• ZIKV
  • The majority of ZIKV infections are asymptomatic [ 6 ], making case detection and control more difficult. (biomedcentral.com)
  • The laboratory investigation is more important in cases suspected of ZIKV infection that have evolved with neurological complications, in pregnant women, abortion or congenital malformations, and is a key part for diagnostic definition. (jbpml.org.br)
  • Results: We show that ZIKV infection in vitro is enhanced in the presence of the 4G2 mAb. (plos.org)
  • Discussion: Our results demonstrate that ADE between ZIKV and DENV is possible and that the 4G2 antibody is a useful tool for the effects of pre-existing anti-DENV antibodies during ZIKV infections. (plos.org)
  • For half a century, ZIKV was described only as causing sporadic human infections in Africa and Asia, which was mostly confirmed by serologic methods ( 2 ). (cdc.gov)
  • ZIKV infection was then confirmed by sequencing of the genomic position 858-1138 encompassing the prM/E protein coding regions of ZIKV (GenBank accession no. (cdc.gov)
  • Interestingly, ZIKV infection markedly impaired the phosphorylation of eIF2α triggered in Ars-treated infected cells, and the abrogation of SG assembly in ZIKV-infected cells is, at least in part, dependent on eIF2α dephosphorylation. (pubmedcentralcanada.ca)
  • We evaluated how ZIKV infection counteracts the assembly of dynamic aggregates of RNA and proteins called stress granules (SGs). (pubmedcentralcanada.ca)
  • zoonotic
  • This report originated in the National Center for Emerging and Zoonotic Infectious Diseases (proposed), Thomas Hearn, PhD, Acting Director, and the Division of Vector-Borne Infectious Diseases, Lyle Petersen, MD, Director. (cdc.gov)
  • DENV
  • Dengue virus (DENV) is the most important mosquito-transmitted flavivirus that is transmitted throughout the tropical and subtropical regions of the world. (ajtmh.org)
  • Key to understanding the transmission of DENV is the relationship between pathogen and vector. (ajtmh.org)
  • Our findings indicate that DENV-2 infection in the Ae. (ajtmh.org)
  • These changes in the salivary gland proteome highlight the virally influenced environment caused by a DENV-2 infection and warrant additional investigation to determine if these differences extend to the expectorated saliva. (ajtmh.org)
  • DENV is a complex of four serotypes and infections can progress to severe disease. (plos.org)
  • It is thought that this is mediated by antibody dependent enhancement (ADE) whereby antibodies from a primary DENV infection are incapable of neutralizing heterologous DENV infections with another serotype. (plos.org)
  • The spread of DENV into the Americas from 1995 to 2010 resulted in greater incidences of infection in Brazil, compared to that found in Ecuador, Paraguay, Peru, Costa Rica, Bolivia, Argentina, Mexico, and Nicaragua. (scielo.br)
  • With sequential infections with the 4 serotypes, DENV can cause symptoms ranging from mild influenza-like symptoms to hemorrhagic fever and death. (scielo.br)
  • susceptibility
  • Studies of laboratory infections in the natural host will help to understand variations in susceptibility and reservoir competence among bird species, as well as in the epidemiological patterns found in different affected areas. (mdpi.com)
  • closely-related
  • Therefore, the results described in this study strengthen that this arbovirus, and its closely-related recombinants, should be under continuous surveillance, at least in the endemic countries of Latin America. (plos.org)
  • dengue fever
  • During the latter half of the 20th century, Dengue fever reemerged as a global disease, with the virus spreading geographically due to urbanization, population growth, increased international travel, and global warming, and continues to cause at least 50 million infections per year, making Dengue fever the most common and clinically important arboviral disease. (wikipedia.org)
  • avian
  • Avian models of West Nile virus (WNV) disease have become pivotal in the study of infection pathogenesis and transmission, despite the intrinsic constraints that represents this type of experimental research that needs to be conducted in biosecurity level 3 (BSL3) facilities. (mdpi.com)
  • Viral and host factors that determine the infection outcome are analyzed in detail, as well as recent discoveries about avian immunity, viral transmission, and persistence achieved through experimental research. (mdpi.com)
  • As of January 2005, the CDC ArboNET has recorded avian or animal WNV infections in every state except Alaska, Hawaii, and Washington. (thefreedictionary.com)
  • birth defects
  • The full range of birth defects caused by infection during pregnancy is not known, but they appear to be common, with large scale abnormalities seen in up to 42% of live births. (wikipedia.org)
  • ticks
  • Other arthropods, like ticks, are also susceptible to WNV infection, and the virus has been repeatedly isolated from both soft and hard ticks [ 9 ], although their role as vectors of WNV transmission is still uncertain. (mdpi.com)
  • viral infection
  • In one embodiment, a patient suffering neurological manifestations of a viral infection is administered a therapeutically active dose(s) of mesenchymal stem cells at a frequency and concentration sufficient to induce amelioration, remission or cure of neurological manifestations. (patents.com)
  • pregnant women
  • One question of interest is what sort of focal or local vector control measures can be implemented to protect pregnant women at home, work, or other sites where pregnant women spend significant amount of time. (biomedcentral.com)
  • Infections in pregnant women can spread to the baby. (wikipedia.org)
  • neurological
  • Some cases of Guillain-Barré syndrome-type neurological complications have been observed following infection in Brazil and French Polynesia. (pasteur.fr)
  • enzootic
  • Introduction of the PE2 gene from an enzootic subtype ID virus into an epizootic IAB or IC genetic backbone resulted in lower infection rates than those of the epizootic parent. (jove.com)
  • cases
  • During another outbreak a year, 9,858 cases of WNV infection were reported, of which over 2,900 were severe in nature and 262 of which resulted in fatality. (thefreedictionary.com)
  • strongly
  • Phylogenetic analysis of the first Brazilian infections have strongly indicated that the circulating virus is the Asian, rather than African, strain of the virus, and was genetically similar to the virus found in the outbreak in French Polynesia. (wikipedia.org)
  • hosts
  • When uninfected vectors become infected from feeding, they are then capable of transmitting the virus to uninfected hosts, resuming amplification of virus populations. (wikipedia.org)
  • mild
  • Concomitant with these investigations, the Department of Health recorded an increased number of patients with a mild dengue-like syndrome and rash who were visiting primary care physicians. (cdc.gov)