• More recent experiments have suggested that Blimp-1 also plays a major role in the formation of primordial germ cells (PGC) in developing mammalian embryos. (davefenwick.com)
  • In these experiments, Blimp-1-deficient mutant mouse embryos form a cluster of PGC-like cells which fail to show the expected migration, proliferation, and repression of homeobox genes that normally accompany specification of primordial germ cells. (davefenwick.com)
  • Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ cells. (omniab.com)
  • Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During Early Migration Front Cell Dev Biol. (usc.edu)
  • Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually co-expressed with another cell surface antibody called IgM. (wikipedia.org)
  • An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
  • The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
  • Since in a biological system antibody molecules face a virtually infinite number of structures, cognate interactions with epitopes are the basis of the primordial intelligence that drives the teleological choices of the immune system. (lih.lu)
  • Description: Blimp-1 Antibody: Blimp-1 was initially identified as a zinc finger-containing protein that drives the maturation of B lymphocytes into immunoglobulin-secreting cells. (davefenwick.com)
  • Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
  • Antibodies are glycoproteins belonging to the immunoglobulin superfamily . (wikipedia.org)
  • Sequence analysis showed that Compact disc147 is normally a single-chain type?We transmembrane (TM) proteins and an associate from the immunoglobulin superfamily (IgSF). (tech-strategy.org)
  • Patients with Bloom syndrome are predisposed to respiratory and gastrointestinal infections as a result of a deficiency of immunoglobulin A. (medscape.com)
  • Clinical spectrum of LIG4 deficiency is broadened with severe dysmaturity, primordial dwarfism, and neurological abnormalities. (ac.ir)
  • The relatively narrow intercellular space of the primordial follicle allows ferritin and possibly other molecules of similar size to cross, whereas in the late stages of rapid follicular growth, the shape of granulosa cells must accommodate the increasing flow of egg yolk precursors that accumulate at the surface of the plasma membrane of the follicle [ 7 ]. (biomedcentral.com)
  • Primordial follicle growth is primarily influenced by paracrine and endocrine factors (6). (balkanmedicaljournal.org)
  • A study on rats demonstrated that the oocyte-derived GDF9-enhanced passage of primordial follicles to the primary stage was required for pre-antral follicle development (10). (balkanmedicaljournal.org)
  • PTEN-hamartoma tumor syndrome (PHTS), Bloom syndrome (BS), microcephalic osteodysplastic primordial dwarfism type II (MOPD-II syndrome), and ligase IV syndrome (Lig4 syndrome) are rare dwarfism syndromes with potentially lethal outcomes. (sdam-svou-kvartiru.ru)
  • The PTEN hamartoma tumor syndrome (PHTS), Bloom syndrome (BS), microcephalic osteodysplastic primordial dwarfism type II (MOPD-II syndrome) and ligase IV syndrome (Lig4-syndrome) are rare short stature syndromes with potentially fatal outcome. (sdam-svou-kvartiru.ru)
  • In such cases, the subcutaneous administration of immunoglobulins is advocated to prevent shock, which can occur in patients with anti-IgA antibodies. (medscape.com)
  • Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies. (omniab.com)
  • The benefits of this extra step are apparent in multiplexing/multicolor-staining experiments (e.g., flow cytometry) where there is potential cross-reactivity with other primary antibodies or in tissue/cell fluorescent staining experiments where there are may be the presence of endogenous immunoglobulins. (thermofisher.com)
  • Anti-Goat secondary antibodies are affinity-purified antibodies with well-characterized specificity for goat immunoglobulins and are useful in the detection, sorting or purification of its specified target. (thermofisher.com)
  • IgD is also produced in a secreted form that is found in very small amounts in blood serum, representing 0.25% of immunoglobulins in serum. (wikipedia.org)
  • We are taking an interdisciplinary approach to studying primordial germ cell (PGC) development in the context of gastrulating embryos by combining the power of molecular genetics with advanced optical imaging within living embryos. (usc.edu)
  • Epigenetic Regulation during Primordial Germ Cell Development and Differentiation. (ericmiskalab.org)
  • by generating a chimeric 2H8 Ab with Fc fragments derived from human immunoglobulin. (morulaivf.com)
  • Primordial stunted growth occurs, in which patients have low birth weight with normal body proportions in the absence of any endocrine disorder. (medscape.com)
  • 1. Cloning and mapping of cat (Felis catus) immunoglobulin and T-cell receptor genes. (nih.gov)
  • 4. Accuracy and coverage assessment of Oryctolagus cuniculus (rabbit) genes encoding immunoglobulins in the whole genome sequence assembly (OryCun2.0) and localization of the IGH locus to chromosome 20. (nih.gov)
  • 5. PCR GeneScan and Heteroduplex Analysis of Rearranged Immunoglobulin or T-Cell Receptor Genes for Clonality Diagnostics in Suspect Lymphoproliferations. (nih.gov)
  • 17. Rearrangements of immunoglobulin and T cell receptor beta and gamma genes are associated with terminal deoxynucleotidyl transferase expression in acute myeloid leukemia. (nih.gov)
  • 19. Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes. (nih.gov)
  • Immunoglobulin chain and T-cell receptor genes are located at these sites. (medscape.com)
  • Years later, the "one gene one protein" dogma was overthrown at least not correct in the case of immunoglobulins which were shown to be assembled from several genes. (nih.gov)
  • Afterwards, the evolution of humoral (every 6 mo) and cellular immunity (once a year) needs to be systematically monitored (until immunoglobulin administration or immunomodulating therapy is started). (medscape.com)
  • 10. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. (nih.gov)
  • 3. (AGCTG) (AGCTG) (AGCTG) (GGGTG) as the primordial sequence of intergenic spacers: the role in immunoglobulin class switch. (nih.gov)
  • This ideally involves multidisciplinary care by specialists in relevant fields, including orthopedists to monitor the associated skeletal dysplasia and immunologists to manage antibiotic treatment of infections and use of immunoglobulin replacement therapy as indicated to avoid life-threatening infections. (nih.gov)
  • Antimicrobial effectiveness of S-IgA was found to be enhanced by their binding to pFv a gut-associated molecule suggesting that these immunoglobulins required part in controlling gut infections [4]. (acancerjourney.info)
  • a job was suggested by some studies for the CDR3 framework region from the heavy immunoglobulin string a domains where even. (acancerjourney.info)
  • Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). (nih.gov)
  • When I had my lab at NIH, I obtained some samples from the Jackson lab rabbits and we did typing tests to characterize their immunoglobulin allotypes using newer methods than the Oudin method. (nih.gov)