• Statins are strong HMGR inhibitors widely prescribed in therapies against hypercholesterolemia and their benefits in preventing atherosclerosis and other cardiovascular diseases are incontrovertible. (nature.com)
  • Simvastatin belongs to the group of medicines called statins. (mayoclinic.org)
  • Simvastatin belongs to a group of medications called HMG CoA reductase inhibitors or "statins. (canadapharmacyonline.com)
  • As increased stiffness leads to increased permeability via and statins have been shown to decrease RhoA activity, this investigation examined the effect of simvastatin (Zocor®), a common statin, on endothelial cell morphology, cell traction forces, cell-cell junction widths, and endothelium permeability for endothelial cells seeded on 2.5, 5, and 10 kPa polyacrylamide substrates, mimicking the stiffness of healthy and aged vessels respectively. (cornell.edu)
  • Indeed, given the overwhelming evidence that statins prevent cardiovascular events and reduce mortality, it is probably worth trying up to three statins before resorting to lipid lowering agents from other classes. (pulsetoday.co.uk)
  • Statins are widely used to prevent cardiovascular diseases. (unibas.ch)
  • Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)
  • Large randomized controlled trials (RCTs) that examined the safety and effectiveness of statins in preventing cardiovascular diseases indicated that statins were not associated with increased cancer risk (5). (cdc.gov)
  • The aim of this study was to investigate, and compare with pravastatin and simvastatin, the tissue-specific distribution of rosuvastatin. (aspetjournals.org)
  • Bolus intravenous doses (5 mg/kg) of radiolabeled rosuvastatin, pravastatin, and simvastatin were administered to rats, and initial uptake clearance (CL uptake ) in various tissues was calculated. (aspetjournals.org)
  • The results of this study indicated that rosuvastatin was taken up by hepatic cells more selectively and more efficiently than pravastatin and simvastatin. (aspetjournals.org)
  • 14 C]Rosuvastatin (1.15 MBq/mg), [ 14 C]pravastatin (1.17 MBq/mg), and [ 14 C]simvastatin (1.85 MBq/mg) were synthesized at Shionogi and Co., Ltd. (Osaka, Japan). (aspetjournals.org)
  • For instance, simvastatin and atorvastatin are relatively lipid-soluble, whereas pravastatin and rosuvastatin are relatively water-soluble and metabolised by different pathways. (pulsetoday.co.uk)
  • However, adrenal CL uptake of simvastatin (1.55 ml/min/g tissue) was larger than hepatic CL uptake , and simvastatin was distributed to other tissues more easily than rosuvastatin. (aspetjournals.org)
  • Rosuvastatin to prevent vascular events in men and women with elevated C-Reactive protein. (thehealthyskeptic.org)
  • Ten years after the start of the 4S trial, a follow-up study published on 28 August 2004 in The Lancet, revealed that of those 2,221 people who continued to take simvastatin, there was a further reduction in number of deaths from CHD when compared to those who had switched from placebo to statin at the five year mark. (wikipedia.org)
  • For patients that require a high-intensity statin or are unable to achieve their LDL-C goal receiving simvastatin 40 mg daily, prescribe alternative LDL-C lowering treatment. (nih.gov)
  • Intensive-dose statin therapy provides a significant benefit for preventing cardiovascular events compared with moderate-dose statin therapy [ 4 ]. (hindawi.com)
  • Treating 1000 patients with a statin would prevent 37 cardiovascular events, and 5 AEs would be observed. (unboundmedicine.com)
  • Our results suggest that statin treatment is unlikely to prevent melanoma development at standard doses. (biomedcentral.com)
  • Inhibition of HMG-CoA reductase by statin in effect prevents the synthesis of mevalonic acid, a precursor of nonsteroidal isoprenoids, lipid attachment molecules for small G proteins, such as Ras, Rho, and Rac. (cdc.gov)
  • As a rule, so-called beta blockers are used as the first choice to prevent migraine attacks, but the researchers found that especially three medicines had better preventive effect than these: CGRP inhibitors, amitriptyline and simvastatin. (eurasiareview.com)
  • For instance, muscle problems are relatively more common with high doses of simvastatin, whereas disturbances in liver function are more common with high doses of atorvastatin. (pulsetoday.co.uk)
  • Drug interactions are more common with simvastatin and atorvastatin, which are metabolised via common cytochrome P450 pathways in the liver. (pulsetoday.co.uk)
  • His current medications were noted as aspirin, simvastatin, and atenolol. (hdc.org.nz)
  • Individuals should be screened for the G6PD defect before being treated with certain drugs such as certain antibiotics, antimalarials and other medications simvastatin and high blood sugar known to trigger hemolysis in G6PD deficient individuals. (ggim.in)
  • Reported that previously serviced on an eye care center and diagnosed with conjunctivitis and was under use of the following medications: allopurinol,nimesulide, simvastatin, omeprazole and front. (bvsalud.org)
  • The aim of the present work was to shed light on the role played by the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and memory consolidation in rodents through the inhibition of the key and rate-limiting enzyme 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) both in vivo and in vitro with simvastatin. (nature.com)
  • The risk increases with higher doses and is highest for patients taking simvastatin 80 mg. (rxwiki.com)
  • High doses of orally administered simvastatin has previously been shown to improve fracture healing in a mouse femur fracture model. (biomedcentral.com)
  • In this study, simvastatin was administered either subcutaneously or directly to the fracture area, with the goal of stimulating fracture repair at acceptable doses. (biomedcentral.com)
  • We therefore conducted a number of experiments on fracture repair in which we administered the simvastatin as one daily subcutaneous injection in doses ranging from 1 to 100 mg/kg body weight. (biomedcentral.com)
  • Our data suggest that simvastatin may be beneficial in preventing atherosclerosis beyond its traditional lipid lowering effects b y decreasing monolayer permeability due to vascular stiffening that naturally occurs with aging. (cornell.edu)
  • Our results show that HMGR inhibition by simvastatin induces anxiogenic-like effects in the social interaction but not in the elevated plus-maze test, and improves memory consolidation in the inhibitory avoidance task. (nature.com)
  • HepG2 mitochondrialrespiration became susceptible to simvastatin-treatment after Akt inhibition, andmitochondrial respiration was rescued in Igf-1-treated C2C12 myotubes. (unibas.ch)
  • Mr A had been living alone in his own home and was non-compliant with his prescribed medication regimen (which included aspirin, simvastatin and atenolol). (hdc.org.nz)
  • However, Mr A was administered atenolol and aspirin at 9am on Days 2, 3 and 4 and simvastatin at 6.30pm on Days 2 and 3. (hdc.org.nz)
  • First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease. (ox.ac.uk)
  • BACKGROUND: Patients with chronic kidney disease are at increased risk for cardiovascular disease, but the efficacy and safety of simvastatin and aspirin are unknown in this patient group. (ox.ac.uk)
  • METHODS: Patients were randomly assigned in a 2 x 2 factorial design to the administration of: (1) 20 mg of simvastatin daily versus matching placebo, and (2) 100 mg of modified-release aspirin daily versus matching placebo. (ox.ac.uk)
  • CONCLUSION: During a 1-year treatment period, simvastatin, 20 mg/d, produced a sustained reduction of approximately one quarter in low-density lipoprotein cholesterol levels, with no evidence of toxicity, and aspirin, 100 mg/d, did not substantially increase the risk for a major bleeding episode. (ox.ac.uk)
  • A drug combination of aspirin and dipyridamole that functions as a PLATELET AGGREGATION INHIBITOR, used to prevent THROMBOSIS and STROKE in TRANSIENT ISCHEMIC ATTACK patients. (bvsalud.org)
  • Maximum recommended dosage is simvastatin 40 mg once daily. (nih.gov)
  • Simvastatin 80 mg daily dosage is restricted to patients who have been taking simvastatin 80 mg daily chronically (e.g., for 12 months or more) without evidence of muscle toxicity. (nih.gov)
  • See full prescribing information for simvastatin dosage modifications due to drug interactions. (nih.gov)
  • Myopathy and Rhabdomyolysis: Risk factors include age 65 years or greater, uncontrolled hypothyroidism, renal impairment, concomitant use with certain other drugs, and higher simvastatin dosage. (nih.gov)
  • Inform patients of the risk of myopathy and rhabdomyolysis when starting or increasing simvastatin dosage. (nih.gov)
  • To investigate the effect of simvastatin on glucose homeostasis in streptozotocin induced type 2 diabetic rats. (hindawi.com)
  • The simvastatin intervention rats were fed with simvastatin during the experiment process, and the simvastatin treatment rats were fed with simvastatin after diabetes rats were induced. (hindawi.com)
  • the simvastatin intervention rats had a higher FPG compared to the diabetic rats and were more easily be induced to diabetes at the end of 4 weeks, FPG level of simvastatin treatment rats was increased compared with diabetic model rats after 12 weeks. (hindawi.com)
  • These data indicate that simvastatin intervention rats may cause hyperglycemia by impairing the function of islet β cells and have an adverse effect on glucose homeostasis, especially on FPG level. (hindawi.com)
  • The target of the present study is to investigate the effect of simvastatin on FPG in STZ-induced diabetic rats. (hindawi.com)
  • Toward this goal, we observed the different effect between simvastatin intervention rats and simvastatin treatment rats, especially on FPG levels of various periods. (hindawi.com)
  • The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats. (medscape.com)
  • Simvastatin is a prescription medication used to treat high cholesterol , high triglycerides, and disease of the heart and blood vessels. (rxwiki.com)
  • See the "Simvastatin Precautions" section. (rxwiki.com)
  • Temporarily discontinue simvastatin in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis. (nih.gov)
  • These include, but are not limited to, (1) preventing hyperacute rejection, (2) preventing acute vascular rejection, (3) facilitating immune accommodation, (4) inducing immune tolerance, (5) preventing the transmission of viruses from xenografts into humans, and (6) addressing the ethical issues surrounding animal sources for xenografts and the appropriate selection of recipients (given that xenotransplantation remains experimental). (medscape.com)
  • Dexmedetomidine prevents acute kidney injury after adult cardiac surgery: a meta-analysis of randomized controlled trials. (medscape.com)
  • Results of a clinical study in people with heart disease and well-controlled cholesterol levels that compared people who took niacin and simvastatin with people who took simvastatin alone and found similar results for the two groups in the rate of heart attacks or strokes. (medlineplus.gov)
  • Apixaban, rivaroxaban, clopidogrel, ticagrelor to prevent platelets clumping together and blocking blood vessels (e.g. in patients who have had a heart attack). (who.int)
  • It helps to prevent heart attacks, strokes, and other serious medical conditions linked to clogged blood vessels. (webmd.com)
  • This medicine may help prevent medical problems caused by clogged blood vessels such as heart attacks and strokes. (mayoclinic.org)
  • Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. (bidrx.com)
  • Of the 4,444 people enrolled in the study, 3,617 were men and 827 women, 2,223 were randomly assigned a placebo and 2,221 were given 20 to 40 mg of simvastatin daily. (wikipedia.org)
  • After 5.4 years, compared to the group that were given placebo, the simvastatin group demonstrated a 35% reduction in LDL-C and 30% reduction in overall mortality. (wikipedia.org)
  • Your doctor will probably order a blood test to measure liver function before you start taking simvastatin. (rxwiki.com)
  • Allocation to simvastatin therapy was not associated with excess risk for abnormal liver function test results or elevated creatine kinase levels. (ox.ac.uk)
  • Sitagliptin and simvastatin combination is used together with a proper diet and exercise to treat type 2 diabetes. (mayoclinic.org)
  • blood sugar level 111 Fasting Blood Sugar How Do You Get Diabetes simvastatin and high blood sugar GGIM. (ggim.in)
  • With current estimates suggesting that 1/4th of women may get diabetes, this is a big risk - especially for a drug that doesn't effectively prevent heart disease. (vitality101.com)
  • The combination of fluticasone and Salmeterol is used to prevent wheezing, shortness of breath, and breathing difficulties caused by asthma and chronic obstructive pulmonary disease. (studystack.com)
  • Chronic migraine can be disabling and may prevent many, especially women, from contributing to working life. (eurasiareview.com)
  • A follow-up of treatment with simvastatin for up to eight years was published in 2000. (wikipedia.org)
  • This study found a dramatic positive effect on biomechanical parameters of fracture healing by simvastatin treatment directly applied to the fracture area. (biomedcentral.com)
  • A very small number of people taking simvastatin may have mild memory problems or confusion. (bidrx.com)
  • In the realm Low Blood Sugar Symptoms blood sugar level 111 of pharmaceutical products, simvastatin and high blood sugar they often use the other way around glucose instead of dextrose just to trim down the confusion. (ggim.in)
  • In 2010, the European Food Safety Authority s simvastatin and high blood sugar Panel on Dietetic Products, Nutrition and Allergies published a scientific opinion on dietary reference values for the intake of carbohydrates and sugars. (ggim.in)
  • If you choose the paw pad for your testing site, it simvastatin and high blood sugar may help to use the lancing device on the side of the paw pad, rather on the bottom part that the pet steps on when walking. (ggim.in)
  • seven 402 of 764 trials were at low risk of simvastatin and high blood sugar bias in random sequence generation and 529 692 were at low risk of bias in allocation concealment. (ggim.in)
  • Test what you know about medical science Blood Sugar simvastatin and high blood sugar by taking this quiz. (ggim.in)
  • Also, it comes with cheap test strips, which is something simvastatin and high blood sugar GGIM simvastatin and high blood sugar you need to look for. (ggim.in)
  • The tetrameric subunits are bound by simvastatin and high blood sugar non covalent bonds without disulfide bonds, the binding between dimers is stronger than the binding between subunits in dimers. (ggim.in)
  • Glucose transporter 1 in the hypothalamic glial cells simvastatin and high blood sugar mediates glucose sensing to regulate glucose production in vivo. (ggim.in)
  • However, elderly patients are more likely to have age-related kidney or muscle problems, which may require caution and an adjustment in the dose for patients receiving sitagliptin and simvastatin combination. (mayoclinic.org)
  • Use another simvastatin product to initiate dosing in such patients. (nih.gov)
  • RÉSUMÉ Nous avions l'objectif d'étudier la prévalence des effets secondaires causés par les statines chez des patients iraniens admis dans un hôpital spécialisé en cardiologie et sous traitement par statines avant leur hospitalisation. (who.int)
  • This antibiotic medication works by killing bacteria or preventing bacterial growth. (webmd.com)
  • In this way, 10 mice received an approximate local dose of simvastatin of 0.1 mg per kg per day for the duration of the experiment and 10 mice received the vehicle compound. (biomedcentral.com)
  • Secondly, subcutaneously implanted osmotic mini-pumps were used to deliver a continuous systemic dose of simvastatin. (biomedcentral.com)
  • 10μM simvastatin caused a decrease in mitochondrial respiration in the primarymouse myocytes and C2C12 myotubes, but had no effect in the HepG2 cells.Mitochondrial integrity is maintained by multiple signaling pathways. (unibas.ch)
  • Our data show that simvastatin results in an elongated cell morphology, reduced endothelial cell contractility, enhanced cell-cell junction integrity, and decreased substratestiffness-dependent and thrombin-dependent increased endothelium permeability on physiologically relevant substrate stiffnesses. (cornell.edu)
  • If so, subcutaneous injections would not work, whereas a continuous subcutaneous release of simvastatin would yield positive results similar to the ones achieved when mixing it in the feed. (biomedcentral.com)
  • Much larger trials are now needed to assess whether these treatments can prevent vascular events. (ox.ac.uk)
  • Prevent and treat osteoporosis ( a condition in which the bones become weak and thin and break easily) and then also in women who have undergone menopause. (studystack.com)
  • Quinine will not treat severe forms of malaria, and it should not be taken to prevent malaria . (cigna.com)
  • Niacin is also used to prevent and treat pellagra (niacin deficiency), a disease caused by inadequate diet and other medical problems. (medlineplus.gov)
  • Discontinue simvastatin if markedly elevated CK levels occur or myopathy is diagnosed or suspected. (nih.gov)
  • They developed the buttonhole technique for anastomosis of donor and recipient vessels in kidney transplantation to prevent thrombus formation. (medscape.com)
  • Data from the 4S trial has frequently been used to analyse the cost-effectiveness of simvastatin in secondary prevention. (wikipedia.org)