Bronchial alveolar lavage fluid (BALF) and lung tissue samples were collected from included patients, and were analyzed for MMP-2 and TIMP-2 expression. (oncotarget.com)
During disease exacerbation, increased inflammatory markers may be found in plasma as described for haptoglobin and serumamyloid A [ 14 ], but local neutrophila in bronchoalveolar lavage fluid (BALF) is considered the most reliable feature [ 15 ]. (biomedcentral.com)
Based on the changing disease pattern of human immunodeficiency virus (HIV) associated pulmonary complications we conducted a prospective study in order to compare the value of laboratory tests in patients with Pneumocystis (P.) carinii pneumonia (PCP) and other pulmonary complications and of different identification methods of P. carinii in bronchoalveolar lavage fluid (BALF) in PCP patients. (unboundmedicine.com)
Alveolar lavage fluid1
The standard method of diagnosis is Pneumocystis detection in broncho alveolar lavage fluid and high-resolution computed tomography can be detected in diffuse interstitial infiltration of both lungs. (ijpsonline.com)
Sensitivity5
The sensitivity, specificity, and positive/negative predictive values (PPV and NPV) of lung function for the detection of allograft dysfunction in these patients were measured. (bmj.com)
Because few organisms are found in sputum and the sensitivity of microscopic examination of induced sputum is variable, the diagnostic "gold standard" for PCP continues to be microscopy of bronchoalveolar lavage (BAL) fluid. (biomedcentral.com)
The sensitivity for detecting single whole AM using CD68 was 0.97 and the positive predictive value was 0.88, respectively, with excellent repeatability. (ersjournals.com)
Sensitivity, specificity, and positive and negative predictive values for this test were 92.5%, 100%, 100% and 99.1% respectively. (who.int)
Sensitivity, specificity and predictive values were calculated with 95% class intervals (CIs). (sciepub.com)
Sputum2
The currently recommended diagnostic methods using induced sputum (IS) and bronchoalveolar lavage (BAL) are neither technically feasible nor affordable for a wider clinical use in developing countries. (unboundmedicine.com)
To measure the diagnostic yield of bronchoalveolar lavage gene Xpert and compare it with traditional mycobacterial cultures in smear-negative and sputum-scarce pulmonary tuberculosis. (sciepub.com)
Endpoints2
however, in many cases, (bronchoalveolar lavage, BAL) and physiologic (Penh) endpoints it may require repeated exposures over weeks or months to to characterize asthma-like responses in rats. (cdc.gov)
Functional and molecular endpoints predictive of adverse health effects in recovered biological fluids of exposed animals that are translatable to human populations were examined. (cdc.gov)
Pneumocystis1
OpGen announced the release of two new peer-reviewed publications, the first demonstrating that the Unyvero LRT BAL panel accurately detects 19 bacteria alongside Pneumocystis jirovecii and 10 antibiotic resistance genes directly from bronchoalveolar lavage fluid, allowing enhanced diagnosis of lower respiratory tract infections, and the second publication highlighting Ares Genetics in best practice techniques for AI-powered prediction of antibiotic susceptibility testing by next-generation sequencing. (opgen.com)
Biomarkers3
Disease-related biomarkers give an indication of the probable effect of treatment on patient (risk indicator or predictive biomarkers), if a disease already exists (diagnostic biomarker), or how such a disease may develop in an individual case regardless of the type of treatment (prognostic biomarker). (wikipedia.org)
Predictive biomarkers help to assess the most likely response to a particular treatment type, while prognostic markers shows the progression of disease with or without treatment. (wikipedia.org)
The aim of our study was to investigate the predictive value of the biomarkers interleukin 6 (IL-6), interleukin 10 (IL-10) and lipopolysaccharide-binding protein (LBP) compared with clinical CRB and CRB-65 severity scores in patients with community-acquired pneumonia (CAP). (biomedcentral.com)
Diagnosis3
However, BAL fluid analysis can be very helpful in the differential diagnosis. (maastrichtuniversity.nl)
On oral wash specimens obtained from HIV-1 infected patients we found positive and negative predictive values of 93 and 91% for the diagnosis of PCP [ 2 ]. (biomedcentral.com)
OpGen announced the publication of the final study results of the Unyvero HPN Panel for diagnosis of bacterial co-infections in ICU patients with COVID-19 pneumonia demonstrating that the panel would enable crucially important rapid diagnosis of pathogens of concern in these patients, as well as a high negative predictive value of 99.8% for pathogen detection. (opgen.com)
Exposure2
A panel of proteins measured from bronchoalveolar lavage fluid (BAL) samples was used to predict exposure to various MWCNT and determine markers that are attributable to MWCNT exposure and toxicity in mice. (cdc.gov)
Whole blood and bronchoalveolar lavage fluid were collected at 7 wk (baseline before WF exposure), 12, and 24 wk to assess blood cell differential and to recover serum, peripheral blood mononuclear cells (PBMCs), and lung phagocytes for epigenetic analysis and immune response. (cdc.gov)
Antibiotic1
During antibiotic treatment for bacterial coinfections, increased BAL fluid levels of several activating and chemotactic factors for monocytes, lymphocytes, and NK cells were detected in patients with COVID-19 whereas concentrations tended to decrease in patients with influenza, highlighting the persistent immunological response to coinfections in COVID-19. (bvsalud.org)
Biological1
It may be defined as a "cellular, biochemical or molecular alteration in cells, tissues or fluids that can be measured and evaluated to indicate normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. (wikipedia.org)
19] LIN F C,CHEN Y C,CHANG S C.Clinical importance of bronchoalveolar lavage fluid and blood cytokines,surfactant protein D,and derbs von lungren 6 antigen in idiopathic pulmonary alveolar proteinosis[J].Mayo Clin Proc,2008,83(12):1344-1349. (ddxbyxb.cn)
Which factors may be predictive of postoperative pulmonary complications among patients with pulmonary diseases? (medscape.com)
Asthma2
Automated chart review utilizing natural language processing algorithm for asthma predictive index. (medscape.com)
Conclusion: Although XRCC3 plays a role in asthma etiology, the variant XRCC3 genotypes do not serve as practicable predictive markers for asthma risk in Taiwanese. (iiarjournals.org)
Respiratory2
To assess the upper respiratory tract in response to exercise, we collected nasal lavage fluid (NALF) from human subjects (1) at rest, (2) after 45 min of moderate-intensity exercise, and (3) after 180 min of moderate-intensity exercise. (bvsalud.org)
To assess immune responses of the lower respiratory tract, we utilized a murine model to examine the effect of exercise duration on bronchoalveolar lavage (BAL) fluid immune cell content and lung gene expression. (bvsalud.org)
In comparison with IS 6110 -based restriction fragment length polymorphism typing, spoligotyping overestimated the number of isolates with identical DNA fingerprints by ≈50%, but showed a 100% negative predictive value. (cdc.gov)
The LAMP assay had a positive predictive value (PPV) of 44.0% and a negative predictive value (NPV) of 99.9% for CPO, and 55.6% PPV and 98.2% NPV for nEcESBL-PE. (biomedcentral.com)
COPD1
23] De TORRES J P,CORDOBA-IANUS E,LBPEZ-AGUILAR C,et al.C-reactive protein levels and clinically important predictive outcomes in stable COPD patients[J].Eur Respir J,2006,27:902-907. (ddxbyxb.cn)
Clinical1
In the follow-up depicting prognosis and response to treatment, BAL fluid analysis has less clinical relevance. (maastrichtuniversity.nl)
Invasive1
Here, we collected bronchoalveolar lavage (BAL) fluids and parallel blood samples of critically ill COVID-19 patients requiring invasive mechanical ventilation and compared BAL fluid parameters with those of mechanically ventilated patients with influenza, as a non-COVID-19 viral pneumonia cohort. (bvsalud.org)
Bronchoalveolar lavage samples are characterized by a lym- phocytic infiltration. (cdc.gov)
Prognosis1
Many risk factors for poor prognosis have been reported, but few studies have created predictive models with these variables to calculate the death rate accurately. (researchsquare.com)
In contrast, α-1 antitrypsin levels and net proteolytic activity were comparable in COVID-19 and influenza BAL fluids. (bvsalud.org)
Cultures1
Bronchoalveolar lavage revealed Aspergillus niger and other species on fungal cultures. (medscape.com)
Cells3
In children, the description of developmental changes in immune receptor expression on alveolar macrophages (AM) has been limited by the small number of cells recovered by bronchoalveolar lavage (BAL). (ersjournals.com)
First, the recommended weight-adjusted bronchoalveolar lavage (BAL) volume 1 , 2 recovers only a small total number of AM. Secondly, normal healthy children must be recruited serendipitously prior to elective surgery, and cells must be stored for several weeks or months before batch processing. (ersjournals.com)
Bronchoalveolar lavage fluid CD4+ T cells of patients with COVID-19 were TH1-skewed and showed de-repression of genes downregulated by VitD, from either lack of substrate (VitD deficiency) and/or abnormal regulation of this system. (bvsalud.org)
Risk2
The simple risk predictive model for earlier recognition of IPA is useful in hospitalized AECOPD patients. (biomedcentral.com)
There is no Risk-Predictive scoring model of IPA currently. (biomedcentral.com)
Disease presentation or activity at the time the BAL is performed as well as the smoking status is crucial for interpretation of individual BAL fluid analysis results. (maastrichtuniversity.nl)