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HemostasisBleeding TimeHemostatic DisordersPlatelet AdhesivenessBlood PlateletsPlatelet Function Testsvon Willebrand FactorPlatelet AggregationPlatelet ActivationHemostasis, SurgicalPlatelet CountThrombosisHemostasis, EndoscopicHemostatic TechniquesHemostaticsBlood CoagulationBlood Coagulation DisordersHemorrhageThrombelastographyBlood Coagulation FactorsBlood Loss, SurgicalCellulose, OxidizedPuncturesPeptic Ulcer HemorrhageFibrinogenPostoperative HemorrhageHemorrhagic DisordersFibrin Tissue AdhesiveGastrointestinal HemorrhageThrombinElectrocoagulationFibrinolysisProthrombin TimeCoagulantsBlood Coagulation TestsPartial Thromboplastin TimeThromboplastinGelatin Sponge, AbsorbableFactor VIIaSurgical InstrumentsFactor XII DeficiencyHemophilia AFactor VIIIBlood Coagulation Factor InhibitorsTissue AdhesivesFactor VIIClot RetractionFibrinHEPESTumor Necrosis Factor-alphaFactor XaSerum Albumin, BovineGelatin
VascularClotSecondary haemostasisEndoscopicBleeding disordersPlatelet functionVesselRisk StratificationDefectsFibrinAssaysHemostaticProphylacticVesselsPlateletsThrombinPatientsOccursInitialInvolvesPromotesGastrointestinalFailLiverPowder2022ClosureTissueVariantsUnitCareInjuryMajorReportJournalPlacementMonitoringMarketNormalSitePeripheral
Vascular7
  • Hemostasis is maintained in the body via three mechanisms: Vascular spasm: Vasoconstriction is produced by vascular smooth muscle cells, and is the blood vessel's first response to injury. (wikipedia.org)
  • Coughlin, S.R. (2005) Protease-activated receptors in hemostasis, thrombosis and vascular biology. (scirp.org)
  • Background: The aim of the study was to demonstrate the safety and effectiveness of a suture-mediated vascular closure device to perform hemostasis after an axillary artery access during endovascular procedures on the aortic valve, the aorta and its side branches. (lu.se)
  • While leukocyte behavior remains a major laboratory focus, we also study a variety of vascular and tissue cells, both primary and immortal lines. (upstate.edu)
  • Endothelial cells (ECs) and endothelial progenitor cells (EPCs) play crucial roles in maintaining vascular health and hemostasis. (nih.gov)
  • Platelets or thrombocytes are a critical component of vascular 'plugs' that form during hemostasis to limit blood loss secondary to vascular damage. (bvsalud.org)
  • In particular, retinal vascular occlusions says for anticardiolipin antibodies and lupus in patients with primary APS, i.e. with an- anticoagulant. (who.int)
Clot3
  • This negative surface provides binding sites for enzymes and cofactors of the coagulation system, resulting in the formation of a clot (secondary hemostasis). (medscape.com)
  • The clot in the esophagus was observed at the site of the primary hemostasis (Figure 1 ). (hindawi.com)
  • These data are consistent with the inhibition of the release of α or dense granules or their contents, thereby inhibiting certain aspects of primary hemostasis, clot formation, and endothelial repair. (cdc.gov)
Secondary haemostasis5
  • To assess the utility of ISTH-BAT to identify probable bleeders with primary or secondary haemostasis defects and to differentiate between severe and non-severe bleeders. (isth.org)
  • A total of 76 controls and 395 patients (primary haemostasis defects n=244, secondary haemostasis defects n=151) were recruited. (isth.org)
  • ISTH-BAT score had overall 98.21% sensitivity, 95% negative predictive value(NPV) to identify bleeders with primary haemostasis defects, and 93.3% sensitivity, 91.9% NPV to identify bleeders with secondary haemostasis defects. (isth.org)
  • ISTH-BAT is very useful screening tool to identify bleeders with primary/secondary haemostasis defects but may not predict bleeding severity. (isth.org)
  • Dave R, Geevar T, Mammen J, Vijayan R, Gowri M, Nair S. Utility of ISTH Bleeding Assessment Tool in identifying bleeders and predicting bleeding severity in inherited primary and secondary haemostasis defects [abstract]. (isth.org)
Endoscopic5
  • Jensen DM, Ohning GV, Kovacs TOG, Ghassemi K, Jutabha R, Dulai GS, Machicado GA. Doppler Endoscopic probe as a guide to risk stratification and definitive hemostasis of peptic ulcer bleeding . (uclahealth.org)
  • However, no strict recommendations exist in regard to the mode of action after a failure of primary endoscopic hemostasis. (hindawi.com)
  • In patients with the MWS and active bleeding or exposed vessels, the endoscopic hemostasis is warranted. (hindawi.com)
  • However, little is known on the effectiveness of endoscopic retreatment in the MWS patients after the primary endoscopic hemostasis failure. (hindawi.com)
  • A randomized controlled trial found that Hemospray TM was as effective as epinephrine injection and clipping as the primary endoscopic treatment for patients with non-variceal acute upper gastrointestinal bleeding 1 . (sages.org)
Bleeding disorders2
  • The Hemostasis & Thrombosis Center at University Hospitals Rainbow Babies & Children's Hospital's Angie Fowler Adolescent & Young Adult Cancer Institute and UH Seidman Cancer Center specializes in the care of children with congenital thrombotic disorders, bleeding disorders such as von Willebrand disease and hemophilia , and other rare conditions that increase risk for bleeding or thrombosis . (uhhospitals.org)
  • Most primary bleeding disorders can be managed. (medlineplus.gov)
Platelet function1
  • On the primary reversal endpoint, which was restoration of activity on the proprietary platelet function assays Verify Now and PRUTest, a rapid restoration of platelet function was achieved in both surgical and major-bleeding patients. (the-hospitalist.org)
Vessel5
  • In biology, hemostasis or haemostasis is a process to prevent and stop bleeding, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage). (wikipedia.org)
  • When endothelium of a blood vessel is damaged, the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor, which initiate the maintenance of hemostasis after injury. (wikipedia.org)
  • Hemostasis involves three major steps: vasoconstriction temporary blockage of a hole in a damaged blood vessel by a platelet plug blood coagulation (formation of fibrin clots) These processes seal the injury or hole until tissues are healed. (wikipedia.org)
  • It potentially results in hemostasis , the cessation of blood loss from a damaged vessel, followed by repair. (wn.com)
  • Haemostasis is the process of changing blood from a fluid to a solid-state to reduce blood loss after vessel injury. (ghoopi.com)
Risk Stratification1
  • Testing for specific mutations in these patients helps to determine the decision on the duration of anticoagulant therapy, risk stratification for primary or secondary prophylaxis. (intechopen.com)
Defects3
  • Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
  • Hemostasis tests help screen and identify patients with hemostatic defects. (medicaldevice-network.com)
  • In comparison, defects in secondary hemostasis result in delayed deep bleeding (eg, into muscles and joints) and the characteristic physical examination finding is hemarthrosis. (medscape.com)
Fibrin2
  • The initial hemostatic plug, composed primarily of platelets, is stabilized further by a fibrin mesh generated in secondary hemostasis. (medscape.com)
  • Secondary hemostasis occurs simultaneously: Additional coagulation factors or clotting factors beyond Factor VII ( listed below ) respond in a complex cascade to form fibrin strands, which strengthen the platelet plug. (wn.com)
Assays1
  • Haemostasis was evaluated by clotting assays, bleeding time and thromboelastography 10 min before and 10 min and 1, 2, 4, 8 and 24 h after factor VII infusion. (ox.ac.uk)
Hemostatic3
Prophylactic1
  • The present study assesses how the increasing awareness of the importance of early prophylaxis affected bleeding before prophylaxis, CVAD use, initial prophylactic regimens, and achievement of primary prophylaxis. (haematologica.org)
Vessels3
Platelets2
  • Platelet plug formation: Platelets adhere to damaged endothelium to form a platelet plug (primary hemostasis) and then degranulate. (wikipedia.org)
  • Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
Thrombin2
  • De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. (scirp.org)
  • The inflammation, thrombin activation, and erythrocyte lysis caused by primary injury could promote the formation of brain edema, which is associated with poor outcome, and could cause more severe and durable injury [ 3 ]. (karger.com)
Patients12
  • The purpose of this analysis was to assess potential predictors of intra-cranial bleeding (ICB) and gastrointestinal bleeding (GIB) in patients with symptomatic peripheral artery disease (PAD) in UK primary care. (thieme-connect.com)
  • After some exclusions for lack of urgency and reclassifications following adjudication, there were 113 surgical cases and 9 major bleeding patients evaluable for hemostasis. (the-hospitalist.org)
  • Adjudicated hemostasis was achieved in 100% of the 113 urgent surgical patients evaluated. (the-hospitalist.org)
  • In the nine major bleeding patients, six achieved excellent hemostasis and one achieved good hemostasis. (the-hospitalist.org)
  • The primary end point was the proportion of week 12 responders (patients with moderate or substantial improvement in IBS symptoms) on the 7-point Likert Global Improvement Scale (GIS). (researchgate.net)
  • Platelet ionized calcium mobilization (Aequorin method) in patients with primary platelet dysfunction' Thrombosis and Haemostasis. (nii.ac.jp)
  • Primary closure success was 90.3% in the 175 patients with sheaths smaller than 16F, performed after the first 5 procedures in each center. (lu.se)
  • Results: In 18 of 20 patients, the primary tumors disappeared or were markedly reduced after radiation therapy. (iiarjournals.org)
  • However, three patients had primary tumor progression at 7, 9, and 15 months after irradiation with total doses of 56.8, 58.4, and 68.3 Gy in EQD2, respectively. (iiarjournals.org)
  • The primary progression-free rate considering all patients was 69% at 1 year and 34% at 2 years. (iiarjournals.org)
  • For patients who are expected to survive for more than 1 year, almost curative-dose irradiation to primary tumors is recommended. (iiarjournals.org)
  • Even in such patients, radiation therapy has been positively used with palliative intent to relieve severe symptoms, including bleeding and pain, via primary tumor control. (iiarjournals.org)
Occurs1
  • 1,2 ] and is termed primary APS when Pakistan, a tertiary care unit with an than2pregnancylosses(intrauterine it occurs in otherwise healthy people averageof3500deliveriesperyear.A and/or neonatal deaths). (who.int)
Initial1
Involves1
  • Haemostasis also involves maintaining blood in a fluid state when there is no injury. (ghoopi.com)
Promotes2
  • Hemospray TM is a proprietary mineral powder that can be administered endoscopically and promotes hemostasis. (sages.org)
  • The adhesive layer provides mechanical compression and promotes hemostasis. (sages.org)
Gastrointestinal1
  • Subsequent studies have displayed that Hemospray TM is safe and effective in treating primary upper and lower gastrointestinal bleeding. (sages.org)
Fail1
  • Wounds, surgical sites, diseased tissue, ulcer beds and gastric varices, among others, are locations where conventional means of hemostasis ray to fail, leading to extended hospital stay or death. (justia.com)
Liver2
  • Correction of both prothrombin time and primary haemostasis by recombinant factor VII during therapeutic alcohol injection of hepatocellular cancer in liver cirrhosis. (ox.ac.uk)
  • We evaluated the efficacy of recombinant factor VII to correct impaired haemostasis in a patient with liver cirrhosis requiring an invasive procedure. (ox.ac.uk)
Powder2
  • This application claims the benefit of U.S. Provisional Application No. 62/616,751, filed Jan. 12, 2018, entitled "Powder for Achieving Hemostasis," the disclosure of which is hereby corporate by reference in its entirety. (justia.com)
  • The powder is delivered in 1-2 second bursts until hemostasis is achieved. (sages.org)
20221
  • In 2022, GlobalData's Market Model methodology determined that the leading player in the hemostasis tests market in Japan was Abbott Laboratories followed by bioMerieux , Bio-Rad Laboratories , Danaher , Diagnostica Stago, F. Hoffmann-La Roche , Quidelortho, Siemens and Werfen Life. (medicaldevice-network.com)
Closure1
  • A threshold of five percutaneous axillary accesses was associated with decreased rates of open conversion, but not with increased primary closure success. (lu.se)
Tissue3
  • Tilley, R. and Mackman, N. (2006) Tissue factor in hemostasis and thrombosis. (scirp.org)
  • The oppression and destruction by hematoma to brain tissue cause the primary brain injury. (karger.com)
  • In the first few hours after ICH onset, primary brain injury by ICH is mainly caused by the oppression and destruction to the near tissue by hematoma formation. (karger.com)
Variants2
  • The effects of pathogenic variants for inherited hemostasis disorders in 140,214 UK Biobank participants. (bvsalud.org)
  • We also demonstrated that common variants identified by genome-wide association studies (GWAS) for platelet count or thrombosis risk may influence the penetrance of rare variants in BTPD DGGs on their associated hemostasis disorders. (bvsalud.org)
Unit1
  • BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Cambridge, United Kingdom. (bvsalud.org)
Care3
  • As the hemostasis was not satisfactory a decision to do perihepatic packing with insertion of a tube drain was taken in view of the hospital setup and the patient was transferred to a secondary care hospital. (contemporaryobgyn.net)
  • METHODS: A cohort of warfarin users aged 18 to 85 years from January 2005 to April 2013 was identified in The Health Improvement Network U.K. primary care database (N = 12,506). (sdu.dk)
  • Genetics in primary care: validating a tool to pre-symptomatically assess common disease risk using an Australian questionnaire on family history. (cdc.gov)
Injury2
  • Currently, treatments for ICH are focusing on the primary injury including reducing intracranial hypertension, blood pressure control, and rehabilitation. (karger.com)
  • Currently, therapy for ICH focuses on the primary injury and preventing bleeding again, including dehydration and hemostasis. (karger.com)
Major4
  • The report offers meticulous analysis of the global hemostasis/coagulation analyzer market by thoroughly studying different assets of the market including major segments, market dynamics, regional market conditions, investment opportunities, and top players functioning in the market. (researchdive.com)
  • Furthermore, these regions are sub-divided to profile detailed panorama of the hemostasis/coagulation analyzer market across major countries in specific regions. (researchdive.com)
  • Apart from these insights, the highlights of major players functioning in the global hemostasis/coagulation analyzer market is also covered in the report. (researchdive.com)
  • Company profile of each player includes several data points such as short overview of the company, major company executives, company's financial status and revenue, major business strategies implemented by company, innovative developments or initiatives taken by company to shove their position and standout among other competitors in the global hemostasis/coagulation analyzer market. (researchdive.com)
Report4
  • The report offers market size and forecast by keenly evaluating every segment of the global hemostasis/coagulation analyzer market. (researchdive.com)
  • The report divides the global hemostasis/coagulation analyzer market into four main regions including Europe, North America, Asia-Pacific, and LAMEA. (researchdive.com)
  • The research report is formed by collating different statistics and information concerning the hemostasis/coagulation analyzer market. (researchdive.com)
  • GlobalData uses proprietary data and analytics to provide a comprehensive report on the hemostasis tests market in Japan. (medicaldevice-network.com)
Journal3
Placement1
Monitoring1
Market3
  • The global hemostasis/coagulation analyzer market is estimated to surpass $5,601.5 million by 2027, exhibiting a CAGR of 4.7% from 2020 to 2027. (researchdive.com)
  • A detailed overview of 10 leading players operating in the global hemostasis/coagulation analyzer market is provided to understand their status and hold over the market share. (researchdive.com)
  • The hemostasis tests market in Japan can expand or contract due to a variety of reasons including population demographics, disease incidence and prevalence, macroeconomic issues, and geopolitical considerations. (medicaldevice-network.com)
Normal1
Site2
  • Then use the microneedle holder to dissect the infrarenal aorta and IVC en bloc from the lateral and dorsal surrounding retroperitoneal tissues to cross-clamp the tissues together, and dissect the surrounding tissues to expose the aortic puncture site at approximately three-quarters of the distance from the left renal vein to the aortic bifurcation. (jove.com)
  • This category will also be used in primary coding to classify bacterial infections of unspecified nature or site. (cdc.gov)
Peripheral1
  • We attempt here to present a similar case of undiagnosed Primary hepatic Pregnancy presenting in a collapsed state at our peripheral hospital, on 5.2.2003. (contemporaryobgyn.net)