• Many controlled clinical trials and numerous systematic reviews of these studies have been published. (meridianhealthnc.com)
  • While advanced age can be a possible factor in sperm motility and health, the sperm of men below 20 years of age has likewise been linked to an increase in birth defects such as neural tube defects, hypospadias, cystic kidney, and Down syndrome. (wikipedia.org)
  • For example, one study of 943,664 children less than 10 years old, found that, with confounding variables controlled, the risk of autism increased with increasing paternal age. (wikipedia.org)
  • Brucellosis can occur in any age group, but mainly found in young men between the ages of 20 and 40 years because of occupational hazards. (bvsalud.org)
  • A 2017 review and meta-analysis found sperm counts among Western men (i.e. men in Australia, Europe, New Zealand, and North America) declined 50-60% between 1973 and 2011, with an average decline of 1.4% per year. (wikipedia.org)
  • The majority of studies using such devices fails to show effects beyond a placebo response. (meridianhealthnc.com)
  • Secondary infertility refers to infertile couples who have been able to achieve pregnancy at least once before (with the same or different sexual partner). (uroweb.org)
  • In 50% of involuntarily childless couples, a male-infertility-associated factor is found, usually together with abnormal semen parameters [ 1749 ]. (uroweb.org)
  • In 30-40% of cases, no male-associated factor is found to explain the underlying impairment of sperm parameters and historically was referred to as idiopathic male infertility. (uroweb.org)
  • Unexplained male infertility is defined as infertility of unknown origin with normal sperm parameters and partner evaluation. (uroweb.org)
  • It is now believed that idiopathic male infertility may be associated with several previously unidentified pathological factors, which include but are not limited to endocrine disruption as a result of environmental pollution, generation of reactive oxygen species (ROS)/sperm DNA damage, or genetic and epigenetic abnormalities [ 1753 ]. (uroweb.org)
  • Advanced paternal age has emerged as one of the main risk factors associated with the progressive increase in the prevalence of male factor infertility [ 1754-1761 ]. (uroweb.org)
  • Table 52 summarises the main male-infertility-associated factors. (uroweb.org)
  • The purpose of this study was to determine the causes of infertility in patients, the appropriate ART treatment, and their prognosis in terms of pregnancy. (bvsalud.org)
  • OBJECTIVE: Congenital FSH deficiency is an exceptional cause of male infertility most often attributed to FSH ß gene mutations. (bvsalud.org)
  • Roux-en-Y gastric bypass surgery, one option for the treatment of morbid obesity, has been shown in one study to seemingly reverse abnormal reproductive hormonal profiles, such that total testosterone is increased and serum estradiol is decreased. (medscape.com)
  • Semen quality is a measure of male fertility, a measure of the ability of sperm in semen to accomplish fertilization. (wikipedia.org)
  • A 2017 review and meta-analysis found sperm counts among Western men (i.e. men in Australia, Europe, New Zealand, and North America) declined 50-60% between 1973 and 2011, with an average decline of 1.4% per year. (wikipedia.org)
  • The decline in sperm count among men in South America, Asia, and Africa is less than men in Western countries, though the amount of decline in these regions is uncertain. (wikipedia.org)
  • Although it is possible for men to father children into old age, the genetic quality of sperm, as well as its volume and motility, all typically decrease with age. (wikipedia.org)
  • In men with a normal level of sperm production (normozoospermia), the percentage of sperm DNA fragmentation is positively correlated with age, and inversely correlated with progressive sperm motility. (wikipedia.org)
  • While advanced age can be a possible factor in sperm motility and health, the sperm of men below 20 years of age has likewise been linked to an increase in birth defects such as neural tube defects, hypospadias, cystic kidney, and Down syndrome. (wikipedia.org)
  • We report the exploration of two young men aged 26 and 27 years with severe sperm abnormalities, moderate testicular hypotrophy and isolated FSH deficiency. (bvsalud.org)
  • Hypogonadism in males encompasses disrupted testicular functions, including deficient steroidogenesis and/or spermatogenesis. (medscape.com)
  • [ 39 ] We will discuss several hypogonadal mechanisms with either testicular or hypothalamic origins that explain the association between obesity and male hypogonadism. (medscape.com)
  • Adipocyte-derived Estrogen & Hypogonadism Adipocyte-derived estrogens in obese men provide feedback inhibition to the HPT axis, modulated by the presence of estrogen receptors (ER-α and -β) localized to the hypothalamus and pituitary, shown in mouse [ 40 ] and rat. (medscape.com)
  • [ 41 , 42 ] A plausible biological mechanism for obesity-induced hypogonadotropic hypogonadism may result, in part, from increased feedback inhibition of the HPT axis due to high serum levels of estrogens in obese males. (medscape.com)
  • Obesity-induced hypogonadism in males may be treated by weight loss, which should reduce estrogen levels to normal and alleviate the HPT feedback inhibition. (medscape.com)
  • Likewise, advanced maternal age must be considered in the management of every infertile couple, and in the subsequent decisions in the diagnostic and therapeutic strategy of the male partner [ 1762 , 1763 ]. (uroweb.org)
  • Research Question: Unlike in men, a very limited number of studies were focused on the specificity of ART management of cystic fibrosis (CF) in women. (bvsalud.org)