Cutaneous lupus erythematosus (CLE) is an interferon (IFN)-driven autoimmune disease that may be limited to the skin or can be associated with systemic lupus erythematosus (SLE). (frontiersin.org)
Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune skin disease that can occur isolated to the skin or with additional systemic manifestation in several organs [systemic lupus erythematosus (SLE)] ( 1 ). (frontiersin.org)
Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)
Systemic lupus erythematosus (SLE) is more common and severe among Black and Asian patients than among White patients. (merckmanuals.com)
Rheumatoid Arthritis (RA) Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
Lupus erythematosus, discoid LE, systemic LE. (cyberderm.net)
F:M = 3:1, in systemic lupus erythematosus 8:1. (cyberderm.net)
Recently, we have implemented and successfully applied a method based on genotype imputation of rare variation, on a set of genes detected by exome sequencing as possible candidates for association to systemic lupus erythematosus (SLE) by mutation in members of Icelandic SLE-multicase families ( 15 ). (frontiersin.org)
Cutaneous lupus erythematosus (CLE) comprises multiple dermatological disorders, which may be skin-limited or found in association with underlying systemic lupus erythematosus (SLE). (cdc.gov)
Discoid lupus erythem5
However, B cells are increasingly considered to have additional functions, supported by studies finding them to occur in highest numbers in chronic discoid lupus erythematosus (CDLE), a subtype in which autoantibodies are often absent. (frontiersin.org)
CCLE can be further subdivided into chronic discoid lupus erythematosus (CDLE), lupus erythematosus profundus (LEP) and chilblain lupus erythematosus (ChLE), of which CDLE represents the most frequent CCLE subtype ( 4 ). (frontiersin.org)
In discoid lupus erythematosus persistent several mm to cm sharply bordered, sometimes confluent, and painful lesions with triad of erythema, follicular keratotic plugs, and atrophy (each of which can dominate clinical picture). (cyberderm.net)
Age-standardized incidence rates stratified by sex and race were calculated for discoid lupus erythematosus (DLE) in particular and for CCLE in general. (cdc.gov)
CLE can be classified based on clinical and histopathologic findings: typical morphological subsets are acute cutaneous (ACLE), subacute cutaneous (SCLE), intermittent cutaneous [ICLE, also termed lupus erythematosus tumidus (LET)], and chronic cutaneous (CCLE) lupus erythematosus ( 2 , 3 ). (frontiersin.org)
Treatment of underlying disease - Suppression of activity of the associated autoimmune disease is suggested based upon the theory that autoimmune disease-related tissue injury contributes to risk for cutaneous calcification ( algorithm 1 ) [ 2 ]. (medilib.ir)
Relative to SLE, epidemiologic studies on chronic cutaneous lupus erythematosus (CCLE) are rare and limited to populations without racial diversity. (cdc.gov)
Profundus1
CCLE: Epidermal atrophy, hyperkeratosis (primarily follicular), vacuolar degeneration of basal keratinocytes, thickened basement membrane zone (PAS stain), edema, dense lymphocytic perivascular and periadnexal infiltrate at all levels, and, including subcutaneous fat in lupus profundus. (cyberderm.net)
Connective-tissue3
It includes lipophagic granulomatous panniculitis and other types of panniculitis, primarily associated with connective-tissue disease. (medscape.com)
Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
Is the underlying autoimmune connective tissue disease adequately treated? (medilib.ir)
Etiology3
The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
CONCLUSION: The presence of ghost adipocytes is a rather unique histopathological feature consistent with pancreatic panniculitis and should be considered in combination with the overall clinical picture to determine the underlying etiology. (bvsalud.org)
The present study aimed to report all the cases of children admitted to our tertiary pediatric hospital with the diagnosis of EN to evaluate the epidemiology, clinical manifestations, etiology, treatment, and the course of this disease in the pediatric age. (bvsalud.org)
Chronic1
Chronic inflammatory autoimmune disease with marked immunogenetic component which involves the skin and/or other organs. (cyberderm.net)
Rarely2
Rarely squamous cell carcinoma (lupus carcinoma) develops in old DLE scars. (cyberderm.net)
Lipophagic lobular panniculitis, an entity of unknown origin, may lead to circumferential fat atrophy of the ankles and may represent an end-stage manifestation of an idiopathic lobular panniculitis of children localized to the lower part of the lower limbs. (medscape.com)
Erythema nodosum (EN), although relatively uncommon in the pediatric population, is the most frequent type of panniculitis in children. (bvsalud.org)
Subcutaneous1
Germline HAVCR2 mutations are frequently detected in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients with/without hemophagocytic lymphohistiocytosis (HLH) but factors associated with variable manifestations remain undetermined. (bvsalud.org)
Occurs1
Connective-tissue disorder-associated lipoatrophic panniculitis may be observed at any age, but it occurs most frequently in adults aged 20-60 years. (medscape.com)
Diagnosis3
This observational study retrospectively considered all children evaluated to the emergency room (ER) of Meyer Children's University Hospital, Florence, Italy, discharged with a diagnosis of EN over a 12-year period (from January 2009 to December 2021). (bvsalud.org)
The etiologic diagnosis of EN was made in 38 children (55.9%): 29 (42.6%) had infection-related EN (in particular EBV and ß-hemolytic streptococcus), 6 (8.8%) had Crohn's disease, 1 celiac disease, 1 Sjogren syndrome, and 1 Hodgkin lymphoma. (bvsalud.org)
In 30 patients (45%), no definitive diagnosis was reached, and they were defined as having idiopathic EN. (bvsalud.org)
Involvement1
Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and autoimmune cytopenias. (merckmanuals.com)
Represents1
The third type represents a sequela from various types of panniculitis and is associated with preceding inflammation. (medscape.com)
Involves1
Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
Dermatology1
The Georgia Lupus Registry used multiple sources for case finding, including dermatology and rheumatology practices, multispecialty healthcare facilities, and dermatopathology reports. (cdc.gov)
Disease1
Pancreatic panniculitis can be a primary presenting feature and possible complication of pancreatic disease. (bvsalud.org)
Association1
Genome-wide association studies have been designed primarily to capture common variation and so far some 10,000 common genetic variants have been robustly associated with a wide range of complex diseases ( 1 ). (frontiersin.org)
Keratinocytes1
Lupus erythematosus (LE) skin lesions typically feature a histopathologic pattern termed interface dermatitis, defined by the presence of necroptotic keratinocytes and an epitheliotropic cytotoxic lymphocytic infiltrate at the dermo-epidermal junction ( 7 , 8 ). (frontiersin.org)
SLE may be precipitated by currently unknown environmental triggers that cause autoimmune reactions in genetically predisposed people. (merckmanuals.com)
Injury1
The specificity of autoimmune injury to cartilaginous tissues has led investigators to test the hypothesis that a cartilage-specific autoantibody is central to the pathogenesis of relapsing polychondritis. (medscape.com)
Patients1
Sixty-eight patients with EN were included. (bvsalud.org)