MyeloidLymphoblasticMyelodysplastic syndromeCytoplasmStemCancersLeukemicDiagnosisDifferentiationCellsClinicalPatientsAbnormalCellSymptomsCommonPromyelocytic leukemiaBone marrowHematopoietic stemMyeloblastic leukemiaNeutrophilicFetalMyeloid cellsBasophilsRecurrent geneticFavorableMyeloblastsLymphoproliferativeOccursNeoplasmGranulesClinical outcomeSecondaryBloodAnemiaCasesExpressionGrowthChildren
Myeloid9
- Granulopoiesis Hematopoiesis Pluripotential hemopoietic stem cell Myeloid leukemia Metcalf D (January 2008). (wikipedia.org)
- Following diagnosis and treatment as pre-B cell acute lymphoblastic leukaemia (pre-B ALL) the patient developed an acute myeloid leukaemia (AML) which was refractory to all available curative therapies. (cambridgemedicine.org)
- These malignancies are further characterized by the maturity and differentiation of the individual cell types and are divided into acute leukemias such as acute myeloid leukemia and acute lymphoblastic leukemia and chronic leukemias such as chronic myeloid leukemia and chronic lymphocytic leukemia. (medscape.com)
- Myeloid malignancies arise from mutations in hematopoietic stem or progenitor cells. (oncomine.com)
- 5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
- 1,2 The 4 primary disorders of MPNs are chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (oncomine.com)
- 12,13 They also have a high propensity to progress to acute myeloid leukemia (AML). (oncomine.com)
- Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
- Epigenetic modifying enzymes such as histone deacetylases (HDACs), p300, and PRMT1 are recruited by AML1/ETO, the pathogenic protein for t(8;21) acute myeloid leukemia (AML), providing a strong molecular rationale for targeting these enzymes to treat this disease. (ashpublications.org)
Lymphoblastic5
- Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers. (medscape.com)
- The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)
- Also, see the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
- Children with acute lymphoblastic leukemia (ALL) often present with signs and symptoms that reflect bone marrow infiltration and/or extramedullary disease. (medscape.com)
- See Acute Lymphoblastic Leukemia Staging for more complete information. (medscape.com)
Myelodysplastic syndrome2
- Sometimes acute myeloblastic leukemia can be initiated by earlier hematologic disorders, like myelodysplastic syndrome, pancytopenia, or hypoplasia of the bone marrow. (wikipedia.org)
- Decreased WBC count, leukopenia, is seen when supply is depleted by infection or treatment such as chemotherapy or radiation therapy, or when a hematopoietic stem cell abnormality does not allow normal growth/maturation within the bone marrow, such as myelodysplastic syndrome or leukemia. (medscape.com)
Cytoplasm2
- The cytoplasm has a basophilic character and is devoid of granules, which is a major difference from the myeloblast's successor, the promyelocyte. (wikipedia.org)
- These blasts were large with basophilic cytoplasm and no granulation. (cambridgemedicine.org)
Stem2
- Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
- Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
Cancers1
- See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
Leukemic1
- There is a progressive accumulation of leukemic cells, because some blast progenitor cells renew themselves and have a limited differentiated division. (wikipedia.org)
Diagnosis2
- The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
- For explanation of diagnosis and management of the acute porphyrias and the acute manifestations of porphyrias with both neurovisceral and cutaneous components, please refer to the companion article Porphyria, Acute. (medscape.com)
Differentiation1
- Next in the differentiation sequence is the monoblast and the promyelocyte, which can develop into one of three different precursor cells: the neutrophilic, basophilic or eosinophilic myelocyte. (wikipedia.org)
Cells2
- The hemopoietic cells are aligned in cords or wedges between these sinuses, with myeloblasts and other granular progenitors concentrated in the subcortical regions of these hemopoietic cords. (wikipedia.org)
- Leukemia control cells are the AZD1080 KIAA0901 initial reported kind of tumor control cells [5]. (immune-source.com)
Clinical1
- The main clinical features of acute myeloblastic leukemia are caused by failure of hemopoiesis with anemia, hemorrhage and infection as a result. (wikipedia.org)
Patients2
- Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
- Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
Abnormal1
- Elevated WBC, leukocytosis, is seen in response to infection, stress, inflammatory disorders (referred to as reactive leukocytosis), or abnormal production as in leukemia. (medscape.com)
Cell2
- Classical Hairy Cell Leukemia (HCL) and HCL-like disorders are a very heterogeneous group of mature B-cell Chronic Lympho proliferative Disorders (B-CLPD). (fortuneonline.org)
- Here we describe the phenotypic and molecular characteristics of the B cell leukemia/lymphoma in the Tg mice. (biomedcentral.com)
Symptoms2
- Porphyrias are divided into two types according to the predominant symptoms: (1) the neurovisceral or acute porphyrias, with abdominal pain, neuropathy, autonomic instability, and psychosis, and (2) the cutaneous porphyrias, with symptoms of photosensitive lesions on the skin. (medscape.com)
- Aminolevulinic acid dehydrase (ALAD) porphyria and acute intermittent porphyria (AIP) cause predominately neurovisceral symptoms, whereas congenital erythropoietic porphyria (CEP), porphyria cutanea tarda (PCT), and erythropoietic porphyria (EP) cause mostly cutaneous symptoms. (medscape.com)
Common1
- The most common problem with malfunctioning myeloblasts is acute myeloblastic leukemia. (wikipedia.org)
Promyelocytic leukemia4
- Mutations in FLT3 are most common in acute promyelocytic leukemia and basophilic leukemia, and in AML patients with primary refractory disease. (medscape.com)
- Acute Promyelocytic Leukemia An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. (nih.gov)
- WHO) Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), and it is treated differently than other types of AML because of its marked sensitivity to differentiating effects of all trans-retinoic acid. (nih.gov)
- Acute promyelocytic leukemia (APL) pathogenesis is based on RARA gene translocations, which are of high importance in the diagnosis of and proper therapy selection for APL. (bvsalud.org)
Bone marrow8
- Sometimes acute myeloblastic leukemia can be initiated by earlier hematologic disorders, like myelodysplastic syndrome, pancytopenia, or hypoplasia of the bone marrow. (wikipedia.org)
- in bone marrow it is found mainly on early progenitor cells. (medscape.com)
- Decreased WBC count, leukopenia, is seen when supply is depleted by infection or treatment such as chemotherapy or radiation therapy, or when a hematopoietic stem cell abnormality does not allow normal growth/maturation within the bone marrow, such as myelodysplastic syndrome or leukemia. (medscape.com)
- For example, patients with sickle cell anemia who already have chronic anemia may develop additional acute anemia due to bone marrow failure (aplastic crisis). (medscape.com)
- Acute Myelogenous Leukemia A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. (nih.gov)
- Furthermore, their in-vitro differentiation from hematopoietic stem- or progenitor cells, which are typically isolated from bone marrow, is inefficient, and there exists no suitable cell-culture model for those of human or murine origin. (forschung3r.ch)
- Generation of conditionally immortalized, basophil-committed progenitor cell lines from the bone marrow of mice. (forschung3r.ch)
- These basophil progenitor lines are generated from murine bone marrow (or fetal livers) using a significantly modified version of a protocol that has been published for the production of murine neutrophils/macrophages (2, 3). (forschung3r.ch)
Hematopoietic stem1
- The purpose of this initiative is to encourage research aimed at providing an understanding of the genetic and molecular mechanisms responsible for controlling hematopoietic stem and progenitor cell self-renewal, commitment, and differentiation. (nih.gov)
Myeloblastic leukemia2
- The most common problem with malfunctioning myeloblasts is acute myeloblastic leukemia. (wikipedia.org)
- The main clinical features of acute myeloblastic leukemia are caused by failure of hemopoiesis with anemia, hemorrhage and infection as a result. (wikipedia.org)
Neutrophilic2
- Next in the differentiation sequence is the monoblast and the promyelocyte, which can develop into one of three different precursor cells: the neutrophilic, basophilic or eosinophilic myelocyte. (wikipedia.org)
- WHO, 2001) An acute myeloid leukemia (AML) characterized by blasts without evidence of significant maturation in the neutrophilic lineage. (nih.gov)
Fetal2
- Furthermore, we demonstrate that the timing of tamoxifen administration in Csf1r-MCM mice can specifically induce recombinase activity in either fetal or adult hematopoietic progenitors. (oncotarget.com)
- We take advantage of this technique to show more rapid monocytosis following Ptpn11E76K expression in fetal progenitors compared with adult progenitors. (oncotarget.com)
Myeloid cells1
- Homeobox genes, such as Hoxb8, have the potential to block the differentiation of myeloid cells, which they often do in leukemias. (forschung3r.ch)
Basophils4
- Basophilic leukocytosis occurs when basophils are greater than 0.1 x 10 9 /L. Causes include rare allergic reactions (IgE mediated). (medscape.com)
- Basophilic granulocytes (basophils) are a rare leukocyte population within the blood, playing crucial roles in innate immune defense, immune regulation and allergic responses. (forschung3r.ch)
- These progenitors can be induced in vitro to differentiate into mature basophils on demand and in well-nigh unlimited quantities (2). (forschung3r.ch)
- Moreover, the basophil-specific mast cell proteases mMCP8 and mMCP11 are highly expressed in the differentiated basophils but not in their progenitors (Figure 2). (forschung3r.ch)
Recurrent genetic1
Favorable1
- 5. Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes. (nih.gov)
Myeloblasts1
- The hemopoietic cells are aligned in cords or wedges between these sinuses, with myeloblasts and other granular progenitors concentrated in the subcortical regions of these hemopoietic cords. (wikipedia.org)
Lymphoproliferative1
- Animal model studies also indicate that FLT3 mutations cooperate with other molecular alterations in the generation of leukemia, since the expression of a mutated FLT3 in primary hematopoietic cells results in the appearance of a lymphoproliferative syndrome and is not sufficient to cause leukemia. (medscape.com)
Occurs1
- An exception is acute anemia that occurs in patients with existing chronic anemia. (medscape.com)
Neoplasm4
- Juvenile Myelomonocytic Leukemia (JMML) is a pediatric myeloproliferative neoplasm (MPN) that has a poor prognosis. (oncotarget.com)
- Juvenile Myelomonocytic Leukemia is a pediatric myeloproliferative neoplasm (MPN) that has limited therapeutic options and a poor prognosis. (oncotarget.com)
- C3268 Nervous System Neoplasm C132009 C9381 Childhood Acute Myeloid Leukemia with Maturation Childhood Acute Myeloid Leukemia with Maturation An acute myeloid leukemia with maturation occurring in children. (nih.gov)
- C35876 Childhood Intracranial Neoplasm C132009 C9158 Childhood Acute Myeloid Leukemia without Maturation Childhood Acute Myeloid Leukemia without Maturation An acute myeloid leukemia without maturation occurring in children. (nih.gov)
Granules1
- The cytoplasm has a basophilic character and is devoid of granules, which is a major difference from the myeloblast's successor, the promyelocyte. (wikipedia.org)
Clinical outcome1
Secondary2
Blood1
- Acute anemia is usually due to acute blood loss or acute hemolysis. (medscape.com)
Anemia1
- In contrast, acute anemia develops suddenly, in a matter of hours or days. (medscape.com)
Cases1
- However, in some cases acute myeloid leukemia (AML) demonstrates APL-like morphological features such as atypical promyelocytes accumulation. (bvsalud.org)
Expression1
- Mixed-phenotype acute leukemia (MPAL), a rare and heterogeneous category of acute leukemia, is characterized by cross-lineage antigen expression. (bvsalud.org)
Growth1
- Mutant Ptpn11 evokes hyperactive Ras signaling among hematopoietic progenitors that causes growth hypersensitivity in the presence of the cytokine GM-CSF [ 4 ]. (oncotarget.com)