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  • Pitavastatin is a HMG-CoA reductase inhibitor that is FDA approved for the treatment of primary hyperlipidemia and mixed dyslipidemia . (wikidoc.org)
  • Pitavastatin is indicated as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia. (wikidoc.org)
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  • Hyperlipidemias are also classified according to which types of lipids are elevated, that is hypercholesterolemia, hypertriglyceridemia or both in combined hyperlipidemia. (wikipedia.org)
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  • Amgen's Repatha (evolocumab) and Sanofi/Regeneron's Praluent (alirocumab) haven't quite broken into diabetes treatment algorithms, but Dr. Farkouh sees a clear niche for these more potent lipid-lowering agents - people with comorbid diabetes and hyperlipidemia despite maximally-tolerated statin therapy. (closeconcerns.com)
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  • ZOCOR has not been studied in conditions where the major abnormality is elevation of chylomicrons (i.e., hyperlipidemia Fredrickson types I and V). (globalrph.com)
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  • Primary hyperlipidemia is usually due to genetic causes (such as a mutation in a receptor protein), while secondary hyperlipidemia arises due to other underlying causes such as diabetes. (wikipedia.org)
  • Hyperlipidemias may basically be classified as either familial (also called primary) when caused by specific genetic abnormalities or acquired (also called secondary) when resulting from another underlying disorder that leads to alterations in plasma lipid and lipoprotein metabolism. (wikipedia.org)
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  • This paper reviews the role of currently available antiplatelet drugs in primary and secondary prevention of vascular events in diabetic patients and the limitations of these drugs, and it discusses the role of novel and more potent antiplatelets and of new agents currently under clinical development. (hindawi.com)
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  • 2] A patient meets the criteria of primary or secondary FSS if painful, restricted active and passive glenohumeral and scapulothoracic motion occurs for at least 1 month and has either reached a plateau or worsened. (medscape.com)
  • We saw new analyses of CANVAS and EXSCEL, investigating differential effects of diabetes drugs in primary vs. secondary CV prevention. (closeconcerns.com)
  • 1. Stanford's Dr. Kenneth Mahaffey discussed a subgroup analysis of CANVAS suggesting consistent CV and renal benefits to Invokana (canagliflozin) therapy across primary and secondary prevention cohorts. (closeconcerns.com)
  • Lipid-lowering therapy is important for secondary prevention for patients with known cardiovascular disease, as well as for primary prevention for those at increased risk. (medscape.com)
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  • Praluent is approved to lower LDL cholesterol in adults with primary hyperlipidemia (high cholesterol). (medicalnewstoday.com)
  • For adults with primary hyperlipidemia, including HeFH, the usual starting dosage of Praluent is either 75 mg once every 2 weeks or 300 mg once every 4 weeks. (medicalnewstoday.com)
  • 3) In adults with HTN, do various antihypertensive drugs or drug classes differ in comparative benefits and harms on specific health outcomes? (pharmacytimes.com)
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  • Drug classes used to treat cardiovascular indications such as hyperlipidemia, hypertension are likely to fuel expansion of the global cardiovascular drugs market from 2017 to 2025. (ipsnews.net)
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  • High on his wish list is a UKPDS-like outcomes study that uses advanced diabetes drug classes to normalize blood glucose in patients very recently-diagnosed with type 2 - we were hooked. (closeconcerns.com)
  • Investigators reviewed 23 studies (including VA studies) to assess the effects of interactive communication between collaborating primary care physicians and key specialists on outcomes for patients receiving ambulatory care who also had received psychiatric, endocrine, or cancer diagnoses. (va.gov)
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  • But over the long term, I wonder if precision medicine and personalized targeting of drugs to specific (and smaller) patient sub-populations will gradually reduce the TAM for each individual drug, resulting in a fragmented competitive landscape where some drugs work for some patients some of the time. (decodingbio.com)
  • Physicians used these PIs in combination with other HIV drugs to great effect, halting the disease in its tracks for many patients. (communitycatalyst.org)
  • When Norvir was taken with PIs, therapeutically effective blood levels of the PIs could be consistently maintained, and the PIs could be taken at smaller doses, sparing patients many of the severe side effects associated with the drugs. (communitycatalyst.org)
  • 70% of patients) is nephrotic syndrome, characterized by generalized edema, massive proteinuria, hypoalbuminemia, and hyperlipidemia. (medscape.com)
  • In both groups, the patient s treatment is performed according to standard treatment procedures for patients with hypertension, hyperlipidemia, and atrial fibrillation, so there is no problem with 1:1 randomization. (who.int)
  • This publication is designed to help the primary care practitioner in the day-to-day management of patients with diabetes. (cdc.gov)
  • Elevated levels are found in patients who chronically take drugs such as phenobarbital and phenytoin. (cdc.gov)
  • Les dossiers de 622 patients âgés en moyenne de 58,3 ans (écart type 12,9) ont été étudiés. (who.int)
  • Des stratégies préventives doivent être mises en oeuvre afin d'améliorer le pronostic à long terme des patients libyens et de réduire la morbidité et la mortalité globales dues à la coronaropathie. (who.int)
  • Since 2000, blockbusters have gradually shifted from primary (e.g., hyperlipidemia) to speciality (autoimmune, oncology). (decodingbio.com)
  • If the safety endpoint was met, the trial would proceed to completion and assess the primary efficacy endpoint of superiority of the drug for MACE plus hospitalisation for unstable angina, heart failure, or any coronary revascularisation. (escardio.org)
  • The composite of MACE plus hospitalisation for unstable angina, heart failure, or any coronary revascularisation occurred in 11.8% of participants taking the drug and 12.1% of those on placebo (p=0.55). (escardio.org)
  • Family history of hyperlipidaemia and coronary artery disease. (syrianclinic.com)
  • Along with hypertension, diabetes, and smoking, hyperlipidemia has consistently been shown to be one of the most significant and modifiable risk factors for coronary artery disease development and progression. (medscape.com)
  • Consequently, measurement of treatment - drugs or diet - purporting a beneficial reduction in CAD, cannot rely on serum blood testing to demonstrate such benefit. (bmj.com)
  • Cholesterol, Triglycerides and the treatment of hyperlipidemias. (bmj.com)
  • Clinical treatment of cerebrovascular diseases usually involves controlling the condition through thrombolysis, anticoagulation and repair of damaged nerves, but there is still a lack of specific drugs and related treatment plans. (ijpsonline.com)
  • Available antiplatelet agents, such as cyclooxygenase-1 (COX-1) inhibitors (aspirin), ADP P2Y 12 receptor antagonists, and GP IIb/IIIa receptor inhibitors, are effective and save in the treatment and prevention of thrombotic events, these drugs interfere with the platelet activation process, including adhesion, release, and aggregation. (hindawi.com)
  • Although not a core focus of the Company, Metabasis has also discovered and developed drug candidates indicated for the treatment of liver diseases such as hepatitis and primary liver cancer, which it now intends to license or partner. (salesandmarketingnetwork.com)
  • Investigators conducted a systematic review of published studies from January 1985 through June 2015 to assess clozapine's effects on treatment response, suicides, adverse drug reaction rates (and associated mortality), as well as the effects on inpatient hospitalization. (va.gov)
  • If all Veterans with treatment-resistant schizophrenia initiated clozapine, it would result in an additional 743 serious adverse drug reactions (ADRs) in year one. (va.gov)
  • HIV-infected persons receive ongoing primary care within the CID one-stop shopping model and experience seamless transitions between diagnosis, assessment, and treatment. (bmc.org)
  • The CID staff creates an individualized treatment plan for each patient receiving HIV treatment and primary care. (bmc.org)
  • They may already be convinced that the only way forward can be through treatment with drugs. (diabetesonthenet.com)
  • The leading treatment provided at ambulatory probability provider-based surveys of care visits was medicinal with 71.3 percent of all visits having one or more visits to nonfederal office-based medications prescribed, up by 10% since 1995 when encounters with drug therapy physicians and EDs and OPDs of represented 64.9 percent of all visits. (cdc.gov)
  • For instance, Crestor launched by Astrazeneca and indicated for the treatment of hyperlipidemia, lost patent in early 2016 and in April 2016, the U.S. FDA approved first generic to this drug to Watson Pharmaceuticals Inc. (ipsnews.net)
  • drugs used for the treatment of high blood ayurvedic blood pressure medicine pressure and stress his or situation. (cnrs.fr)
  • While Kaletra was a very effective boosted PI treatment, it was associated with serious side effects, including hyperlipidemia, lipodystrophy, and gastric problems. (communitycatalyst.org)
  • Several NTM strains are resistant to many antimicrobial drugs, making treatment difficult ( 3 ). (cdc.gov)
  • Drug : According to the current atrial fibrillation guidelines, the target number of single-center, prospective study-blind randomization targets was calculated at a ratio of 1:1 between the simultaneous targeted upstream therapy group and the general treatment group. (who.int)
  • The 1982 publication of The Prevention and Treatment of Five Complications of Diabetes: A Guide for Primary Care Practitioners was an initial attempt to provide straightforward and practical information that primary care practitioners could immediately apply in their practice in the diagnosis and prevention of complications of diabetes. (cdc.gov)
  • Factors that may contribute to this greater platelet reactivity are not completely elucidated and include metabolic abnormalities as hyperglycemia, hyperlipidemia, insulin resistance, and conditions as oxidative stress, inflammation, and endothelial dysfunction [ 3 ]. (hindawi.com)
  • AMPK has received considerable attention over the past several years based on its potential as a drug target for metabolic diseases. (salesandmarketingnetwork.com)
  • We look forward to continuing our strong relationship with Merck and its talented team of scientists on this attractive drug target for metabolic diseases. (salesandmarketingnetwork.com)
  • Metabasis' core area of focus is on the discovery and development of drug candidates to treat metabolic diseases such as hyperlipidemia and diabetes, among others. (salesandmarketingnetwork.com)
  • However, scientists and physicians soon noticed that Norvir had a striking effect on certain metabolic pathways in the liver, dramatically slowing the metabolism of many types of drugs, including PIs. (communitycatalyst.org)
  • If the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus and the lack of known clinical benefit with continued use during pregnancy. (wikidoc.org)
  • Merck will continue to fund research efforts at Metabasis for this project and has primary responsibility, including financial responsibility, for clinical development of any resulting therapeutic candidates as well as the right to market any products derived from the collaboration worldwide. (salesandmarketingnetwork.com)
  • Hyperlipidemia is a common disease state encountered in the clinical setting and guidelines have been recently updated to discuss the role of therapies, therapeutic goals, and other clinical considerations. (freece.com)
  • This partially helps explain why positive clinical data that de-risks novel biology in a historically graveyard indication or modality results in a flurry of investment and activity as others rush to follow (I have a weird mental model that likens drug development to a minefield). (decodingbio.com)
  • Risk factors include age 65 years or greater, uncontrolled hypothyroidism, renal impairment, concomitant use with certain other drugs, and higher pravastatin sodium dosage. (nih.gov)
  • Praluent belongs to a group of drugs known as PCSK9 inhibitors. (medicalnewstoday.com)
  • Launch of PCSK9 inhibitors (Praluent) for treating hyperlipidemia in 2016 is likely to fuel expansion of anti-hyperlipidemia drugs market segment by 2025 augmenting global cardiovascular drugs market. (ipsnews.net)
  • Drug therapy should be one component of multiple-risk-factor intervention in individuals who require modifications of their lipid profile. (wikidoc.org)
  • Drug therapy is indicated as an adjunct to diet when the response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has been inadequate. (globalrph.com)
  • Adjuctive therapy to diet in the management of primary hyperlipidemia or mixed hyperlipidema. (unboundmedicine.com)
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  • In pregnancy as mentioned earlier the lipid concentration in blood increases, if the concentration of the lipids in the blood is not controlled it results in the increase in the concentration of the lipid in the perinatals and may be leads obesity and/or hyperlipidemia [ 25 - 31 ]. (omicsonline.org)
  • A person with hyperlipidemia, for example, may exhibit the signs and symptoms associated with obesity and an imbalanced diet (shortness of breath, numerous skin diseases, and extra body fat). (postmyblogs.com)
  • For these uses, your doctor may prescribe Zetia along with other drugs to reduce high cholesterol . (healthline.com)
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  • Praluent is a brand-name biologic drug. (medicalnewstoday.com)
  • For information on the dosage of Praluent, including its form, strengths, and how to take the drug, keep reading. (medicalnewstoday.com)
  • Introduction of new anti-hyperlipidemia drug such as PCSK9 Inhibitor (Praluent) and increasing incidences of hyperlipidemia is likely to propel expansion of the segment. (ipsnews.net)
  • The drug has a half-life of 5 h through liver metabolism and will not remain in the body, resulting in high safety. (ijpsonline.com)
  • but residual dyslipidaemia may in such cases be due to primary disorders of metabolism. (bvsalud.org)
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  • The advent of this powerful new class of drugs helped transform HIV disease from a death sentence into a chronic, manageable illness. (communitycatalyst.org)
  • By inhibiting the production of LDL and VLDL the risk factors for the hyperlipidemia can be controlled, Bile acid sequestrants like Cholestyramine, Colestipol and Colesevelam are used to regulate high serum levels by binding the bile acid which is secreting from liver to metabolize the triglycerides [ 20 - 24 ]. (omicsonline.org)
  • Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
  • A person with hyperlipidemia will typically not have any specific symptoms other than those related with risk factors and/or causes. (postmyblogs.com)
  • HEARTS is the core technical package of the initiative and takes a public health approach to treating hypertension and other CVD risk factors at the primary health care level. (cdc.gov)
  • Recent developments in biologic cardiovascular drugs such as Pfizer's PCSK9 inhibitor, Esperion Therapeutics' novel LDL-lowering drug ETC-1002 and Merck's CETP inhibitor anacetrapib, uncovers the potential of these drugs. (ipsnews.net)
  • Fibrate drugs may increase the amount of cholesterol in your bile, which could lead to gallstones . (healthline.com)
  • An animal study of Zetia found that the drug increased cholesterol in bile, but it's not known if this effect also happens in humans. (healthline.com)
  • More than half (57%) had diabetes, 90% had hypertension, 94% had hyperlipidaemia, and 20% had renal insufficiency. (escardio.org)
  • pulmonary arterial hypertension drug companies.These how long for diuretic to lower blood pressure function are used in the form of renal magnesium in the body. (atime.org)
  • In her discussant, Oxford's Dr. Angelyn Bethel was skeptical that Invokana's benefits to three-point MACE apply in a primary prevention population (she posed important questions related to mechanism to build her argument), but she expressed more confidence that the drug's heart failure and renal benefits do translate. (closeconcerns.com)
  • He highlighted non-significant p-values for interaction - 0.2 for all-cause death and 0.79 for the primary outcome of three-point MACE (non-fatal MI, non-fatal stroke, or CV death). (closeconcerns.com)
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  • This includes trials powered for superiority and trials that look more closely at primary prevention. (closeconcerns.com)
  • OBJECTIVE: To estimate the costs of implementing the HEARTS program for hypertension control and cardiovascular disease (CVD) prevention in the primary care setting in Ethiopia for adult primary care users in the catchment area of five examined facilities. (cdc.gov)
  • Hyperlipidemia is abnormally high levels of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood. (wikipedia.org)
  • The drug also led to small improvements in levels of triglycerides, blood glucose, heart rate and blood pressure. (escardio.org)
  • Hyperlipidemia is characterized by unusually high levels of lipids (fats) in the blood, which include cholesterol and triglycerides. (postmyblogs.com)
  • John C , Neal W. Screening children for hyperlipidemia by primary care physicians in West Virginia. (wvu.edu)
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  • Interactive communications between collaborating primary care physicians (PCPs) and specialists were associated with improved patient outcomes. (va.gov)
  • Interactive communication methods included: initial joint patient consultations, regular specialist attendance at primary care team meetings, telepsychiatry with primary care physicians, scheduled phone discussions, and shared electronic progress notes. (va.gov)
  • however, the consistency of the effects across different primary care-specialty collaborations, healthcare conditions, and study designs suggests the potential for improvement across other specialties and conditions. (va.gov)
  • Poor coordination between primary and specialty care can contribute to avoidable patient morbidity and mortality. (va.gov)
  • However, it is uncertain whether collaborative care models that enable interactive communication - timely two-way exchange of patient information between primary care and specialists - improve patient outcomes. (va.gov)
  • Physician offices are further classified were combined to produce averaged annual estimates of ambulatory medical care by the physician specialty: primary care, utilization. (cdc.gov)
  • Black persons had higher visit rates than white persons to Disease Control and Prevention's hospital OPDs and EDs, but lower visit rates to office-based primary care and to National Center for Health Statistics. (cdc.gov)
  • One-half of ambulatory medical care visits (49.0 percent) were to primary care physicians in office-based practices. (cdc.gov)
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  • 1.The aim is to improve the provision of health services to the population through well organized primary health care services. (who.int)
  • Data regarding staffing, availability of essential services, drugs and equipments in the studied PHC f facility was analysed, and the primary results revealed that no declared catchment area and both a quantitative & qualitative inadequacy in all health resources at the studied primary health care facility. (who.int)
  • Determining the tasks and who will accomplish them, determining the time and cost for every task, assigning the data collectors, and selection of the primary health care facility to be studied. (who.int)
  • For selection of a primary health care facility that will be studied, one district in Benghazi was selected randomly at first. (who.int)
  • RESULTS: The estimated cost per adult primary care user was USD 5.3 for hypertension control and USD 19.3 for integrated CVD risk management. (cdc.gov)
  • The drugs which are used lower the low density lipoproteins (LDL) in the blood by preventing the conversion of them from high density lipoproteins by interrupting the various steps during lipolysis [ 6 - 11 ]. (omicsonline.org)
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  • According to our latest study, the global Rosuvastatin Drugs market size is USD million in 2022 from USD million in 2021, with a change of % between 2021 and 2022. (marketandresearch.biz)
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  • The number of rare disease drugs has increased to the point that 57% of drugs approved by the FDA in 2022 were orphan drugs. (decodingbio.com)
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  • For more information about some of these interactions, see the "Drug interactions explained" section below. (healthline.com)
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  • See full prescribing information for dosage modifications due to drug interactions ( 2.5 , 7 ). (nih.gov)
  • The drug also modulates nitric oxide synthase (NOS) expression and reduces ischemic-reperfusion injuries in rat hearts (PMID: 15914111). (pediatriconcall.com)
  • The controversy over the risk benefit ratio of these lipid lowering drugs and dietary regimens represents a problem, not only because of information not being released by BigPharma, but because of information not being released by BigFood and purported dietary pundits. (bmj.com)