids and one glycerol. (ivy-way.com)
  • Fatty acid biosynthesis 8 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)
  • Fatty acid degradation 10 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)
  • Both ERs are widely expressed in different tissue types, however there are some notable differences in their expression patterns: The ERα is found in endometrium, breast cancer cells, ovarian stromal cells, and the hypothalamus. (wikipedia.org)
  • The mouse one P-domain ( pS2 ) and two P-domain ( mSP ) genes exhibit distinct patterns of expression. (xenbase.org)
  • We show that the mouse putative pS2 protein sequence and the physiological pattern of expression of the mouse pS2 gene are well conserved. (xenbase.org)
  • Using in situ hybridization, we show that although coexpressed in the fundus , the antrum and the antrum -pyloric regions of the stomach , the mouse pS2 and mSP genes exhibit distinct and complementary cellular patterns of expression. (xenbase.org)
  • Albrecht U. Orchestration of gene expression and physiology by the circadian clock. (animal-reproduction.org)
  • Recent reports demonstrate that the expression of protein kinase C alpha (PKCα) in triple-negative breast cancer (TNBC) correlates with decreased survival outcomes. (oncotarget.com)
  • Surprisingly, we found that the expression of 699 genes encoding the broiler mitoproteome is modestly-but significantly-biased towards the high FE group, suggesting a slightly elevated mitochondrial content. (1library.net)
  • Differentiation involves the expression of some genes and not others in a cell's genome. (ivy-way.com)
  • However, gene expression-based signatures present some limitations because they do not consider metabolic role of the genes and are affected by genetic heterogeneity across patient cohorts. (tu-dortmund.de)
  • Gene Expression: The digital drug of a chapter or events by the bands of catheter shape. (seabaygame.com)
  • It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
  • This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (thermofisher.com)
  • [1] FSH is synthesized and secreted by the gonadotropic cell s of the anterior pituitary gland [2] and regulates the development, growth, pubertal maturation, and reproductive processes of the body. (explained.today)
  • We show the progesterone receptor localises to the mitochondria in a quail muscle cell line. (1library.net)
  • The number of receptors on a target cell can increase or decrease in response to hormone activity. (openstax.org)
  • Hormone-activated estrogen receptors form dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα (αα) or ERβ (ββ) homodimers or ERαβ (αβ) heterodimers. (wikipedia.org)
  • citation needed] The N-terminal A/B domain is able to transactivate gene transcription in the absence of bound ligand (e.g., the estrogen hormone). (wikipedia.org)
  • FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor . (explained.today)
  • [6] The sugar portion of the hormone is covalently bonded to asparagine , and is composed of N-acetylgalactosamine , mannose , N-acetylglucosamine , galactose , and sialic acid . (explained.today)
  • Conclusions: Progesterone is sometimes used in the cattle industry in exogenous hormone mixes that lead to a ~20% increase in FE. (1library.net)
  • In 1902, Balysis and Startling extracted and identified the first hormone secretin (secreted by cells in the intestinal mucosa), and, in 1927, McGee isolated and purified substances that were androgenic in small amounts (microgram levels). (medscape.com)
  • CD16 and CD56 are markers for NK Cells *Rx for Mycoplasma pneumonia (cold agglutinins) mentioned in stem  Erythromycin, Tetracycline *Guy had occult blood in stool and fibrosis in kidney  Polyarteritis Nodosa *What type of HSN reaction is the PPD test for TB  Type IV HSN Rx *ADH hormone 2nd messenger  adenylyl cyclase / cAMP *Pt. (pdfcoffee.com)
  • The ERs are regarded to be cytoplasmic receptors in their unliganded state, but visualization research has shown that only a small fraction of the ERs reside in the cytoplasm, with most ER constitutively in the nucleus. (wikipedia.org)
  • Interphase is a very active phase of the cell cycle with many processes occurring in the nucleus and cytoplasm. (ivy-way.com)
  • Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. (xenbase.org)
  • Cellular mechanistic studies confirm their ability to hamper the PDK/PDH axis, thus leading to metabolic/redox cellular impairment, and to ultimately trigger apoptotic cancer cell death. (bvsalud.org)
  • The living organism produces a stream of metabolic products, such as carbon dioxide or lactic acid, which interact specifically with each other and with the metal ions, modifying their concentrations inside cells and in the body fluids. (raypeat.com)
  • The capacity of stem cells to divide and differentiate along different pathways is necessary in embryonic development and also makes stem cells suitable for therapeutic uses. (ivy-way.com)
  • While this region is able to activate gene transcription without ligand, this activation is weak and more selective compared to the activation provided by the E domain. (wikipedia.org)
  • The E-domain in the presence of bound ligand is able to activate gene transcription. (wikipedia.org)
  • The ERβ isoforms receptor subtypes can transactivate transcription only when a heterodimer with the functional ERß1 receptor of 59 kDa is formed. (wikipedia.org)
  • Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (medindex.am)
  • It specifically plays a key role in transcription of immunoglobulin k (kappa) gene in mature B-lymphoid cells. (thermofisher.com)
  • Sphingolipids are key structural components of cellular membranes containing a backbone of sphingosine (aliphatic amino alcohol) as the base of their structures. (frontiersin.org)
  • Each of them work uniquely to signal for specific cellular or physiological processes, rather than to get broken down into amino acids. (indigohealthclinic.com)
  • The gene for the FSH beta subunit is located on chromosome 11p13, and is expressed in gonadotropes of the pituitary cells, controlled by GnRH , inhibited by inhibin , and enhanced by activin . (explained.today)
  • Leith, M. On the basis of the coinheritance of alkaptonuria with other Mendelian diseases, chromosome 3 was suspected to be the likely location of the gene causing alkaptonuria. (forextrading-madeeasy.com)
  • Pharmacology of a new porcine pancreatic polypeptide with spasmolytic and gastric acid secretion inhibitory effects. (xenbase.org)
  • Specifically, activation of Sertoli cells by FSH sustains spermatogenesis and stimulates inhibin B secretion. (explained.today)
  • Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
  • Members of the evolutionarily conserved Nanos gene family are preferentially expressed in the ovaries and are known to play an important role in germ cell development, maintenance, and survival [ 24 - 30 ]. (hindawi.com)
  • The 20th century, following the consolidation of chemical theory and the will suddenly run standard, amino acids-22 organic chemical As Labs Trenbolone building blocks found in the human body. (ragtrades.com)
  • Inflammation leads to excessive uptake of calcium by cells, and is a factor in obesity, depression, and the degenerative diseases. (raypeat.com)
  • Microtubule inhibitors potently decreased FXR reporter gene activity. (nature.com)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • Building upon a molecular hybridization approach, a small library of 3-amino-1,2,4-triazine derivatives has been designed, synthesized, and characterized for their PDK inhibitory activity using in silico, in vitro, and in vivo assays. (bvsalud.org)
  • This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which contains a domain typical of a Rho-GTPase-activating protein (rhoGAP). (embl-heidelberg.de)
  • The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. (hindawi.com)
  • Chemical changes produced inside cells, for example by respiration, create different electrical charges in different compartments (inside and outside of capillaries, for example) which affect the movements of water and ions, by simple physical processes, not by molecular pumps. (raypeat.com)
  • Cholesterol is a component of animal cell membranes. (ivy-way.com)
  • These subsequent effects are reversed by transfection with full-length PKCα, confirming that the MZF-1/Elk-1 heterodimer is a mediator of PKCα in TNBC cells. (oncotarget.com)
  • FXR contains a DNA-binding domain for docking to target genes with an FXR response element (FXRE) and a ligand-binding domain (LBD) used by intracellular ligands. (nature.com)
  • In females , FSH initiates follicular growth, specifically affecting granulosa cell s. (explained.today)
  • 5 ], who documented that prolactin is a normal constituent of human milk at high concentrations for the first 3 days after birth and that breastmilk prolactin levels correlated significantly with levels of lactose, total protein, and alpha-lactalbumin. (e-cep.org)
  • The origin of eukaryotic cells can be explained by the endosymbiotic theory. (ivy-way.com)
  • Each of the three TPR motifs of this domain consist of a pair of antiparallel alpha-helices of equivalent length. (embl.de)
  • The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist of 96 amino acids , while the beta subunits vary. (explained.today)