Primary stem cells. Medical search. Frequent questions

Embryonic stem cells are pluripotent stem cells derived from the inner cell mass of the blastocyst. (wikipedia.org)
Until recently, the principal source of human embryonic stem cells has been donated embryos from fertility clinics. (wikipedia.org)
In January 2007, researchers at Wake Forest University reported that "stem cells drawn from amniotic fluid donated by pregnant women hold much of the same promise as embryonic stem cells. (wikipedia.org)
In 1998, privately funded research led to the breakthrough discovery of human Embryonic stem cells (hESC). (wikipedia.org)
Rb homeostasis is also essential for self-renewal and survival of human embryonic stem cells 10 . (biolegend.com)
Progenitor cells are similar to embryonic stem cells in their capacity to differentiate into various cell types. (ddw-online.com)
The need to control differentiation of embryonic stem cells in vitro presents another set of challenges. (ddw-online.com)
These same molecules are found in embryonic stem cells. (medindia.net)
Embryonic stem cells, which must be extracted from embryos three to five days old (known as blastocysts, which contain only about 150 cells at this point of development). (articlecity.com)
Adult stem cells, which are present in small amounts in adult tissue but less adaptable than embryonic stem cells, making their use in medical treatments more challenging. (articlecity.com)
They have many of the positive characteristics of embryonic stem cells while sourcing material is far less challenging, since postpartum tissue can be used. (articlecity.com)

OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
Additionally, 5% to 10% of recipients have suffered from primary graft dysfunction (PGD) after heart transplantation(3). (researchsquare.com)
Summary of Research Progress: Our research aims to identify the optimal culture conditions and the best hESC lines for the derivation of nerve lineage cells in therapeutic cell transplantation. (ca.gov)
Finally, cell transplantation in a mouse stroke model will be used to study the mechanisms and efficacy of different types of hESC-derived neural cells in neural repair. (ca.gov)
Finally, we also made excellent progress on the procedure of cell transplantation. (ca.gov)
We have found a suitable substrate that can be used to enhance neuronal survival after cell transplantation and we expect to publish a research paper in this new method of cell transplantation. (ca.gov)
Amit has taken 5 volunteers who would eventually undergo heart transplantation after a few months and injected adult stem cells into the patients' hearts. (cellmedicine.com)
Removing and studying the hearts that have been injected with adult stem cells a few months prior to transplantation is a possibility. (cellmedicine.com)
In an earlier study he had shown that "Autologous stem cell transplantation led to significant improvement in cardiac function in patients undergoing off-pump coronary artery bypass grafting for ischemic cardiomyopathy. (cellmedicine.com)
We were able to show that transplantation of the old treated muscle stem cell population repaired the damage and restored strength to injured muscles of old mice," Cosgrove said. (stanford.edu)
For example, because hematopoietic stem cells can reconstitute the entire blood system, bone marrow transplantation has long been used in the clinic to treat various diseases. (articlecity.com)
Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
Introduction To observe the short-term and long-term effects of extensive fascial resection combined with autologous limbal stem cell sharing transplantation for pterygium. (researchsquare.com)
Methods A retrospective case series analysis was performed with 403 patients (420 eyes) who underwent extensive fascial resection combined with autologous limbal stem cell sharing transplantation in the Department of Ophthalmology, Second People's Hospital of Yunnan Province from January 2017 to June 2018. (researchsquare.com)
Discussion and conclusion Extensive fascial resection combined with autologous limbal stem cell sharing transplantation for the treatment of pterygium, the patient's appearance satisfaction is higher, and the recurrence probability is lower than the average recurrence rate of limbal stem cell transplantation. (researchsquare.com)
Pterygium excision combined with autologous conjunctival flap transposition, pterygium excision combined with amniotic membrane transplantation, pterygium excision combined with autologous limbal stem cell transplantation and so on [12] . (researchsquare.com)
Treatment is often supportive, but Janus kinase 2 (JAK2) inhibitors, such as ruxolitinib , fedratinib , or pacritnib, may decrease symptoms and stem cell transplantation may be curative. (msdmanuals.com)
Stem cell transplantation may be an option in cases of severe recalcitrant ALPS. (medscape.com)

Use of adult mesenchymal stem-stromal cells (mscs) are currently in clinical trial in us/internationally. (healthtap.com)
Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). (hindawi.com)
Previous studies have demonstrated that MSCs overexpressing Chemokine (C-X-C motif) receptor 4 (CXCR4) could increase the quantity of transplanted cells to local tissues. (hindawi.com)
It has been observed that mesenchymal stem cells (MSCs) could home and engraft within the injured tissues and differentiate into vascular cells and alveolar cells to regenerate the damage in the irradiated mouse lung [ 10 ]. (hindawi.com)

If we ever want to prevent hair loss from happening or resurrect hair growth once you start to lose your hair, we need to focus on maintaining the function of these hair follicle dermal stem cells," says Biernaskie, associate professor of comparative biology and experimental medicine at UCVM, and the Calgary Firefighters Burn Treatment Society Chair in Skin Regeneration and Wound Healing. (ucalgary.ca)
Dr Eric Hill, Senior Lecturer in Stem cell Biology at Aston University, said: "Our ability to turn human stem cells into brain cells has revolutionised the study of the human brain. (eurekalert.org)
The research, "Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence," is published in the journal BMC Cell Biology . (sciencedaily.com)
Blau, who directs Stanford's Baxter Laboratory for Stem Cell Biology , and postdoctoral scholar Ben Cosgrove , PhD, found that growing muscle stem cells from elderly laboratory mice (a 24-month-old mouse is roughly equivalent to an 80-year-old human, based on average lifespans) in a specialized matrix called hydrogel, coupled with a drug treatment to block an inhibitory pathway, caused the cells to divide rapidly. (stanford.edu)
Mattias Magnusson joined the Research School in Stem Cell Biology as its Executive Coordinator earlier in 2023. (lu.se)
Lund Stem Cell Center's Research School in Stem Cell Biology has a new Executive Coordinator, Mattias Magnusson. (lu.se)
However, around five years ago, I shifted my research towards lung biology, specifically the airway epithelium, studying stem cells in the airway and their connection to chronic lung diseases and lung cancer. (lu.se)
Transitioning from a well-established field like hematopoietic stem cells to the relatively new field of lung biology required starting over in many aspects. (lu.se)
Q: What inspired you to take on the role of executive coordinator of the Research School in Stem Cell Biology? (lu.se)
I am very passionate about teaching and inspiring students in stem cell biology and regenerative medicine. (lu.se)

Potency is a measure of a cell's differentiation potential, or the number of other cell types that can be made from that stem cell. (wikipedia.org)
And TGF-β, just going back to that, is specific to cellular function in terms of cell growth, proliferation, differentiation. (chiroeco.com)
The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
Toward this goal, we propose to compare the behavior of nerve cell differentiation in multiple lines of hESCs in one laboratory setting. (ca.gov)
We will further characterize molecular changes during directed cell differentiation and identify the cells that exhibit a pattern of DNA modification, namely DNA methylation, similar to primary neural cells in human brain. (ca.gov)
We are now ready to compare the property of different lines of nerve cells such as the efficiency of nerve cell differentiation and the preferential production of specific nerve cells in culture. (ca.gov)
By engineering stem cells carrying different levels of methylation, we aim to find the optimal levels of DNA methylation for efficient nerve cell differentiation. (ca.gov)
Surface Functionalized Polyaniline Nanofibers:Chitosan Nanocomposite for Promoting Neuronal-like Differentiation of Primary Adipose Derived Mesenchymal Stem Cells and Urease Activity. (bvsalud.org)
Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)
Our scientists have developed a wide array of stem cell-focused reagents and resources for many applications including flow cytometry , western blotting , ELISAs , and recombinant proteins for cell differentiation. (biolegend.com)
RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. (biolegend.com)
These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages 2,3 . (biolegend.com)
However, the use of bFGF for human ES cell culture, particularly at the high levels used by some for 'feeder-free' culture, must be considered carefully, as bFGF may drive ES cells towards differentiation. (ddw-online.com)
Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. (articlecity.com)
First, we screened 513 natural compounds on primary AML cells and identified a novel diterpene (H4) that preferentially induced differentiation of FLT3 wild-type AMLs, while FLT3-ITD/mutations conferred resistance. (lu.se)
By combinatorial screening using H4 and molecules with defined targets, we demonstrated that H4 induces differentiation by the activation of protein kinase C (PKC) signaling pathway, and in line with this, activates PKC phosphorylation and translocation of PKC to the cell membrane. (lu.se)

These stem cells can differentiate into all other cells in the human body and are the subject of much scientific research. (wikipedia.org)
Stem cells are unique due to their ability to limitlessly self-renew and differentiate into each cell type in the adult body. (biolegend.com)
The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
However, progenitor cells can only differentiate into a limited number of cell types. (ddw-online.com)
The cancer stem cell markers include Nanog and BMI1, both of which contribute to stem cells' defining ability to renew themselves and differentiate into different cell types, Dr. Vasko said. (medindia.net)
They are able to differentiate into any cell of an organism and have the ability of self-renewal. (articlecity.com)

Here we report application of human umbilical cord mesenchymal stem cell (HUCMSC)-derived therapy for pulmonary arterial hypertension (PAH). (nature.com)
Stem cell treatments are a type of cell therapy that introduce new cells into adult bodies for possible treatment of cancer, diabetes, neurological disorders and other medical conditions. (wikipedia.org)
California Institute for Regenerative Medicine (CIRM) Bridges programs are designed to prepare students for highly productive careers in stem cell research and therapy development. (csus.edu)
Information on parkinson's stem cell therapy? (healthtap.com)
What is stem cell therapy? (healthtap.com)
While this type of therapy does offer hope, it is mostly investigational at this time and very few stem cell therapies have been proven to be both safe and effective. (healthtap.com)
Be warned that a lot of people advertising stem cell therapy are not really doing it. (healthtap.com)
Durable Responses and Low Toxicity After Fast Off-Rate CD19 Chimeric Antigen Receptor-T Therapy in Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia. (nih.gov)
Breast cancer stem cells (BCSCs) are drivers of therapy-resistance, therefore are responsible for poor survival. (yorksj.ac.uk)
This may result in clinicians opting out of pursuing this choice of stem cell therapy. (ivis.org)
All he has to do is succeed in his ongoing clinical trials using cell therapy in congestive heart failure. (cellmedicine.com)
He is the director of the Center for Cardiac Cell Therapy at the university. (cellmedicine.com)
Our data pave the way for such a stem cell therapy. (stanford.edu)
In the present study, we conducted overexpressing CXCR4 human umbilical cord mesenchymal stem cell (HUMSC) therapy for RILI. (hindawi.com)
Our experiments suggest that some treatments could be producing more cancer stem cells that then are capable of metastasizing, because these cells are trying to find a way to survive the therapy," said one of the study's investigators, Vasyl Vasko, M.D. Ph.D., a pathologist at the Uniformed Services University of the Health Sciences in Bethesda, Md. (medindia.net)

In May 2005, the House of Representatives voted 238-194 to loosen the limitations on federally funded embryonic stem-cell research - by allowing government-funded research on surplus frozen embryos from in vitro fertilization clinics to be used for stem cell research with the permission of donors - despite Bush's promise to veto if passed. (wikipedia.org)
The Senate passed the first bill, 63-37, which would have made it legal for the Federal government to spend Federal money on embryonic stem cell research that uses embryos left over from in vitro fertilization procedures. (wikipedia.org)
Today, many preclinical research domains depend upon cell-based in vitro assays requiring either primary cells/cell-based models or subcellular fractions isolated from various species to analyze drug metabolic activities. (kosheeka.com)
02:47 and red blood cells in vitro. (yale.edu)
ITGA7 was found to be significantly downregulated in BCSCs, and low expression significantly correlated with reduced survival in patients treated with chemotherapy, and with chemoresistance in breast cancer cells in vitro. (yorksj.ac.uk)
Primary rat microglia in vitro were polarized towards a M1 phenotype by LPS, or to a M2 phenotype by IL4, while simultaneous exposure to LPS plus IL4 resulted in a hybrid phenotype expressing both M1- and M2-characteristic markers. (biomedcentral.com)
In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
Every cell type has its own unique needs when grown in vitro and stem cells are no exception. (ddw-online.com)

They closely interact with endogenous neural stem cells (NSCs) residing in distinct niches of the adult brain. (biomedcentral.com)

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
The clinical trial for 'Autologous Bone Marrow Progenitor Cell Treatment for Heart Failure,' at the University of Pittsburgh Medical Center is lead by Dr. Amit. (cellmedicine.com)

Our contribution to IDEAL is to determine the role of DNA methylation in haematopoietic stem cell aging. (ucl.ac.uk)

Pluripotent stem cells can also be derived from Somatic cell nuclear transfer which is a laboratory technique where a clone embryo is created from a donor nucleus. (wikipedia.org)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Starting with cell source, choice of donor and recipient, as well as isolation methods, we will then discuss existing expansion protocols (two-/three-dimensional cultivation, basal medium, medium supplements, static/dynamic conditions, and hypoxic/normoxic conditions) and influence of these strategies on the cell functionality after implantation. (frontiersin.org)

Routine stem cell therapies for certain types of heart disease will become a reality in 3-5 years according to Dr. Amit of the University of Pittsburgh Medical Center. (cellmedicine.com)
Researchers have recently debated the notion that some therapies are not capable of eradicating cancer because they do not target the cancer stem cells responsible for tumor development. (medindia.net)
Some novel therapies are already being tested against cancer stem cells, he added. (medindia.net)

Adult (or tissue-specific) stem cells reside in many different organs and play important roles in maintaining the integrity of those tissues," says Shin, the lead author of the paper and an Alberta Innovates MD PhD scholar. (ucalgary.ca)
Stem cells are transplanted to replace damaged cells or tissues in the body that are unable to heal themselves. (healthtap.com)
Primary amyloidosis is a rare disorder in which abnormal proteins build up in tissues and organs. (medlineplus.gov)
The major cause of this syndrome is depletion of immature parenchymal stem cells in specific tissues. (cdc.gov)
As we age, our tissues accumulate senescent cells which are alive but do not grow or function as they should. (sciencedaily.com)

During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional rounds of cell divisions, and differentiating daughter cells, populating the developing cortex. (elifesciences.org)
Previous work in the embryonic rodent brain suggested that the preferential inheritance of the pre-existing (older) centrosome to the self-renewed progenitor cell is required to maintain stem cell properties, ensuring proper neurogenesis. (elifesciences.org)
Use of progenitor cell lines can eliminate the need to culture challenging human ES cells. (ddw-online.com)

But a study from the University of Calgary Faculty of Veterinary Medicine (UCVM) has found that it's actually a small population of specialized cells within the hair follicle called fibroblasts, and the dermal stem cells that maintain them, that may cause hair loss. (ucalgary.ca)
A loss of dermal stem cells prevents production of new fibroblasts and so the population can't be maintained. (ucalgary.ca)
Shin compared fibroblasts from different aged animals - young, middle-aged and older - to understand which particular genes are changing with advanced age and how they might contribute to the cell dysfunction. (ucalgary.ca)
There is good evidence that similar fibroblasts, or progenitor cells, reside in most organs in the body and so they may undergo similar age-related degeneration to what Wisoo has uncovered in the hair follicle," says Biernaskie. (ucalgary.ca)
The loose connective tissue under the epithelium contains a large number of fibroblasts and abundant capillaries, which indicates that the pterygium epithelial cells have a strong ability to proliferate and migrate. (researchsquare.com)
Here, we demonstrated that single-walled CNTs induced FSC acquisition and fibrogenic responses in primary human lung fibroblasts. (cdc.gov)
These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)

Somatic cell nuclear transfer is also tightly regulated amongst various countries. (wikipedia.org)
We also begin to produce and characterize a new type of human stem cells, namely induced pluripotent cells that are obtained by converting somatic cells into stem cell through reprogramming. (ca.gov)
The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)

Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways. (lu.se)
The properties of HUCMSCs were validated by untargeted label-free quantitation of the cell and CM proteome, suggesting increased activity of regeneration, autophagy and anti-inflammation pathways and mitochondrial function. (nature.com)
If scientists understood the pathways cancer stem cells use to survive treatment or increase their ranks, then therapeutic targets could be developed, Dr. Vasko said. (medindia.net)

Neuroendocrine Tumors (NETs) are a heterogeneous group of neoplasms which arise from the hormone-producing cells of the bodyís nervous and endocrine systems and affect 1/50,000 in the UK population. (ucl.ac.uk)
Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs). (msdmanuals.com)

2. Omitting that the diseases everyone is talking about curing (diabetes, Parkinson's, paralysis) have already been treated with adult stem cells. (alexchediak.com)
The U.S. Food and Drug Administration (FDA) has made Amit the only individual in the entire nation to gain its endorsement to undertake clinical trials for treating heart patients by directly injecting adult stem cells into the heart. (cellmedicine.com)
So far all FDA approval has been for using adult stem cells for treating heart patients due to the ethical dilemmas surrounding embryonic stem cell research. (cellmedicine.com)

We have shown here that IM induces autophagy in CML blast crisis cell lines, CML primary cells, and p210BCR/ABL-expressing myeloid precursor cells. (lu.se)
However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)
CML), essential thrombocytopenia (ET), primary myeloid significant cluster of PV cases near the intersection of the 3 fibrosis (PMF), and other related and unclassifiable MPNs, counties. (cdc.gov)

On the other hand, for primary teeth, enzymatic digestion always promoted a higher cell proliferation. (bvsalud.org)

109-30-Gal4 drives UAS-tauGFP expression in follicle stem cells and their progeny cells (see also CIL# 13752). (ucsd.edu)

This is a really important study in highlighting how aging impacts tissue-resident stem cells and the molecular changes behind this degenerative process. (ucalgary.ca)
Stem cells have been used to repair tissue damaged by disease or age. (wikipedia.org)
Pulp cells cultures were established by two approaches: enzyme digestion (3 mg/mL type I colagenase and 4 mg/mL dispase), or culture of the tissue explants in cell culture dishes. (bvsalud.org)
Today's webinar, "Breakthrough in Stem Cell Activation: The First Oral Protein Complex for Tissue Regeneration. (chiroeco.com)
Dr. Patterson, thank you for taking the time to participate in our webinar, and for sharing your expertise in stem cells, and helping our audience get a better understanding of stem cells and tissue regeneration. (chiroeco.com)
So one is to activate stem cells and the second is to regenerate tissue. (chiroeco.com)
Microglia-the resident immune cells of the brain-are activated after brain lesions, e.g., cerebral ischemia, and polarize towards a classic "M1" pro-inflammatory or an alternative "M2" anti-inflammatory phenotype following characteristic temporo-spatial patterns, contributing either to secondary tissue damage or to regenerative responses. (biomedcentral.com)
On the one hand, this (sterile) neuroinflammation eliminates degenerating tissue, thus supporting a restorative milieu for neuroprotection, axonal regeneration, remyelination, and stem cell-mediated tissue repair. (biomedcentral.com)
In a resting state, microglia are involved in the maintenance of cell homeostasis surveying their microenvironment and communicating with the neuronal tissue via extremely motile processes and protrusions [ 8 ]. (biomedcentral.com)
Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
Bone marrow and adipose tissue have emerged as excellent sources of progenitor cells. (ivis.org)
With this raw material, biomedical firms can create stem cell lines that, among other things, aid recuperation via the regeneration of tissue that has been lost or damaged. (articlecity.com)
Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. (articlecity.com)

OUTLINE: Conditioning: Patients undergo low dose total body irradiation followed by infusion of allogeneic peripheral blood stem cells (PBSC) on day 0. (knowcancer.com)

A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. (nature.com)
The project, funded by the European Commission's Future and Emerging Technologies (FET) programme and involving partner institutions in the UK, France, Spain, Switzerland and Israel, is also expected to produce new knowledge about the functioning of the brain which could be used to develop novel stem cell-based treatments. (eurekalert.org)
Since then, Goldstein, who is a scientist at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research working on new treatments for prostate cancer, and Braeden have become friends. (uclahealth.org)
The research paper presented by the American Association for Cancer Research's second International Conference on Molecular Diagnostics in Cancer Therapeutic Development say that anti-cancer treatments might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease though quite often they effectively shrink the size of tumors. (medindia.net)
This may help explain why the expression of stem cell markers has been associated with resistance to chemotherapy and radiation treatments and poor outcome for patients with cancers including prostate, breast and lung cancers," Dr. Vasko said. (medindia.net)
But analysis of stem cell expression before and after treatment revealed that even as some anti-cancer treatments shrank tumors, they increased expression of Nanog and BMI1. (medindia.net)
These treatments were not enough to completely inhibit tumor growth, and the cancer stem cell markers were still present," Dr. Vasko said. (medindia.net)
Today, it has become a distinct source of stem cells and, therefore, a critical element in advancing medical treatments for everything from hair loss, the treatment of wounds, and surgical procedures. (articlecity.com)

The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response. (yorksj.ac.uk)
We hypothesize that the tumor escapes from chemotherapy by induction of stem cell marker expression," he said. (medindia.net)

During human brain development, neural progenitor cells (NPCs) undergo two modes of cell division. (elifesciences.org)
For example, neural progenitor cells derived from a human ES cell line are easily propagated and require less handling than human ES cells. (ddw-online.com)

Dr. Vasko doesn't know how this happens, but theorizes that "dying cells could secrete a lot of factors that induce expression of stem cell markers in other cancer cells. (medindia.net)
This was indicated by increased expression of stem cell markers (e.g. (cdc.gov)

Transcriptomes of fluorescently sorted BCSCs and matched non-stem cancer cells were determined using RNA-seq (n = 6). (yorksj.ac.uk)
ITGA7 expression was examined in breast cancers using immunohistochemistry (n = 305), and its functional role was tested using siRNA in breast cancer cells. (yorksj.ac.uk)

The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)
Identifying the right cocktail of media conditions, supplements and growth factors that successfully drive stem cells toward a desired lineage on a reproducible basis is a time-consuming, iterative exercise. (ddw-online.com)
Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)

After surgical treatment of pterygium, there will still be a small number of mutant epithelial stem cells remaining. (researchsquare.com)

We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells. (lu.se)
Here, we identify the consistent transcriptome of primary BCSCs shared across breast cancer subtypes, and we examine the clinical relevance of ITGA7, one of the genes differentially expressed in BCSCs. (yorksj.ac.uk)
Our data suggests that using chemicals to switch back on the major class of genes that are switched off as we age might provide a means to restore function to old cells. (sciencedaily.com)
These old cells lose the ability to correctly regulate the output of their genes. (sciencedaily.com)
When activated, genes make a message that gives the instructions for the cell to behave in a certain way. (sciencedaily.com)
Most genes can make more than one message, which determines how the cell acts. (sciencedaily.com)
The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
Found within Wharton's jelly - which is easily harvested from what would otherwise be post-natal medical waste - are several distinct stem cell genes. (articlecity.com)

Human glioblastoma (GBM) is the most common primary malignant brain tumor. (nature.com)
Glioblastoma (GBM) is the most common and aggressive type of primary brain tumor 1 . (nature.com)
These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)
To test this hypothesis, Dr. Vasko, along with scientists from the CRTRC Institute for Drug Development in San Antonio and from the Johns Hopkins University, set out to measure both stem cells markers and tumor volume before and after treatment in a mouse model. (medindia.net)
Use of the agents Velcade and Docetaxel led to the most significant increase in stem cell markers within the treated tumor, while ifosfamide and Avastin inhibited expression of the markers in this cancer subtype. (medindia.net)
The small number of cells that survive the treatment could then generate another tumor that metastasizes. (medindia.net)

How to Harvest Bone Marrow Derived Mesenchymal Stem Cells for Expansion and Injection. (ivis.org)

In 2000, the NIH, under the administration of President Bill Clinton, issued "guidelines that allow federal funding of embryonic stem-cell research. (wikipedia.org)
No federal law ever did ban stem cell research in the United States, but only placed restrictions on funding and use, under Congress's power to spend. (wikipedia.org)
In February 2001, George W. Bush requested a review of the NIH's guidelines, and after a policy discussion within his circle of supporters, implemented a policy in August of that year to limit the number of embryonic stem cell lines that could be used for research. (wikipedia.org)
In April 2004, 206 members of Congress, including many moderate Republicans, signed a letter urging President Bush to expand federal funding of embryonic stem cell research beyond what Bush had already supported. (wikipedia.org)
On July 29, 2005, Senate Majority Leader William H. Frist (R-TN), announced that he too favored loosening restrictions on federal funding of embryonic stem cell research. (wikipedia.org)
On July 18, 2006, the Senate passed three different bills concerning stem cell research. (wikipedia.org)
The third bill would encourage research that would isolate pluripotent, i.e., embryonic-like, stem cells without the destruction of human embryos. (wikipedia.org)
The research team is now embarking on a three-year study to demonstrate how human brain stem cells grown on a microchip can be taught to solve problems from data, laying the foundations for a "paradigm shift" in machine learning technology. (eurekalert.org)
Professor Rémi Monasson, Director of Research at the Centre National de la Recherche Scientifique (CNRS), said: "In Neu-ChiP, we will not only model a system made of many extraordinarily complex components - human neural cells - but we will try to go far beyond. (eurekalert.org)
The goal of our MS Biotechnology/Stem Cell Program is to provide advanced coursework and a cutting edge research experience to prepare graduates for success in the stem cell workforce. (csus.edu)
In addition to conducting research at UC Davis, students also take courses on stem cell laboratory techniques and Good Manufacturing Practices (GMP) at UC Davis. (csus.edu)
To read about the research students in our program can participate in, click UCD Stem Cell Research below. (csus.edu)
By the end of the first semester (fall) students will have identified and interviewed in research labs of interest within the UC Davis Stem Cell Program (although limited to a list of participating research investigators, students get to choose which research labs to interview and, ultimately, conduct research in). (csus.edu)
After advancement, students begin the summer with a week of intensive training on stem cell research techniques at UC Davis. (csus.edu)
The University of Exeter research team, working with Professor Richard Faragher and Dr Elizabeth Ostler from the University of Brighton, found that splicing factors can be switched back on with chemicals, making senescent cells not only look physically younger, but start to behave more like young cells and start dividing. (sciencedaily.com)
Dr Eva Latorre, Research Associate at the University of Exeter, who carried out the experiments, was surprised by the extent and rapidity of the changes in the cells. (sciencedaily.com)
Guided by the mentorship of physician-scientist Dr. Owen Witte, professor of microbiology, immunology and molecular genetics at UCLA and director of the Broad Stem Cell Research Center, Goldstein was the first author of a study that identified the cells in which prostate cancer originates. (uclahealth.org)
This piece will focus on the medical technology being developed using Wharton's jelly as a source material for stem cells, but will also delve into broader aspects of stem cell research, one of the most fascinating current areas of scientific study. (articlecity.com)
Q: Can you tell us a little about your background and journey in stem cell research? (lu.se)

02:14 progenitors that make red blood cells. (yale.edu)

Bone marrow is the source of stem cells for the experiment. (cellmedicine.com)

Other iPSC-based models affecting neural crest lineages include Schwann cell and melanocyte-related disorders, including our effort to model human melanoma in pluripotent stem cells. (mskcc.org)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)

A comparative analysis of single-cell RNA sequencing data collected from three HUCMSCs and two human umbilical vein endothelial cell (HUVEC) controls identified eight common cell clusters, all of which indicated regenerative potential specific for HUCMSCs. (nature.com)

Molecular signatures of BCSCs from primary cancers remain undefined. (yorksj.ac.uk)
This study is the first to define the molecular profile of BCSCs from a range of primary breast cancers. (yorksj.ac.uk)
That tells us that understanding how to target these markers and these cells could prove useful in treating these cancers. (medindia.net)

We are particularly focused on improving the iPSC-based tools for modeling late-onset disorders such as Parkinson's disease using state-of-the-art genetic tools for gene repair, cell purification, and manipulation of cell maturation and age. (mskcc.org)
When this process occurs without other blood cell disorders, it's called essential thrombocythemia. (nih.gov)
All of the MPNs are hematopoietic rates from 2001 (when MPNs first became reportable) stem cell disorders of common clonal heritage, character- through 2005 in these 3 counties. (cdc.gov)

But there needs to be a sufficient number of fibroblast cells available to send a strong enough signal to trigger this process to occur. (ucalgary.ca)
F urther complicating matters, human ES cells are typically co-cultured with feeder layers of mouse fibroblast cells. (ddw-online.com)

I returned to Sweden after that and worked as a postdoc for one year before starting my own lab, initially focusing on human hematopoietic stem cell regulation in normal and malignant hematopoiesis. (lu.se)

The use of mouse feeder layers and animal serum are particularly problematic in the culturing of stem cells for possible therapeutic applications. (ddw-online.com)

In humans there are many types of stem cells, each with varying levels of potency. (wikipedia.org)

image: SEM image of a primary rat neuronal culture grown on the 3D CMOS-MEA. (eurekalert.org)

The remarkable potential of stem cells to generate several hundred differentiated cell types is driving their use for regenerative medicine and for supporting the traditional drug discovery and development process (Figure 1). (ddw-online.com)

Download this chapter from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition . (primaryimmune.org)
Thousands of individuals living with primary immunodeficiency diseases, including Chronic Granulomatous Disease (CGD), go undiagnosed. (primaryimmune.org)

RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)

Later, I pursued my Ph.D. at Lund University, focusing on the regulation of hematopoietic stem cells using genetic mouse models under the guidance of Stefan Karlsson. (lu.se)
After completing my Ph.D., I joined Hannah Mikkolas' group at UCLA in Los Angeles, where I continued studying blood stem cell regulation, this time using human primary cells and establishing a disease model for leukemia. (lu.se)

A new way to rejuvenate old cells in the laboratory, making them not only look younger, but start to behave more like young cells, has now been discovered. (sciencedaily.com)
Now a report in Nature Medicine outlines some interesting findings from the laboratory of Stanford microbiologist and immunologist Helen Blau , PhD, suggesting it may be possible to perk up a population of elderly stem cells through a combination of biophysical and biochemical cues. (stanford.edu)

In this study, we sought to describe characteristics, risk factors, and outcomes of Rhodococcus infection among solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients in the United States. (cdc.gov)

The ability to induce age-like features in PD-iPSC-derived dopamine nerve cells has yielded late-stage disease phenotypes not commonly observed in standard PD-iPSC models. (mskcc.org)

Anatomy57

Organisms16

Diseases12

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science2

Named Groups1

Health Care1

Embryonic stem11

Transplantation20

MSCs8

Biology10

Differentiation16

Differentiate7

Therapy15

Vitro8

Endogenous neural stem1

Autologous2

Haematopoietic stem1

Donor3

Therapies3

Tissues5

Progenitor cell3

Fibroblasts7

Somatic3

Pathways3

Neoplasms2

Adult stem3

Myeloid3

Proliferation1

Progeny cells1

Tissue13

Peripheral1

Treatments8

Chemotherapy3

Neural progenitor cells2

Expression of stem cell markers2

Cancer cells2

Lineage3

Epithelial1

Genes8

Tumor6

Bone Marrow Derived1

Research19

Progenitors1

Source of stem cells1

Lineages2

Umbilical1

Cancers3

Disorders3

Fibroblast cells2

Malignant1

Therapeutic Applications1

Potency1

Neuronal1

Regenerative medicine1

Immunodeficiency Diseases2

Regulates1

Regulation2

Laboratory2

Transplant1

Induce1