Presence histocompatibility antigens. Medical search. Frequent questions

Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)
Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
Insufficient persistence and effector function of chimeric antigen receptor (CAR)-redirected T cells have been challenging issues for adoptive T cell therapy. (biomedcentral.com)

Presence or absence of MICA antibodies may assist clinicians in determining the survival of organ transplant patients. (loinc.org)
However, staining in the presence of antibodies reactive with ILT receptors revealed that the interaction of HLA-G tetramers with blood monocytes was largely due to binding to ILT4. (ox.ac.uk)
The cellular response is mainly a lymphocyte-mediated reaction, whereas the humoral response includes production of antibodies against the antigen by the plasma cells. (medscape.com)
Immunoglobulins (Igs), the term is sometimes used interchangeably with "antibodies," are glycoprotein molecules produced by B lymphocytes and plasma cells in response to an immunogen or after recognition of specific epitopes on the antigen. (medscape.com)
The antibodies then specifically bind to only those particular antigens. (medscape.com)
HLA class I sensitization was determined by the presence of anti-HLA class I antibodies. (emmes.com)
The recipient was tested at regular intervals post-transplant for the presence and/or development of HLA-specific antibodies. (uabmedicine.org)
Expression of Ia and four other plasma membrane antigens was monitored by quantitative binding and radioautographic studies with 125 I-monoclonal antibodies. (rockefeller.edu)
Major histocompatibility complex class III associations have also been observed, as has a high frequency of anti-human leukocyte antigen antibodies. (medscape.com)
Immunogenetic studies found a significant association between HLA-DR3 and the presence of antisynthetase antibodies (P = 0.049), anti-PM-Scl antibodies (P = 0.017), and interstitial lung disease (P = 0.03). (nih.gov)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
Pemphigus vulgaris (PV) is a chronic, vesiculobullous, mucocutaneous autoimmune fatal disease, characterized by the presence of antibodies against adhesion molecules (desmoglein, Dsg3) present on the surface of keratinocytes, leading to the loss of cellular adhesion or acantholysis and is typically associated with oral lesions 1-5 . (bvsalud.org)

Superantigens simultaneously bind to major histocompatibility complex class II molecules and T-cell receptor molecules bearing a particular V-β region. (cdc.gov)
The present study was designed to test the hypothesis that signals delivered via the B cell antigen (Ag) receptor (membrane immunoglobulin, mIg) and major histocompatibility complex (MHC) class II molecules enhance B cell responsiveness to CD40‐mediated signals, providing specificity to the Ag‐nonspecific, MHC‐unrestricted CD40 signal. (uthscsa.edu)
However, anergy but not suppression was observed in co-cultures restimulated with anti-T-cell antigen receptor (TCR) mAbs/syngeneic APCs and suppression could be restored by the addition of I-Ab+ APCs. (ox.ac.uk)
The levels of three other non-major histocompatibility complex (MHC) antigens, including the trypsin-resistant Fc receptor, were similar in cells exposed to both sources of LK. (rockefeller.edu)
They can be distinguished from other lymphocyte types, such as B cells and NK cells by the presence of a special receptor on their cell surface called the T cell receptor (TCR). (wikidoc.org)
The interaction between the T cell receptor (TCR) and the antigen-presenting major histocompatibility complex (pMHC) on a contacting T cell and APC, is widely accepted to be the key interaction. (lu.se)

However, there is death by apoptosis of thymocytes that do not interact with MHC molecules or have high-affinity receptors for self MHC plus self antigen a process referred to as negative selection. (wikipedia.org)
Bishop, GA, Warren, WD & Berton, MT 1995, ' Signaling via major histocompatibility complex class II molecules and antigen receptors enhances the B cell response to gp39/CD40 ligand ', European Journal of Immunology , vol. 25, no. 5, pp. 1230-1238. (uthscsa.edu)
Antigens are the molecules that are recognized and stimulate the cells of immune system. (medscape.com)
Variable region constitutes the antibody binding region of the molecule to the different antigens as it consists of about 110 amino acids that vary widely among the different antibody molecules. (medscape.com)
Abnormal expression of major histocompatibility complex class II molecules in the placenta may trigger the initiating immunologic event in this organ, which is followed by cross-reactivity with an antigen present in the skin and the characteristic cutaneous signs of the disease. (medscape.com)
Major histocompatibility complex (MHC) class I and II molecules which are called human leukocyte antigens (HLA), play an important role in the immune response (16). (ac.ir)
These molecules of cell surface play a critical role in antigen processing and T cell activity. (ac.ir)
A small fraction of T cells recognizes alloantigen as antigenic peptide(s) presented by other major histocompatibility complex class I molecules and tolerance can be induced in this population by soluble alloantigen. (uni-muenchen.de)
Unlike conventional T cells that recognize peptide antigen presented by major histocompatibility complex (MHC) molecules, NKT cells recognize glycolipid antigen presented by a molecule called CD1d. (wikidoc.org)
However, γδ T cells are not MHC restricted and seem to be able to recognise whole proteins rather than requiring peptides to be presented by MHC molecules on antigen presenting cells. (wikidoc.org)
Upon the stage of tumorigenesis, down-regulation of the major histocompatibility complex class-I (MHC-I) molecules and also the overexpression of the stress-induced ligands on the surface of malignant cells to avoid recognition by cytotoxic T-lymphocytes (CTLs), make them more sensitive to NK cell-mediated death. (biomedcentral.com)
Eosinophils function as antigen presenting cells as they express major histocompatibility complex (MHC) class II molecules. (medscape.com)
In the final part of the thesis, the interaction of TCR-pMHC in the presence of adhesion molecules of different length and density is studied. (lu.se)
To better understand how, and if, adhesion molecules of different lengths influences TCR-pMHC binding the 2D Kd of TCR-pMHC in the presence of differently-sized adhesion molecules was studied. (lu.se)

The nonclassical MHC class I molecule human histocompatibility leukocyte antigen (HLA)-G is selectively expressed on fetal trophoblast tissue at the maternal-fetal interface in pregnancy. (ox.ac.uk)
In contrast, only transgenic mice failed to generate a cytolytic T-cell response to soluble H-2Kk antigen expressed by recombinant vaccinia virus and presented by the H-2Db molecule. (uni-muenchen.de)
This population is not affected by tolerance induction to the soluble major histocompatibility complex class I molecule. (uni-muenchen.de)
Naturally occurring T reg cells can be distinguished from other T cells by the presence of an intracellular molecule called FoxP3 . (wikidoc.org)
On a virus-infected host cell, the antigen is made up of an MHC molecule and attendant virus protein. (lu.se)

Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells. (ox.ac.uk)
This report from CITR presents pre- and posttransplant human leukocyte antigen (HLA) class I sensitization rates in islet-alone transplantation. (emmes.com)
The UAB Comprehensive Transplant Institute performs human leukocyte antigen (HLA) testing prior to organ transplantation, to help ensure a good match between donor and recipient and reduce the risk of rejection. (uabmedicine.org)
Leading up to UAB's first clinical-grade pig-to-human kidney xenotransplant, the laboratory, under the direction of Vera Hauptfeld-Dolejsek, PhD , developed swine leukocyte antigen (SLA) testing protocols for similarly determining how well a pig's organs would match with a particular human recipient. (uabmedicine.org)
Homocitrullinated peptides were identified and assessed in vitro for HLA-A2 binding and in vivo in human leukocyte antigen (HLA) transgenic mouse models for immunogenicity. (scancell.co.uk)
HLA-A and HLA-B (major histocompatibility complex, class I, A, and B) are closely related proteins in the human leukocyte antigen (HLA) complex. (swissprot20.org)
A clear association has been made between reactive arthritis and a genetic factor called the human leukocyte antigen (HLA) B27 genotype. (marlerblog.com)
Patients carrying the major histocompatibility complex (MHC) class 1 human leukocyte antigen ( HLA )-B27 are at risk of developing levamisole related agranulocytosis [5]. (dermnetnz.org)
HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. (cdc.gov)
13 Our study substantially expands this work by not only analysing imputed classical human leukocyte antigen (HLA) alleles, but also examining variant HLA amino-acid positions in conjunction with single-nucleotide polymorphism (SNP) genotypes across the extended MHC region (chromosome 6: 26-34 Mb). (cdc.gov)

Although graft or bone marrow rejection can have detrimental effects, there are immunotherapy benefits when cytotoxic T lymphocytes are specific for a self antigen and can target antigens expressed selectively on leukemic cells in order to destroy these tumor cells referred to as graft-versus- leukemia effect (GVL). (wikipedia.org)
The major cytokines released from antigen-presenting cells and T cells after activation by SAgs are tumor necrosis factor alpha (TNF-α), tumor necrosis factor beta (TNF-β), interleukin (IL)-1, and IL-2 ( 11 - 14 ). (cdc.gov)
Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
Human tumor samples were analyzed by targeted mass spectrometry for presence of homocitrullinated peptides. (scancell.co.uk)
While tumor imaging and radiotherapy strategies are crucial for tumor identification and treatment, the presence of metastasis and radiation resistance has reduced the efficacy of treatment in cancer patients. (biomedcentral.com)

Minor histocompatibility antigen (also known as MiHA) are peptides presented on the cellular surface of donated organs that are known to give an immunological response in some organ transplants. (wikipedia.org)
Minor histocompatibility antigens (MiHAs) are diverse, short segments of proteins and are referred to as peptides. (wikipedia.org)
These peptides are normally around 9-12 amino acids in length and are bound to both the major histocompatibility complex (MHC) class I and class II proteins. (wikipedia.org)
This contrasts with MHC class II molecules's antigens which are peptides derived from phagocytosis/endocytosis and molecular degradation of non-self entities' proteins, usually by antigen-presenting cells. (wikipedia.org)

Minor histocompatibility antigens are due to normal proteins that are in themselves polymorphic in a given population. (wikipedia.org)
Even when a transplant donor and recipient are identical with respect to their major histocompatibility complex genes, the amino acid differences in minor proteins can cause the grafted tissue to be slowly rejected. (wikipedia.org)
Major histocompatibility complex class I chain-related antigen A (MICA) proteins are like HLA class I gene products. (loinc.org)
Prime candidates are the streptococcal superantigens (SAgs), a family of highly mitogenic proteins secreted individually or in certain combinations by many Streptococcus pyogenes strains ( 7 - 10 ), although other virulence factors, such as Streptolysin O and various cell wall antigens can also cause toxic shock ( 11 ). (cdc.gov)
Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. (scancell.co.uk)
MHC (Major Histocompatibility Complex) is a complex of proteins that constitutes an important part of the immune system, helping to reveal the presence of bacteria or a virus in cells, for example. (lu.se)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Normally, immune cells can differentiate between healthy "self" and "other" cells by inspecting for the presence or absence of the normal "self" major histocompatibility complexes, also called human leukocyte antigens, present on the surface of every cell that contains a nucleus. (osmosis.org)
Suppression mediated by anergic CD4+ T cells requires stimulation by MHC-peptide complexes and can be induced in the presence of costimulation. (ox.ac.uk)
Multiple genetic susceptibility loci have been identified in genomic studies, and specific major histocompatibility complexes are also linked to lupus. (lww.com)
7 It is possible that these major histocompatibility complexes bind antigens in such a way that they increase the likelihood of T-cells mounting an immune response to self-antigens. (lww.com)

Whereas there is little evidence to indicate whether self-antigens in SLE are aberrant in sequence or structure, there is evidence that the aberrant handling of self-antigens could facilitate lupus pathogenesis. (biomedcentral.com)

The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA matched gene or a developing fetus's MiHAs during pregnancy may not be recognized by T cells and marked as foreign leading to an immune response. (wikipedia.org)
The MiHAs encoded by the Y chromosome are known as HY antigens. (wikipedia.org)

however, the challenge for T cells is to recognize tumour antigens whilst minimizing cross-reactivity with antigens associated with healthy tissue. (scancell.co.uk)

Neither anergy nor suppression was observed in Th0 cells upon restimulation with anti-CD3 in the presence of syngeneic antigen-presenting cells (APCs). (ox.ac.uk)
This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
Interactions between immune cells such as T cells and antigen-presenting cells (APCs) are integral for mounting an adaptive immune response. (lu.se)

Expression of major histocompatibility antigens in human chronic pancreatitis. (bmj.com)
The field of the subject invention is the use of major histocompatibility complex antigen lacking cells and organs which may serve as universal donors in cellular and organ therapies including transplantation and to produce chimeric non-human mammals. (justia.com)
The gene-modified pigs do not express red blood cell antigens and therefore are "universal donors" with respect to human blood type. (uabmedicine.org)
A role for the involvement of major histocompatibility complex class II antigens seems likely because of the association with human leukocyte antigens DR3 and DR4. (medscape.com)
HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)

MiHA antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells. (wikipedia.org)
Some of these antigens are ubiquitously expressed in nucleated male cells, and the presence of these antigens has been associated with a greater risk of developing GVHD allogeneic stem cell transplantation for a HLA matched gene when there's a male recipient and female donor. (wikipedia.org)
Aberrant MHC expression by exocrine pancreatic epithelial cells occurring in the presence of an appreciable T-cell infiltration confirmed that the appropriate cellular conditions were present for cell mediated cytotoxicity to contribute to the pathogenesis of chronic pancreatitis. (bmj.com)
This binding results in the activation of a large proportion of antigen-presenting cells and T cells, with subsequent release of high systemic levels of cytokines ( 12 - 15 ). (cdc.gov)
Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
To test this hypothesis, both an Ag‐specific mouse B cell clone CH12.LX, and freshly isolated resting splenic B cells were cultured with either soluble or membrane‐bound forms of the T cell ligand for CD40 (CD40L), in the presence or absence of additional signals provided by Ag or anti‐IgM, interleukin‐4, and class II‐specific monoclonal antibody (mAb). (uthscsa.edu)
Although the anergic and suppressive states of Th0 cells were stable in the presence of exogenous interleukin-2, this was not the case for Th1 cells. (ox.ac.uk)
The transduced CD19CAR T cells were expanded in the presence of IL-2 (50U/mL) and Akt inhibitor (Akti) (1 μM) that were supplemented every other day. (biomedcentral.com)
To evaluate this hypothesis, we transduced and expanded CD19CAR T cells in the presence of an Akt inhibitor. (biomedcentral.com)
Non-stimulated DCs and T cells interacted much less frequently and even more transiently while antigen and chemokine-loaded DCs and T cells depicted extremely stable interactions furthermore to transient and sequential get in touch with. (thetechnoant.info)
Soluble products from antigen stimulated Trypanosoma cruzi-immune spleen cells enhanced the expression of Ia antigens on proteose-peptone-elicited mouse peritoneal macrophages (Mphi). (rockefeller.edu)
Some tumour cells, including those associated with viral infections, have clear, tumour-specific antigens that can be targeted by T cells. (scancell.co.uk)
These data imply the presence of two populations of alloreactive cytolytic T cells. (uni-muenchen.de)
Memory T cells are a subset of antigen -specific T cells that persist long-term after an infection has resolved. (wikidoc.org)
They quickly expand to large numbers of effector T cells upon re-exposure to their cognate antigen, thus providing the immune system with "memory" against past infections. (wikidoc.org)
Antisera directed against histocompatibility-2 antigens of the mouse suppress the formation of spleen colonies by pluripotent hemopoietic stem cells. (tno.nl)
In vitro proliferation of haemopoietic cells in the presence of adherent cell layers. (tno.nl)
T-lymphocytes recognise a foreign substance, an antigen, on the surface of foreign or infected cells. (lu.se)

Systemic lupus erythematosus (SLE) is a complex disease characterized by the appearance of autoantibodies against nuclear antigens and the involvement of multiple organ systems, including the kidneys. (biomedcentral.com)
The presence of high titers of autoantibodies against nuclear antigens is the hallmark of SLE. (biomedcentral.com)

Both HLA class I and II alleles have been found to present these antigens. (wikipedia.org)
12 - 15 These studies focused mainly on major histocompatibility complex (MHC) class II genes, and found evidence that class II alleles such as HLA-DRB1*03:01 are associated with auto-antibody production. (cdc.gov)

As expression of major histocompatibility (MHC) antigens is a prerequisite for organ specific autoimmunity, the expression of HLA class I (beta 2-microglobulin) and class II (HLA-DR) determinants have been analysed, together with the presence of T-lymphocytes, in 93 patients (64 men and 29 women, mean age 40.6 years) having an operation for chronic pancreatitis. (bmj.com)
sub.2 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. (justia.com)
Each host has a personal set of Class I and II MHC antigens, which serve to distinguish that host from other hosts. (justia.com)

Association of BRC with the HLA-A29 major tissue histocompatibility (MHC) antigen was first reported in 1982, 2 years after the entity was originally described. (bmj.com)

The properties of transmembrane and soluble transplantation antigens were compared with respect to the induction of tolerance and the selection of the T-cell repertoire. (uni-muenchen.de)

As part of the system for the self-versus-foreign recognition, the surface membrane protein major histocompatibility complex (MHC) antigens serve an important role. (justia.com)
Diagnosis is made on the basis of the presence of a subepidermal vesicle on routine histologic examination and of linear deposition of the third component of complement along the basement membrane zone of perilesional skin. (medscape.com)

The recipient developed GVHD despite having a HLA- matched genes at the Major Histocompatibility locus. (wikipedia.org)
H-Y antigens are encoded by genes on the Y chromosome. (wikipedia.org)
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. (justia.com)

Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)

Despite the presence of H-2Kk antigen, these mice were still able to generate an H-2Kk-specific T-cell response. (uni-muenchen.de)

Immune LK selectively enhanced expression of Ia and, to a lesser extent, H-2D relative to control LK from antigen-stimulated noninfected spleen. (rockefeller.edu)

The recognition of a mature T cell to this self antigen should not induce an immune response. (wikipedia.org)
The lymphoid system is predicated upon recognition of the presence of such MHC antigens as self. (justia.com)

The body's immune system can react adaptively against the antigen via 2 pathways: cellular or humoral. (medscape.com)

Epitopes are a component of the antigen that are recognized by the immune system and determine whether the cellular or the humoral arm of the immune system shall be activated against that particular antigen. (medscape.com)

In the 1950s Pierard described the presence of clusters of neutrophils and eosinophils in the dermal papillae, especially in more recent lesions. (scielo.br)

Other research suggests that the joint inflammation characteristic of this disorder may result from improper folding of the HLA-B27 protein or the presence of abnormal forms of the protein on the cell surface. (medlineplus.gov)

They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC). (wikipedia.org)
It is generally assumed that sarcoidal granulomas are initiated when macrophages phagocytose an inciting antigen in a classic major histocompatibility complex (MHC) II restricted pathway. (mtbcuae.com)
Although genetic variation within the major histocompatibility complex (MHC) is associated with SLE, its role in the development of clinical manifestations and autoantibody production is not well defined. (cdc.gov)

The RAS etiology is less described, despite the overall agreement about the role of autoimmune reaction to oral mucosa or cross-reactive antigens. (ac.ir)

We found that Akt inhibition did not compromise CD19CAR T cell proliferation and expansion in vitro, independent of the T cell subsets, as comparable CD19CAR T cell expansion was observed after culturing in the presence or absence of Akt inhibitor. (biomedcentral.com)
HLA polymorphism can directly affect the bonding capacity of antigens and thus affect antigen-specific T-cell response (17). (ac.ir)
When the T-lymphocyte and antigen connect, the T-cell releases substances that kill the cell. (lu.se)

A fourth hypothesis employs H- Y antigen to select preimplantation embryos. (limotravel.info)

The presence of a foreskin may promote chronic irritation or serve to maintain a friendly environment for an as-yet unidentified infectious agent. (medscape.com)

Lymphokine enhances the expression and synthesis of Ia antigens on cul" by Ralph M. Steinman, Natalia Nogueira et al. (rockefeller.edu)
1980. "Lymphokine Enhances the Expression and Synthesis of Ia Antigens on Cultured Mouse Peritoneal Macrophages. (rockefeller.edu)

Several studies have reported the presence and absence of a relationship between HLA and RAS (18-20). (ac.ir)

Tests should be done to confirm the presence of genotypes that affect sensitivity to specific drugs. (swissprot20.org)

The present study aimed to examine the relationship between one of the histocompatibility antigens (HLA DRB1) and its sub-groups with the incidence of recurrent aphthous ulcers in North East of Iran (Mashhad) population. (ac.ir)

Patients with DH and CD may have the same association with histocompatibility antigens (HLA), the presence of circulating IgA against transglutaminase autoantigens and clinical remission on gluten-free diet. (scielo.br)
In the presence of low back pain without symptoms of radiculopathy, there is no need to request studies as most of the patients improve in a couple of weeks. (mtbcuae.com)

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