AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
Benzo(a)pyrenePyrenesBenzopyrenes7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideDihydroxydihydrobenzopyrenesDNA AdductsPolycyclic Hydrocarbons, AromaticCarcinogensPolycyclic CompoundsBiotransformationMutagensBenzopyrene HydroxylaseEpoxy CompoundsMethylcholanthreneBenz(a)AnthracenesCytochrome P-450 CYP1A1Mutagenicity TestsChrysenesCoal TarCarcinogens, EnvironmentalAryl Hydrocarbon HydroxylasesStereoisomerismPhenanthrenesBenzoflavonesGlycolsBiological ProductsCytochrome P-450 Enzyme SystemDNAMolecular Sequence DataBase SequenceKineticsEnzyme InductionReceptors, Aryl HydrocarbonAnisolesCreosoteMetabolic Detoxication, DrugBiodegradation, EnvironmentalTrichloroepoxypropanebeta-NaphthoflavoneDeoxyguanosineFluorenesNeoplasms, ExperimentalChromatography, High Pressure LiquidPapillomaLiverCocarcinogenesisEnvironmental PollutantsAmino Acid SequenceMolecular StructureStructure-Activity RelationshipDNA DamageTetrachlorodibenzodioxinCell LineSpectrometry, FluorescencePhenols9,10-Dimethyl-1,2-benzanthraceneCokeEthers, CyclicMicrosomes, LiverMicrosomesMutationMixed Function OxygenasesCricetinaeFundulidae2-AcetylaminofluoreneDairy ProductsButylated HydroxyanisoleAroclorsSalmonella typhimuriumWater Pollutants, ChemicalSmokeEscherichia coli
ChryseneCarcinogenicPerylenePAHsCarcinogensPolycyclic aromatic hyBenzeneMetaboliteOxidativeCarcinogenEpoxideSubstancesRodentHumansCigarettesGenesMainstream smokeDeterminationStabilitySmokeSpeciesChemicalsTobacco productsLungOrganicReductionSubstanceFormationHydrocarbonsContaminantsIncompleteEvidenceCombustionToxicRelatesFoundMethodHighMilk productsCategoryLevelsCrudeOffersAnalyticalCommonChemistryGoodsImpactListFoodServices
Chrysene2
  • The ability of prostaglandin synthetase (PGS) to cooxidize benzo( a )pyrene, benzo( a )anthracene, chrysene, and several of their dihydrodiol derivatives to mutagenic products was tested with Salmonella typhimurium strains TA98 and TA100. (aacrjournals.org)
  • The microsomal fraction of ram seminal vesicles, a known source of PGS, in the presence of the PGS substrate arachidonic acid, metabolized benzo( a )pyrene-7,8-dihydrodiol, benzo( a )anthracene-3,4-dihydrodiol, and chrysene-1,2-dihydrodiol to mutagenic products. (aacrjournals.org)
Carcinogenic4
  • Benzopyrenes are harmful because they form carcinogenic and mutagenic metabolites (such as (+)-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide from benzo[a]pyrene) which intercalate into DNA, interfering with transcription. (wikipedia.org)
  • The diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a potent mutagen and possibly the ultimate carcinogenic form of benzo(a)pyrene. (lookformedical.com)
  • But then, what about the polycyclic aromatic hydrocarbon products of combustion that are "suspected to be carcinogenic" and DNA-damaging? (nutritionfacts.org)
  • Most PAHs are not carcinogenic, although a few are (such as pyrene and benzopyrene). (amorcatz.com)
Perylene3
  • Benzopyrene is a component of pitch and occurs together with other related pentacyclic aromatic species such as picene, benzofluoranthenes, and perylene. (wikipedia.org)
  • They found four discrete benzo[e]pyrene + benzo[ghi]perylene + coronene -Hg enrichments. (sciencedaily.com)
  • We believe the extinction was the product of large volcanic eruptions because the benzo[e]pyrene + benzo[ghi]perylene + coronene anomaly could only be seen around the time frame of the mass extinctions," said Kaiho. (sciencedaily.com)
PAHs5
  • In February 2014, NASA announced a greatly upgraded database for tracking polycyclic aromatic hydrocarbons (PAHs), including benzopyrene, in the universe. (wikipedia.org)
  • Benzo(a)pyrene (B(a)P) is one of many identified PAHs. (swedishmatch.com)
  • Grilled and smoked products contain the highest levels of PAHs, while cereal products and spreads containing low levels. (swedishmatch.com)
  • OCPs were detected less frequently than PAHs in these products, and none of the OCPs had mean concentrations over 1 ng/g. (gerstel.com)
  • Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. (biomedcentral.com)
Carcinogens2
  • In a preclinical study published in the journal Frontiers in Pharmacology , researchers from the USA investigated the potential chemopreventive effects of a mushroom - Ganoderma lucidum (GL)-derived commercial product named GLSF in vitro and in mice with lung carcinogenesis induced by two tobacco smoke carcinogens, namely benzo[a]pyrene (B[a]P) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (news-medical.net)
  • Various products of these genes are enzymes involved in the activation or degradation of carcinogens/pro-carcinogens. (bvsalud.org)
Polycyclic aromatic hy1
  • Benzo(a)pyrene is a polycyclic aromatic hydrocarbon (PAH) with cancer-causing properties. (leanweb.org)
Benzene1
  • Benzene, benzo(a)pyrene (BaP), and lead in mainstream smoke from cigars, roll-your-own (RYO) cigarette and pipe tobaccos were sampled to evaluate their potential health significance. (nih.gov)
Metabolite2
  • The effect of inhibitors on the spectrophotometric assay correlates well with the results obtained from benzo(a)pyrene metabolite analysis using high-pressure liquid chromatography. (lookformedical.com)
  • Differences in benzo(a)pyrene metabolite pattern have been shown by rodent liver microsomes (Sprague-Dawley) and rodent embryo cells from Syrian hamsters and NIH Swiss mice. (lookformedical.com)
Oxidative1
  • Optical spectral repetitive scan analysis during the oxidative metabolism of benzo(a)pyrene by liver microsomal suspensions reveals the time-dependent formation of an intermediate(s) of which the visible spectra resemble those of several benzo(a)pyrene phenols. (lookformedical.com)
Carcinogen2
  • Furthermore, a known carcinogen (Benzo(a)pyrene) was detected in field-generated roofing fumes. (cdc.gov)
  • These results are indicative of a region-specific attack on the carcinogen by the cell monooxygenases which is distinct from the liver attack of microsomal enzymes on benzo(a)pyrene. (lookformedical.com)
Epoxide2
  • An epoxide hydrase inhibitor, 1,1,1-trichloropropene-2,3-oxide, enhanced phenol formation regardless of the source of liver microsomes, and 7,8-benzoflavone inhibited control and 3-methylcholanthrene-induced microsomal metabolism of benzo(a)pyrene, 7,8-Benzoflavone did not effect benzo(a)pyrene metabolism by liver microsomes from phenobarbital-pretreated rats. (lookformedical.com)
  • The hepatic nuclear fraction isolated from 3-methylcholanthrene (MC)-treated rats contained enhanced levels of cytochrome P-450 and aryl hydrocarbon hydroxylase [benzo(a)pyrene (BP) monooxygenase], whereas the activities of epoxide hydrase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and the concentration of cytochrome b5 were not altered. (lookformedical.com)
Substances6
  • International laws and regulations governing the chemicals allowed in products are continually updated to prevent harmful substances from polluting the environment and causing health hazards to consumers. (com.de)
  • At QIMA, we perform stringent standardized tests to detect the levels of harmful substances in consumer products, helping manufacturers ensure their goods meet European health and safety requirements under REACH, which are also the standard for many other countries outside the EU. (com.de)
  • REACH (Registration, Evaluation, Authorization and restriction of Chemicals) restricts a number of chemical substances used in a vast range of products sold in the EU. (com.de)
  • It is unacceptable that industrial substances and consumer products exceed standards. (riwa-maas.org)
  • A few examples of this category of substances that exceed standards or target values are Fluoride, Di-isopropylether, Tributylphosphate, complexing agents and Benzo(a)pyrene. (riwa-maas.org)
  • Melanin can bind to many different compounds, including nicotine and benzopyrene present in the tobacco smoke, and these substances can stimulate melanocytes to produce melanin. (medscape.com)
Rodent1
Humans2
  • Mandated lowering of levels of toxicants per mg nicotine in cigarette smoke will make regulation of cigarettes consistent with other regulatory approaches which mandate reduction of known toxicants in products used by humans. (blogspot.com)
  • 2018. Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. . (oregonstate.edu)
Cigarettes1
  • The intake of nicotine increases the chances of addiction and this is the problem when it comes to smoking in general whether waterpipe, cigarettes, or any tobacco containing product. (who.int)
Genes1
  • Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of carcinogenesis with respect to oral mucosa. (bvsalud.org)
Mainstream smoke1
  • ISO 22634-1:2017 specifies a method for the determination of benzo[a]pyrene (B[a]P) in the total particulate matter of cigarette mainstream smoke using gas chromatography/mass spectrometry (GC/MS) with methanol as extraction solvent. (iso.org)
Determination1
  • ISO 15302:2017 specifies a method for the determination of benzo[ a ]pyrene in crude or refined edible oils and fats by reverse-phase high performance liquid chromatography (HPLC) using fluorimetric detection in the range 0,1 µg/kg to 50 µg/kg. (iso.org)
Stability1
  • It is the improved generation and high quality Omega-3 EPA/DHA TG concentrates with high TG (Triglycerides 80% or 90%) level, no EE (Ethyl Ester) Residue, low MG (Mono-Glycerides), low Oligomer, PAH -Benzo(a)pyrene free, high Stability and Purity. (nutraingredients.com)
Smoke1
  • The ultimate recommendation of the Study Group is as follows: "TobReg recommends a strategy for regulation based on product performance measures with the goal of reducing toxicant levels in mainstream cigarette smoke measured under standardised conditions. (blogspot.com)
Species2
  • Two isomeric species of benzopyrene are benzo[a]pyrene and the less common benzo[e]pyrene. (wikipedia.org)
  • These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps. (lookformedical.com)
Chemicals1
  • Receive the latest updates in product chemicals, custom synthesis, and company news delivered to your inbox. (sarchemlabs.com)
Tobacco products3
  • These tobacco products are now required to bear a health hazard warning when sold in California. (nih.gov)
  • The current limit value for B(a)P in the GOTHIATEK-standard is lower than both the limit value regulated by the Swedish Food Agency and the limit value recommended by WHO for smokeless tobacco products. (swedishmatch.com)
  • The World Health Organization (WHO) Study Group on Tobacco Product Regulation (TobReg) has published a number of reports that serve as what it purports to be the "scientific basis" for the regulation of the constituents in tobacco products. (blogspot.com)
Lung3
  • Evidence exists to link benzo[a]pyrene to the formation of lung cancer. (wikipedia.org)
  • Could a mushroom-derived product be the future of lung cancer prevention? (news-medical.net)
  • However, the effects of GL or GL-derived products have not been studied for the prevention of tobacco-smoking-induced lung carcinogenesis. (news-medical.net)
Organic2
  • A benzopyrene is an organic compound with the formula C20H12. (wikipedia.org)
  • All around us, ads brag that products are "100% natural" or "organic" or chemical free. (acsh.org)
Reduction2
  • Additional pattern changes were found in mouse and hamster embryo secondary cultures with a reduction of the K-region metabolites and a marked increase in 9-hydroxybenzo(a)-pyrene. (lookformedical.com)
  • Nonenzymatic reduction of benzo(a)pyrene diol-epoxides to trihydroxypentahydrobenzo(a)pyrenes by reduced nicotinamide adenine dinucleotide phosphate. (lookformedical.com)
Substance1
  • When emissions are not coming from the producer of a substance but from a user of an end product we address them both. (riwa-maas.org)
Formation3
  • The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes. (lookformedical.com)
  • When 3-hydroxybenzo(a)pyrene was used as a standard for comparison of activity, the rates of formation of phenols were compared when measured by fluorometric, spectrophotometric, or high-pressure liquid chromatographic analytical techniques. (lookformedical.com)
  • Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA. (lookformedical.com)
Hydrocarbons2
  • Structurally speaking, the colorless isomers of benzopyrene are pentacyclic hydrocarbons and are fusion products of pyrene and a phenylene group. (wikipedia.org)
  • Contamination caused by petroleum products will contain a variety of these hydrocarbons. (cdc.gov)
Contaminants1
  • EMODnet Chemistry aims to provide access to marine chemistry data sets and derived data products concerning eutrophication, ocean acidification and contaminants. (europa.eu)
Incomplete1
  • It is a by-product of incomplete wood combustion, pulp and paper production, stationary internal combustion engines and turbines, and wastewater processing. (toronto.ca)
Evidence2
  • Lower yield products will be marketed to consumers throughout the world, misleading them into believing that these products are safer, but without any evidence that they are actually safer. (blogspot.com)
  • There is absolutely no difference between what TobReg proposes to do here and what the tobacco companies have found themselves guilty of perpetrating by Judge Kessler: deception of the public about the relative safety of lower-yield products without scientific evidence to substantiate the improved safety of these products. (blogspot.com)
Combustion1
Toxic4
  • Just to put things in perspective, even the darkest roast coffee might only max out at a fraction of a nanogram of benzopyrene per cup-considered to be "the most toxic" of these compounds-whereas a single medium portion of grilled chicken could have over 1,000 times more. (nutritionfacts.org)
  • There are two main factors which affect toxic product yields which are ventilation of the fire and the chemical composition of the materials involved. (backtoearth.co.uk)
  • It is these types of fires that we are discussing when looking at the toxic products released from the various products below. (backtoearth.co.uk)
  • Some of the most significant levels of toxic gases are released by a product called Polyamide. (backtoearth.co.uk)
Relates2
  • The mechanism of action of benzo[a]pyrene-related DNA modification has been investigated extensively and relates to the activity of cytochrome P450 subclass 1A1 (CYP1A1). (wikipedia.org)
  • Al-Wakeel pointed out that the medical potency of the different commercial CBD products relates to their composition in terms of both concentration and constituent cannabinoids. (cosmeticsbusiness.com)
Found3
  • Natural fibres tend to burn very slowly with by-products that would be found in any wood burning stove or fireplace, products that are fairly well understood and not generally regarded as hazardous. (backtoearth.co.uk)
  • The initial directive was issued in 2002 (2002/95/EC), restricting the use of six hazardous materials found in electrical and electronic products. (com.de)
  • Studies have also found that nicotine and tobacco-specific compounds (N -nitrosamines and benzopyrene) may accumulate in melanin-containing human tissues and affect melanogenesis. (medscape.com)
Method1
  • This method enables accurate, precise, and sensitive quantification of POPs in plant-extract based dietary supplement products commercially available in the United States. (gerstel.com)
High1
  • Seemingly, the high activity of CYP1A1 in the intestinal mucosa prevents major amounts of ingested benzo[a]pyrene from entering portal blood and systemic circulation. (wikipedia.org)
Milk products2
  • There are many types of milk products, such as raw or processed and those classi fied by fat content levels (low-fat, non-fat, and so on). (shimadzu.com)
  • Milk and milk products (or fat coming from milk and milk products) are excluded from the scope of this document. (iso.org)
Category1
  • Businesses supplying EEE products to the EU are required to fully comply with RoHS 2 by July 22, 2019 or sooner, depending on the product category. (com.de)
Levels3
  • However, doing this would likely increase the overall tar levels, as well as the level of benzo[a]pyrene. (blogspot.com)
  • Therefore, we simply do not know whether lowering nitrosamine levels would result in a safer product. (blogspot.com)
  • The levels of Hydrogen Cyanide gas given off by these products, even in a small fire, can be five to six times the lethal dose required. (backtoearth.co.uk)
Crude1
  • Crude oils can vary in how much of each chemical they contain, and so can the petroleum products that are made from crude oils. (cdc.gov)
Offers1
  • That pumpkin pie (made from scratch, of course)offers benzo(a)pyrene. (acsh.org)
Analytical1
  • We provide analytical testing with every delivery and if there are questions about the application of the product, we have a team of experienced chemists to advise and assist. (sarchemlabs.com)
Common1
  • The common view of whether a building product is 'fire safe' is generally based on whether the product burns or not. (backtoearth.co.uk)
Chemistry1
  • Our broad portfolio of innovative chemistry products and have been utilized in biomedical, electronics, engineering, and energy applications. (sarchemlabs.com)
Goods1
  • Fumes that develop from fat dripping on blistering charcoal are rich in benzopyrene, which can condense on grilled goods. (wikipedia.org)
Impact1
  • In this article we discuss the effect of fire on synthetic insulation materials rather than natural fibres such as wood fibre, as the impact of these products is a relatively recent phenomenon. (backtoearth.co.uk)
List1
  • If there is a product not in our list, please reach out to us. (sarchemlabs.com)
Food1
  • Chloropropanols/esters have also been linked with the thermal treatment of processed food products. (amorcatz.com)
Services2
  • CDC and ATSDR, our planners, and our presenters wish to disclose they have no financial interests or other relationships with the manufacturers of commercial products, suppliers of commercial services, or commercial supporters. (cdc.gov)
  • Please let us know what you think of our products and services. (mdpi.com)