Precursor cells osteoclasts. Medical search. Frequent questions

PMID 9582524 Taylor R, Knowles H, Athanasou NA (2011) Ewing sarcoma cells express RANKL and support osteoclastogenesis. (wikipedia.org)
We also found that rapid application of the osteoclast-activation factor RANKL converted many N osteoclasts to R, suggesting a novel point of action in RANKL-mediated control of mature osteoclast function. (jci.org)
Furthermore, we showed that Th17 cells, a subset of RANKL-expressing CD4 + T cells, could induce rapid N-to-R conversion of mature osteoclasts via cell-cell contact. (jci.org)
These findings provide new insights into the activities of mature osteoclasts in situ and identify actions of RANKL-expressing Th17 cells in inflammatory bone destruction. (jci.org)
In contrast, TNF often acts on cell types other than osteoclasts, or synergically with RANKL to indirectly promote osteoclastogenesis and bone resorption. (frontiersin.org)
Osteoclast differentiation is induced by the master osteoclastogenic factor, RANKL, which acts in concert with M-CSF and ITAM-mediated co-stimulatory signaling. (frontiersin.org)
Recently, Th17 was reported to express RANKL itself as well as directly inducing mature osteoclasts via cell-to-cell contact, substantiating its role in inflammatory bone destruction [ 6 ]. (hindawi.com)
Prolia binds to RANKL, a transmembrane or soluble protein essential for the formation, function, and survival of osteoclasts, the cells responsible for bone resorption. (druglib.com)
Prolia prevents RANKL from activating its receptor, RANK, on the surface of osteoclasts and their precursors. (druglib.com)
Prevention of the RANKL/RANK interaction inhibits osteoclast formation, function, and survival, thereby decreasing bone resorption and increasing bone mass and strength in both cortical and trabecular bone. (druglib.com)
Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. (ebi.ac.uk)
Binding stimulates osteoblasts to increase their expression of RANKL , which can bind to osteoclast precursors containing RANK, a receptor for RANKL. (bionity.com)
The binding of RANKL to RANK stimulates these precursors to fuse, forming new osteoclasts which ultimately enhances the resorption of bone. (bionity.com)
Non-Canonical (RANKL-Independent) Pathways of Osteoclast Differentiation and Their Role in Musculoskeletal Diseases. (ox.ac.uk)
in the canonical pathway of osteoclastogenesis, these cells fuse and differentiate to form specialised bone-resorbing osteoclasts in the presence of receptor activator for nuclear factor kappa B ligand (RANKL). (ox.ac.uk)
This review summarises the evidence for these RANKL substitutes in inducing osteoclast differentiation from tissue-derived and circulating mononuclear phagocytes. (ox.ac.uk)
In this study, we examined the potential of SF extract (SFE) to inhibit receptor activator of NF-κB ligand (RANKL) -induced osteoclast differentiation in cultured mouse-derived bone marrow macrophages (BMMs). (biomedcentral.com)
BMMs, that act as osteoclast precursors, were cultured with M-CSF (50 ng/ml) and RANKL (100 ng/ml) for 4 days to generate osteoclasts. (biomedcentral.com)
SFE inhibited the RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1). (biomedcentral.com)
SFE attenuated the RANKL-mediated induction of NF-κB through inhibition of IκBα phosphorylation, which contributed to inhibiting of RANKL-induced osteoclast differentiation through downregulation of NFATc1. (biomedcentral.com)
Macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) are two cytokines secreted mainly by osteoclast. (biomedcentral.com)
Osteoclasts and odontoclasts are multinucleated cells derived from hematogenous bone marrow, from the monocyte/macrophage cell lineage, and are formed by the fusion of these cells under the action of colony stimulating factor 1 (CSF-1), macrophage colony stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1) and RANKL (receptor activator of nuclear factor kappa-B ligand), which also have a role in chemotaxis and cell differentiation [1]. (oatext.com)
The differentiation of the osteoclast precursor into a mature osteoclast requires RANKL binding to its receptor RANK (receptor activator of nuclear factor kappa-B). However, OPG binding to RANKL will block RANKL binding to RANK, which will result in inhibition of osteoclastogenesis (Figure 1) [3]. (oatext.com)
OPG binds RANKL as a decoy receptor, inhibiting the activation of RANK by RANKL and preventing the differentiation of bone marrow precursor (monocyte/macrophage) cells to osteoclasts - cells that are central in the process of bone resorption [ 2 ]. (biomedcentral.com)
Osteoblasts express RANKL constitutively on their cell surface. (biomedcentral.com)
Interaction of RANKL with RANK on mature osteoclasts results in their activation and prolonged survival. (biomedcentral.com)
We show that H3 monomethylation at lysine 27 (H3K27me1) is essential for MMP-9-dependent H3NT proteolysis during RANKL-induced osteoclast differentiation. (biomedcentral.com)
The binding of RANKL to its cognate receptor RANK on pre-osteoclast cell membrane stimulates the expression of key determinants of osteoclast differentiation such as NF-κB, c-Fos, and NFATc1 at the early stage of the process [ 1 , 8 ]. (biomedcentral.com)
Active Notch signaling in MM cells induces the secretion of the key osteoclastogenic factor, RANKL, which can be boosted in the presence of stromal cells. (oncotarget.com)
In turn, MM cells-derived RANKL causes the upregulation of its receptor, RANK, and Notch2 in pre-osteoclasts. (oncotarget.com)
Notch2 stimulates osteoclast differentiation by promoting autocrine RANKL signaling. (oncotarget.com)
DAP12 -/- osteoclasts developed in vitro with macrophage colony-sfimulating factor (M-CSF) and RANKL formed only intensely TRACP + mononuclear cells and failed to generate multinuclear osteoclasts. (elsevierpure.com)

Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistological distinction and implications for osteoclast ontogeny and function. (wikipedia.org)
In contrast, osteoclasts are derived from the monocyte/macrophage lineage. (medscape.com)
Osteoclasts are bone resorbing, multinucleate cells that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursor cells. (jci.org)
Osteoclasts are bone cells derived from monocyte/macrophage lineage and are exclusively responsible for bone resorption, which contributes to skeletal development, bone homeostasis, and remodeling. (frontiersin.org)
Previously, we reported that distinct murine osteoclast precursor subsets, such as early blasts (CD31hi Ly-6C−), myeloid blasts (CD31+ Ly-6C+), and monocytes (CD31− Ly-6Chi), respond differently to the osteoclastogenesis-inducing cytokines, macrophage colony-stimulating factor, and receptor activator for nuclear factor κB ligand. (vu.nl)
Cells were cultured on plastic or on bone slices in the presence of macrophage colony-stimulating factor and receptor activator for nuclear factor κB ligand, without or with interleukin 1β (0.1-10 ng/ml). (vu.nl)

Recent studies have uncovered key intrinsic mechanisms by which TNF acts on osteoclast precursors to restrain osteoclastogenesis, including the mechanisms mediated by RBP-J signaling, RBP-J and ITAM (Immunoreceptor tyrosine-based activation motif) crosstalk, RBP-J mediated regulatory network, NF- κ B p100, IRF8, and Def6. (frontiersin.org)
The inhibitory effect of RGE on Th17 differentiation and osteoclastogenesis observed in mice was also confirmed in the subsequent experiments performed using human peripheral blood mononuclear cells. (hindawi.com)
This study aims to investigate the effect of interleukin 1β on osteoclastogenesis derived from different mouse bone marrow precursors. (vu.nl)
Based on these lines of evidence, we hypothesize that HMGB1-mediated suppression of ACdase in senescent osteoclast precursors leads to the increased levels of intracellular ceramides that actively signal and, in turn, promote osteoclastogenesis in periodontal lesions of the aging population. (nova.edu)
Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. (joplink.net)
Similar to E2, the complex I inhibitor Rotenone decreased osteoclastogenesis by promoting osteoclast progenitor apoptosis via Bak/Bax. (bvsalud.org)
Here we present evidences that MM can efficiently drive osteoclastogenesis by contemporaneously activating Notch signaling on tumor cells and osteoclasts through the aberrant expression of Notch ligands belonging to the Jagged family. (oncotarget.com)
Such synergism between tumor cells and pre-osteoclasts in MM-induced osteoclastogenesis can be disrupted by silencing tumor-derived Jagged1 and 2. (oncotarget.com)
RAW264.7 cells were transfected with FLAG-tagged DAP12 or TREM2 and stimulated by anti-FLAG antibody during in vitro osteoclastogenesis. (elsevierpure.com)
Restoration of DAP12 expression by retroviral transduction of DAP12 -/- osteoclast precursors rescued in vitro osteoclast multinucleation, Direct sfimulation of DAP12 expressed in RAW264.7 during in vitro osteoclastogenesis led to a marked increase in the number of TRACP + multinucleated osteoclast-like cells formed. (elsevierpure.com)

His work was the first to show that the human osteoclast shares specific surface antigens with macrophages and that the mononuclear human osteoclast precursor circulates in the (CD14+) monocyte fraction. (wikipedia.org)
1998). Human tumour-associated macrophages differentiate into osteoclastic bone-resorbing cells. (wikipedia.org)
The tumors are typically composed of a small number of these cells and a high percentage of myeloid precursors (monocytes and macrophages) that have CSF-1 receptors (CSF-1R). (msdmanuals.com)
Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. (bvsalud.org)

1996) The human mononuclear osteoclast precursor circulates in the monocyte fraction. (wikipedia.org)

In pancreatic β cells, glucose stimulates the biosynthesis of insulin at transcriptional and post-transcriptional levels. (molcells.org)
The CSF-1 stimulates the growth of these myeloid precursor cells. (msdmanuals.com)

The exact cause of GCTs is not fully understood, but they are thought to be related to abnormal proliferation and differentiation of osteoclast precursors. (medicinenet.com)
Interleukin 1β particularly accelerated proliferation of early blasts and the most small osteoclasts (3-5 nuclei) formed on plastic. (vu.nl)
Our results indicate that the different bone marrow osteoclast precursors are differently stimulated by interleukin 1β with respect to proliferation, multinucleation, life span, and bone resorption. (vu.nl)
Augments the ability of dendritic cells to stimulate naive T-cell proliferation. (joplink.net)
The Notch pathway plays a key role in different types of cancer and drives several biological processes relevant in MM, including cell localization within the bone marrow, proliferation, survival and pharmacological resistance. (oncotarget.com)

The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
The ontogeny and fate of stem cells have been extensively investigated by lineage-tracing approaches. (nature.com)
Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. (bvsalud.org)
Osteoblasts are mononucleated mesenchymal stem cells that form bone matrix, whereas osteoclasts are bone-resorbing multinucleated cells that differentiate from hematopoietic progenitors of the myeloid lineage [ 3 , 4 , 5 ]. (biomedcentral.com)
Introduction: Osteoclasts are bone-resorbing cells derived from hematopoietic precursors in the myeloid lineage. (elsevierpure.com)

elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)
In this application, Specific Aim 1 will establish the role of HMGB1 in ceramide accumulation in cytoplasm of senescence osteoclast precursors via downregulation of ACdase activity in vitro. (nova.edu)
In Specific Aim 2, we will elucidate the molecular mechanisms underlying ceramide-mediated fusion of senescent osteoclast precursors in vitro through a cathepsin B-induced Myh9 degradation pathway. (nova.edu)
We identify specific DAP12-associated receptors expressed by osteoclasts and examine function of DAP12 in murine osteoclasts in vivo and in vitro. (elsevierpure.com)
Materials and Methods: Osteoclasts from DAP12 -/- or control mice were analyzed in vitro for morphology, function, and for osteoclast markers. (elsevierpure.com)

Current treatments for excessive bone resorption utilize RANK receptor blockers or neutralizing antibodies, which are able to inhibit osteoclast formation. (frontiersin.org)
However, inhibition of osteoclast formation via blocking RANK signaling can result in long-term bone remodeling defects. (frontiersin.org)
This interacts with its cognate receptor RANK, which is expressed on osteoclast precursors and promotes osteoclast differentiation. (biomedcentral.com)

It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
Differentiation of induced pluripotent stem cells (iPSCs) into stromal cells and hematopoietic precursors. (nih.gov)
showed that the osteoclastic potential of mandibular bone marrow stromal cells and the number of osteoclasts are higher compared to long-bone marrow stromal cells [2]. (oatext.com)
OPG is secreted primarily by osteoblasts and stromal cells. (biomedcentral.com)

Reversible proteasome inhibition disrupts pathways supporting cell growth, thus decreasing cancer cell survival. (medscape.com)
Interaction with extracellular ligands induces receptor clustering at the nanoscale, assembly of the signaling complexes in the cytosol and activation of downstream signaling pathways, regulating cell response. (ibecbarcelona.eu)
These factors then initiate multiple signal transduction pathways to turn on downstream genes and activate quiescent osteoclast precursor (OCP) cells to become mature osteoclasts [ 1 , 8 ]. (biomedcentral.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

With TJ Chambers he developed the osteoclast lacunar bone resorption assay system. (wikipedia.org)
This led to the discovery of cellular and molecular mechanisms of pathological bone resorption associated with primary and secondary bone tumours, particularly breast cancer metastasis, Ewing sarcoma and giant cell-rich lesions such as giant cell tumour of bone and pigmented villonodular synovitis. (wikipedia.org)
1984). Resorption of bone by isolated rabbit osteoclasts. (wikipedia.org)
Given the rate of transition from static to motile behavior of the osteoclasts, these areas are likely to be those undergoing resorption by previously static cells shortly before obtaining the image and characterizing the osteoclasts at motile. (jci.org)
Under inflammatory conditions, abnormal osteoclast differentiation and function often results in excessive bone resorption, which is a common characteristic of many diseases, such as osteoporosis, rheumatoid arthritis (RA), psoriatic arthritis and periodontitis ( 1 - 5 ). (frontiersin.org)
We found that interleukin 1β stimulated multinucleation and bone resorption of osteoclasts derived from the 3 precursors at different rates. (vu.nl)
20 nuclei) and highest level of bone resorption (16.3%) was by myeloid blast-derived osteoclasts. (vu.nl)
[2] Bone resorption is the normal destruction of bone by osteoclasts , which are indirectly stimulated by PTH. (bionity.com)
The possible mechanisms involved in osteoclasts recruitment from external granuloma and various dentin resorption patterns in internal root resorption will be discussed based on a case in which the upper lateral incisor with a history of pulp necrosis treated endodontically, developed an internal root resorption in association with external granuloma. (oatext.com)
Bone resorption is initiated by osteoclasts and resorption of hard dental structures by odontoclasts. (oatext.com)
Osteoclasts recruitment and activation, and angiogenesis in maxillary alveolar processes in internal root resorption associated with external granuloma. (oatext.com)
Once migrated to the bone marrow, MM cells unbalance bone formation and resorption via the recruitment and maturation of osteoclast precursors. (oncotarget.com)
These mononuclear cells are functional osteoclast-like cells because, by RT-PCR, they express other osteoclast markers and generate resorption pits on dentine slices, although quantitative assessment of bone resorption shows decreased resorption by DAP12 -/- osteoclasts compared with C57BL/6 osteoclasts. (elsevierpure.com)

Early blasts, myeloid blasts, and monocytes were sorted from mouse bone marrow cells using flow cytometry. (vu.nl)
Monocytes needed the longest time (95 h) for the generation of such large osteoclasts, but these cells had a longer life span (50 h). (vu.nl)

One of the central objectives of this project was the development and characterization of a 3D mineralized tissue model system in which the effects of mechanical load (e.g., compression loading, tension, vibration, etc.) on the cellular responses of osteoblasts and osteoclasts could be investigated. (techbriefs.com)
Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. (ebi.ac.uk)

while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. (patsnap.com)

Nature of mononuclear cells positive for acid phosphatase activity in bone marrow of patients with renal osteodystrophy. (bmj.com)
Fifty two of 63 patients with renal osteodystrophy had one or more mononuclear cells positive for acid phosphatase in the marrow. (bmj.com)

Although RA was conventionally conceived as Th1-driven inflammatory disease, it is becoming clear that Th17, rather than Th1, is a major pathogenic cell that orchestrates the complex network of the sustained inflammation and disease progression [ 2 - 4 ]. (hindawi.com)
It is unknown, however, how these cell types respond to the osteoclast-stimulating inflammatory cytokine interleukin 1β. (vu.nl)

Human primary osteoblast/osteoclast 3D construct development following 21 days of culture (~4 mm diameter spheroids). (techbriefs.com)
Remarkably, the nucleated cells do not express osteoblast markers, indicating differentiation to the in vivo cell type known as the osteocyte. (techbriefs.com)
Effects on osteoclast and osteoblast development and function. (nih.gov)

More recent data show that OPG is also produced in breast tumor cells, and that it can promote tumor growth and metastasis [ 5 , 6 ]. (biomedcentral.com)

Osteoblasts are responsible for synthesizing bone matrix and thereby creating an environment that supports the growth, maturation, and function of osteoclasts. (medscape.com)
Transforming growth factor- (TGF-) β and IL-6 primes initial differentiation and IL-23 promotes functional maturation of Th17 cells [ 7 ]. (hindawi.com)

Studies employ a transgenic animal model of spondyloarthritis and cells from human subjects including induced pluripotent stem cells (iPSC), to evaluate effects of HLA-B27 expression and misfolding on ER stress and its consequences for cytokine production and cellular function. (nih.gov)

Ceramides that comprise the cell membrane of vertebrates are attracting interest as signaling mediators in a variety of cellular events, including apoptosis and cell senescence. (nova.edu)
We report that 17ß- estradiol (E2) decreased osteoclast number by promoting the apoptosis of early osteoclast progenitors, but not mature osteoclasts . (bvsalud.org)
Later, viral vectors were also applied in vivo to promote apoptosis of tumour cells. (binaryoptionsforex625.com)

Osteoclasts can tightly attach to the bone matrix by integrin receptors to form a sealing zone, within which is a sequestered, acidified compartment. (medscape.com)
This is achieved by the activation of calcium-sensing receptors located on parathyroid cells. (bionity.com)
Cells sense their environment through the cell membrane receptors. (ibecbarcelona.eu)
Nanoclusters of receptors can be further organized hierarchically in the cell membrane at the meso- and micro-levels to exert different biological functions. (ibecbarcelona.eu)

Through the recognition of H3K27me1 mark, MMP-9 localizes and generates H3NT proteolysis at the genes encoding osteoclast differentiation factors. (biomedcentral.com)

These cells break down and resorb bone tissue during normal bone remodeling. (medicinenet.com)
Osteopetrosis is a clinical syndrome characterized by the failure of osteoclasts to resorb bone. (medscape.com)

Osteoclasts Osteoclasts are very large multinucleate cells that are responsible for the breakdown of bones. (patsnap.com)

Osteoblasts arise from multipotent mesenchymal stem cells. (medscape.com)
Preliminary biological studies were conducted to evaluate adhesion (6 h) of human mesenchymal stem cells (hMSC) to the patterns in terms of cell number and morphology. (ibecbarcelona.eu)

Although previous studies have revealed important molecular signals, how the bone resorptive functions of such cells are controlled in vivo remains less well characterized. (jci.org)
Mature osteoclasts expressing TRAP-tdTomato signals ( A ), green fluorescent signals from high H + concentration ( B ), and merged images ( C ). Green fluorescent signals from the H + probes overlapped with static (low CDI, arrowheads) but not moving (high CDI, asterisk) osteoclasts, suggesting that former cells are secreting protons actively and resorbing bone tissues when observed in vivo. (jci.org)

Normal bone remodeling requires a delicate balance between the activities of major bone cell types: bone-resorbing osteoclasts and bone-forming osteoblasts, as well as osteocytes. (frontiersin.org)

As Nicholas Athanasou he has written widely on bone, joint and soft tissue pathology and on the pathobiology of osteoarticular cells and tissues. (wikipedia.org)
2005). Phenotypic and molecular studies on giant cell tumours of bone and soft tissues. (wikipedia.org)
Here, we visualized fluorescently labeled mature osteoclasts in intact mouse bone tissues using intravital multiphoton microscopy. (jci.org)
Gram-negative bacteria not only have different factors of virulence and generate products and sub-products that are toxic to apical and periapical tissues, but also contain endotoxin in the outer membrane of their cell wall. (bvsalud.org)
COX-1 is expressed constitutively and is isolated throughout most cell lines in almost all mammalian tissues. (medscape.com)

Pharmaceutical inhibition of osteoclast differentiation is a current therapeutic approach for the treatment of bone loss-related diseases. (biomedcentral.com)

In addition, as is characteristic to native periosteum, osteoclast precursor cells were imaged and proven to naturally arrange as an outer layer of the mineralized bone tissue construct. (techbriefs.com)
A recent study identified cathepsin K ( Ctsk )-Cre expressing PSCs as a unique class of skeletal stem cells residing in the periosteum 3 . (nature.com)

However, it remains unclear whether there is functional crosstalk between these two types of skeletal stem cells. (nature.com)

Mineralized 3D bone constructs fluorescently stained to track osteoclast precursor cells, revealed as white portions in the image. (techbriefs.com)

His work on hip and knee implants focused on the importance of biomaterial wear particles on promoting osteoclast formation, osteolysis and implant loosening. (wikipedia.org)
36: 945 - 954 PMID 16153456 Taylor R, Knowles H, Kashima T, Gibbons CLMH, Whitewell D, Athanasou NA, (2011) Osteoclast formation and function in pigmented villonodular synovitis. (wikipedia.org)
The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
Periosteal stem cells (PSCs) and growth plate resting zone stem cells (RZSCs) critically contribute to intramembranous and endochondral bone formation, respectively. (nature.com)
In endochondral bone formation, parathyroid hormone-related protein (PTHrP)-expressing RZSCs are the source of growth plate chondrocytes, which give rise to bone-forming osteoblasts as well as bone marrow skeletal stem cells 1 . (nature.com)
Bone biopsy from the iliac region revealed numerous multinucleated giant cells with haphazard new bone formation and diagnosis of polyostotic Paget's disease was confirmed. (jocr.co.in)
These data show a new role for DAP12 signaling in regulating formation of multinucleated osteoclasts. (elsevierpure.com)
Conclusion: Our studies indicate that stimulation of the DAP12 adapter protein plays a significant role in formation of multinuclear osteoclasts and that DAP12 and DARs likely participate in the regulation of bony remodeling. (elsevierpure.com)

Is GCT (Giant Cell Tumor) Cancerous? (medicinenet.com)
However, 2 conditions-synovial chondromatosis and tenosynovial giant cell tumor (pigmented villonodular synovitis)-occur in the lining (synovium) of joints. (msdmanuals.com)
Tenosynovial giant cell tumor (previously called pigmented villonodular synovitis) is considered a benign neoplastic tumor of the synovium that can occur around as well as in a joint. (msdmanuals.com)
When the tumor involves a tendon, it is called a giant cell tumor of tendon sheath. (msdmanuals.com)
Tenosynovial giant cell tumor is usually monarticular but may be polyarticular. (msdmanuals.com)
Diffuse tenosynovial giant cell tumor has a high local recurrence rate that often leads to further surgery and morbidity. (msdmanuals.com)

The tumors arise from neoplastic synovial cells that overexpress a growth factor CSF-1 (colony stimulating factor-1). (msdmanuals.com)

Osteoclast differentiation was measured by tartrate-resistant acidic phosphatase (TRAP) staining and the TRAP solution assay. (biomedcentral.com)
These cells are also tartrate resistant and non-specific esterase negative, and are believed to be precursors to osteoclasts and other acid phosphatase positive cells resorbing bone on the trabecular surface. (bmj.com)

Compared to saline treatments, bone-resorbing osteoclasts and bone marrow osteoclast precursor populations were also increased in ODE-treated WT but not IL-6 KO mice. (cdc.gov)

The H + secretion index was defined as the ratio of the number of osteoclasts overlapping with green fluorescent acid pH signals divided by the total number of osteoclasts of the indicated type that were imaged ( n = 3, from 3 independent experiments). (jci.org)
In response to aging, the amount of ceramides increases in the cytoplasm of cells in conjunction with the diminished levels of acid ceramidase (ACdase), a lipid hydrolase that degrades ceramides. (nova.edu)
Their distinct biosynthetic activity includes an endoperoxidase synthase reaction that oxygenates and cyclizes polyunsaturated fatty acid precursors (eg, arachidonic acid) to form prostaglandin G 2 (PGG2), and a peroxidase reaction that converts PGG2 to prostaglandin H 2 (PGH2), as shown below. (medscape.com)

Osteoclast differentiation marker genes were analyzed by the quantitative real-time polymerase chain reaction analysis. (biomedcentral.com)
Instead, using microarray analysis we have elucidated that ERα-mediated estrogen signaling in osteoclast progenitors decreases " oxidative phosphorylation " and the expression of mitochondria complex I genes . (bvsalud.org)
By using RNAi and small molecule inhibitor approaches, we also confirmed that G9a is the major methyltransferase to catalyze H3K27me1 for MMP-9-dependent H3NT proteolysis and trigger the expression of osteoclast-specific genes. (biomedcentral.com)

D ) The H + secretion index of mature osteoclasts. (jci.org)

abstract = "Osteoclasts are bone-resorbing cells and targets for treating bone diseases. (vu.nl)

Endocrinology 139: 4058 -4060 PMID 8756585 Athanasou N. (1996) The cellular biology of bone-resorbing cells. (wikipedia.org)
The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)
It will also allow a mechanistic approach in the modulation of cell signaling at the cellular level within the bone matrix. (techbriefs.com)
In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts. (patsnap.com)

These findings demonstrate that estrogens decrease osteoclast number by attenuating respiration , and thereby, promoting mitochondrial apoptotic death of early osteoclast progenitors. (bvsalud.org)

rather, PTH binds to osteoblasts, the cells responsible for creating bone. (bionity.com)

Although the exact molecular mechanism of the RA pathogenesis remains elusive, proinflammatory cytokines including tumor necrosis factor- (TNF-) α and interleukin- (IL-) 1 β and autoreactive T cells are known to play central roles in the development and progression of RA [ 1 ]. (hindawi.com)

These tumors are also called osteoblastoma or giant cell reparative granuloma. (medicinenet.com)
If there is a connection between the two pathological process through a lateral accessory canal is possible that some cells to be recruited from external granuloma. (oatext.com)
We are reporting a case of fibrous dysplasia (FD) which was associated with a central giant cell granuloma (CGCG) and discussing the hypothetical pathogenesis of giant cells. (jcdr.net)

During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation. (joplink.net)
Here, we report that glucose induces the expression of PTBP1 via the insulin receptor (IR) signaling pathway in β cells. (molcells.org)

Anatomy60

Organisms20

Diseases10

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes52

Disciplines and Occupations1

Information Science3

RANKL32

Macrophage6

Osteoclastogenesis10

Macrophages4

Monocyte1

Stimulates2

Proliferation5

Lineage5

Vitro5

RANK3

Stromal cells8

Pathways4

Resorption13

Monocytes2

Osteoblasts and osteoclasts2

Differentiate1

Mononuclear cells2

Inflammatory2

Osteoblast3

Tumor cells1

Maturation2

Cytokine1

Apoptosis3

Receptors4

Differentiation factors1

Resorb bone2

Multinucleate cells1

Mesenchymal stem2

Vivo2

Osteocytes1

Tissues5

Inhibition1

Periosteum2

Functional1

Fluorescently1

Formation8

Giant Cell Tumor6

Synovial1

Tartrate-resistant2

Populations1

Acid3

Genes3

Secretion1

Abstract1

Cellular4

Progenitors1

Binds1

Cytokines1

Granuloma3

Induces2