Processes heterocyclic compounds aza compounds. Medical search. Frequent questions

As one of the longest-running Gordon Research Conferences, the 2023 Heterocyclic Compounds GRC will continue to provide a platform for disclosures of new strategies for the discovery, synthesis, incorporation, and application of powerful heterocycles. (grc.org)
The present report focuses on the advancement of aza-Diels-Alder reaction for the synthesis of optically active and inactive quinoline derivatives. (heterocycles.jp)
In recent years, however, new developments towards the enantioselective synthesis of various heterocycles and other useful compounds have evolved which take advantage of the unique properties of chiral Pd-aqua complexes. (uni-leipzig.de)
Phthalhydrazide is one of the useful starting material toward the synthesis of heterocyclic compounds, and considered as a valuable structural unit in organic synthesis due to its significant pharmacological and biological activities. (heterocycles.jp)
Nowadays, organocatalysis is especially applied to asymmetric synthesis and a huge number of organocatalysts has been introduced in last three decades for the asymmetric synthesis of acyclic, carbocyclic, heterocyclic, and polycyclic molecular architectures with high molecular complexity. (beilstein-journals.org)
Total synthesis of the fused heterocyclic natural product based on the microwave-assisted azaelectrocyclic reaction and seeking of lead compound. (nii.ac.jp)
A new method of synthesis of 2-(1,2-diferrocenylvinyl)benz- and azabenzimidazoles (3a-f), (4a-f) and 1'H,3'H(Me)-spiro-[(aza)benzimidazoline-2',3-(1,2-diferrocenylcyclopropenes)] (5a-f) via reactions of diferrocenyl(methylsulfanyl)cyclopropenylium iodide (1) with aromatic o -diamines (2a-f) in the presence of Et 3 N (80 °C - 82 °C ) is described. (scirp.org)
New pathways for the synthesis of various carbohydrates were developed using inexpensive and abundantly available compounds as starting materials, and by the application of chemo-enzymatic reactions. (keio.ac.jp)
Diversity-oriented synthesis is a synthetic method for producing a large number of compounds with different molecular skeletons from a single starting material. (keio.ac.jp)
In particular, "diversity-enhanced extracts," which combine diversity-oriented synthesis with search for natural compounds, can yield a group of new compounds with structural diversity that exceeds that of natural compounds obtained from plants and microorganisms. (keio.ac.jp)
To achieve these aims we are involved in the development of new reactions, new asymmetric processes and new strategies for synthesis. (ox.ac.uk)
Sulfondiimines are the di-aza analogues of sulfones and have potential value in medicinal chemistry owing to their attractive physicochemical properties, but there are limited ways for their synthesis. (ox.ac.uk)

In particular, PAHs are compounds containing only carbon and hydrogen atoms (i.e. unsubstituted PAHs and their alkyl-substituted derivatives), while the more general name of "polycyclic aromatic compounds" also includes functional derivatives (e.g. nitro-PAHs) and heterocyclic analogues (e.g. aza-areas). (umanaloggia.it)
Friedel, R. A. and M. Orchin (1951) Ultraviolet Spectra of Aromatic Compounds. (photochemcad.com)

Industrial hygiene surveys were conducted, and air samples were collected for analysis of polynuclear aromatic hydrocarbons, polynuclear aza heterocyclic hydrocarbons, aromatic amines, metals, common toxic gases, and other organic compounds. (cdc.gov)
Sampling results indicated that workers were exposed to polynuclear aromatic hydrocarbons in the low microgram per cubic meter range, with the light molecular weight compounds in higher concentrations than the four through seven ring compounds. (cdc.gov)
Physical properties and chemical reactivity of alternant hydrocarbons and related compounds. (cas.cz)

P. A new model for C-C bond formation processes derived from the Molecular Electron-Density Theory in the study of the mechanism of [3+2] cycloaddition reactions of carbenoid nitrile ylides with electron-deficient ethylenes. (luisrdomingo.com)
Hydroacylation reactions and aza-benzoin reactions have attracted considerable attention from experimental chemists. (cyberleninka.org)
reported an interesting reaction of N-heterocyclic carbene (NHC)-catalyzed addition of aldehyde to enamide, in which both hydroacylation and aza-benzoin reactions may be involved. (cyberleninka.org)
The work should provide valuable insights for rational design of switchable NHC-catalyzed hydroacylation and aza-benzoin reactions with high stereoselectivity. (cyberleninka.org)
This review assembles recent advances in asymmetric aza-Friedel-Crafts reactions mediated by organocatalysts. (beilstein-journals.org)
Kinetics and mechanisms of the gas-phase reactions of the hydroxyl radical with organic compounds under atmospheric conditions. (cdc.gov)
Although polypharmacology might be associated with compound promiscuity, it should be considered a different category since the so-called promiscuous drugs are instead a class of compound that show a wide spectrum of biological activities and adverse reactions [ 1 ]. (biomedcentral.com)
The increased stability of the intermediates (such as compounds of formula (III)) against competing hydrolysis reactions, removes the need to work under anhydrous conditions. (allindianpatents.com)

Capillary chromatographic analysis of volatile organic compounds in the indoor environment. (cdc.gov)

these can be hydrolysed into primary amines 23 (the Staudinger reaction), react with carbonyl compounds to give imines 24 (the aza-Wittig reaction), or undergo other transformations. (wikipedia.org)
An attractive feature for NHCs is that they can catalyze the polarity reversal of various carbonyl compounds and generate acyl anion equivalents, which provide an elegant access to a wide range of organic transformations3'4. (cyberleninka.org)

The Chemistry of Heterocyclic Compounds. (cbcconf.com)
This Conference continues the series of international meetings first held in 2001 on the Chemistry and Biological Activity of Synthetic and Natural Compounds. (cbcconf.com)
Progress in Heterocyclic Chemistry, G. Gribble and John Joule Eds. (uva.es)
2022) Chemistry of Heterocyclic Compounds, 58 (11), pp. 567-581. (org.ua)
Sulfur(VI) based moieties, in particular, sulfonamide and sulfone-containing compounds have been widely used in medicinal chemistry, for a variety of disease targets. (ox.ac.uk)

The imino halide products are intermediates in the preparation of antibiotic compounds. (gc.ca)
The disclosure also provides intermediates and processes for the preparation of the intermediates useful in the preparation of cerdulatinib or a salt thereof. (justia.com)
The present invention relates to a novel process for the conversion of steroidal carboxylic acids to carbothioate derivatives such as fluticasone propionate via novel intermediates. (allindianpatents.com)

Oxetanes have garnered further interest as isosteres of carbonyl groups and as molecular tools to fine-tune physicochemical properties of drug compounds such as pKa, LogD, aqueous solubility and metabolic clearance. (imperial.ac.uk)
12. The process of claim 10, wherein the polyethyleneimine has a molecular weight between 10,000 and 100,000 Daltons. (patentsencyclopedia.com)

This present disclosure is related to the field of to N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxamide compounds and their derivatives and to the use of these compounds as fungicides. (justia.com)

An enantioselective alkoxycarbonylation-amination cascade process of terminal allenes with CO, methanol, and arylamines proceeds under mild conditions (r.t., ambient pressure CO) via oxidative Pd(II) catalysis using a chiral aromatic spiroketal-based diphosphine ligand and a Cu(II) salt as an oxidant to afford various α-methylene-β-arylamino acid esters in good yields with excellent enantioselectivity and high regioselectivity. (organic-chemistry.org)

The aza-Diels-Alder reaction is a [4+2] cycloaddition, involving the insertion of nitrogen atom into dienes or dienophiles. (heterocycles.jp)
Both tungsten compounds are formed by reaction of water and oxygen with the acetylene complex PPh 4 [WCl 5 (Ph - C ≡ C - C (Br) = C(Br) -Ph)] in CH 2 Cl 2 solutions, and in the presence of PPh 4 Cl. (degruyter.com)
Steric interactions controlling the syn diastereofacial selectivity in the [3+2] cycloaddition reaction between acetonitrile axide and 7-oxanorborn-5-en-2-ones. (luisrdomingo.com)
The addition of NHC to aldehydes formed Breslow intermediate, which can go through cross-coupling with enamide via hydroacylation reaction or its imine isomer via aza-benzoin reaction. (cyberleninka.org)
The aza-benzoin reaction requires relatively lower free energy barrier than the hydroacylation reaction. (cyberleninka.org)
Interestingly, both hydroacylation and aza-benzoin reaction mechanisms may be involved in the special reaction, and some important mechanistic questions need to be answered. (cyberleninka.org)
2) The Breslow intermediate can react with 2 via hydroacylation pathway, while it can also react with 2' via aza-benzoin reaction pathway. (cyberleninka.org)
The aza-Friedel-Crafts reaction allows an efficient coupling of electron-rich aromatic systems with imines for the facile incorporation of aminoalkyl groups into the aromatic ring. (beilstein-journals.org)
This reaction has a great scope of forming aza-stereocenters which can be tuned by different asymmetric catalysts. (beilstein-journals.org)
Therefore, harsh reaction conditions and the necessity of an external activator like catalysts are common prerequisites for processes involving C-H bond breaking. (beilstein-journals.org)
We showed that heterocyclic allyl sulfones can function as latent sulfinate reagents, undergoing deallylation to release the sulfinate functionality under the reaction conditions used for the cross-coupling. (ox.ac.uk)

In fact, many medicines have been developed from natural compounds produced by plants, fungi, bacteria, and other microorganisms. (keio.ac.jp)
Thus, natural compounds are the resources for drug discovery. (keio.ac.jp)
We conduct research to find natural product that can be used as resources for drug discovery, or to create them using natural compounds as motifs. (keio.ac.jp)
On the other hand, as a result of the vigorous search for natural compounds, new natural compounds are being depleted. (keio.ac.jp)
Therefore, it is not possible to conduct innovative drug discovery research by simply searching for natural compounds in the conventional way. (keio.ac.jp)
As a new drug discovery resource, we will focus on " unexploited organisms" which are different from conventionally used organisms, such as plants, fungi, and bacteria, for the search of natural compounds. (keio.ac.jp)

The composition of the conference covered a wide range of organic chemists working in the field of biologically active heterocyclic compounds. (cbcconf.com)
The interest in azides among organic chemists has been relatively modest due to the reported instability of these compounds. (wikipedia.org)
Whether medicinal or process chemists, speakers include aspects from initial hit discovery to process scale formulations. (grc.org)
Aromatic C-H bond functionalizations have gained considerable attention by organic chemists because of the strategic importance of this process as well as the ability to synthesize functionalized aromatic molecules in a straightforward way. (beilstein-journals.org)
They will have the potential to be medicinal and/or process chemists in pharmaceutical industry, and also be researchers and manufactures in chemical, petroleum and food industries, and in academic fields industries, and in academic fields. (keio.ac.jp)

1,3-Oxathiolan-5-ones are a hitherto very poorly studied class of sulfur heterocycles some of which have been shown to be important precursors for HIV drugs or bioactive, anticarcinogenic compounds. (uni-leipzig.de)
The aromatic heterocycles include such compounds as pyridine, where nitrogen replaces one of the СН groups in benzene, and pyrrole , in which the aromatic sextet is supplied by the four electrons of the two double bonds and the lone pair on nitrogen. (medmuv.com)

Aromatic amines, phenolic compounds and simple aromatic solvents were occasionally present at very low levels. (cdc.gov)
The azo-transfer compounds, trifluoromethanesulfonyl azide and imidazole-1-sulfonyl azide react with amines to give the corresponding azides. (wikipedia.org)
This process uses a moisture-stable sulfinylamine reagent, TrNSO, as a linchpin, in combination with widely available organometallic reagents and amines. (ox.ac.uk)

A facile nickel-catalyzed oxidation of primary alcohols with tetrabutylammonium peroxydisulfate in the presence of ammonium hydrogen carbonate under basic aqueous conditions provides access to various aliphatic, aromatic and heterocyclic nitriles in excellent yields with very high purity. (organic-chemistry.org)

As powerful organocatalysts, N-heterocyclic carbenes (NHCs) have been widely used in various carbon-carbon and carbon-heteroatom bonds forming reactions1'2. (cyberleninka.org)

This method witnessed as a powerful tool for the construction of a diverse range of biological active quinoline scaffolds and other nitrogen containing heterocyclic compounds due to its operational modesty, high atom economy, regio- and stereoselectivity. (heterocycles.jp)

Biological activities of those compounds against bacteria, including Xac (Xanthomonas axonopodis pv. (bvsalud.org)

The heterocyclic motif was confirmed by X-ray diffraction analysis. (uni-leipzig.de)
The structure of one compound, cis -2-(1,2-diferrocenylvinyl)-1-methylbenzimidazole (3b), is confirmed by X-ray diffraction analysis. (scirp.org)

During each formation process, PAHs are always present as a class (never as individual compounds) in complex mixtures containing other substances and chemical classes. (umanaloggia.it)

We report herein an asymmetric cooperative process for the enantioselective 1,6-addition of β-ketoesters to in situ generated para-quinone methides with chiral Pd−aqua complexes as mixed Brønsted acid−base catalysts. (uni-leipzig.de)

The structures of the resultant compounds are established using IR, 1 H and 13 C NMR spectroscopy, mass spectrometry and elemental analysis. (scirp.org)

Furthermore, the hydroxylated products can readily be converted into vicinal tricarbonyl compounds, which are useful synthetic precursors. (organic-chemistry.org)
Possible solutions and improvements include further research to elucidate the biological effects of this compound and the development of new synthetic methods to improve efficiency and yield. (thebiotek.com)

We are interested in exploring alternatives to heterocyclic boronic acids in coupling processes, and have established the use of heteroaromatic sulfinates as nucleophilic cross-coupling reagents. (ox.ac.uk)

The more polar characteristic of C=N group in the imine isomers, and the more advantageous stereoelectronic effect in the carbon-carbon bond forming transition states in aza-benzoin pathway were identified to determine that the imine isomer can react with the Breslow intermediate more easily. (cyberleninka.org)

3-Methylthiophene-2-carboxylic acid is a heterocyclic organic compound that belongs to the thiophene family. (thebiotek.com)

The majority of these compounds exhibited excellent antibacterial activity in vitro. (bvsalud.org)

Furthermore, the target compounds were assessed for their antifungal activity against ten plant pathogenic fungi. (bvsalud.org)

The complex interactions leading to a wide range of biological activity can be probed, enhanced, and harnessed through heterocyclic compounds. (grc.org)

The X-ray structure, IR, Raman, 1 H NMR , and 13 C NMR spectra of this first organogermyl magnesium compound are reported. (degruyter.com)
Hirayama, K. (1967) Handbook of Ultraviolet and Visible Absorption Spectra of Organic Compounds. (photochemcad.com)

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (lookformedical.com)
Heterocyclic compounds are cyclic compounds in which one or more ring atoms are not carbon (that is, hetero atoms). (medmuv.com)

The present disclosure provides processes for the preparation of cerdulatinib, which is of formula I: or a salt thereof. (justia.com)

The strength of heterocyclic bases. (cdc.gov)

A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. (lookformedical.com)

From a foundation of heterocyclic compounds, scientists forge solutions to benefit humans and to expand human knowledge. (grc.org)
Clinical trials are needed to determine the safety and efficacy of this compound in humans. (thebiotek.com)

It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group. (lookformedical.com)

An organic azide is an organic compound that contains an azide (-N3) functional group. (wikipedia.org)
Instead your research group can rapidly analyze new compounds as they are synthesized in the lab without having to queue up in the departmental core facility. (rigaku.com)

This compound has been reported to exhibit various biological activities, including antimicrobial, antifungal, and anticancer activities. (thebiotek.com)

1.6 What do standard heats of formation tell us about chemical bonding and ground-state properties of organic compounds? (dattanibookagency.in)
The nonaromatic compounds have physical and chemical properties that are typical of the particular hetero atom. (medmuv.com)
The electrochemical properties of compounds 3a, 3b, 3d and 5f a re investigated using cyclic square wave voltammetry. (scirp.org)

Compound 5f is the most active compound with a modest cytotoxic activity against six human cancer cell lines: U-251 (glioma), PC-3 (prostate cancer), K-562 (leukemia), HCT-15 (colon cancer), MCF-7 (breast cancer) and SKLU-1 (lung cancer). (scirp.org)

Based on this analysis, we provide an overview of the potential benefits of appending an oxetane to a drug compound, as well as potential pitfalls, challenges, and future directions. (imperial.ac.uk)
The XtaLAB mini II comes complete with CrysAlis Pro , our user-inspired data collection and data processing software for single crystal analysis. (rigaku.com)

This compound has gained significant attention in the scientific community due to its potential biological and industrial applications. (thebiotek.com)

Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane. (lookformedical.com)

Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired resistance to gemcitabine. (justia.com)
The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target. (biomedcentral.com)
We will conduct research to utilize these compounds as resources for drug discovery. (keio.ac.jp)
By separating, purifying, and structurally determining these extracts, we can construct a library of structurally diverse compounds and obtain seed compounds for drug discovery research. (keio.ac.jp)

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes3

Synthesis12

Aromatic compounds2

Hydrocarbons3

Reactions8

Volatile organic c1

Carbonyl compounds2

Chemistry5

Intermediates3

Molecular2

Derivatives1

Enantioselectivity1

Reaction11

Natural Compounds6

Chemists5

Heterocycles2

Amines3

Nitriles1

Organocatalysts1

Stereoselectivity1

Bacteria1

Diffraction analysis2

PAHs1

Asymmetric1

Mass spectrometry1

Synthetic2

Heteroaromatic1

React1

Thiophene1

Vitro1

Fungi1

Biological Activity1

Spectra2

Atoms2

Thereof1

Bases1

Ring structure1

Humans2

Reduction1

Group2

Activities1

Properties3

Modest1

Analysis2

Potential1

Active1

Drug4