Of primary adrenal tumors, ACC is less common than cortical adenoma and pheochromocytoma. (cap.org)
Advanced imaging techniques often reveal adrenal tumors in asymptomatic patients. (cap.org)
It is important to distinguish the histological variants of conventional ACC as they share similar features to secondary tumors that not infrequently involve the adrenal gland. (cap.org)
Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
Objectives: This study aimed to evaluate the stability, safety, and efficacy of alpha-targeted therapy with [225Ac]Ac-DOTATATE in patients with grade 1/2 metastatic neuroendocrine tumors (NETs). (bvsalud.org)
Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. (findzebra.com)
When such tumors arise outside of the adrenal gland, they are termed extra-adrenal pheochromocytomas, or paragangliomas. (medscape.com)
Liver3
unfortunately, many cases are metastatic at the time of diagnosis , with the most common sites of spread being the local periadrenal tissue, lymph nodes, lungs, liver, and bone. (medscape.com)
In particular, human organic cation transporter 2 (hOCT2) and multidrug and toxin extrusion proteins 1 and 2-K (hMATE1/2-K) likely mediate renal secretion of mIBG, whereas hOCT1 and hOCT3 may contribute to mIBG uptake into normal tissues such as the liver, salivary glands, and heart. (aspetjournals.org)
Results: Patients had 73% (n=8) lymph node metastases, 91% (n=10) liver metastases, 36% (n=4) lung metastases, and 73% (n=8) bone metastases. (bvsalud.org)
Benign4
Incidentally found adrenal masses can be further classified as benign or malignant and primary adrenal versus metastatic using radiologic-cytologic or pathologic correlation. (cap.org)
A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. (lookformedical.com)
Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (lookformedical.com)
However, specific histologic features help to differentiate adrenal pheochromocytomas with a potential for biologically aggressive behavior from those that behave in a benign fashion. (medscape.com)
Carcinoma4
This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2018, Case 23, and is an adrenal cortical carcinoma of the adrenal gland. (cap.org)
These findings are consistent with adrenal cortical carcinoma (ACC). (cap.org)
A 68-year-old woman with a large right upper quadrant primary adrenocortical carcinoma with curvilinear calcification. (medscape.com)
Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. (ukw.de)
Computed tomography2
Adrenal computed tomography (CT) scanning and magnetic resonance imaging (MRI) are the imaging studies of choice in AC. (medscape.com)
approximately 2% of the general adult population (7% of those over age 70 years) may have adrenal incidentalomas , biochemically and clinically asymptomatic adrenal masses found incidentally during unrelated imaging investigations , such as abdominal computed tomography (CT) scanning or magnetic resonance imaging (MRI). (medscape.com)
Endocrine4
The current World Health Organization (WHO) endocrine edition distinguishes adult ACC from adrenal adenoma based on the Weiss criteria. (cap.org)
Pancreatic neuroendocrine neoplasms (pNENs) are an increasingly common group of malignancies that arise within the endocrine tissue of the pancreas. (rarediseases.org)
Neoplasms that arise from endocrine tissue may also secrete hormones, resulting in excessive levels of these hormones in the body and potentially a wide variety of symptoms. (rarediseases.org)
Targeted Metabolomics as a Tool in Discriminating Endocrine From Primary Hypertension. (ukw.de)
Neuroendocrine1
Nonfunctioning neuroendocrine neoplasms can still cause symptoms relating to tumor size and location such as obstruction or internal bleeding. (rarediseases.org)
Malignancy2
These different genes produce pheochromocytomas with different ages of onset, secretory profiles, locations, and potential for malignancy. (medscape.com)
Only the presence of metastases defines malignancy. (medscape.com)
Pheochromocytomas4
About 85% of pheochromocytomas are located within the adrenal glands, and 98% are within the abdomen. (medscape.com)
Extra-adrenal pheochromocytomas develop in the paraganglion chromaffin tissue of the nervous system. (medscape.com)
Common locations for extra-adrenal pheochromocytomas include the organ of Zuckerkandl (close to the origin of the inferior mesenteric artery), bladder wall, heart, mediastinum, and carotid and glomus jugulare bodies. (medscape.com)
Approximately 10% of pheochromocytomas and 35% of extra-adrenal pheochromocytomas are malignant. (medscape.com)
Asymptomatic1
however, an increasing number of ACs are identified in asymptomatic patients, as an incidental finding on imaging performed for other reasons (ie, adrenal incidentalomas). (medscape.com)
Pathological1
Pathological processes that tend eventually to become malignant. (lookformedical.com)
Methods: This retrospective cohort included patients (n=11) with metastatic NETs from different primary sites (bronchial, pancreatic, nonpancreatic gastroenteropancreatic NETs, paraganglioma, and unknown primary site) treated with [225Ac]Ac-DOTATATE with a mean activity of 8.2±0.6 MBq (range: 7.5-10.0 MBq) at our institution between November 2019 and March 2022. (bvsalud.org)
Although vascular and capsular invasion cannot be assessed, cytologic features on fine needle aspiration (FNA) such as hypercellularity, necrosis, and cellular dyscohesion, in conjunction with radiologic features of tumor size (greater than 4.0 cm), heterogeneity, and enhancement, favor ACC over other adrenal neoplasms. (cap.org)
Among the features that suggest a malignant course are large tumor size and an abnormal DNA ploidy pattern (aneuploidy, tetraploidy). (medscape.com)
Arise1
A p heochromocytoma is another, rarer type of NET that usually develops in the adrenal gland , but can also arise in other parts of the body. (findzebra.com)
Cortisol1
A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. (lookformedical.com)
Hormone1
Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. (lookformedical.com)
Epithelial1
This is followed by coverage of neoplasms in the more traditional categories of epithelial, mesenchymal, and other categories. (abdominalkey.com)
URINARY BLADDER1
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. (lookformedical.com)
Prostate1
For patients with advanced-stage metastatic castration-resistant prostate cancer (mCRPC) who do not respond to [177Lu]Lu-PSMA therapy, there are limited treatment options. (bvsalud.org)
Imaging shows a large right adrenal mass, which is resected. (cap.org)
Atypical1
There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant. (lookformedical.com)
Functional1
Only a small number of adrenal incidentalomas (up to 10%) are functional, and only about 2% prove to be ACs. (medscape.com)
Common1
Conclusion: PTC was the most common type of DTC and presented with considerable rates of lymph node and pulmonary metastases. (bvsalud.org)
Invasion1
Patients with lymph node and pulmonary metastases were more likely to have extrathyroidal extension and lymphovascular invasion. (bvsalud.org)
Patients1
Radiologic and FNA cytologic studies are also useful in staging patients with possible metastatic lesions. (cap.org)
Presence1
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. (lookformedical.com)
Cases1
The tumor is malignant in 10% of cases but may be cured completely by surgical removal. (medscape.com)
Mass2
The mass grossly invades the adjacent adrenal gland. (cap.org)
The typical case is characterized by a large unilateral adrenal mass with irregular edges. (medscape.com)
Studies1
However, prospective studies are needed to determine the impact of treatment on overall survival and to uncover potential side effects. (bvsalud.org)
Suggest1
While open laparotomy for adrenalectomy represents the standard of care, several reports suggest a role for laparoscopic resection if the adrenal tumor is small and there is no preoperative evidence of metastatic disease. (medscape.com)