• pathologies
  • For several decades, it has been known that CR, when started in many strains of young or middle-aged rodents and maintained thereafter, extends maximum and average life span by as much as 40% and delays many age-related changes and pathologies such as kidney disease, diabetes, several types of tumors, and declines in immune function. (nih.gov)
  • Targeting cancer prevention pathways with anti-cancer agents may confer longevity effects by offering protection from metabolic pathologies during aging, independently of effects on cancer. (wikipedia.org)
  • mechanisms
  • According to the standard information-processing model for mental development, the mind's machinery includes attention mechanisms for bringing information in, working memory for actively manipulating information, and long term memory for passively holding information so that it can be used in the future. (wikipedia.org)
  • The neurological mechanisms responsible for face recognition are present by age five. (wikipedia.org)
  • secondary
  • The research data clearly indicate that this is specifically an expression of the favorable effect of habitual energy expenditure on secondary aging. (humankinetics.com)
  • Athletes who maintain high levels of sport activity through their adult years can expect to benefit from limited secondary aging. (humankinetics.com)
  • The National Institute on Aging (NIA) invites applications for short-term (up to two years) projects involving secondary analysis of CALERIE (Comprehensive Assessment of Long-term Effects of Restricting Intake of Energy) data set and / or stored biospecimens. (nih.gov)
  • urine
  • While the AGE free adducts are released directly into the urine, AGE peptides are endocytosed by the epithelial cells of the proximal tubule and then degraded by the endolysosomal system to produce AGE amino acids. (wikipedia.org)
  • AGE free adducts are the major form through which AGEs are excreted in urine, with AGE-peptides occurring to a lesser extent but accumulating in the plasma of patients with chronic kidney failure. (wikipedia.org)
  • normally
  • In laboratory studies, oral administration of Navitoclax to either sublethally irradiated or normally aged mice reduced senescent cells, including bone marrow hematopoietic stem cells and muscle stem cells. (wikipedia.org)
  • Both the sizes and weights of the testes normally decrease with age. (wikipedia.org)
  • species
  • In Maryland, an old growth forest is defined as a minimum of five acres in size with a preponderance of old trees, of which the oldest trees exceed at least half of the projected maximum attainable age for that species, and that exhibits most of the following characteristics: Shade tolerant species are present in all age/size classes. (wikipedia.org)
  • affects
  • The perception of a positive or negative emotion on a face affects the way that an individual perceives and processes that face. (wikipedia.org)
  • genetics
  • Age as a factor affecting behavior was not considered in animal studies of behavior genetics, and in general has not been seriously examined in animal behavioral research. (springer.com)
  • Factors such as genetics, diet and overall health can affect timing. (wikipedia.org)
  • known
  • Whether high levels of physical activity can extend the natural, or primary, aging process is not known, but at present, no evidence supports that idea. (humankinetics.com)
  • The first period usually begins between twelve and fifteen years of age, a point in time known as menarche. (wikipedia.org)
  • AGEs are now known to play a role as proinflammatory mediators in gestational diabetes as well. (wikipedia.org)
  • preference
  • Specifically, while newborns show a preference for faces, this behavior is reduced between one- to four months of age. (wikipedia.org)
  • Around three months of age, a preference for faces re-emerges and interest in faces seems to peak late during the first year but then declines again slowly over the next two years of life. (wikipedia.org)
  • Interestingly, the re-emergence of a preference for faces at three months of age may be influenced by the child's own motor abilities and experiences. (wikipedia.org)
  • theory
  • Busse, Ewald W. Theory and Therapeutics of Aging. (wikipedia.org)
  • The use of information processing theory in cognition looks at the role of the three stages of memory related to retrieving information, transferring and recalling. (wikipedia.org)
  • The theory is based on the idea that humans process the information they receive, rather than merely responding to stimuli. (wikipedia.org)
  • In this theory, information is thought to be processed in a serial, discontinuous manner as it moves from one stage to another. (wikipedia.org)
  • rats
  • Beginning at 4 months of age, 62 rats were housed in cages with running wheels. (humankinetics.com)
  • There have been exceptions, including the early age-related research studies of rats by Slonaker (1912), Richter (1922), and Stone (1929). (springer.com)
  • exposure
  • A paintings conservator may also be called upon to consult with the RCM and an exhibition design team to ensure a work is stable enough for display, and determine how much exposure to environmental factors, such as humidity or light, it can withstand. (wikipedia.org)
  • body
  • The NT Factor® formula may help with the much-required nutrition to individual cells and mitochondrial membranes in the body. (pureformulas.com)
  • The aging process has an inevitable impact on a person's body shape. (wikipedia.org)
  • These factors result in women's waist-hip ratio (WHR) being lower than for males, although males tend to have a greater upper-body to waist-hip ratio (WHR) giving them a V shape look because of their greater muscle mass e.g. they generally have much larger, more muscular & broader shoulders, pectoral muscles, teres major muscles & latissimus dorsi muscles. (wikipedia.org)
  • diabetes
  • Under certain pathologic conditions, such as oxidative stress due to hyperglycemia in patients with diabetes, and hyperlipidemia,[citation needed] AGE formation can be increased beyond normal levels. (wikipedia.org)
  • experimental
  • Although the science of aging is generally clouded in mystery, one piece of experimental data has been repeatedly established: In animals, a low-calorie diet that is sufficient in specific nutrients (does not lead to malnutrition) will extend life span. (humankinetics.com)
  • This process is experimental and the keywords may be updated as the learning algorithm improves. (springer.com)
  • study
  • People who live under stress should try to get rid of their habit because a study done by Brigham and Women's Hospital in Boston found that stress can make people age faster than those who are stress-free. (onlymyhealth.com)
  • Post-excavation analysis constitutes processes that are used to study archaeological materials after an excavation is completed. (wikipedia.org)
  • years
  • It is a randomized controlled trial in young and middle-aged healthy non-obese individuals, who are randomized to a program targeting 25% CR below their habitual ad libitum intake for two years or to maintaining their usual diet. (nih.gov)
  • Menstruation stops occurring after menopause which usually occurs between 45 and 55 years of age. (wikipedia.org)
  • The average age of menarche is approximately 12.5 years in the United States, 12.7 in Canada, 12.9 in the UK and 13.1 years in Iceland. (wikipedia.org)
  • The average age of menopause in women is 52 years, with anywhere between 45 and 55 being common. (wikipedia.org)
  • The variability of menstrual cycle lengths is highest for women under 25 years of age and is lowest, that is, most regular, for ages 25 to 39. (wikipedia.org)
  • Finally, the new leader's Age is important because he or she will need to have an appropriate career path after stepping down five years from now. (wikipedia.org)
  • This legacy we can see today as most of our older forests are the same age and are approximately 100 years old. (wikipedia.org)
  • implications
  • Busse, Ewald W. Therapeutic Implications of Basic Research with the Aged: The Fourth Annual Institute of Pennsylvania Hospital Award Lecture in Memory of Edward A. Strecker, M.D. [Nutley, NJ: Roche Laboratories, (wikipedia.org)
  • causes
  • The hormone drop causes the uterus to shed its lining in a process termed menstruation. (wikipedia.org)
  • The syndrome is more common in people over the age of 50 because osteoarthritis in the neck region causes weakening of the vertebrae. (wikipedia.org)
  • A slow, chronic cause in this age group is when the cord gets caught and squeezed between a posterior intervertebral disc herniation against the anterior cord and/or with posterior pressure on the cord from hypertrophy of the ligamentum flavum (Lhermitte's sign may be the experience that causes the patient to seek medical diagnosis). (wikipedia.org)
  • levels
  • They are produced in both men and women, but their levels are significantly higher in women, especially in those of reproductive age. (wikipedia.org)
  • treatments
  • Ultraviolet Light Ultraviolet light examinations are used to reveal varnishes and their ages, as well as previous treatments to a painting. (wikipedia.org)
  • young
  • Infants as young as two days of age are capable of mimicking the facial expressions of an adult, displaying their capacity to note details like mouth and eye shape as well as to move their own muscles in a way that produces similar patterns in their faces. (wikipedia.org)
  • cause
  • All these problems cause you to age prematurely. (onlymyhealth.com)
  • The ages of the female turtles in the north suggest that this population has experienced temperatures that cause this imbalance since at least the 1990s. (slashdot.org)
  • important
  • Experience is the most important criterion with respect to reaching the goal, followed by Charisma, Education, and Age. (wikipedia.org)
  • The important factor in this process is that the trees have the opportunity to reach old age if natural disturbances do not intercede. (wikipedia.org)
  • major
  • higher quality of life - therefore older people are a major social, political and economic factor in society. (slideserve.com)
  • months of age
  • Running distances gradually decreased, falling to 965 meters daily at 34 months of age. (humankinetics.com)
  • By at least seven months of age, infants are also able to use facial expressions to understand others' behavior. (wikipedia.org)