Proto-Oncogene Proteins c-bcl-2bcl-2-Associated X ProteinApoptosisApoptosis Regulatory Proteinsbcl-Associated Death ProteinCaspasesCaspase 3bcl-2 Homologous Antagonist-Killer Proteinbcl-X ProteinProto-Oncogene ProteinsBH3 Interacting Domain Death Agonist ProteinMitochondriaCell Line, TumorCell SurvivalCytochromes cSignal TransductionInhibitor of Apoptosis ProteinsIn Situ Nick-End LabelingMembrane ProteinsCarrier ProteinsTumor Suppressor Protein p53DNA FragmentationCells, CulturedX-Linked Inhibitor of Apoptosis ProteinIron Regulatory Protein 1Caspase InhibitorsCaspase 9Enzyme ActivationMolecular Sequence DataCell LineApoptosis Inducing FactorBlotting, WesternCaspase 8Iron Regulatory Protein 2Myeloid Cell Leukemia Sequence 1 ProteinTransfectionTumor Cells, CulturedProtein BindingPhosphorylationCell DeathDown-RegulationAmino Acid SequenceFas Ligand ProteinCell ProliferationRNA, MessengerRNA, Small InterferingGenes, bcl-2Cytochrome c GroupDNA-Binding ProteinsTranscription FactorsAntineoplastic AgentsCell CycleBase SequenceHeLa CellsProto-Oncogene Proteins c-aktFlow CytometryJurkat CellsMutationGene Expression RegulationPoly(ADP-ribose) PolymerasesLeucine-Responsive Regulatory ProteinMice, KnockoutUp-RegulationTime FactorsEnzyme InhibitorsIntracellular Signaling Peptides and ProteinsTranscription, GeneticApoptotic Protease-Activating Factor 1Dose-Response Relationship, DrugTNF-Related Apoptosis-Inducing LigandMice, Inbred C57BLMitochondrial MembranesCASP8 and FADD-Like Apoptosis Regulating ProteinProtein-Serine-Threonine KinasesReverse Transcriptase Polymerase Chain ReactionTumor Suppressor ProteinsReactive Oxygen SpeciesNitrophenolsImmunoblottingCell DivisionPromoter Regions, GeneticTumor Necrosis Factor-alphaMitochondrial ProteinsProtein Structure, TertiaryModels, BiologicalRNA InterferenceNeoplasm ProteinsProtein TransportNF-kappa BProteinsImmunohistochemistryGene Expression Regulation, NeoplasticIron-Regulatory ProteinsAdaptor Proteins, Signal TransducingDrug SynergismRecombinant ProteinsStaurosporineBinding SitesNuclear ProteinsImmunoprecipitation