• Prochlorperazine (Compazine) is contraindicated in hepatic disease. (surenapps.com)
  • It is important also to remember that metoclopramide, prochlorperazine and a number of other drugs given for nausea or other gut disturbances are essentially the same drugs as the APs, and can cause tardive and respiratory dyskinesias as well as the other problems linked to these medicines. (rxisk.org)
  • metoclopramide decreases levels of dopamine by pharmacodynamic antagonism. (medscape.com)
  • We theorize that CYP2D6 governs the risk of metoclopramide-related acute dystonia through its role in the synthesis of serotonin, which inhibits the dopamine tone. (nih.gov)
  • STUDY OBJECTIVE: To compare the efficacy and frequency of akathisia and dystonia between the dopamine antagonist headache medications olanzapine, metoclopramide and prochlorperazine. (bvsalud.org)
  • We report two cases of metoclopramide-induced acute dystonia in pregnant women and consider the role of genetic variation in the pathogenesis of the adverse effect. (nih.gov)
  • Together, the two factors may create a hyper-dopaminergic state that is easily upset by metoclopramide, resulting in acute dystonia. (nih.gov)
  • CONCLUSION: During initial ED visit and up to 72 h after receiving olanzapine, metoclopramide or prochlorperazine, we found no difference in risk for requiring rescue medication or developing akathisia or dystonia. (bvsalud.org)
  • She reported a "bad reaction to tablets for nerves" in the past and had suspected that haloperidol and metoclopramide had been causing the agitation but was aggrieved that she had not been listened to until the previous day. (antidepressantsfacts.com)
  • 12. [Benefit and risk of high-dose metoclopramide in comparison to high-dose haloperidol or triflupromazine in cisplatin-induced vomiting]. (nih.gov)
  • The aim of this review was to evaluate the efficacy and safety of prochlorperazine (PCP) in patients with acute migraine headache in the emergency department (ED). (nih.gov)
  • 20. Comparison of the antiemetic efficacy of two high-dose benzamides, metoclopramide and alizapride, against cisplatin-induced emesis. (nih.gov)
  • The next stage of Yellepeddi's research is to test the safety, efficacy, and pharmacokinetic studies of the prochlorperazine nasal spray in rat animal models. (sciencedaily.com)
  • Researchers are developing a novel prochlorperazine nasal spray formulation as a potential new treatment for migraines. (sciencedaily.com)
  • Venkata Yellepeddi, Ph.D., along with his colleagues from Roseman University of Health Sciences, developed a preservative-free device-driven prochlorperazine nasal spray that could prove useful for compounding pharmacists specifically in the field of pain medicine. (sciencedaily.com)
  • Currently, there are no marketed nasal spray formulations of prochlorperazine available for the treatment of migraine. (sciencedaily.com)
  • Yellepeddi and his team hypothesize that a nasal spray version of prochlorperazine will not only be effective, but fast acting and have better patient compliance overall. (sciencedaily.com)
  • The first two randomised controlled trials1 2 show a significantly better outcome with prochlorperazine 10 mg versus metoclopramide 10 mg The third study3 shows no significant difference between prochlorperazine and a higher dose of metoclopramide. (bestbets.org)
  • However, elderly patients are more likely to have side effects such as tardive dyskinesia, confusion, or drowsiness, and age-related kidney problems, which may require an adjustment in the dose for patients receiving metoclopramide. (mayoclinic.org)
  • Experiences with the use of high-dose metoclopramide combined with chlopromazine and prochlorperazine]. (nih.gov)
  • 13. Dose-response relationships of the objective and subjective antiemetic effects and of different side effects of metoclopramide against cisplatin induced emesis. (nih.gov)
  • 15. Clinical pharmacokinetics of high-dose metoclopramide in cancer patients receiving cisplatin therapy. (nih.gov)
  • 18. A randomized, double-blind comparison of the antiemetic effect of metoclopramide and lorazepam with or without dexamethasone in patients receiving high-dose cisplatin. (nih.gov)
  • The recommended adult dose of metoclopramide for symptoms resulting from delayed stomach emptying ranges from 5 mg to 10 mg 3 or 4 times daily before meals. (rxhealthmed.ca)
  • 17. [Antiemetic combination of metoclopramide and methylprednisolone for cisplatin-induced vomiting]. (nih.gov)
  • 11. Enhancement of the antiemetic action of metoclopramide against cisplatin-induced emesis by transdermal electrical nerve stimulation. (nih.gov)
  • Prochlorperazine injection has been upgraded to a highly recommended level because of the rich clinical experience for this treatment. (bvsalud.org)
  • 6. Control of cisplatin-induced delayed emesis with metoclopramide and dexamethasone: a randomized controlled trial. (nih.gov)
  • 8. High doses of metoclopramide or droperidol in the prevention of cisplatin-induced emesis. (nih.gov)
  • 16. Maintenance of antiemetic effect of a metoclopramide-dexamethasone combination during subsequent cisplatin courses. (nih.gov)
  • Metoclopramide is used to treat the symptoms of slow stomach emptying (gastroparesis) in patients with diabetes. (mayoclinic.org)
  • He reported that the symptoms were very similar to the time he had taken metoclopramide (10 mg four times a day) during his chemotherapy. (antidepressantsfacts.com)
  • metoclopramide increases toxicity of lurasidone by antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. (medscape.com)
  • metoclopramide decreases levels of cabergoline by inhibition of GI absorption. (medscape.com)
  • Metoclopramide may increase the side effects of antipsychotic agents. (medicinenet.com)
  • Prochlorperazine is only available in tablet form, which has delayed onset of action. (sciencedaily.com)
  • Metoclopramide is also used to treat heartburn for patients with gastroesophageal reflux disease (GERD). (mayoclinic.org)