Primary myeloid myeloid lymphoid leukemia protein. Medical search. Frequent questions

EVs were isolated from the serum of acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL) patients, and healthy volunteers. (nature.com)
In the setting of chronic leukemia, cutaneous involvement can indicate blast transformation. (medscape.com)
Cutaneous infiltration by neoplastic lymphocytes may be seen in acute myeloid leukemia , acute lymphocytic leukemia , chronic myeloid leukemia , chronic lymphoid leukemia , hairy cell leukemia, prolymphocytic leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndromes . (medscape.com)
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome. (thermofisher.com)
Here we provide an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemia). (atlasantibodies.com)
Acute (AML) and chronic (CML) myeloid leukemia are cancers of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (atlasantibodies.com)
Calreticulin mutations appear to be absent in polycythemia vera, acute myeloid leukemia, chronic myeloid leukemia, systemic mastocytosis, lymphoid malignancies and are rare in atypical chronic myeloid leukemia and chronic myelomonocytic leukemia. (cornell.edu)
Classical Hairy Cell Leukemia (HCL) and HCL-like disorders are a very heterogeneous group of mature B-cell Chronic Lympho proliferative Disorders (B-CLPD). (fortuneonline.org)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Common types of MPNs include chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (medicalbiochemist.com)
1. Which of the following is NOT a primary characteristic feature of chronic myeloid leukemia (CML)? (medicalbiochemist.com)
6. Which of the following is a characteristic feature of chronic lymphocytic leukemia (CLL)? (medicalbiochemist.com)
2. Characteristics of CD11c+ CD5+ Chronic B cell Leukemias and the Identification of Novel Peripheral Blood B cell Subsets with Chronic Lymphoid Leukemia Immunophenotypes. (nordicmubio.com)
Immunophenotypes in Classical B-cell Chronic Lymphocytic Leukemia. (nordicmubio.com)
1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). (cancerindex.org)
Furthermore, this 5-hmc defect was more pronounced in tumor T cells from acute patients than from chronic ones and correlated with reduced expression of TET2 protein. (oncotarget.com)
Bone marrow fibrosis is also detected in the spent phase of chronic myelogenous leukemia and polycythemia vera. (medscape.com)
Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
Dasatinib (Sprycel): Indicated for the treatment of adult patients with chronic myeloid leukemia in chronic, accelerated, or myeloid or lymphoid blast phase who are resistant or intolerant to prior therapy including imatinib. (medscape.com)
In previous research, the authors demonstrated that the methanol extract of Artemisia vulgaris (AVM) has the ability to inhibit chronic myeloid leukemia (CML) cell proliferation. (spandidos-publications.com)
Chronic myeloid leukemia (CML) is a malignancy of the blood and bone marrow that affects children and adults. (spandidos-publications.com)
Indicator for the onset of chronic lymphocytic leukemia and multiple myeloma. (targetwoman.com)
Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. (cdc.gov)
Unfortunately, at 54 years of age, she developed a secondary cancer of therapy-related (t-) chronic myelomonocytic leukemia (t-CMML). (frontiersin.org)
Treatment protocols for chronic myelogenous leukemia (CML) are provided below for chronic phase, accelerated phase, and blast phase. (medscape.com)
Хронічний лімфолейкоз (ХЛЛ) Chronic lymphocytic leukemia (CLL) is characterized by progressive accumulation of phenotypically mature malignant B lymphocytes. (msdmanuals.com)

Using tumor cell lines and primary patient samples representing multiple B-cell malignancies, we have demonstrated that constitutive phosphatidylinositol-3-kinase pathway activation is p110δ-dependent. (ashpublications.org)
Leukemia and lymphoma are blood malignancies that affect people of all ages and result in approximately 23,000 deaths in the United States per year [ 1 ]. (nature.com)
Effective immune surveillance of patients with hematologic malignancies such as leukemia is mediated by cellular and noncellular arms of the innate and adaptive immune system. (nature.com)
[ 1 , 2 , 3 ] Owing to the variety of hematologic malignancies or proliferative disorders that may be associated with leukemia cutis, terms such as myeloid or lymphoid leukemia cutis have been used to further classify the leukemic cells. (medscape.com)
NHL encompasses a diverse group of lymphoid malignancies that can arise from B cells, T cells, or natural killer (NK) cells. (medicalbiochemist.com)
It is also used as an effective prognostic marker in case of malignancies such as leukemia . (targetwoman.com)
The NCI group has published a recent update of one of their studies, with an additional 10 years of follow-up, and it continues to suggest a possible link between formaldehyde exposure and mortality due to lymphohematopoietic malignancies, particularly myeloid leukemia (Beane Freeman, Blair et al. (who.int)

Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells). (blogspot.com)
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. (thermofisher.com)
While other cells like mast cells, macrophages, and lymphocytes are involved in the inflammatory response, neutrophils are the primary cell type during the early stages of acute inflammation. (labtestsguide.com)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. (thermofisher.com)
Since these tissues are all intimately connected through both the circulatory and the immune system, a disease affecting one system will often affect the other as well, making myeloproliferation (leukemias) and lymphoproliferation (lymphomas) closely related and often overlapping conditions. (atlasantibodies.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Integrated Genomic DNA/RNA Profiling vs Fluorescence in Situ Hybridization in the Detection of MYC and BCL2 (and BCL6) Rearrangements in Large B-Cell Lymphomas: Updates Amid the New WHO Classification of Lymphoid Neoplasms. (cdc.gov)
Неходжкінські лімфоми Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (msdmanuals.com)

HCL is a well-defined entity in the 2017 revision of the World Health Organization (WHO) classification of the tumours of haematopoietic and lymphoid tissues. (fortuneonline.org)

Recent study showed that iASPP could impact the proliferation and apoptosis of leukemia cells by interacting with FHL2 . (nature.com)
Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. (nature.com)
Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
MPNs are characterized by the neoplastic proliferation of multipotent myeloid stem cells in the bone marrow. (medicalbiochemist.com)
Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
Myeloproliferative diseases are a heterogenous group of disorders characterized by cellular proliferation of 1 or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)

Ponatinib is a targeted tyrosine kinase inhibitor (TKI) that works by inhibiting proteins called tyrosine kinases on leukemia cells, in particular the abnormal BCR-ABL protein that causes the disease. (mdanderson.org)
It works by directing the T cells to target and bind with the CD19 protein on the surface of the leukemia cells. (mdanderson.org)
Latrophilin-1 is an adhesion G protein-coupled receptor that mediates the effect of α-latrotoxin, causing massive release of neurotransmitters from nerve terminals and endocrine cells. (bvsalud.org)
Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)
The primary function of the red cell is to carry oxygen to tissue cells and to carry carbon dioxide away. (ivis.org)
To facilitate this exchange, red cells consist essentially of gas-carrying soluble protein (hemoglobin) surrounded by a protective cell membrane. (ivis.org)
The subtype of leukemia is determined by the hematopoietic lineage of neoplastic cells and the stage at which maturational arrest occurs. (medscape.com)
Leukemia cutis is defined by migration of leukemic cells to the skin. (medscape.com)
Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. (acrobiosystems.com)
FHL2 interacts with iASPP and impacts the biological functions of leukemia cells. (nature.com)
CSCs were first identified in hematological cancer such as acute myeloid leukemia in the late '90s when scientists isolated a subpopulation of leukemia cells that expressed the surface marker CD34 but not CD38. (atlasantibodies.com)
In the lymphoid based contribution to the immune response, we observed a significant reduction in the percentage of CD4+FoxP3+ T cells (Figure 2F), commonly referred to as Treg cells and CD4+CD8+ T cells (Figure 2H) in the heart with a coincidental increase in the percentage of CD4+CD8+ T cells in the spleen (Figure 2I) four days after MI in the cardiomyocyte treated group compared to the MI control. (cell-signaling-pathways.com)
Cell-free circulating tumor DNA (ctDNA), shed into the blood stream by apoptotic or necrotic tumor cells of either primary or metastatic sites, became an extensively investigated and very promising analyte in oncology research. (irispublishers.com)
3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
Hairy cells are small to medium-sized lymphoid cells with an oval or indented nucleus with homogeneous and spongy chromatin. (fortuneonline.org)
These are a group of disorders characterized by abnormal growth and development of cells in the myeloid lineage, which includes granulocytes, monocytes erythrocytes, platelets, etc. (medicalbiochemist.com)
A clot is formed when fibrin, a fibrous protein, forms a mesh that entraps blood cells, primarily platelets and red blood cells, to stop bleeding and seal a wound when there is vascular injury. (labtestsguide.com)
CD5=Derived from the hybridization of mouse NS-1/Ag4 myeloma cells with spleen cells of BALB/c mice immunized with human t-acute lymphoblastic leukemia (ALL) cells. (nordicmubio.com)
6. In Vivo and In Vitro Expression of Myeloid Antigens on B-lineage Acute Lymphoblastic Leukemia Cells. (nordicmubio.com)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
Acute myeloid leukemia (AML) is a heterogeneous disease in terms of genetic basis, clinical, biological and prognostic, and is a malignant clonal disease of leukemia stem cells (LSCs). (biomedcentral.com)
In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
The class I antigens are expressed in the lymphoid cells. (targetwoman.com)
show that this approach can detect characteristic changes that affect blood cells as a result of malaria, spherocytosis, bacterial and viral infections, and leukemia. (elifesciences.org)
Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
RUNX1-positive leukemia cells in preclinical models. (lu.se)
Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. (msdmanuals.com)
The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)

A diagnosis of leukemia cutis in the setting of acute leukemia generally portends a poor prognosis and strongly correlates with additional sites of extramedullary involvement. (medscape.com)

The more aggressive forms of hematopoietic and lymphoid tissue diseases require treatment with chemotherapy, radiotherapy, immunotherapy and, in some cases, a bone marrow transplant. (atlasantibodies.com)
While transferrin receptor is essential for the development of all hematopoietic lineages, Picalm was dispensable for myeloid and B-lymphoid development. (elsevierpure.com)

Numerous epidemiological and preclinical studies support a role of vitamin D compounds in cancer prevention and treatment in colorectal, breast, prostate, ovarian, bladder, lung and skin cancers and leukemia ( 1 , 5 , 6 ). (jcancer.org)
Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. (wjgnet.com)

2. Which of the following genetic abnormalities is commonly associated with the majority of acute lymphoblastic leukemia (ALL)? (medicalbiochemist.com)

GzB primarily initiates apoptosis either through direct proteolytic processing and activation of initiator (caspase 8) or executioner (caspases 3 and 7) caspases, or through disruption of mitochondrial outer membrane potential via cleavage of the Bid protein [ 2 ]. (biomedcentral.com)
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. (nature.com)

Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the epidermis, the dermis, or the subcutis, resulting in clinically identifiable cutaneous lesions. (medscape.com)

Some antecedents are specific to a leukemia subtype, such as the association of acute T-cell leukemia-lymphoma (ATL) with human T-lymphotropic virus type I (HTLV-1). (medscape.com)
Examples of hematologic cancer include leukemia, lymphoma, and multiple myeloma. (atlasantibodies.com)
Mutations in TET2 , encoding one of the TET members responsible for the conversion of DNA cytosine methylation to hydroxymethylation (5-hmc), have been recently described in Human T-lymphotropic virus type 1-associated adult T-cell leukemia/lymphoma (ATLL). (oncotarget.com)
Primary Mediastinal B-Cell Lymphoma: A 2021 Update on Genetics, Diagnosis, and Novel Therapeutics. (cdc.gov)
Clinical Significance of BCL2 , C- MYC , and BCL6 Genetic Abnormalities, Epstein-Barr Virus Infection, CD5 Protein Expression, Germinal Center B Cell/Non-Germinal Center B-Cell Subtypes, Co-expression of MYC/BCL2 Proteins and Co-expression of MYC/BCL2/BCL6 Proteins in Diffuse Large B-Cell Lymphoma: A Clinical and Pathological Correlation Study of 120 Patients. (cdc.gov)

This gene encodes a protein with protease activity and is expressed in the placenta. (cancerindex.org)
PICALM, which encodes the clathrin adaptor protein PICALM, was originally identified as a component of the CALM/AF10 leukemia oncogene. (elsevierpure.com)

EVs were characterized by transmission electron microscopy and fluorescence nanoparticle tracking analysis, and EV surface protein profiles were analyzed by multiplex bead-based flow cytometry to identify tumor- or immune system-related EVs of AML, ALL, CLL, and healthy samples. (nature.com)
The protein may be useful as a tumor marker. (cancerindex.org)

Class II mutations cause defects in myeloid cell differentiation. (medscape.com)
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? (nature.com)
Recurrent hotspot mutations of U2AF1 encoding a protein belonging to the spliceosome were detected in 15% of vHCL. (fortuneonline.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Non-FA (or underlying FA) patients harboring heterozygous germline FA gene mutations may also face an increased risk of developing bone marrow failure, primary immunodeficiency disease, and hereditary cancer predisposition syndromes. (frontiersin.org)

Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency. (acrobiosystems.com)
Less commonly, patients develop hyperviscosity due to the large amounts of high molecular weight monoclonal IgM proteins circulating in plasma, but most patients do not develop problems related to high IgM levels. (msdmanuals.com)

Clinical studies on this respective protein affirms its importance as independent predictor of the asymptomatic multiple myeloma. (targetwoman.com)

9. Which of the following is a characteristic feature of hairy cell leukemia (HCL)? (medicalbiochemist.com)

Leukemic blasts with prominent granules, often resembling multiple Auer rods, are a characteristic feature of Acute Myeloid Leukemia (AML). (labtestsguide.com)

GPR91 is a G protein-coupled cell surface receptor for extracellular succinate (Sucnr1). (haematologica.org)

Nearly half of adult AML patients exhibit a cytogenetic normal acute myeloid leukemia (CN-AML). (biomedcentral.com)

Somatic insertions and deletions in exon 9 of calreticulin that cause a +1bp frameshift and a novel carboxy-terminal peptide in mutant calreticulin have been reported in 70% of JAK2/MPL-negative essential thrombocythemia (ET)and 56-88% of JAK2/MPL-negative primary myelofibrosis(PMF). (cornell.edu)
Peripheral smear of a patient with agnogenic myeloid metaplasia (myelofibrosis) shows leukoerythroblastosis. (medscape.com)
The peripheral smear below shows leukoerythroblastosis and giant platelets in a patient with agnogenic myeloid metaplasia (myelofibrosis). (medscape.com)

Leukemia cutis usually occurs in the setting of a previously diagnosed systemic leukemia or lymphoproliferative disorder/myelodysplastic syndrome. (medscape.com)
In rare cases, leukemia cutis may be the first manifestation of systemic disease. (medscape.com)
Accurate diagnosis has tremendous prognostic significance and may establish a diagnosis in cases in which leukemia cutis is the harbinger of a systemic leukemic process. (medscape.com)
Leukemia cutis can also be a manifestation of a relapse of previously treated systemic leukemia. (medscape.com)

However, whether they have prognostic significance in acute myeloid leukemia (AML) is unknown. (nature.com)

Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
In addition, the expression of stemness genes/proteins is also used to identify CSCs. (atlasantibodies.com)

A combination of ponatinib and blinatumomab was found to be safe and highly effective in patients with newly diagnosed or relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to researchers at The University of Texas MD Anderson Cancer Center . (mdanderson.org)
Leukemia cutis has been described in patients with myeloid and lymphoid types of leukemias. (medscape.com)
Approximately 10% of CML patients show primary imatinib resistance within 3?months of imatinib treatment [9,10]. (abic2004.org)
MDS are considered preleukemia and there is an increased risk of developing acute leukemia (AML) in these patients. (medicalbiochemist.com)
Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. (cancerindex.org)

Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases. (acrobiosystems.com)
Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. (acrobiosystems.com)
Primary immunodeficiency diseases (PIDs) are intrinsic defects of the immune system. (lu.se)

These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)

All types of leukemia result from the abnormal development of leukocytes in the bone marrow. (medscape.com)

There is also strong support for a mechanism of action for nasopharyngeal carcinogenesis in which inhaled formaldehyde causes DNA-protein crosslinks in nasopharyngeal tissue. (who.int)

The pathogenesis of leukemia is well-characterized in the two-hit hypothesis of acute myeloid leukemia. (medscape.com)

Diagnosis requires bone marrow examination and demonstration of M-protein. (msdmanuals.com)
Primary sites of disease include peripheral blood, bone marrow. (msdmanuals.com)

The primary red cell metabolic pathway is anaerobic glycolysis. (ivis.org)
Freeze-etch electron microscopy of primary erythroblasts and live-cell imaging of murine embryonic fibroblasts revealed that Picalm function is required for efficient clathrin coat maturation. (elsevierpure.com)
Isolation of multiple types of molecules (DNA, RNA, or protein) from a single cell simultaneously, stands at the beginning of each approach and having standardized and validated protocols for single cell solutions is surely the foundation of all the herein described approaches. (frontiersin.org)
Utilizing single cell genome, methylome, chromatin accessibility, while RNA or protein from the same cell can be used to profile the transcriptome, and proteome, different single cell omics profiles alone or in combination can serve as building blocks to construct a multi-omics profile for the same cell. (frontiersin.org)
Beta 2 Microglobulin is a protein that is found in the cell membrane. (targetwoman.com)
Objectives: Primary Objectives: To induce cellular and humoral immunity in allogeneic stem cell donors and recipients against the unique idiotype expressed by the recipient's myeloma. (drugpatentwatch.com)
Secondary Objectives: To evaluate the effect of the Fludarabine-(etoposide, doxorubicin, vincristine, prednisone, cyclophosphamide) EPOCH regimen on host T cell depletion and myeloid depletion prior to allogeneic SCT. (drugpatentwatch.com)

An exaggeration of it could be the clinical manifestation of dementia, with intraneuronal accumulation of protein aggregates deranging the metabolic state. (ijpmonline.org)

In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (lookformedical.com)

Raised beta microglobulin levels indicate the presence of disorders pertaining to kidneys, which is a primary indication of renal failure. (targetwoman.com)
Excessive amounts of IgM M-proteins (monoclonal immunoglobulin protein, which may consist of both heavy and light chains or of only one type of chain) can also accumulate in other disorders, causing manifestations similar to macroglobulinemia. (msdmanuals.com)

Special EV surface protein patterns in serum have the potential as noninvasive biomarker candidates to distinguish several disease-related patterns ex vivo or in vivo. (nature.com)

GCA (grancalcin) is usually a cytosolic protein that is translocated to the granule membrane upon neutrophil activation [26,27]. (abic2004.org)

The dermatologist is often instrumental in the diagnosis of leukemia cutis. (medscape.com)

Similarly, some genetic or chromosomal abnormalities are found in specific leukemia subtypes. (medscape.com)

In this condition the B2M is an effective indicator to rule out the presence of myeloid-dysplastic syndromes. (targetwoman.com)

Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C ( 4 ). (jcancer.org)

Ten Eleven Translocation (TET) protein-catalyzed 5mC oxidation not only creates novel DNA modifications, such as 5hmC, but also initiates active or passive DNA demethylation. (researchgate.net)

A patient with typical plum-colored lesions seen in leukemia cutis. (medscape.com)
This patient had acute myelogenous leukemia. (medscape.com)
A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)

Comprehensive Genomic Analysis of Noonan Syndrome and Acute Myeloid Leukemia in Adults: A Review and Future Directions. (cdc.gov)
The objective of this study was to investigate the association between persistent statin use and the risk of primary cancer in adults. (cdc.gov)

Anatomy15

Organisms7

Diseases34

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes15

Information Science3

Chronic28

Malignancies7

Lymphocytes5

Lymphomas5

Haematopoietic and lymphoid tissues1

Proliferation6

Cells35

Poor prognosis1

Hematopoietic2

Cancers2

Majority of acute1

Apoptosis2

Neoplastic1

Lymphoma5

Encodes2

Tumor2

Mutations5

Molecular2

Multiple myeloma1

Hairy1

Characteristic feature1

Extracellular1

Cytogenetic1

Myelofibrosis3

Systemic4

Prognostic1

Expression2

Patients5

Diseases3

Transcriptional3

Abnormal1

Tissue1

Pathogenesis1

Bone2

Cell7

Aggregates1

Liver1

Disorders2

Disease1

Granule1

Diagnosis1

Subtypes1

Syndromes1

Kinase1

Eleven Translocation1

Patient3

Adults2