Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. (cdc.gov)
Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) was originally discovered in tissue from patients with familial prostate cancer homozygous for a missense mutation in the RNase L gene, R462Q ( 1 ). (cdc.gov)
A new study reveals that XMRV is present in respiratory secretions. (virology.ws)
XMRV was present in eight of twenty (40%) cases in patients with familial prostate cancer that were homozygous at the R462Q locus for the QQ allel. (biomedcentral.com)
Neither in the 76 specimens homozygous for the QQ allele, nor in any of the other samples could XMRV or a related gammaretrovirus be detected. (biomedcentral.com)
No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected. (medscape.com)
Conclusions: Overall, the replication-competent retrovirus XMRV, present in a high number of laboratories, is able to infect human lymphoid tissue and produce infectious viruses, even though they were unable to establish a new infection in fresh tonsillar tissue. (x-rx.net)
Murine2
One specific gammaretrovirus that is commonly used as a retroviral vector is the Moloney murine leukemia virus. (wikipedia.org)
There have also been claimed discoveries of murine gammaretroviruses in lung cancer cell lines. (wikipedia.org)
Endogenous4
Many endogenous retroviruses, closely related to exogenous gammaretroviruses, are present in the DNA of mammals (including humans), birds, reptiles and amphibians. (wikipedia.org)
This gammaretrovirus called Tursiops truncates endogenous retrovirus, was thought to be from extant mammalian endogenous gammaretroviruses. (wikipedia.org)
The Tursiops truncates endogenous retrovirus original invasion dates back to approximately 10-19 million years ago, and was identified in killer whale endogenous gammaretrovirus which invaded over 3 million years ago. (wikipedia.org)
In 2009, another endogenous gammaretroviruses were detected in a species of killer whale, as well as nine other cetacean genomes. (wikipedia.org)
Lentivirus1
Several retroviruses, including members of the genera Lentivirus , Gammaretrovirus , and Deltaretrovirus have been shown to cause disease in the CNS. (biomedcentral.com)
Retroviruses1
Gammaretroviruses are similar to other retroviruses and reverse transcribe a positive single strand RNA into double stranded DNA. (wikipedia.org)
Genus1
Gammaretrovirus is a genus in the Retroviridae family. (wikipedia.org)
Tumor1
most tumors present with non-specific symptoms mainly related to tumor location. (liverpool.ac.uk)
Gene therapy3
As a potential vector for gene therapy, gammaretroviruses have some advantages over HIV as a lentiviral vector. (wikipedia.org)
Further, while gene therapy has been used mainly for the treatment of cancer, it finds growing use in the treatment of numerous uncommon disease for which there is no treatment at present. (emergenresearch.com)
Despite the significant health benefits provided by cell and gene therapy, they typically entail high upfront costs that present further challenges to healthcare systems for sustainability and budget. (emergenresearch.com)
Sequences1
Estimates of ages for these sequences are reassuring, in the sense of suggesting present infections are rare. (phoenixrising.me)
Species2
Researchers also looked into several different types of bat species to solidify the claim that bats are the main reservoir for gammaretroviruses. (wikipedia.org)
Arthritis was radiographically present in 88 %, affecting the spine in 45 % of patients. (mdmpathway.com)
Patients with CFS present to the emergency department with a complex list of symptoms, including orthostatic intolerance, fatigue, postexertional malaise (PEM), and diarrhea. (medscape.com)
Such patients do not present with the physical findings or abnormal laboratory findings that characterize CFS. (medscape.com)
It is especially important to rule out systemic disorders, particularly lymphoreticular malignancies, in patients who present with fatigue. (medscape.com)
Laboratory1
Gammaretroviruses are very popular retroviral vectors in laboratory studies. (wikipedia.org)
Terminal3
If present, long terminal repeats (LTRs) have been highlighted in blue. (gydb.org)
Griffithsin's antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. (mdpi.com)
Another design strategy was developed using gammaretroviruses backbone where 2 domains were substituted with HIV epitopes in the N-terminal part of the ectodomain and the membrane proximal external region (MPER) respectively. (europa.eu)
However, bats are the primary reservoir for many gammaretroviruses. (wikipedia.org)
Expression1
A heritable chemical modification of DNA (replacement of cytosine by 5-methyl cytosine) that, when present in a control region, usually suppresses expression of the corresponding gene. (nationalacademies.org)