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Viral Nonstructural ProteinsAntigensAntigens, BacterialAntigens, SurfaceAntigens, NeoplasmAntigens, ViralAntigens, CDMolecular Sequence DataAmino Acid SequenceCell LineAntigens, CD8Antigens, CD3Virus ReplicationProtease InhibitorsAntibodies, MonoclonalMinute virus of miceRNA, ViralEpitopesViral ProteinsT-LymphocytesBase SequenceAntigens, ProtozoanHepacivirusDengue VirusAntigens, CD34Mice, Inbred BALB CAntigens, CD38Enzyme-Linked Immunosorbent AssayImmunoglobulin GCD4-Positive T-LymphocytesAntigens, CD40Antigens, CD19Serine EndopeptidasesLymphocyte ActivationPolyproteinsSindbis VirusRNA HelicasesHLA AntigensImmunizationAntigens, Polyomavirus TransformingCross ReactionsRecombinant ProteinsAntigens, FungalAntigens, CD20Antibodies, BacterialAntigens, CD28H-2 AntigensHIV ProteaseAntibodies, ViralAntigens, CD1Antibody FormationB-LymphocytesCD40 LigandAntigens, DifferentiationRepliconParvovirusAntigens, HelminthCells, CulturedAntigens, CD14OvalbuminGenome, ViralAntigens, CD44Antigens, CD7Antigens, CD2Flow CytometryHistocompatibility Antigens Class IIVero CellsImmune SystemAntibody SpecificityCercopithecus aethiopsImmune SeraMolecular WeightPeptide HydrolasesImmune ToleranceAntigens, CD80Antigens, CD5Mice, Inbred C57BLReceptors, Antigen, T-CellHLA-DR AntigensRNA ReplicaseMutationViral Core ProteinsRecombinant Fusion ProteinsCarcinoembryonic AntigenCD4-CD8 RatioBacterial ProteinsFoot-and-Mouth Disease VirusRotavirusAntigens, Viral, TumorFluorescent Antibody TechniqueCysteine EndopeptidasesSpleenMembrane GlycoproteinsAntigens, CD56Encephalitis Virus, JapaneseSemliki forest virusEndopeptidasesCloning, MolecularAntigens, Differentiation, MyelomonocyticAntigens, CD45
CellularViralHighlySystemDomain
Cellular2
  • The large pre-protein is later cleaved by cellular and viral proteases into the 10 smaller proteins that allow viral replication within the host cell, or assemble into the mature viral particles. (wikipedia.org)
  • In contrast, free cellular spike protein is selectively cleaved into S1 and S2 subunits in a lysosomal-dependent manner. (bvsalud.org)
Viral5
  • This is why on publicly available databases, such as the European Bioinformatics Institute, the viral proteome only consists of 2 proteins. (wikipedia.org)
  • citation needed] At the 5′ and 3′ ends of the RNA are the untranslated regions (UTR), that are not translated into proteins but are important to translation and replication of the viral RNA. (wikipedia.org)
  • The mature nonstructural proteins (NS2 to NS5B) generation relies on the activity of viral proteinases. (wikipedia.org)
  • NS1 (p7) protein is dispensable for viral genome replication but plays a critical role in virus morphogenesis. (wikipedia.org)
  • ACE2 interacts with the spike protein and facilitates viral attachment and entry into host cells. (bvsalud.org)
Highly3
  • domain 3 (residues 175-191) is highly hydrophobic and acts as a signal sequence for E1 envelope protein. (wikipedia.org)
  • Both envelope proteins (E1 and E2) are highly glycosylated and important in cell entry. (wikipedia.org)
  • SARS-CoV-2 viruses are highly transmissible and immune evasive. (bvsalud.org)
System4
Domain1
  • The crystal structure of Nb4 in complex with the receptor-binding domain (RBD) of BA.1 Spike protein reveals that Nb4 interacts with an epitope on the RBD overlapping with the receptor-binding motif, and thus competes with angiotensin-converting enzyme 2 (ACE2) binding. (bvsalud.org)