RESULTS: The study administered propranolol and dohongsamul-tang orally for 10 weeks to investigate their effects on cardiac hypertrophy induced by transverse aortic contraction (TAC) surgery. (bvsalud.org)
Changes in phosphorylation levels of Ser-98 and Ser-179 in Ldb3 were further confirmed in NRVMs and other pathological/physiological hypertrophy models, including transverse aortic constriction and swimming models, using site-specific phospho-antibodies. (molcells.org)
Consistent with the direct transactivation of numerous cardiac genes reactivated in response to hypertrophic stimulation, cardiac transcription factors are profoundly involved in the generation of cardiac hypertrophy or in cardioprotection from cytotoxic stress in the adult heart. (wikipedia.org)
Of the NK-2 genes, NKX2-5 transcription factor is mostly involved in cardiac development and defects with this gene can lead to congenital heart defects including, but not limited to atrial septal defects. (wikipedia.org)
NKX2-5 is expressed in precursor cardiac cells and this expression is necessary in order to lead to proper cardiac development. (wikipedia.org)
In early cardiogenesis, cardiac precursor cells from the cardiac crescent congregate along the ventral midline of the developing embryo and form the linear heart tube. (wikipedia.org)
NKX2-5 is a transcription factor that regulates heart development from the Cardiac Crescent of the splanchnic mesoderm in humans. (wikipedia.org)
There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
The DH based on the characteristics of its medicinal properties has discovered the potential of alleviating cardiac hypertrophy. (bvsalud.org)
AIM OF THE STUDY: In cardiovascular disease, cardiac hypertrophy refers to a change in the shape of the heart's structure due to pressure overload. (bvsalud.org)
Therefore, suppressing cardiac hypertrophy may be a major factor in lowering the morbidity, mortality, and heart failure associated with cardiovascular disease. (bvsalud.org)
Therefore, the study was performed to investigate whether DH, traditionally used, has effects on improving and alleviating cardiac injury and fibrosis caused by cardiac hypertrophy. (bvsalud.org)
The resulting cardiac hypertrophy and heart remodeling was induced and maintained for 8 weeks. (bvsalud.org)
Dohongsamul-tang treatment also downregulated collagen I and III through the TGF-ß/Smad2 signaling pathway and improved hematological biomarkers of cardiac hypertrophy. (bvsalud.org)
In addition, dohongsamul-tang treatment improved renal function-related biomarkers, such as blood creatinine, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin, which were increased by TAC-induced cardiac hypertrophy. (bvsalud.org)
CONCLUSIONS: Taken together, dohongsamul-tang treatment inhibited cardiac remodeling due to pressure overload in the TAC-induced cardiac hypertrophy model, and this effect is thought to be manifested by improving the functional and morphological changes through the calcineurin/NFATc4 and reducing the cardiac fibrosis by suppressing TGF-ß/Smad2 signaling pathways. (bvsalud.org)
A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. (molcells.org)
Cardiac hypertrophy can be characterized as the response of the heart to various hemodynamic stresses. (molcells.org)
Although cardiac hypertrophy is initiated by various receptors at cell membranes sensing biomechanical signals and hormones, it is generally mediated by cellular signaling cascades. (molcells.org)
In cardiac hypertrophy, phosphorylation-dependent functional modulation of proteins, especially sarcoplasmic reticulum (SR) and sarcomere proteins, has been demonstrated. (molcells.org)
Differentiation1
NKX2-5 in vertebrates is equivalent to the 'tinman' gene in Drosophila and directly activates the MEF2 gene to control cardiomyocyte differentiation. (wikipedia.org)
Genes2
NK-2 homeobox genes are a family of genes that encode for numerous transcription factors that go on to aid in the development of many structures including the thyroid, colon, and heart. (wikipedia.org)
The expression of the hub genes in the BMSCs and hepatocytes was verified by reverse transcription-quantitative PCR (RT-qPCR). (aging-us.com)
Hypertrophic1
A cell-based functional assay system measuring hypertrophic cell growth of neonatal rat ventricle cardiomyocytes (NRVMs) following phenylephrine treatment was applied, and changes in phosphorylation of individual differentially phosphorylated sites were induced by incorporation of phosphorylation competition peptides conjugated with cell-penetrating peptides. (molcells.org)
Gene2
Repression of either gene results in the differentiating cardiomyocytes to move towards atrial chamber identity. (wikipedia.org)
4 Acute hyperglycaemia leads to chronic metabolic and haemodynamic derangements, 5 which trigger chromatin structural changes, transcription factor activation, and gene expression. (emjreviews.com)
Interact1
NKX2-5 has been shown to interact with GATA4 and TBX5. (wikipedia.org)
Renal1
It is histologically defined by renal glomerular hypertrophy, expansion of mesangial and tubular compartments, accumulation of mesangial extracellular matrix proteins, and podocytopenia associated with foot process effacement. (emjreviews.com)
Pathway1
NKX2-5 is dependent upon the JAK-STAT pathway and works along with MEF2, HAND1, and HAND2 transcription factors to direct heart looping during early heart development. (wikipedia.org)
Function1
May also function as a paracrine antifibrotic factor in the heart. (cusabio.com)
State1
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
Control1
NKX2-5 influences HAND1 and HAND2 transcription factors that control the essential asymmetrical development of the heart's ventricles. (wikipedia.org)
Complex2
After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)
DN is a complex multifactorial disease caused by multiple genetic and environmental factors. (emjreviews.com)
Stress1
If ER stress is a significant factor that affects the disease development, it would be important to find a drug that alters these mechanisms and UPR. (helsinki.fi)
NK-2 homeobox genes are a family of genes that encode for numerous transcription factors that go on to aid in the development of many structures including the thyroid, colon, and heart. (wikipedia.org)
NKX2-5 is dependent upon the JAK-STAT pathway and works along with MEF2, HAND1, and HAND2 transcription factors to direct heart looping during early heart development. (wikipedia.org)