• The A29-Cw16-B44-DR7-DQ2 haplotype is in strong linkage disequilibrium particularly in Northwestern Europe. (wikipedia.org)
  • This haplotype is found in Korea but not Japan, in fact Japan is an antinode of DR7. (wikipedia.org)
  • The cause of the clinically apparent hepatotoxicity from abacavir is hypersensitivity in some cases and is typically associated with the HLA-B*57:01 haplotype. (nih.gov)
  • Human leukocyte antigen (HLA) haplotype DQ2 or DQ8 identified by molecular genetic testing of HLA-DQA1 and HLA-DQB1 . (nih.gov)
  • The association between aPL antibodies and particular human leukocyte antigen (HLA) alleles and HLA-linked epitopes has been reported in studies of patients with lupus erythematous (eg, HLA-DR7, HLA-DR4). (medscape.com)
  • The HLA-DR3 phenotypes seem to predispose to the formation of aCL antibodies and antinuclear antibodies (ANAs), but this has not been confirmed in patients, and particular HLA alleles associated with recurrent miscarriage have not been reported. (medscape.com)
  • HLA-DRB1 and DQB1 alleles were typed using amplified DNA hybridized with sequence-specific primers. (nih.gov)
  • Compared to controls, PAPS patients exhibited a nonsignificantly increased frequency of DR53-associated alleles, and SAPS patients presented an increased frequency of HLA-DRB1*03 alleles (corrected P = 0.05). (nih.gov)
  • The frequency of aCL among SLE patients presenting or not HLA-DRB1*03 alleles was closely similar. (nih.gov)
  • Role of HLA-DQB1 alleles in the risk, signs and symptoms, and severity of celiac disease in a Venezuelan population. (cdc.gov)
  • Differential expression of predisposing HLA-DQ2.5 alleles in DR5/DR7 celiac disease patients affects the pathological immune response to gluten. (cdc.gov)
  • Association between HLA alleles and risk of celiac disease in Iranian patients. (cdc.gov)
  • DR7-DQ2/DR5-DQ7 phenotype (transhaplotype encoded isoform DQα5β2) is the primary risk DQ isoform in celiac disease. (wikipedia.org)
  • HLA Genotyping in Romanian Adult Patients with Celiac Disease, their First-degree Relatives and Healthy Persons. (cdc.gov)
  • Enhanced Extracellular Transfer of HLA-DQ Activates CD3 Lymphocytes towards Compromised Treg Induction in Celiac Disease. (cdc.gov)
  • HLA-DQ genotype distribution and risk evaluation of celiac disease in Northwest China. (cdc.gov)
  • Human Leukocyte Antigen DQ (HLA-DQ) genotypes and haplotypes and their association with phenotype in patients with celiac disease in India. (cdc.gov)
  • Low-Risk Human Leukocyte Antigen Genes and Mild Villous Atrophy Typify Celiac Disease With Immunoglobulin A Deficiency. (cdc.gov)
  • HLA-DQ genotypes relative risks for celiac disease in Arabs: A case-control study. (cdc.gov)
  • HLA-DQB1*02 allele in children with celiac disease: Potential usefulness for screening strategies. (cdc.gov)
  • Influence of HLA on clinical and analytical features of pediatric celiac disease. (cdc.gov)
  • Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 allelic variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. (nih.gov)
  • The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. (wjgnet.com)
  • Women with the clinical features of APS should be tested for 3 antiphospholipid antibodies that have proven association with the diagnosis of APS: lupus anticoagulant (LAC), anticardiolipin (aCL) antibody, and anti-beta-2glycoprotein I antibody. (medscape.com)
  • DR53-DR7 may be associated with sclerosis/lupus associated anti-apolipoprotein antibodies. (wikipedia.org)
  • To assess whether the major histocompatibility complex (MHC) profile of patients presenting with primary antiphospholipid syndrome (PAPS) is different from that of patients with secondary antiphospholipid syndrome (SAPS), we studied 123 patients, 34 of whom presented PAPS and 35 SAPS due to systemic lupus erythematosus (SLE), 54 SLE patients without antiphospholipid syndrome (APS), and 166 controls. (nih.gov)
  • Is HLA class II susceptibility to primary antiphospholipid syndrome different from susceptibility to secondary antiphospholipid syndrome? (nih.gov)
  • Primary APS is diagnosed in patients demonstrating the clinical and laboratory criteria for the disease without other recognized autoimmune disease. (medscape.com)
  • Animals immunized with aCL or with the cofactor beta-2 glycoprotein I (b2GPI) develop clinical manifestations of APS, including fetal loss, thrombocytopenia, and neurologic and behavioral dysfunction, along with elevated levels of aPL antibodies. (medscape.com)
  • The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. (wjgnet.com)
  • Goodpasture's name has been used in a more specific clinical condition known as Goodpasture disease, which is the pulmonary renal syndrome specifically associated with anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
  • Before starting abacavir, she had tested negative for the HLA B*57:01 allele and had normal serum aminotransferase levels. (nih.gov)
  • In vivo infusion of each of the anti-b2GPI antibodies into BALB/c mice followed by administration of the corresponding specific peptides prevents the peptide-treated mice from developing experimental APS. (medscape.com)
  • Abacavir binds to the antigen-binding cleft of the HLA-B*57:01 molecule and alters its peptide binding repertoire. (nih.gov)
  • Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. (wjgnet.com)
  • Collagenous Colitis Is Associated With HLA Signature and Shares Genetic Risks With Other Immune-Mediated Diseases. (cdc.gov)
  • In the airway, the innate immune response to environmental agents gives rise to inflammation, enhancement of antigen presentation, and development of the primary (acquired) immune response. (nih.gov)
  • It has been suggested that the primary acquired immune response to a given antigen is influenced by the nature of the innate immune system (and its associated cytokine response). (nih.gov)
  • APS is classified as primary or secondary, depending on its association with other autoimmune disorders. (medscape.com)
  • Taken together, these results indicate that the association of SAPS with HLA-DRB1*03 is due to the association with SLE and is not due to aCL, and suggest that the HLA class II profile of PAPS is different from that of SAPS. (nih.gov)
  • Exposure of endothelial cells to anti-b2GPI antibodies and their corresponding peptides leads to the inhibition of endothelial cell activation, as shown by decreased expression of the adhesion molecules E-selectin, intercellular adhesion molecule, and vascular cell adhesion molecule and of monocyte adhesion. (medscape.com)
  • The Col 4α3NC1 epitope is thought to be less accessible for anti-GBM binding in the lung, and partial denaturation of NC1 domains may be required for full exposure of this sequestered epitope to the antibody. (medscape.com)
  • These antibodies predispose to clotting in vivo, predominantly by interfering with the antithrombotic role of PLs. (medscape.com)
  • The discovery of the role of anti-GBM antibodies by Lerner et al in 1967 helped provide both a better understanding of the pathogenesis for this specific form of pulmonary renal syndrome and a more rational approach to treatment. (medscape.com)
  • Anti-GBM disease is defined as the triad of glomerulonephritis (usually rapidly progressive or crescentic), pulmonary hemorrhage, and anti-GBM antibody formation. (medscape.com)
  • DR7-DQ2/DR5-DQ7 (/DR11-DQ7 or /DR12-DQ7) is a clarifying identifier for the at risk transhaplotype. (wikipedia.org)
  • Because pulmonary renal syndrome is discussed extensively elsewhere (see Wegener Granulomatosis ), this article focuses on the specific form of this syndrome associated with anti-GBM antibodies. (medscape.com)
  • The aCL antibodies bind to b2GPI, or a complex formed by this b2GPI is a platelet adhesin glycoprotein and cardiolipin. (medscape.com)
  • It only set of three individual notions: a real everything, a time of antibody, and an complex and Basic thrombosis. (geile-internetseiten.de)
  • In patients with primary APS, the presence of the 3 aCL isotypes plus LAC has been associated with a higher number of recurrent spontaneous abortions, compared with other possible combinations of aCL isotypes. (medscape.com)