Multiple endocrineAmine precursorsTumorsTumorAdrenalNeuralSecretionNeoplasmsAminesGastrointestinal tractPearseNeuronsRegulatesPancreaticHormoneHighTotalPresentDecarboxylation CellsAPUDomaPolypeptideAriseGastricOriginateDiffuseNeuroendocrine cellsSyndromeConverselyMorphologicalSystemOrganFunctionalProstateTypeLungAbilityStudiesProduceFunctionTypesBloodSmall
Multiple endocrine2
- [ 8 ] Approximately 5% of VIPomas are associated with multiple endocrine neoplasia (MEN) type 1 syndrome . (medscape.com)
- Carcinoid tumors and related syndromes may be a part of multiple endocrine neoplasia . (medscape.com)
Amine precursors2
- Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. (wakehealth.edu)
- The name is derived from an acronym, referring to the following: Amine Precursor Uptake - for high uptake of amine precursors including 5-hydroxytryptophan (5-HTP) and dihydroxyphenylalanine (DOPA). (wikipedia.org)
Tumors8
- Carcinoid tumors arise from neuroendocrine cells, which are widespread in the human body, especially in the organs derived from the primitive intestine (see the image below). (medscape.com)
- however, tumors can originate from any cell of the amine precursor uptake and decarboxylation system and, therefore, produce several intestinal hormones. (medscape.com)
- In 1914, Gosset and Masson demonstrated that carcinoid tumors might arise from enterochromaffin cells (Kulchitsky cell) within glands of Lieberkühn using silver impregnation techniques. (medscape.com)
- In 1928, Masson established characterization of carcinoids as argentaffin cell tumors. (medscape.com)
- In 1980, the World Health Organization (WHO) applied the term carcinoid to all tumors of the diffuse endocrine system (synonymous with amine precursor uptake and decarboxylation [APUD] and neuroendocrine cell system). (medscape.com)
- APUDOMA is a general term collectively applied to tumors associated with APUD cells. (wakehealth.edu)
- Amyloid deposits are not uncommon in endocrine neoplasms and can also occur in pituitary tumors. (scirp.org)
- The current neuroendocrine classification of cells and tumors uses immunohistochemical (IHC), ultrastructural, and molecular biologic features to define members of the DNS ( 6 , 7 and 8 ). (basicmedicalkey.com)
Tumor2
- Microscopy: Hematoxylin and eosin staining revealed a monotonous population of round to polygonal tumor cells with round to oval nuclei and variable amounts of eosinophilic cytoplasm. (scirp.org)
- Rare catecholamine-secreting tumor derived from chromaffin cells. (preparingtobecome.com)
Adrenal3
- They originate in amine precursor uptake and decarboxylation (APUD) cells of the gastroenteropancreatic endocrine system and in adrenal or extra-adrenal neurogenic sites. (medscape.com)
- Adenohypophysis Neurons of Hypothalamus Chief Cells of Parathyroid Adrenal Medullary Cells Glomus cells in Carotid Body Melanocytes of Skin Cells of Pineal Gland Renin producing cells in the kidney Apudoma Enteroendocrine cell Neuroendocrine cell List of human cell types derived from the germ layers Boyd, C. A. R. (March 2001). (wikipedia.org)
- The steroid-producing endocrine cells of the adrenal cortex, ovary, and testis, as well as the thyroid hormone-producing follicular cells in the thyroid gland, do not form part of the DNS. (basicmedicalkey.com)
Neural3
- Neural crest cells are precursors of APUDoma and neurogenic cells. (medscape.com)
- This is a property of endocrine cells of neural and non-neural origin. (wakehealth.edu)
- Although the APUD concept provided a unifying theory for explaining some endocrine diseases and ectopic hormone productions, the hypothesis that the cells were all of neural crest origin, as postulated by Pearse, was later disproved by the experiments of LeDouarin ( 5 ) and others. (basicmedicalkey.com)
Secretion3
- In pancreatic islets, GLUT2 allows a rapid equilibration of glucose between the extracellular space and the interior of the cells and it may play a crucial role in the glucose signaling mechanism leading to insulin secretion (43). (justia.com)
- Endocrine function of bombesin regulates the secretion of gastric acid and its motility. (fusabil.org)
- Neurotensin regulates several biological processes, such as intestinal motility, secretion, vascular smooth muscle activity, and intestinal epithelial cell proliferation, but recent evidence indicates that in neurotensin there is also a potent neuroimmunomodulator 24 . (fusabil.org)
Neoplasms2
- The cells and neoplasms of the neuroendocrine and paracrine systems make up the DNS. (basicmedicalkey.com)
- The principal cells and neoplasms that form the DNS are listed in Table 11.1 . (basicmedicalkey.com)
Amines3
- Decarboxylase - for high content of the enzyme amino acid decarboxylase (for conversion of precursors to amines). (wikipedia.org)
- These cells share the ability to produce many biologically active amines, peptides, and other substances. (basicmedicalkey.com)
- Paracrine regulation refers to the production of amines and hormones by cells that exert a local effect on the target cells by diffusion through the extracellular space. (basicmedicalkey.com)
Gastrointestinal tract4
- Feyrter ( 2 ) considered the clear cells of the gastrointestinal tract to be peripheral endocrine or paracrine cells. (basicmedicalkey.com)
- Gastrointestinal endocrine cells are distributed in the mucosa of the gastrointestinal tract and they synthesize various kinds of gastrointestinal hormones. (fusabil.org)
- The existence of endocrine cells has been immunohistochemically demonstrated in the gastrointestinal tract mucosa of different fish species 8 - 18 . (fusabil.org)
- Trk-like (A-B-C) proteins which are secreted by the cells making up the sub-population of the endocrine cells carry out the neurotrophin synthesis, amine and/or peptide storage as well as the regulation of the blood circulation of the gastrointestinal tract. (fusabil.org)
Pearse2
- APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. Pearse, who developed the APUD concept in the 1960s based on calcitonin-secreting parafollicular C cells of dog thyroid. (wikipedia.org)
- The detailed study of neuroendocrine cells by Pearse ( 3 , 4 ) led to the development of the concept of amine precursor uptake and decarboxylation (APUD). (basicmedicalkey.com)
Neurons1
- insulin-secreting cells, the basolateral membrane of intestinal and kidney absorptive cells, in hepatocytes and in a subset of neurons (21,31,44). (justia.com)
Regulates1
- The production of somatostatin by the pancreatic islets, which regulates insulin and glucagon production in neighboring islet cells, is an example of paracrine regulation. (basicmedicalkey.com)
Pancreatic2
- Pancreatic non-beta-cell hyperplasia is rare but has been reported in children. (medscape.com)
- pancreatic cells to glucose remains debated. (justia.com)
Hormone1
- These cells share the common function of secreting a low molecular weight polypeptide hormone. (wikipedia.org)
High1
- High risk of acute pulmonary toxicity with both myeloablative and non-myeloablative total body irradiation-based conditioning for allogeneic stem cell transplantation. (dukecancerinstitute.org)
Total1
- This graph shows the total number of publications written about "APUD Cells" by people in this website by year, and whether "APUD Cells" was a major or minor topic of these publications. (wakehealth.edu)
Present1
- The DNS consists of a wide variety of cells that are present in the central and peripheral nervous system and in many classic endocrine organs ( Table 11.1 ). (basicmedicalkey.com)
Decarboxylation Cells2
- APUDomas or APUD tumors arise from APUD cells which have the ability of amine precursors uptake and intracellular decarboxylation, before converting them into active amines, hence the name, amine precursor uptake, and decarboxylation cells. (statpearls.com)
- 5. Production of calcitonin, adrenocorticotropic hormone, and beta-melanocyte-stimulating hormone in tumors derived from amine precursor uptake and decarboxylation cells. (nih.gov)
APUDoma4
- Neural crest cells are precursors of APUDoma and neurogenic cells. (medscape.com)
- An apudoma is any endocrine tumor that arises from an APUD cell (APUD, meaning amine precursor uptake and decarboxylation) properties. (illnessopedia.org)
- Adenohypophysis Neurons of Hypothalamus Chief Cells of Parathyroid Adrenal Medullary Cells Glomus cells in Carotid Body Melanocytes of Skin Cells of Pineal Gland Renin producing cells in the kidney Apudoma Enteroendocrine cell Neuroendocrine cell List of human cell types derived from the germ layers Boyd, C. A. R. (March 2001). (wikipedia.org)
- El término APUDOMA es un término genérico amplicado colectivamente para los tumores asociados con células APUD. (bvsalud.org)
Polypeptide2
- These cells share the common function of secreting a low molecular weight polypeptide hormone. (wikipedia.org)
- 11. Histochemical identification of fish ultimobranchial cells with polypeptide hormone producing APUD cells. (nih.gov)
Arise1
- Gastrinoma (PanNETs) arise from the endocrine pancreas Pancreas The pancreas lies mostly posterior to the stomach and extends across the posterior abdominal wall from the duodenum on the right to the spleen on the left. (lecturio.com)
Gastric4
- 4. [APUD cells in gastric cancer]. (nih.gov)
- It is produced in the gastric chief cells of the stomach lining and is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food . (wikipedia.org)
- Pepsin's proenzyme , pepsinogen , is released by the gastric chief cells in the stomach wall, and upon mixing with the hydrochloric acid of the gastric juice , pepsinogen activates to become pepsin. (wikipedia.org)
- In the stomach, gastric chief cells release pepsinogen. (wikipedia.org)
Originate1
- They originate in amine precursor uptake and decarboxylation (APUD) cells of the gastroenteropancreatic endocrine system and in adrenal or extra-adrenal neurogenic sites. (medscape.com)
Diffuse2
- [2] This was then disproven by the concept of the origin of APUD cells from multipotent stem cells before being implanted in different body organs, hence the diffuse endocrine system. (statpearls.com)
- The lung is a primary target of cell injury in patients receiving cytotoxic drugs, and in many cases the reaction is severe enough to produce diffuse pulmonary fibrosis. (nih.gov)
Neuroendocrine cells1
- Furthermore, neuroendocrine cells typically have neurosecretory granules. (statpearls.com)
Syndrome1
- [ 8 ] Approximately 5% of VIPomas are associated with multiple endocrine neoplasia (MEN) type 1 syndrome . (medscape.com)
Conversely1
- Conversely, morphological observations of characteristic types of cell-specific injury in the lung may suggest a likely biochemical mechanism of toxicity for the particular chemical involved. (nih.gov)
Morphological1
- 15. [Morphological characteristics of mucinous cancer of the breast containing endocrine cells]. (nih.gov)
System3
- 7. [Content of endocrine cells of the APUD-system of the lungs in cancer of that organ]. (nih.gov)
- 10. [Changes in the APUD system of the large intestine as a risk factor for colorectal cancer]. (nih.gov)
- 12. [Morphofunctional state of the APUD-system cells of the lungs in hyaline membrane disease of newborn infants]. (nih.gov)
Organ1
- This organ has both exocrine and endocrine tissue. (lecturio.com)
Functional1
- 3. [Functional morphology of breast APUD cells in dysplasia and neoplastic processes]. (nih.gov)
Prostate1
- 14. A.P.U.D. type endocrine tumour of the prostate. (nih.gov)
Type5
- this is followed by the accumulation of interstitial edema and later by necrosis of Type I epithelial cells. (nih.gov)
- In normal repair, rapid proliferation of Type II cells, followed by differentiation to Type I, restores the epithelial surface without fibrosis. (nih.gov)
- However, after bleomycin, Type II cell proliferation is frequently followed by abnormal differentiation to a metaplastic form of epithelium. (nih.gov)
- Fibroblast proliferation accompanies this abnormal epithelial response which is related either to selective retention of bleomycin by epithelial cells or to the toxic effects of administering more drug at the time of Type II cell division. (nih.gov)
- Prior knowledge about the metabolism, disposition and mechanism of bioactivation of a particular compound may allow prediction of the type of lung cell damage it is likely to produce. (nih.gov)
Lung3
- 18. [Possible causes for an increased content of blood peptide hormones in small-cell lung cancer]. (nih.gov)
- Metabolic activation and lung toxicity: a basis for cell-selective pulmonary damage by foreign chemicals. (nih.gov)
- The specific types of lung cells damaged may depend upon factors such as preferential exposure or accumulation of parent compounds and/or metabolites, differences in cellular defense mechanisms, or the specific mechanism of activation of the toxicant. (nih.gov)
Ability1
- The name " enterochromaffin " refers to the ability to stain the cell with potassium chromate (chromaffin), a feature of cells that contain serotonin . (wikidoc.org)
Studies1
- 16. Immunocytochemical studies of APUD cells in airways: effects of nitrosodiethylamine and nitrogen dioxide. (nih.gov)
Produce1
- Aplastic anemia is a condition wherein the bone marrow does not produce enough new cells to replenish the blood cells. (illnessopedia.org)
Function2
- Anemia is the disorder that results in having lesser red blood cells than normal, which are needed to function properly. (illnessopedia.org)
- NADPH, reduced glutathione) necessary for normal cell function. (nih.gov)
Types1
- Administration of amphiphilic drugs to experimental animals causes formation of myelinoid bodies in many cell types, accumulation of foamy macrophages in pulmonary alveoli and pulmonary alveolar proteinosis. (nih.gov)
Blood1
- platelets, white blood cells and red blood cells. (illnessopedia.org)
Small1
- Well-differentiated NETs are composed of small cells organized in islets, gyriform, and trabeculae, with finely granular cytoplasm, commonly referred to as "salt and pepper" chromatin pattern. (statpearls.com)