Processes transcription genetic. Medical search. Frequent questions

To diagnose and treat genetic diseases, scientists must predict the biological consequences of both existing mutations and those they plan to introduce. (utoronto.ca)
Deep Genomics is also releasing its first product, called SPIDEX, which provides information about how hundreds of millions of DNA mutations may alter splicing in the cell, a process that is crucial for normal development. (utoronto.ca)
Most of these mutations change single protein building blocks in the FUS protein and often affect the region of the protein involved in DNA binding and mRNA processing. (medlineplus.gov)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
Somatic mutations were identified in NXK2-5 and its molecular partners, TBX5 and GATA4 , as well as the transcription factor HEY2 in formalin fixed tissue taken from a collection of hearts with atrial septal defects (ASD), 8 ventricular septal defects (VSD), and atrioventricular canal defects (AVCD). (cdc.gov)

However, as similar as they may appear to those newly introduced to these concepts, replication and transcription have unique roles to play in cellular activity. (aboutdarwin.com)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
DNA is the substrate of many cellular processes including DNA replication, transcription and chromatin remodeling. (umass.edu)
A study of cellular processes involved in the Central Dogma: DNA replication, transcription and translation. (graceland.edu)
There's a lot of interest in new drugs that target core cellular processes. (umassmed.edu)
Transcriptional inhibitors are anticancer drugs that act on gene transcription, a core cellular process by which genetic information encoded by DNA is read out in the form of RNA. (umassmed.edu)
Dr. Arthur Kornberg shared the 1959 prize with Severo Ochoa of New York University for their work on how genetic information is transferred from one strand of DNA to another during cellular replication. (chicagotribune.com)
Roger Kornberg won for his work illuminating the process in which genetic information in cells is translated into the proteins that control cellular structure and function. (chicagotribune.com)
FABP5 improves learning and memory both because it delivers endocannabinoids to cellular machinery that breaks them down and because it shuttles compounds to a transcription factor that increases the expression of cognition-associated genes," Noy said. (neurosciencenews.com)
6, 7 BRCA1 interacts with a variety of proteins and is involved in multiple cellular processes including DNA repair, transcription, and checkpoint control. (bmj.com)
HBS1L encodes a protein with apparent GTP binding activity and is included in different cellular processes while MYB encodes a transcription factor for erythroid differentiation in hematopoiesis [10]. (scirp.org)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)

BACKGROUND: The complexity of messenger RNA processing is now being uncovered by experimental techniques that are capable of detecting individual copies of mRNA in cells, and by quantitative real-time observations that reveal the kinetics. (cnrs.fr)
This processing is commonly modelled by permitting mRNA to be transcribed only when the promoter is in the on state. (cnrs.fr)
METHODOLOGY: In this paper, we explore the impact on the mRNA distribution of representing the elongation process in more detail. (cnrs.fr)
The results also suggest that some form of coupling between the promoter and a rate-limiting step in transcription may explain the cell's inability to maintain high mRNA levels at low noise-a prediction of the on/off model that has no supporting evidence. (cnrs.fr)
At the ribosome, the processed mRNA is translated to produce proteins from amino acid units. (cdc.gov)
We identified 410 proteins, including key DNA replication factors and proteins associated with transcription, chromatin organization, DNA repair and mRNA splicing. (umass.edu)
The FUS protein is also involved in processing molecules called messenger RNA (mRNA), which serve as the genetic blueprints for making proteins. (medlineplus.gov)
Once the FUS protein processes the mRNA, it transports the mRNA out of the nucleus where it gets taken up by other cell structures to be further processed into a mature protein. (medlineplus.gov)
21 Furthermore, interaction between the BARD1/BRCA1 heterodimer and cleavage stimulation factor subunit 1 (CSTF1, also called CstF-50) represses the polyadenylation machinery, presumably to prevent inappropriate mRNA processing at sites of DNA repair. (bmj.com)

Replication, in the world of genetics, is a mesmerizing process through which a cell makes an exact copy or, to draw a more precise picture - duplicates its DNA. (aboutdarwin.com)
Informed by more than 50 years experience and experimentation in teaching genetics, authors Mark Sanders and John Bowman share their excitement about genetics and the dynamism at work in the field with Genetic Analysis: An Integrated Approach . (biggerbooks.com)
To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy (GenDIP) Consortium assembled genome-wide association studies (GWAS) of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. (lu.se)
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The core transcription machinery of RNA polymerase copies the information found in DNA genes onto messenger RNA molecules that then govern the production of proteins. (sciencedaily.com)
The complex regulates histone H2B ubiquitination, histone H3 methylation, RNA polymerase II carboxy-terminal domain (CTD) Ser2 phosphorylation, and RNA 3' end processing. (embl-heidelberg.de)
Strong evidence indicates that transcription elongation by RNA polymerase II (pol II) is a highly regulated process. (embl-heidelberg.de)
The transcription process is carried out by an enzyme called RNA polymerase. (chicagotribune.com)
But Kornberg persisted, gradually assembling the RNA polymerase crystals needed for the study as advances in computer processing and X-ray crystallography imaging were made by others. (chicagotribune.com)
The polymerase then traverses the genetic material, and continues to yield RNA until it identifies a gene's transcription termination sequence, stopping the process. (jove.com)
Proteins called repressors bind to these regions, preventing polymerase-promoter association, inhibiting transcription. (jove.com)

Identification of Molecular Processes Underlying Abiotic Stress Plants Adaptation Using "Omics" Technologies. (routledge.com)
Like discovering a car that has more than one engine under the hood, cell biologists are learning to their surprise that alternate molecular machines can drive the basic process of transcription that orchestrates the expression of genes. (sciencedaily.com)
Human cells have evolved multiple molecular mechanisms (for example, gene silencing) to keep selfish genetic elements like LINE1s at bay. (genengnews.com)
Lecture 2, 04/09/09, thu In this lecture we reviewed some general background in molecular biology, particularly the central genetic process (from DNA to Proteins). (ubc.ca)
Lastly students will study and perform different molecular genetic techniques used in laboratories today: pipetting, DNA gel electrophoresis, PCR and DNA cloning. (graceland.edu)
Using genetic tools to implant genes that produce fluorescent proteins in the DNA of transparent C. elegans worms, John Calarco, a Bauer Fellow at the Faculty of Arts and Sciences Center for Systems Biology, and postdoctoral researcher Adam Norris were able to gather hard evidence that the alternative splicing process frequently works differently in different types of neurons.The study was described in a recent paper in Molecular Cell. (harvard.edu)
With all six genotypes of citrus tested including Eureka lemon, a cultivar difficult to be transformed, our results demonstrate that the kn1 gene may provide an effective molecular tool to enhance genetic transformation efficiencies of various citrus varieties. (springer.com)
Kornberg "was the first to create an actual picture of this process at the molecular level," reads the Nobel citation. (chicagotribune.com)

In addition, activated eIF2α can trigger production of certain proteins called transcription factors, which control gene activity. (medlineplus.gov)
The transcription factors regulated by eIF2α control the activity of genes involved in processes that help reduce the stress on the cell. (medlineplus.gov)
Transcription Factors, Gene Regulatory Networks, and Agronomic Traits. (routledge.com)
Researchers know that many factors contribute to the aging process. (genengnews.com)
A direct and effective approach for clarifying the action mechanisms of F. equiseti is the identification of the genetic factors directly related to its functions. (researchsquare.com)
Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)
In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
The common plant regulatory factors (CPRFs) from parsley are transcription factors with a basic-leucine-zipper motif that bind to cis-regulatory elements frequently found in promoters of light-regulated genes. (embl-heidelberg.de)
CPRF5, CPRF6 and CPRF7 are transcription factors that exhibit sequence-specific DNA-binding as well as transactivation abilities, whereas the function of CIP remains elusive. (embl-heidelberg.de)
Despite the requirement for a number of transcription factors and secreted signalling molecules in sex determination, intracellular signalling components functioning in this process have not been defined. (plos.org)
Researchers repaired what is otherwise irreversible damage in the animals' ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells. (the-scientist.com)
They looked to genes that encode transcription factors that de-differentiate cells. (the-scientist.com)
In a 2016 Cell paper, a different group of scientists had activated these transcription factors in mice with progeria, a condition that causes premature aging, and found that the treatment alleviated symptoms and extended their lifespan by a matter of weeks. (the-scientist.com)
The next challenge: to see if these transcription factors could successfully revert old and injured neurons back to a more youthful and healthy state. (the-scientist.com)
To test whether adult mice can regain this ability, the researchers crushed the optic nerves of some mice and induced glaucoma in another set of mice by inserting tiny beads into their eyes, then injected the virus encoding the three transcription factors into all the mice's eyes. (the-scientist.com)
Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)
Evidence continues to accumulate to suggest important roles for inflammation and genetic factors in the process of atherosclerosis and specifically in stroke. (medscape.com)
Host genetic factors, moreover, may modify the response to these environmental challenges and are responsible for developmental vascular instability. (medscape.com)
Abnormal cardiac development appears to occur through a process that is heterogeneous and complex, with both environmental and genetic risk factors. (cdc.gov)

Our comprehensive analysis of the whole genome of F. equiseti provides basic data for studies of gene expression, regulatory and functional mechanisms, evolutionary processes, as well as disease prevention and control. (researchsquare.com)
We discussed the structure, function, and string representation of DNA, proteins and RNA and started discussing the basic processes of gene expression (transcription and translation). (ubc.ca)
The study will include how gene expression is regulated at various levels, such as at the transcription level and post-translational level. (graceland.edu)
One of the modifications affected by SARS-CoV-2, known as m6A (a multifaceted regulator of gene expression), is highly important for RNA's basic functions, including transportation of data to the protein-making parts of the cell, and transcription and translation into amino acids there. (sflorg.com)
However, these intergenic regions carry important elements that regulate gene activity, for instance, the promoter where transcription starts, and enhancers and silencers that fine-tune gene expression. (jove.com)
Second, FABP5 regulates gene expression, a process that essentially gives cells their marching orders on structure, appearance and function. (neurosciencenews.com)
Examples of 2-omics analyses include expression quantitative trait locus eQTL (Franke & Jansen, 2009) and methylation quantitative trait locus meQTL (Smith, Kilaru, Kocak, Almli, & Mercer, 2014) that, respectively, assess the influence of genetic and epigenetic markers on gene expression. (researchgate.net)
These evidences are often based on the derivation of standard measures of association, linking (epi-)genetic markers to gene expression combined with gene expression analysis (Wagner, Busche, Ge, Kwan, & Pastinen, 2014). (researchgate.net)

Launched July 22, Deep Genomics was spun out of research at the University of Toronto and its founders say it will transform genetic testing, pharmaceutical development and personalized medicine. (utoronto.ca)
The genome contains a catalogue of genetic variation that is our DNA blueprint for health and disease," said Professor Stephen Scherer , director of The Centre for Applied Genomics at SickKids and the McLaughlin Centre atU of T, a CIFAR Senior Fellow, and an advisor to Deep Genomics. (utoronto.ca)

The FUS protein attaches (binds) to DNA and regulates an activity called transcription, which is the first step in the production of proteins from genes. (medlineplus.gov)
FABP5 controls the biological actions of small compounds that affect memory and learning and that activate a transcription factor, which regulates neuronal function. (neurosciencenews.com)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)

Rhizosphere Metabolomics: A Study of Biochemical Processes. (routledge.com)
Introduces chemical and biochemical reaction kinetics, methods of evaluating kinetic parameters for reaction rate data, and prediction of the performance of biological and biochemical processes. (washington.edu)

Two such fundamental processes that keep the wheels of life turning are Replication and Transcription. (aboutdarwin.com)
This interplay forms the foundation of processes like Replication and Transcription. (aboutdarwin.com)
Although recent studies in T. brucei indicate functional links among DNA replication and transcription, the underlying mechanisms remain unknown. (umass.edu)

This type of genetic change, called a somatic mutation, is not inherited. (medlineplus.gov)

In this project we investigate the role transposable elements have played in this process. (lu.se)
As a consequence, a large portion of genetic information specific to primates and humans is stored in transposable elements. (lu.se)
We also use human induced pluripotent stem cells to investigate how polymorphic transposable elements contribute a genetic component to these disorders, using X-linked dystonia Parkinsonism as our current focus. (lu.se)

general transcription and translation. (wikipedia.org)
RNA carries this encoded information to the cells for transcription and translation. (sflorg.com)
At the time, the RNA molecule was seen as a mere messenger which decodes (transcribes) information from genetic sequences of DNA, in the form of a messenger RNA, which is then used as a template when the protein molecules are combined (translation). (lu.se)

However, these mechanisms become less efficient during the aging process, allowing LINE1s to be reactivated. (genengnews.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)

Uses computational and experimental projects covering methods to acquire, process, and analyze signals from physiological and biochemical origins. (washington.edu)
Even though endocannabinoids affect essential physiological processes from appetite to memory, the "cannabinoid" part of the word signifies that these natural biological compounds act similarly to drugs such as marijuana and hashish. (neurosciencenews.com)

Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)
Here we present genetic results that indicate a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)

Studies the principles of combined mass transport in homogeneous and heterogeneous reaction systems as applied to biological processes. (washington.edu)
Notwithstanding its characterization as an endothelial cell marker, the full spectrum of biological processes associated with ALK1 is essentially unexplored. (lu.se)

The maize homeobox gene knotted1 ( kn1 ) encodes an AP2/ERF transcription factor (Hake et al. (springer.com)

The study of genetic aberrations commonly associated with urothelial carcinoma provides a more objective assessment for diagnosing and detecting recurrent disease. (medscape.com)
4, 5 However, a significant portion of genetic aberrations predisposing to these cancers, especially in relatively small risk families, still remains unexplained. (bmj.com)

Genetic polymorphism in the intergenic region (HBS1L-MYB) between GTP-binding elongation factor HBS1L and myeloblastosis oncogene MYB on chromosome 6q is associated with high fetal hemoglobin levels. (scirp.org)

The process involves a "transcription factor" (which controls genetic expression) called ATF6 that may provide a drug target for future therapies. (scripps.edu)
Proposed to function in concert with members of other transcription factor families, CPRFs regulate the transcriptional activity of many target genes. (embl-heidelberg.de)
They performed imaging studies comparing the activation of a key transcription factor in the brain tissue of normal mice and in FABP5-deficient mice. (neurosciencenews.com)
Transcription factor is a protein the controls the flow of genetic information). (neurosciencenews.com)
Then, that degraded product is picked up by the same protein (FABP5) and shuttled to the cell nucleus - specifically, to a transcription factor within it (station 2). (neurosciencenews.com)
Binding of the degraded product activates the transcription factor and allows it to induce expression of multiple genes. (neurosciencenews.com)
26 The suggested role in TP53 dependent apoptotic signalling 27 and interaction with the ankyrin repeats of proto-oncoprotein BCL3, thereby possibly modulating the activity of transcription factor NFKB, 28 represent BRCA1 independent functions of BARD1. (bmj.com)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)
and (iv) enrichment of GDM associations mapping to genomic annotations in diabetes-relevant tissues and transcription factor binding sites. (lu.se)
This homeobox transcription factor is expressed during early cardiac morphogenesis and serves as a master regulatory protein. (cdc.gov)

Splicing is an essential process in gene regulation that happens in most eukaryotic cells, all the time," Calarco said. (harvard.edu)

These processes are coordinated to maintain genome integrity and ensure accurate duplication of genetic and epigenetic information. (umass.edu)
If epigenetic loss drives aging, can you recover it, thereby reversing the aging process, and if you do that, do you get the youthful function of a complex tissue back again? (the-scientist.com)

Unluckily, both AHS and CHS challenge the genetic, nutritional, pharmaceutical, and management developments made by the animal farming industries that cause a considerable drop in production, proving to be one of the major hurdles to achieve efficient livestock farming in many regions of the world ( 9 , 10 ). (frontiersin.org)

A study by Sokolova et al of 9 genetic markers for detecting urothelial carcinoma showed that polysomy of chromosomes 3, 7, and 17 and deletion of 9p21 were the most sensitive and specific markers, detecting 95% of recurrent urothelial carcinomas. (medscape.com)

Pathway analysis indicated that these genes are associated with antigen processing and presentation, and other immune pathways. (cdc.gov)
Genetic pathways to primary and secondary glioblastomas. (who.int)

Our results provide support for the hypothesis that GDM and T2D are part of the same underlying pathology but that, as exemplified by the HKDC1 locus, there are genetic determinants of GDM that are specific to glucose regulation in pregnancy. (lu.se)

For more than 30 years, Kornberg has been studying a process known as transcription, in which genetic information contained in DNA in a cell's nucleus is translated into messenger RNA. (chicagotribune.com)
Along with the complex arrangement of genetic material in a cell's nucleus, human genes also demonstrate their own unique organization. (jove.com)

Briefly put, both DNA (Deoxyribonucleic Acid) and RNA (Ribonucleic Acid) carry genetic information of all life forms guiding their biological functions. (aboutdarwin.com)
DNA (deoxyribonucleic acid) is the cell's genetic material, contained in chromosomes within the cell nucleus and mitochondria. (msdmanuals.com)

The effects of a maize knotted1 ( kn1) gene under the control of the cauliflower mosaic virus 35S promoter on genetic transformation efficiencies of six citrus genotypes were tested. (springer.com)

These results provide new insights into the genetic architecture of DA and serve as a basis for future functional and mechanistic studies. (cdc.gov)

DNA replication is an intricate dance of molecules, a fundamental process essential to life. (aboutdarwin.com)

Huntington's disease is an example of an autosomal dominant genetic disorder. (genome.gov)
Sickle cell anemia is an example of an autosomal recessive genetic disorder. (genome.gov)
It is a genetic disorder that results from a mutation in the hemoglobin gene, causing red blood cells to become sickle-shaped. (proprofs.com)
Because errant splicing is behind many diseases and disorders, including cancers and autism spectrum disorder, SPIDEX has immediate and practical importance for genetic testing and pharmaceutical development. (utoronto.ca)
Sickle cell disease is an inherited genetic disorder, resulting from homozygous and compound heterozygote mutation in the β globin gene as a single base-pair point mutation (GAG to GTG) results in the substitution of glutamic acid (hydrophilic) to Valine (hydrophobic) in the 6th position of the β-chain of hemoglobin resulting in hemoglobin S formation [7]. (scirp.org)

Overall, genetic urinary biomarkers are a very heterogeneous group of tests that currently cannot replace cystoscopy and cytology, which remain the gold standard for surveillance of non-muscle-invasive bladder cancer (NMIBC). (medscape.com)

These processes include elongation, which has a minimum time for completion and processing that is not captured in the model. (cnrs.fr)

An animal model is a non-human species used in biomedical research because it can mimic aspects of a biological process or disease found in humans. (genome.gov)
This process, which normally functions to protect humans from viruses and foreign DNA, recognizes leaked LINE1 copies in the old cells and triggers a false alarm in the form of age-related inflammation. (genengnews.com)
A similar process, "alternative splicing," is at work inside the bodies of billions of creatures - including humans. (harvard.edu)

But what is common in animal aging is inflammation, which scientists think may be intensified by repetitive selfish genetic elements that do not seem to offer any benefit to their hosts but serve only to propagate themselves by inserting new copies into their host genomes. (genengnews.com)
Harvard scientists say they've now been able to observe that process within the nervous system of a living creature. (harvard.edu)
That allowed scientists to study each atom involved in the complex process and to deduce precisely how it is carried out. (chicagotribune.com)
In an attempt to address these issues with a genetic intervention, scientists reprogrammed neurons in mouse eyes to regrow after inducing glaucoma or crushing the optic nerve, and restored visual acuity in healthy, middle-aged mice to that of younger mice by expressing a set of genes known to revert cells to a pluripotent state, according to a study published in Nature Wednesday (December 2). (the-scientist.com)

Genetic sequences of the bases are read in groups of three (called a triplet), with a possibility of 64 configurations or "words" in which to code information. (cdc.gov)

DNA, a double-stranded molecule, is the primary genetic material directly responsible for development and inheritable traits. (aboutdarwin.com)

Direct and indirect ionization of DNA is ultimately responsible for the DNA alterations that adversely affect the structural and genetic integrity of the system. (cdc.gov)
2 - 4 Because of its critical role in cardiogenesis, NKX2-5 has been a prime candidate in studies to identify the genetic basis of structural congenital heart defects. (cdc.gov)

Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
Source: All physical and genetic interaction annotations listed in SGD are curated by BioGRID . (yeastgenome.org)

DNA Replication and RNA Transcription, although seemingly complex terms, hold within them concepts that are beautifully precise, methodical - true marvels of nature. (aboutdarwin.com)
A global analysis of DNA replication initiation in T. brucei showed that TbORC1 (subunit of the origin recognition complex, ORC) binding sites are located at the boundaries of transcription units. (umass.edu)
What this suggests is that this process is happening pretty frequently, and is very complex, even in an animal - like C. elegans - that has just 302 neurons," Calarco said. (harvard.edu)
Transcription is crucial not only in keeping each cell alive, but also in determining which of the 30,000 genes in every human cell will be used and thus whether a cell will become a muscle cell, a nerve fiber or any of the myriad other types required by a complex organism. (chicagotribune.com)
Enzymes are complex proteins that control and carry out nearly all chemical processes and reactions within the body. (msdmanuals.com)

We also observed accelerated reprogramming of differentiated cells in the absence of Kdm5b, demonstrating that KDM5B is a barrier to the reprogramming process. (nih.gov)
By understanding the impacts of retrotransposons, researchers can better recognize the processes by which cells age and how to combat the deleterious effects of aging, according to Gorbunova and Seluanov. (genengnews.com)
Chromosomes are thread-like structures located inside the nucleus of cells that contain genetic information. (proprofs.com)
Just as a film editor can change the story with a few cuts, alternative splicing allows cells to stitch genetic information into different formations, enabling a single gene to produce up to thousands of different proteins. (harvard.edu)
Genetic material in the body's cells consists of DNA, which serves as long-term storage of genetic information. (sflorg.com)
It has been shown that RNA modifications take place in various viruses, but exactly how the viruses affect the RNA modification processes when they infect cells is unknown. (sflorg.com)
The FUS protein also helps repair errors in DNA, which prevents cells from accumulating genetic damage. (medlineplus.gov)

When turned on, eIF2α stimulates processes that reduce protein production, which helps conserve amino acids. (medlineplus.gov)

The genetic changes associated with these cancers are rearrangements (translocations) of genetic material between chromosome 16 (where the FUS gene is located) and other chromosomes. (medlineplus.gov)

These findings provide functional insight into the role for KDM5B in regulating ES cell differentiation and as a barrier to the reprogramming process. (nih.gov)

However, the genetic alterations driving this evolutionary process are poorly understood. (lu.se)

Its goal: to transform the way genetic diseases are diagnosed and treated. (utoronto.ca)

Homozygous loss of band 9p21, the site for the tumor suppressor gene P16 , is a known early genetic event in the development of papillary carcinoma and urothelial carcinoma in situ (CIS). (medscape.com)

By turning off transcription, these drugs robustly induce cell death. (umassmed.edu)

These processes enable them to make proteins, which perform most intracellular tasks. (sflorg.com)

Anatomy15

Organisms9

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes84

Disciplines and Occupations1

Information Science3

Mutations5

Cellular12

MRNA9

Genetics4

Polymerase7

Molecular8

Factors20

Gene expression8

Genomics2

Regulates3

Biochemical Processes2

Replication and Transcription3

Somatic1

Transposable Elements3

Translation3

Mechanisms2

Physiological2

Saccharomyces2

Biological processes2

Encodes1

Aberrations2

Polymorphism1

Factor11

Eukaryotic1

Epigenetic2

Regions1

Markers1

Pathways2

Regulation1

Cell's nucleus2

Deoxyribonucleic Acid2

Promoter1

Insights1

Molecules1

Disorder5

Heterogeneous1

Elongation1

Humans3

Scientists4

Sequences1

Primary genetic1

Structural2

Annotations2

Complex5

Cells7

Protein production1

Chromosome1

Functional1

Alterations1

Diseases1

Tumor1

Induce1

Intracellular1