Pretreatment cell degranulation. Medical search. Frequent questions

Using bone marrow-derived mast cells and AgNPs of varying physicochemical properties we tested the hypothesis that AgNP physicochemical properties influence mast cell degranulation and osteopontin production. (nih.gov)
In the present study, an ethanol extract of Biyeom-Tang (EBT) was investigated for anti-allergic properties on bone-marrow derived mast cells (BMMC) and in vivo models. (biomedcentral.com)

Staphylococcal enterotoxins are 23- to 29-kDa polypeptides in the bacterial superantigen protein family that act by cross-linking HLA-DR or DQ molecules and T-cell receptors. (cdc.gov)
IPH2101 (anti-KIR) is a fully human mAb blocking interaction between KIR inhibitory receptors on NK cells and their ligands. (medscape.com)
Our lab has characterized a third mechanism to achieve hypothermia through A3AR mast cell degranulation and central histamine H1 receptors. (nih.gov)
We show that cannabinoids mitigate mast cell activation, inflammation and neurogenic inflammation in sickle mice via both cannabinoid receptors 1 and 2. (haematologica.org)
Cannabinoid receptors, CB1R and CB2R, are expressed in both the central nervous system and non-central nervous system tissues, including inflammatory cells. (haematologica.org)
3 Cannaboid receptors are important modulators of vascular function with an anti-ischemic effect and direct anti-inflammatory effects by inhibiting mast cell degranulation. (haematologica.org)
1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
Extracellular-regulated kinase (1 and 2) phospho-activations and the levels of three estrogen receptors in the cell membrane (ERα, ERβ, and GPER) were measured using a quantitative plate immunoassay of fixed cells either permeabilized or nonpermeabilized (respectively). (biomedcentral.com)

Using genetic depletion of the isoprenylation enzymes farnesyltransferase and geranylgeranyl transferase 1 or their substrate K-Ras, we show a significant reduction in FcÎµRI-mediated degranulation and cytokine production. (bvsalud.org)
We identify that exhausted CD8 T cells increase ADRB1 expression and that exposure of ADRB1 T cells to catecholamines suppresses their cytokine production and proliferation. (salk.edu)
Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T cell death. (bioxcell.com)

In the present study we investigated the effect of the mast cell degranulation in neutrophil migration failure observed in diabetic mice after polymicrobial sepsis induced by cecal ligation and puncture (CLP). (biomedcentral.com)
However, diabetic mice submitted to MS and daily pretreatment with compound 48/80 did not display failure of neutrophil migration to infectious focus. (biomedcentral.com)
These results suggest that in diabetic mice undergoing polymicrobial infection, mast cells play a key role in the neutrophil migration failure due to reduction of the CXCR2 expression, resulting in bacterial spreading and systemic release of mediators, and as a consequence augmented susceptibility to sepsis development. (biomedcentral.com)
A significant upregulation of transcripts associated with NETosis [the formation of neutrophil extracellular traps (NETs)] and neutrophil degranulation pathways was linked to the presence of a myeloid-derived suppressor cell signature in NRs. (qxmd.com)
In response to infection, polymorphonuclear neutrophils (PMN) are recruited in the infectious sites, and employ three major strategies to fight against the microbes including phagocytosis, degranulation, and neutrophil extracellular traps (NETs). (nature.com)

Human γ 9 δ 2 T cells potently inhibit pathogenic microbes, including intracellular mycobacteria, but the key inhibitory mechanism(s) involved have not been identified. (prolekarniky.cz)
We report a novel mechanism involving the inhibition of intracellular mycobacteria by soluble granzyme A. γ 9 δ 2 T cells produced soluble factors that could pass through 0.45 µm membranes and inhibit intracellular mycobacteria in human monocytes cultured below transwell inserts. (prolekarniky.cz)
We previously found that statins inhibit IgE-induced mast cell function, but these effects varied widely among mouse strains and human donors, likely due to the upregulation of the statin target, 3-hydroxy-3-methylgutaryl-CoA reductase. (bvsalud.org)
15 11 CB1R and CB2R activation on mast cells has been shown to inhibit degranulation and inflammation, respectively. (haematologica.org)
Thus, we screened sera of Trastuzumab-resistant HER2 +patients with breast cancer for molecules that could inhibit NK cell ADCC. (bmj.com)
Results We found that sera from Trastuzumab-refractory patients could inhibit healthy NK cell ADCC in vitro. (bmj.com)

Vancomycin has a large, complex and unusual structure and is believed to act by inhibition of bacterial cell wall synthesis via binding to the cell wall precursor molecules. (nih.gov)
Traumatic brain injury (TBI) initiates interrelated inflammatory and coagulation cascades characterized by wide-spread cellular activation, induction of leukocyte and endothelial cell adhesion molecules and release of soluble pro/antiinflammatory cytokines and thrombotic mediators. (biomedcentral.com)
Flow cytometry was used to analyze leukocyte cell-surface adhesion (CD62L, CD11b) and degranulation (CD63, CD66b) molecules. (biomedcentral.com)
HSD blunted the expression of these cell-surface activation/adhesion molecules at all time-points to levels approaching control values. (biomedcentral.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

We conclude that a cross-talk exists between endothelial cell-derived humoral mediators and the intestinal mast cell system. (portlandpress.com)
Mast cells orchestrate allergic immune responses through degranulation and release of pre-formed mediators. (nih.gov)
These symptoms are primarily induced by allergic mediators released from mast cells, basophils, eosinophils, lymphocytes, and epithelial cells. (biomedcentral.com)
Anaphylaxis is an acute, potentially fatal, multiorgan system reaction caused by the release of chemical mediators from mast cells and basophils. (medscape.com)
After the activation of mast cells, degranulation is triggered, which results in the release of mediators, such as products of arachidonic acid metabolism, cytokines, proteases and histamine ( 4 , 5 ). (spandidos-publications.com)
In mast cell-mediated inflammatory responses, histamine is one of the most well-characterized and important mediators involved in the acute phase of immediate hypersensitivity ( 6 , 7 ). (spandidos-publications.com)
Activated mast cells can release histamine and other inflammatory mediators, such as eicosanoids, proteoglycans and a number of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-13 ( 5 , 9 ). (spandidos-publications.com)
These findings support an important modulatory role of HSD resuscitation in attenuating the upregulation of leukocyte/endothelial cell proinflammatory/prothrombotic mediators, which may help ameliorate secondary brain injury after TBI. (biomedcentral.com)

The cAMP and intracellular calcium levels were measured to clarify the mechanisms by which AEDK inhibits the release of histamine from mast cells. (spandidos-publications.com)
AEDK inhibited the release of histamine and β-hexosaminidase from mast cells by modulating cAMP and intracellular calcium levels. (spandidos-publications.com)
Immediate-type hypersensitivity is mediated by histamine in response to the antigen cross-linking of immunoglobulin E (IgE) bound to FcɛRI on mast cells ( 3 ). (spandidos-publications.com)
In the peripheral lung, the release of histamine and eicosanoids (leukotrienes and prostaglandins) from activated inflammatory cells, such as mast cells and macrophages, may contribute significantly to the symptoms of allergic rhinitis and asthma [ 5 - 8 ]. (biomedcentral.com)

Earlier studies showed that mast cell activation contributes to neurogenic inflammation and pain in sickle mice. (haematologica.org)
Although it is clear that chronic antigen contributes to CD8 T cell exhaustion, less is known about how stress responses in tissues regulate T cell function. (salk.edu)

These changes were inhibited significantly by pretreatment with the ET A receptor antagonists, but not with the ET B receptor antagonist. (portlandpress.com)
In addition, the pretreatment of diabetic mice with compound 48/80 significantly blocked the increase of serum TNFα and MIP-2 levels after septic stimulus. (biomedcentral.com)
Among the 5 fish with a nonuniform plasmodia distribution, 3 had a significantly higher burden in the belly flap, 1 in the area just posterior Ro-3306 cell line to the belly flap, and 1 in the cheek muscle. (trpv-antagonist.com)
Results: Both the scores of IPSS and the levels of quality of life in EPIC were significantly worse at 1 month postoperatively compared to the pretreatment baseline, and thereafter progressively improved in both groups. (fakinhibitors.com)
Addition of the PPP inhibitor S3 to antibody therapy achieved significantly prolonged overall survival in an aggressive B-cell lymphoma mouse model. (sfb1530.de)

The key immune cells involved in combating pulmonary conditions such as pneumonia, TB, RSV infection, and ARDS are neutrophils, lymphocytes, alveolar macrophages, and the cells responsible for innate immune responses. (nih.gov)
Second, HIV penetrates the urethra, which will be one topic of today, and target directly macrophages, but not T cell. (nih.gov)
Therefore, we reconstructed urethral mucosa made of fibroblast macrophages overlaid by urethral epithelial cell, and after 17 days, the reconstruction polarized was inserted into microscopic device and inoculated in situ with gag-GFP-HIV-infected T cell producing GFP viruses or with cell-free viruses. (nih.gov)
Macrophages in the B-cell lymphoma microenvironment represent a functional node in progression and therapeutic response. (sfb1530.de)
Moreover, macrophages provided decreased support for survival of lymphoma cells. (sfb1530.de)

This study suggests that exposure to AgNPs may elicit adverse mast cell responses that could contribute to the initiation or exacerbation of allergic disease. (nih.gov)
1 Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md. (nih.gov)
IgE-mediated mast cell activation is a driving force in allergic disease in need of novel interventions. (bvsalud.org)
Among these cells, mast cells are one of the most important cells in the allergic response such as AR [ 2 ]. (biomedcentral.com)
This study aimed to investigate the protective effects of the aqueous extract of Diospyros kaki (AEDK) on mast cell-mediated allergic inflammation and to determine its possible mechanisms of action by using in vitro and in vivo mast cell-based models. (spandidos-publications.com)
Mast cells are broadly distributed throughout mammalian tissues and play an important role as regulators of allergic inflammation in various allergy-related disorders, such as asthma, atopic dermatitis, eczema and sinusitis. (spandidos-publications.com)
Therefore, the inhibition of these inflammatory cytokines produced by mast cells is one of the most important targets for the reduction of allergic inflammatory symptoms. (spandidos-publications.com)
Individuals with α-gal-specific IgE have also reported severe allergic reactions to drugs derived from mammalian cells and tissue that contain α-gal residues ( 10 , 14 , 15 ). (frontiersin.org)

While γ 9 δ 2 T cells comprise only 3% to 5% of total human blood lymphocytes they can expand to high frequencies in vivo and develop effector functions protective against multiple major human pathogens [1] , [2] . (prolekarniky.cz)
We argue for the notion of immunotherapies as "pro-drugs" that act to augment or modulate T cells, which ultimately serve as the drug in vivo, and for the importance of overall immune health in cancer treatment and prevention. (salk.edu)
In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)
In vivo, CHI3L1 administration drastically impairs the control of NK cell-sensitive tumors, while CHI3L1 blockade synergizes with ADCC to cure mice with HER2 +xenografts. (bmj.com)
And using ex vivo explant infection as well as reconstruction infection -- mucosal reconstruction infection, we have shown that HIV can penetrate by two pathway to penetrate the penile tissue, first through the foreskin where HIV target Langerhans cells trans-infect CD4 T cell. (nih.gov)

Mast cell degranulation was not dependent on AgNP dissolution but was prevented by tyrosine kinase inhibitor pretreatment. (nih.gov)
Mast cell activation is initiated by the phosphorylation of tyrosine kinase which leads to the activation of protein kinase C, nuclear factor (NF)-κB and the expression of pro-inflammatory cytokines ( 4 , 8 ). (spandidos-publications.com)
Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). (thermofisher.com)

We performed bulk RNA-sequencing (RNA-seq) on total peripheral blood mononuclear cells (PBMCs) of seven non-responders (NRs) and four responders (Rs). (qxmd.com)
Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. (thermofisher.com)

Our previous studies reported that HMGB1 plays a critical role in inducing pyroptosis of Mϕ and vascular endothelial cell (EC) 13 , 14 . (nature.com)

ET-1 induced dose-dependent alterations in the haemodynamic and morphological parameters, and caused significant mast cell degranulation. (portlandpress.com)
Mast cell responses were found to be dependent on the physicochemical properties of the AgNP. (nih.gov)
EBT strongly inhibited a degranulation reaction in a dose dependent manner with an IC 50 value of 35.6 μg/ml. (biomedcentral.com)
Sickle mice display neurogenic inflammation and hyperalgesia via a mast-cell-dependent mechanism. (haematologica.org)
In this study, by using a mouse sepsis model, we identified a novel mechanism by which NETs induce macrophage (Mϕ) pyroptosis, a caspase-1-dependent regulated cell death. (nature.com)
Exhausted CD8 T cells cluster around sympathetic nerves in an ADRB1-dependent manner. (salk.edu)
Methods NK cell antibody-dependent cellular cytotoxicity (ADCC) is a major determinant of the clinical efficacy of some therapeutic antibodies including the anti-HER2 Trastuzumab. (bmj.com)
These data indicate that PD-1 facilitates apoptosis in alloreactive T cells by increasing ROS in a process dependent upon the oxidation of fat. (bioxcell.com)
We studied the effects of low concentrations of endogenous estrogens (estradiol, estriol, and estrone) at 10 pM (representing pre-development levels), and 1 nM (representing higher cycle-dependent and pregnancy levels) in combinations with the same levels of xenoestrogens in GH 3 /B6/F10 pituitary cells. (biomedcentral.com)
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. (elifesciences.org)

In addition, encouraging data are emerging showing that the combination of a proteasome inhibitor with a mAb induces myeloma cell death in a synergistic way, through independently targeting the same pathway or via inhibition of different signaling cascades. (medscape.com)
Granzyme A Produced by γδ T Cells Induces Huma. (prolekarniky.cz)

Therefore, symptoms of mild exposure are anticipated to resemble T-cell-mediated recall responses, similar to a Mantoux skin test. (cdc.gov)
Furthermore, occasional clinical responses have been achieved in selected patients with CD20 + myelomatous plasma cells. (medscape.com)
Further, we determined a role for scavenger receptor B1 in AgNP-induced mast cell responses. (nih.gov)
Furthermore, γ 9 δ 2 T cells can develop memory responses critical for long-term vaccine-induced protective immunity [4] - [6] . (prolekarniky.cz)
In a pancreatic cancer model resistant to ICB, β-blockers and ICB synergize to boost CD8 T cell responses and induce the development of tissue-resident memory-like T cells. (salk.edu)
Background Natural killer (NK) cells require a functional lytic granule machinery to mediate effective antitumor responses. (bmj.com)
Finally, we discuss existing data more generally focused on tick-mediated immunomodulation, and highlight possible mechanisms for how cutaneous exposure to tick bites might affect B cell responses in the skin and gut that contribute to loss of oral tolerance. (frontiersin.org)
These results reveal a crucial role for cFLIP cleavage in controlling the amplitude of cell death responses occurring upon tissue stress to ensure the execution of repair programs. (sfb1530.de)

Statin inhibition of mast cell function appeared to be mediated not by cholesterol reduction but by suppressing protein isoprenylation events that use cholesterol pathway intermediates. (bvsalud.org)

Cl-ENBA and AMP hypothermia remained intact in KitW-sh/W-sh mice and after pretreatment with pyrilamine. (nih.gov)
We, therefore, examined cannabinoid receptor-specific mechanisms to mitigate mast cell activation, neurogenic inflammation and hyperalgesia, using HbSS-BERK sickle and cannabinoid receptor-2-deleted sickle mice. (haematologica.org)
2 We showed earlier that mast cells contribute to neurogenic inflammation and hyperalgesia in sickle mice. (haematologica.org)
We used transgenic HbSS-BERK mice, hereafter referred to as sickle mice, which show features of pain and inflammation similar to patients with SCA, 20 5 4 and sickle mice with deletion of CB2R, to examine the contribution of each cannaboid receptor in mast cell activation, neurogenic inflammation, and pain. (haematologica.org)

Pre-treatment of neurones with Ginkgo biloba was reported to reduce cell death rate during the exposure to oxidative stress and to defend against cell apoptosis and DNA fragmentation induced by hydroxyl radicals (42,43). (energywave.com)
Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
In vitro, abrogation of cFLIP cleavage sensitizes cells to tumor necrosis factor(TNF)-induced necroptosis and apoptosis by favoring complex-II formation. (sfb1530.de)

PAF is an inflammation mediator involved in various pathophysiological conditions affecting heart, lung, brain and vessels due to its potent chemotactic activity on neutrophils inducing superoxide release, aggregation and degranulation. (energywave.com)
Predominantly this graveyard is filled with the dead bodies of neutrophils 9 - massive cells of innate immunity, which play a role of utmost importance in anti-bacterial protection. (optimunity.com)
Neutrophils are the most abundant immune cells in the blood. (optimunity.com)
Neutrophils, the most prevalent innate immune cells in humans, have garnered significant attention in recent years due to their involvement in cancer progression. (biomedcentral.com)
Neutrophils have two specific characteristics: a short lifespan and an inability to proliferate, which distinguishes them from other immune cells. (biomedcentral.com)
Neutrophils not only constitute the preeminent population of circulating cells within the human bloodstream but also exhibit a remarkable propensity for infiltration into the intricate milieu of the tumor microenvironment (TME) in substantial quantities [ 4 , 5 ]. (biomedcentral.com)

This study provides 'proof of principle' for the potential of cannabinoid/cannabinoid receptor-based therapeutics to treat several manifestations of sickle cell anemia. (haematologica.org)
Here we show a new link between the stress-associated catecholamines and the progression of T cell exhaustion through the β-adrenergic receptor ADRB1. (salk.edu)
PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. (bioxcell.com)
The coinhibitory receptor programmed death-1 (PD-1) maintains immune homeostasis by negatively regulating T cell function and survival. (bioxcell.com)

Cell death coordinates repair programs following pathogen attack and tissue injury. (sfb1530.de)

The elimination of tumor cells using mAbs depends on immunoglobulin-mediated mechanisms, including ADCC and CDC, to activate immune effector cells to lyze target tumor cells, a mechanism that is completely different and may be synergistic to chemotherapy. (medscape.com)
However, despite the failure of simple phosphoantigens to induce mycobacteria-inhibitory γ 9 δ 2 T cells, effector memory γ 9 δ 2 T cells expanded with live BCG or mycobacterial lysates can display potent effector functions relevant for protective TB immunity including production of Th1 cytokines and cytolytic activity after co-culture with mycobacteria-infected human monocytes [7] - [10] . (prolekarniky.cz)
Most forms of effective cancer immunotherapy involve CD8 T cell effector function. (salk.edu)
Ablation of β-adrenergic signalling limits the progression of T cells towards the exhausted state in chronic infection and improves effector functions when combined with immune checkpoint blockade (ICB) in melanoma. (salk.edu)

The histological analysis shows that the infiltration of inflammatory cells increased by OVA-sensitization was also reduced. (biomedcentral.com)

When administrated orally, EBT ameliorated the mast cell-mediated PCA reaction. (biomedcentral.com)

The characteristics of pyroptosis include cell swelling, rapid plasma membrane rupture, and release of proinflammatory contents 16 . (nature.com)
It is predominantly expressed intracellularly in the lysosomal/endosomal membrane in nearly all cells. (thermofisher.com)
Lipopolysaccharides - major components of the cell membrane of bacteria. (optimunity.com)

PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. (bioxcell.com)

This novel form of food allergy develops worldwide in adults who have tolerated meat consumption for years and is mediated predominantly by IgE antibodies specific for the carbohydrate galactose-α-1,3-galactose (α-gal) that is expressed on cells and tissues of dietary meat ( 1 - 11 ). (frontiersin.org)

PD-L1 overexpression results in increased resistance of tumor cells to CD8 T cell mediated lysis. (bioxcell.com)

Overall survival and progression-free survival were found to be similar for early-stage nodal DLBCL and DLBCL-bone, but inferior in EN-DLBCL. (bvsalud.org)
Advanced stage disease involving the bone had a similar 5-year progression-free survival to nodal disease and EN-DLBCL. (bvsalud.org)
2015). "Programmed death-1 controls T cell survival by regulating oxidative metabolism" J Immunol 194(12): 5789-5800. (bioxcell.com)
Downstream of PD-1, elevated ROS levels impaired T cell survival in a process reversed by antioxidants. (bioxcell.com)

Mechanistically, the cell death-sensitizing effect of the D377A mutation depends on glutamine-469. (sfb1530.de)

This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although the mechanisms for such regulation are diverse. (mdpi.com)
In this review, we describe the latest findings describing the effects of omega-3 fatty acids on different cells from the immune system and their possible molecular mechanisms. (mdpi.com)
In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)
In doing so, the overarching goal of the Collaborative Research Center is to create and strengthen synergies towards the discovery of patho-mechanisms and the identification of innovative therapeutic strategies beyond the lymphoma cell-autonomous level. (sfb1530.de)
In summary, the SFB1530 will undertake a holistic and interdisciplinary effort, which will create a comprehensive inventory of the major patho-mechanisms that define high-risk B cell malignancies in their specific microenvironment as a molecular framework for mechanism-based therapies. (sfb1530.de)
Progression through the cell cycle critically relies upon post-translational mechanisms including changes in activity of cell cycle kinases and phosphatases, and ubiquitin-mediated degradation of specific components once their function is complete. (elifesciences.org)

In vitro studies examining the effects of CRH1 antagonists on the Hypothalmic-Pituitary-Adrenal (HPA) axis showed that Antalarmin inhibited ACTH release in rat anterior pituitary cells, as well as inhibited cortisol synthesis and release in human adrenal cells. (wikipedia.org)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

Targeting CHI3L1 could mitigate immune escape and potentiate antibody and cell-based immunotherapies. (bmj.com)

For the generation of the experimental data, the canine osteosarcoma primary cell cultures were plated in 384 well plates at a seeding density of 2000 cells per well over graded concentrations of 60 small molecule kinase inhibitors. (microrna1.com)
The IC50 for Inhibitors,Modulators,Libraries each drug was then determined by identification of the two concentrations bracketing 50% cell viability and application of the following formula DA where cell viabil ity value above 50% A and cell viability value below 50% B. The experimentally generated IC50 values are included as Additional file 2. (microrna1.com)

Since NK cells play a critical role in ADCC, lyzing tumor target cells via therapeutic mAbs, and inhibitory-cell KIRs negatively regulate NK cell-mediated killing of HLA class I-expressing tumors, mAbs targeting KIR might prevent their inhibitory signaling leading to enhanced ADCC. (medscape.com)
Induced PD-L1 expression is common in many tumors including squamous cell carcinoma, colon adenocarcinoma, and breast adenocarcinoma. (bioxcell.com)

Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. (bioxcell.com)

Influence of physicochemical properties of silver nanoparticles on mast cell activation and degranulation. (nih.gov)
Little data exists on understanding interactions of AgNPs with mast cells and the properties that influence activation and degranulation. (nih.gov)
Although phosphoantigens (e.g.-isopentenyl pyrophosphate) can induce polyclonal γ 9 δ 2 T cell activation and anti-tumor immunity, we have shown that these same activation conditions do not generate γ 9 δ 2 T cells capable of inhibiting intracellular mycobacterial growth [7] . (prolekarniky.cz)
Vaccines or, alternatively, the utilization of genetically engineered memory T cells could be methods of engaging and creating cancer-specific T cells with superb memory, lenient activation requirements, potent antitumor cytotoxicity, tumor surveillance, and resilience against immunosuppressive factors in the tumor microenvironment. (salk.edu)
In this review we analyze memory T cell subtypes based on their potential utility in cancer immunoprevention with regard to longevity, localization, activation requirements, and efficacy in fighting cancers. (salk.edu)
Nevertheless, it has been proven that solely targeting the activation of T cells to enhance the immune system's cytotoxic potential is insufficient to address the underlying challenge of immunosuppression in the context of cancer [ 8 ]. (biomedcentral.com)
Targeting of BP180 by autoantibodies leads to activation of the complement system, which mediates a series of inflammatory events, including dermal mast cell degranulation, generation of eosinophil-rich infiltrates, and subsequent blister formation [ 3 , 4 ]. (oncotarget.com)

Effects of polychlorinated biphenyls on dopamine release from PC12 cells. (cdc.gov)

This PD-1(Hi)ROS(Hi) phenotype was specific to alloreactive T cells and was not observed in syngeneic T cells during homeostatic proliferation. (bioxcell.com)

Improved patient outcomes can only be achieved in an interdisciplinary approach and strengthening of synergies towards the discovery of pathomechanisms and the identification of innovative therapeutic strategies beyond the lymphoma cell-autonomous level. (sfb1530.de)

Investigations of other soluble factors produced by γ 9 δ 2 T cells identified a highly significant correlation between the levels of granzyme A produced and intracellular mycobacterial growth inhibition. (prolekarniky.cz)

However, recent research suggests that the simplistic dichotomy of immune cells in cancer may not provide a comprehensive depiction of the entire landscape. (biomedcentral.com)

In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)

Furthermore, purified granzyme A alone induced inhibition of intracellular mycobacteria, while knockdown of granzyme A in γ 9 δ 2 T cell clones blocked their inhibitory effects. (prolekarniky.cz)
Ginkgo biloba protects endothelial cells against the negative effects of oxygen produced by the hypoxanthine/xanthine oxidase system by inhibiting the lipid peroxidation and by preventing the decrease of intracellular glutathione. (energywave.com)
Applications Tested: This eBioH4A3 antibody has been pre-titrated and tested by intracellular staining and flow cytometric analysis of the Jurkat cell line. (thermofisher.com)

Immunotherapy seems promising and may prove effective in eradicating the malignant stem cell pool that is nonproliferating and generally resistant to chemotherapy. (medscape.com)
Malignant disease is associated with increased catecholamine levels in patients, and our results establish a connection between the sympathetic stress response, tissue innervation and T cell exhaustion. (salk.edu)

We then provide recent insights into the role of B cells in IgE production in human patients with mammalian meat allergy and in a novel mouse model of meat allergy. (frontiersin.org)

Table 2 shows the binding affinities of each compound in various cell lines. (wikipedia.org)

We found that both murine and human alloreactive T cells concomitantly upregulated PD-1 expression and increased levels of reactive oxygen species (ROS) following allogeneic bone marrow transplantation. (bioxcell.com)

We demonstrate that recombinant CHI3L1 inhibits both ADCC and innate NK cell cytotoxicity. (bmj.com)

Neutralization of TNF-α in co-cultures of infected monocytes and γ 9 δ 2 T cells prevented inhibition, suggesting that TNF-α was the critical inhibitory factor produced by γ 9 δ 2 T cells. (prolekarniky.cz)
Cellular FLICE-like inhibitory protein (cFLIP) is a crucial regulator of cell death and a substrate of Caspase-8. (sfb1530.de)

Preclinical results in MM cell lines and murine explant models, and preliminary clinical results in patients with relapsed/refractory MM, suggest that mAbs are likely to act synergistically with traditional therapies including dexamethasone, cytotoxic drugs, immune modulators (thalidomide, lenalidomide) and other novel therapies (e.g., the first-class proteasome inhibitor bortezomib). (medscape.com)

RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)
Our results provide evidence that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replication. (elifesciences.org)

[ 162 ] Finally, new insights suggest that circulating CD20 + clonotypic B cells, which may act as precursors or 'neoplastic stem cells' in MM patients, representing the proliferative compartment of the disease, play an important role in determining relapse after effective treatments. (medscape.com)
We conducted a single-center, investigator-initiated, phase II study of immunochemotherapy incorporating lenalidomide, without autologous stem cell transplant consolidation, enriching for patients with high-risk MCL (NCT02633137). (bvsalud.org)
A particular focus is on how both tissue-resident memory T cells and stem memory T cells could be promising subtypes for engaging in immunoprevention. (salk.edu)
Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)

Next, by observing live imaging recording was -- we could measure that the time required for the infected T cell to form a productive synapse with epithelial, which lasts approximately a half an hour before the T cell is able to shed virus for another hour and leave its site of (inaudible) as you just show. (nih.gov)

We discuss factors that influence CD8 T cell differentiation and function in cancer through a framework that incorporates the classic three-signal model and a fourth signal-metabolism-and also consider the impact of the tumor microenvironment from a T cell perspective. (salk.edu)
Blockade of PD-1 increases the severity of graft-versus-host disease (GVHD), but the interplay between PD-1 inhibition and T cell metabolism is not well studied. (bioxcell.com)

A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)

Anatomy15

Organisms9

Diseases13

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes16

Bone marrow-derived mast cells2

Receptors8

Cytokine production3

Neutrophil5

Inhibit6

Molecules5

Mediators8

Histamine4

Contributes2

Significantly5

Macrophages5

Allergic8

Vivo5

Tyrosine3

Peripheral blood mononuclear cells2

Vascular1

Dependent10

Induces2

Responses8

Inhibition of mast cell1

Mice4

Apoptosis4

Neutrophils6

Receptor4

Tissue injury1

Effector4

Inflammatory cells1

Mast cell-mediated1

Membrane3

Myeloid cells1

Tissues1

Tumor cells1

Survival4

Mechanistically1

Mechanisms6

Vitro2

Immunotherapies1

Concentrations2

Tumors2

Lymphocytes1

Activation7

Release1

Proliferation1

Therapeutic1

Soluble1

Suggests1

Methods1

Intracellular3

Malignant2

Mammalian1

Compound1

Human1

Inhibits1

Inhibitory2

Murine1

Results2

Stem4

Epithelial1

Metabolism2

Antibody1