Previously interleukin 2. Medical search. Frequent questions

This cross-linking results in potentially patho- important to healthcare workers evaluating persons with logic levels of proinflammatory cytokines, such as tumor potential exposures to these agents, including in the con- necrosis factor , interleukin 2, and interferon- (1,2). (cdc.gov)
Interleukin 36 receptor antagonist (IL-36RA) is a member of the interleukin-36 family of cytokines. (wikipedia.org)
The protein is known to inhibit the effects of Interleukin-36 cytokines (IL-36α, IL-36β and IL-36γ) via competing with their receptor IL-36R/IL1RL2 and thereby inhibiting their proinflammatory effects. (wikipedia.org)
We have previously shown that the in vitro culture of Spirulina with human peripheral blood mononuclear cells (PBMCs) modulated the production of cytokines. (nih.gov)
In the present study, we evaluated the impact of a Spirulina-based dietary supplement (Earthrise Nutritionals, Inc., Irvine, CA) on patients with allergic rhinitis by assessing the production of cytokines [interleukin (IL)-4, interferon (IFN)-gamma, and IL-2] critical in regulating immunoglobulin E-mediated allergy. (nih.gov)
Although Spirulina seemed to be ineffective at modulating the secretion of Th1 cytokines (IFN-gamma and IL-2), we discovered that Spirulina, administered at 2,000 mg/day, significantly reduced IL-4 levels by 32% from PHA-stimulated cells. (nih.gov)
T MK-3697 cells expressing type 1 [interferon-and interleukin-2 (IL-2)] and type 17 (IL-17F) cytokines. (fabretp.org)
Models of inflammatory bowel disease have been described in animals in which particular cytokines such as interleukin (IL)-2 and IL-10 have been eliminated. (ppdg.net)

We believe that our composition inhibits the synthesis and expression of interferon gamma and interleukin-2, stimulates the PPARy receptor and inhibits the NF kappaB factor. (naturalproductsinsider.com)
Results: EvCAR-KHYG-1 cells produced interleukin-2, interferon-γ, and tumour necrosis factor-α on EGFRvIII-expressing U87MG cells. (iiarjournals.org)

Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. (diabetesjournals.org)
Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. (lu.se)
Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. (lu.se)

[ 2 ] The American Cancer Society estimates that 7650 people will die from melanoma in 2022. (medscape.com)
In 185 patients with locally advanced stage III or stage IV melanoma, patients receiving gp100 plus interleukin-2 had higher response rates and progression-free survival (PFS) than did patients taking interleukin-2 alone. (hcplive.com)
In this phase III trial, 502 patients with previously untreated metastatic melanoma were randomized to receive either ipilimumab plus dacarbazine, or dacarbazine plus placebo. (hcplive.com)
gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. (hcplive.com)
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. (hcplive.com)
1 , 2 ] Since the early 2000s, the incidence of melanoma in people younger than 50 years declined by about 1% per year in men and stabilized in women. (cancer.gov)
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
Background The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ( GRAVID ).Methods The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatment and tumor stage on the risk of COVID-19 complications. (unav.edu)
21 day cycles) was administered to 60 unresectable stage IV melanoma patients and response rates were assessed using a combination of 2-[ 18 F]-fluoro-2-deoxy-glucose (FDG)-positron emission tomography (PET) and computed tomography (CT) imaging. (biomedcentral.com)
KEYNOTE-022 Part 3: Phase 2 randomized study of first-line dabrafenib and trametinib plus pembrolizumab or placebo for BRAF-mutant advanced melanoma. (medscape.org)
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. (medscape.org)
A phase 2 study to evaluate the safety and efficacy of intratumoral (IT) injection of the TLR9 agonist IMO-2125 (IMO) in combination with ipilimumab (ipi) in PD-1 inhibitor refractory melanoma. (medscape.org)
We have previously shown that treatment of C57BL/6 mice with specific anti-B16 melanoma monoclonal antibody (Mab) significantly reduced the number of established liver metastases. (johnshopkins.edu)
In contrast to results obtained when treating liver metastases, treatment of B16 melanoma lung metastases with Mab and recombinant interleukin 2 was unsuccessful when recombinant interleukin 2 was given concomitantly or after priming with high doses of recombinant interleukin 2. (johnshopkins.edu)
A retrospective analysis of the outcomes of 500 patients with metastatic renal cell carcinoma (RCC) (n = 186) or melanoma (n = 314) treated with high-dose IL-2 between 1997 and 2012 at Providence Cancer Center was performed. (biomedcentral.com)
IL-2 should remain part of the treatment paradigm in selected patients with melanoma and RCC. (biomedcentral.com)

Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. (medscape.org)

The cytokine interleukin 2 (IL-2) is involved in the activation of T cells and has been shown to play a central role in cancer immunotherapy. (nih.gov)
In vitro, long-term exposure to high glucose and the peptide hormone leptin secreted by adipose tissue induce β-cell apoptosis and production of the proinflammatory cytokine interleukin (IL)-1 in β-cells and pancreatic islets, respectively ( 7 , 8 ). (diabetesjournals.org)

Individuals exposed to dusts from concentrated animal feeding operations report increased numbers of respiratory tract symptoms, and bronchoalveolar lavage samples from such individuals demonstrate elevated lung inflammatory mediators, including interleukin (IL)-8 and IL-6. (cdc.gov)
Interestingly, NPM interacts with Toll-like receptor (TLR)4 in these cells and activates an NF-kB-dependent inflammatory pathway upregulating interleukin IL-6 and COX-2 gene expression. (frontiersin.org)
We have previously categorised stable adult asthma into four inflammatory phenotypes based on induced sputum inflammatory cell counts [ 2 ]. (ersjournals.com)
Treatment with recombinant IL-1Ra improves glycemia and β-cell function and reduces inflammatory markers in patients with type 2 diabetes. (diabetesjournals.org)
More importantly, this treatment inhibited interleukin 2 production, an essential inflammatory cytokine, and the enzyme activity of endogenous β-Glucuronidase, a key factor in the formation of bile pigment. (eur.nl)
On Alzheimer's he noted PPARy agonists were shown to inhibit the beta-amyloid-stimulated expression of the genes for inflammatory compounds such as interleukin-6 and tumor necrosis factor- (TNFa) and the expression of COX-2. (naturalproductsinsider.com)
Borax entering the body in the ROS form will cause several responses, i.e. borax will seek ion pairs that might cause damage to the cell membrane and activate the Kupffer cell and TLR4 as pro-inflammatory to express IL-2 [ 2 ]. (jmchemsci.com)
Psoriatic arthritis (PsA) is an inflammatory arthritis with no gender preference and has an estimated incidence of 6 per 100,000 per year and a prevalence of 1 to 2 per 1000 in the general population. (medscape.com)
During the course of the coronavirus disease 2019 (COVID-19) ings, complications, laboratory test results including those pandemic, reports of a new multisystem inflammatory syn- from SARS-CoV-2 testing, imaging findings, treatments, drome in children (MIS-C) have been increasing in Europe and outcomes. (cdc.gov)

We hypothesized that cattle feedlot dusts would also generate bronchial epithelial interleukin release in vitro. (cdc.gov)
Background/Aim: We previously established a novel type of epidermal growth factor receptor variant III (EGFRvIII)-specific chimeric antigen receptor (CAR)-expressing natural killer (NK) cell line, designated EvCAR-KHYG-1, which inhibited the growth of glioblastoma (GBM) cells in vitro via apoptosis. (iiarjournals.org)

These survival algorithms have been applied to assess outcomes in patients receiving T-cell checkpoint inhibitory immunotherapy and tyrosine kinase inhibitor therapy, but have not been applied extensively to patients receiving high dose interleukin-2 (HD IL-2) immunotherapy. (bmj.com)
Methods Survival of 810 mRCC patients treated from 2006 to 2017 with high dose IL-2 (aldesleukin) and enrolled in the PROCLAIM SM registry data base was assessed utilizing the International Metastatic RCC Database Consortium (IMDC) risk criteria. (bmj.com)
High-dose interleukin-2 (IL-2) has been FDA-approved for over 20 years, but it is offered only at a small number of centers with expertise in its administration. (biomedcentral.com)
We analyzed the outcomes of patients receiving high-dose IL-2 in relation to the severity of toxicity to ascertain if response or survival were adversely affected. (biomedcentral.com)

Feedlot dust stimulation of interleukin-6 and -8 requires protein kinase Cepsilon in human bronchial epithelial cells. (cdc.gov)
We previously found that exposure of bronchial epithelial cells to hog barn dusts resulted in a protein kinase C (PKC)-dependent increase in IL-6 and IL-8 release. (cdc.gov)
Interleukin-2 (IL-2) is a small protein released by cells which increases immune system activity. (tigerfitness.com)
Long-term activation of protein kinase C by 2 h exposure to PMA caused a dose-dependent increase in Na/H antiporter activity 24 h later. (jci.org)
We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
ONTAK) is a recombinant fusion protein product of diphtheria toxin and IL-2 that selectively binds to the IL-2 receptor of cells and, following internalization, inhibits protein synthesis, causing cell death [ 16 ]. (biomedcentral.com)
We examined the relationship between peripheral blood levels of SARS-CoV-2 S (Spike protein)1/M (Membrane protein)-reactive IFN-γ-producing CD4 + and CD8 + T cells, serum levels of biomarkers of clinical severity, and mortality in critically ill COVID-19 patients. (nature.com)
Serum levels of interleukin-6, ferritin, D-Dimer, lactose dehydrogenase and C-reactive protein in paired sera were known. (nature.com)

We sought to identify a region of IL-2 that is responsible for the induction of vasopermeability (leaky tumor endothelium), a property associated with the toxicity of the molecule. (nih.gov)
Intact IL-2 or overlapping synthetic peptides of IL-2 that were chemically conjugated to tumor-targeting monoclonal antibodies (TNT-1 or Lym-1) were injected into groups of mice (n = 4) that had previously been xenotransplanted with human tumor cells (ME-180 cervical carcinoma and Raji lymphoma). (nih.gov)
Pretreatment of mice with an antibody/IL-2 immunoconjugate resulted in an approximately fourfold increase in radiolabeled tracer antibody uptake in the xenograft tumor as compared with uptake in mice injected with antibody alone. (nih.gov)
Moreover, histoincompatible cells engineered to secrete IL-2 allow the rejection of syngeneic tumor cells when both cells are inoculated together. (pasteur.fr)
Survival and anti-tumor response were analyzed by diagnosis, severity of toxicity, number of IL-2 cycles and subsequent therapy. (biomedcentral.com)

Autologous TILs were expanded ex vivo from minced tumors cultured with interleukin-2. (nature.com)
NKTR-214 (CD122-biased agonist) plus nivolumab in patients with advanced solid tumors: preliminary phase 1/2 results of PIVOT. (medscape.org)
We previously found that in mice the cure rate of subcutaneous transplanted tumors treated by electrochemotherapy is increased by repeated systemic interleukin-2 (IL-2) injections. (pasteur.fr)
In this study of preestablished tumors in mice we show that after electrochemotherapy, delayed peritumoral injections of histoincompatible IL-2-producing cells result in the cure of almost all the tumors. (pasteur.fr)

Hill T, Krougly O, Nikoopour E, Bellemore S, Lee-Chan E, Fouser LA, Hill DJ and Singh B. The involvement of Interleukin-22 in the expression of Pancreatic Beta cell Regenerating REG genes. (bepress.com)
PerioPredict® measures variations in genes for Interleukin-1 (IL-1), a key mediator of inflammation, and identifies individuals who are at increased risk for moderate to severe periodontal disease. (baycitycapital.com)

We showed previously that immunotherapy with Bacillus Calmette-Guerin (BCG) or complete Freund's adjuvant (CFA) of non-obese diabetic (NOD) mice can prevent disease process and pancreatic β-cell loss. (bepress.com)
These results, which were obtained using allogeneic as well as xenogeneic IL-2-secreting cells, suggest that electrochemotherapy combined with such cellular immunotherapy might be a useful approach for the treatment of metastasizing cancers. (pasteur.fr)

The full therapeutic potential of IL-2, however, has not been realized because of its dose-limiting systemic toxicity. (nih.gov)
β-Cell mass is reduced through apoptosis ( 5 ) and type 2 diabetes is associated with a low-grade systemic inflammation ( 6 ), but the mechanisms underlying β-cell failure and destruction in type 2 diabetes remain elusive. (diabetesjournals.org)

These patients might not have positive SARS-CoV-2 PCR or when no abstract was available, the full paper was examined. (cdc.gov)

Model components highlighted existing knowledge and revealed previously unreported biology, including a critical role for the interleukin-2-dependent STAT5ab signaling pathway in modulating T cell function during pregnancy. (altmetric.com)

Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells. (uchc.edu)

Treatment options for severe forms of COVID-19 include oxygen, corticosteroids, and interleukin-6 receptor blockers. (who.int)
1 272 585 (16 296), 1.3%] combination with both corticosteroids, of its effectiveness against circulating and Interleukin-6 or IL-6 receptor Omicron variants. (who.int)

The 150 mg/2 mg dose will be evaluated further in a phase III clinical trial. (hcplive.com)
Fifteen patients received either a level 1 dose (3.0 g), a level 2 dose (7.5 g), or a level 3 dose (12.0 g). (lifeseasons.com)
IL-2 was administered at a dose of 600,000 international units per kg by IV bolus every 8 hours for up to 14 doses. (biomedcentral.com)

We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)

Patients received cyclophosphamide and fludarabine lymphodepletion, TIL infusion and interleukin-2, followed by maintenance nivolumab. (nature.com)

However, the combination of Ab1 and Ab2 (preincubated for 2 h at 22 degrees C) binds to platelets in a saturation-dependent manner at an optimum ratio range of 10-20:1. (jci.org)

In that study, there was significant upregulation of Toll-like receptor (TLR)2 gene expression and a corresponding increase in CXC ligand 8 (interleukin (IL)-8) in NA. (ersjournals.com)
This research showed that lycopene in tomato paste likely protected the liver from borax because the IL-2 expression was decreased. (jmchemsci.com)
The study to determine the level of expression of IL-2 in the administration of tomato paste on the histopathological appearance of the mouse liver exposed to borax after administration of tomato paste, with the hypothesis that IL-2 is not expressed in the liver of mice exposed to borax previously protected with tomato paste. (jmchemsci.com)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

gp100 peptide vaccine and interleukin-2. (hcplive.com)
One synthetic fragment consisting of amino acids 22-58 contained 100% of the vasopermeability activity of IL-2 and was designated permeability-enhancing peptide (PEP). (nih.gov)

We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
The origin of this low-grade inflammation in patients with CKD is not clear, but it could be a complication related to either impaired kidney function or dialysis treatment per se, or both [ 2 ]. (hindawi.com)
Interleukin-1 receptor type 2 (sIL-1R2) plasma levels increase during inflammation. (bvsalud.org)
Seminal studies in experimental autoimmune encephalomyelitis , a mouse model of multiple sclerosis , showed that IL-23 was responsible for the inflammation observed, not IL-12 as previously thought. (wikidoc.org)
and 5) absence of severe respiratory illness (to concurrently received positive test results for SARS-CoV-2, exclude patients in which inflammation and organ dysfunc- the virus that causes COVID-19, by polymerase chain reaction tion might be attributable simply to tissue hypoxia). (cdc.gov)

This response is mediated via innate immune activation and evidence of innate immune dysregulation in adults with NA has previously been reported [ 3 ]. (ersjournals.com)

The discovery of the central role of these T helper cells carrying large numbers of IL-2 receptors in uveitis and the potential value of daclizumab has also spurred intense research activity in other autoimmune diseases, such as multiple sclerosis and ulcerative colitis, in which similar immune mechanisms have been implicated. (nih.gov)

Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. (diabetesjournals.org)

Interleukin used obesity-related risk factors and IL-1 genetic variations along with other well established risk factors to analyze for significant associations and interactions relative to periodontitis progression. (baycitycapital.com)

Fig. 2: Clinical activity of TILs and patient survival. (nature.com)
Using a longitudinal clinical database, the new evidence presented today demonstrates how the functional IL-1 gene variants, shown to influence periodontitis (PD) severity, affect the previously demonstrated association between obesity and PD progression," stated Lynn Doucette-Stamm, Ph.D., Vice President Development and Clinical Operations. (baycitycapital.com)
Enumeration of peripheral blood levels of SARS-CoV-2-S1/M-reactive IFN-γ CD4 + and CD8 + T cells does not predict viral clearance from the lower respiratory tract or poor clinical outcomes in critically ill COVID-19 patients. (nature.com)

Previously, automated mechanical peripheral somatosensory stimulation (AMPSS) enhanced cardiac vagal modulation. (bvsalud.org)

To test this, we used interleukin ELISAs and direct PKC isoform assays. (cdc.gov)

We will focus on the 356 patients who received IL-2 alone, and evaluate outcome by risk factor categories. (bmj.com)

than were interleukin-2-treated patients (16% vs 6%, P =.03) Patients receiving the combination also had increased average survival (by 7 months) over the single agent-from 11.1 months to 17.8 months. (hcplive.com)

Type 2 diabetes is caused by inability of the functional β-cell mass to compensate for increased insulin needs due to insulin resistance ( 1 ). (diabetesjournals.org)
WALTHAM, Mass.-(BUSINESS WIRE)-Interleukin Genetics, Inc. (OTCQB: ILIU) announced today a poster presentation at the 2015 International Association for Dental Research General Session & Exhibition, taking place March 11-14, 2015, in Boston. (baycitycapital.com)
Concentrations of the marker metabolites (3-amino-2-oxazolidinone (AOZ), 3-amino-5-methylmorpholino-2-oxazolidinone (AMOZ), 1-aminohydantoin (AHD), and semicarbazide (SEM)) were determined through an enzyme-linked immunosorbent assay (ELISA) and verified using liquid chromatography-mass spectrometry (LC-MS/MS). Consumer groups were identified based on their average daily intake of foods. (bvsalud.org)
The average particle deposition per surface area of the epithelium was 2.29 10(7) 1.47 10(7) particle/cm(2), equivalent to an estimated average particle mass of 0.144 0.042g/cm(2). (cdc.gov)

We previously found that carbamate pesticides induced significant apoptosis in human natural killer cells. (researchgate.net)

Subgroup evaluations were performed by separating patients by prior or no prior therapy, IL-2 alone, or therapy subsequent to IL-2. (bmj.com)

Efficacy and safety of entinostat (ENT) and pembrolizumab (PEMBRO) in patients with non-small cell lung cancer (NSCLC) previously treated with anti-PD-(L)1 therapy. (medscape.org)
The aim of this study was to systemically review the efficacy and safety of inhibitors of interleukin 6 (IL-6): clazakizumab, IL-12/23: ustekinumab, and IL-17A: secukinumab, brodalumab, and ixekizumab in psoriatic arthritis (PsA). (medscape.com)

C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
CP and CP-HSA stimulated neutrophil Lum-CL and Luc-Cl by 2-3 times vs. spontaneous values while for CP-Muc the effect was 10-fold and higher. (romj.org)

Significantly, the actions of both GLP-1 and forskolin were abolished by the selective Ca 2+ /calmodulin-dependent phosphatase 2B (calcineurin) inhibitor, FK506, as well as by the chelation of intracellular Ca 2+ by BAPTA (bis(2-aminophenoxy)ethane- N,N,N ′ ,N ′-tetraacetate). (diabetesjournals.org)
A study on NK cell-derived exosomes previously exposed to L-type calcium channel Inhibitor review neuroblastoma cells exhibited antitumor properties [47]. (glucagon-receptor.com)

Background: We previously found that a forest bathing (shinrin-yoku) program significantly reduced the scores for depression, anxiety, anger, fatigue, and confusion and increased the score for vigor in the profile of mood states (POMS) test and showed a potential preventive effect on the depressive status in both males and females. (researchgate.net)

infection by SARS-CoV-2. (researchgate.net)
antigen test results, and antibody testing might be needed to The references were reviewed to identify additional relevant confirm previous SARS-CoV-2 infection. (cdc.gov)

We previously found that ziram, a carbamate pesticide, significantly reduced perforin, granzyme A (GrA), granzyme B (GrB), granzyme 3/K (Gr3/K), and granulysin (GRN) levels in NK-92MI cells, a human natural killer (NK) cell line. (researchgate.net)
Proximal tubule cells exposed to PMA for 2 h demonstrated a two- to threefold increase in Na/H antiporter mRNA (mRNANa/H) abundance 4 h later. (jci.org)
Treg cells express high levels of the alpha chain of the IL-2 receptor (CD25) and a single administration of DAB/IL2 (9 or 12 μg/kg) has been found by Curiel et al . (biomedcentral.com)
Further work observed that the T helper cells that attack the eye have large numbers of interleukin-2 (IL-2) receptors on their surface. (nih.gov)
In laboratory studies, NEI investigators, collaborating with researchers from the National Cancer Institute, found that daclizumab, which blocks IL-2 receptors and thereby prevents the immune response triggered by T helper cells, showed promise in treating an experimental model of uveitis. (nih.gov)
SARS-CoV-2 T cells (either CD4 + , CD8 + or both) were detectable in 70 patients. (nature.com)
SARS-CoV-2 RNA load in TA decreased over time, irrespective of the dynamics of SARS-CoV-2-reactive CD8 + and CD4 + T cells. (nature.com)

27 kg/m 2 and were randomly assigned to receive 13 weeks of anakinra, a recombinant human IL-1Ra, or placebo, 67 completed treatment and were included in this double-blind 39-week follow-up study. (diabetesjournals.org)

Excisional biopsy should extend down to the subcutaneous fat, with a small (2-3 mm) peripheral margin. (medscape.com)

During the course of the disease, β-cell function progressively declines irrespective of treatment with glucose-lowering drugs ( 2 , - 4 ). (diabetesjournals.org)
Even with all the apparatus and technology available, endodontic treatment many times fails 2 . (bvsalud.org)

Therefore, symptoms of mild exposure are anticipated to itary practitioners, since SEB has been previously resemble T-cell-mediated recall responses, similar to a developed as an incapacitating biowarfare agent. (cdc.gov)
SARS-CoV-2 IFN-γ CD4 + T-cell responses were documented more frequently than their CD8 + counterparts (62 vs. 56 patients) and were of greater magnitude overall. (nature.com)
Detectable SARS-CoV-2 S1/M-reactive CD8 + and CD4 + T-cell responses were associated with higher SARS-CoV-2 RNA loads in TA. (nature.com)
This was the same group of patients for whom we had previously studied CD4+ T-cell responses.10 The TB was diagnosed on the basis of positive sputum smear using fluorescence microscopy and positive cultures on LowensteinCJensen medium. (fabretp.org)

IL-1 gene variants have been previously shown to amplify the detrimental effects of smoking and diabetes on periodontitis severity. (baycitycapital.com)

CoV-2 was launched in Wuhan on February 4, 2020. (researchgate.net)
On October 2, 2020, this report was posted as an MMWR Early cases. (cdc.gov)

A smaller study of nine moderately trained males consumed six grams of spirulina or placebo daily for four weeks and performed a 2-hour run on the treadmill at 70-75% of their VO2max as well as ran at 95% of their VO2max to exhaustion. (tigerfitness.com)
Those in the spirulina group significantly increased their time to fatigue, decreased carbohydrate oxidation by 10.3%, and increased fat oxidation rate by 10.9% during the 2-hour run. (tigerfitness.com)

Anatomy46

Organisms10

Diseases10

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes33

Disciplines and Occupations1

Information Science3

Health Care2

Cytokines8

Interferon2

Receptor antagonist3

Melanoma16

Recombinant interleukin1

Cytokine interleukin2

Inflammatory9

Vitro2

High dose4

Protein8

Tumor5

Tumors4

Genes2

Immunotherapy2

Systemic2

Abstract1

Signaling pathway1

Dendritic1

Corticosteroids2

Dose3

Leptin1

Cyclophosphamide1

Binds1

Expression4

Peptide2

Inflammation5

Innate1

Autoimmune1

Secretion1

Genetic1

Clinical3

Stimulation1

Assays1

Outcome1

Combination1

Mass4

Apoptosis1

Subsequent1

Efficacy2

Neutrophil2

Inhibitor2

Background1

Infection2

Cells7

Human1

Peripheral1

Treatment2

Responses4

Variants1

20202

Spirulina2