• 3) that were divided into two major clusters corresponding to the main phases observed during the preadipocyte culture: proliferation and differentiation. (biomedcentral.com)
  • Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
  • Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
  • Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
  • BNP treatment increased their proliferation but not their differentiation capacity. (elifesciences.org)
  • One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
  • In the study, Monje and her colleagues showed that nerve activity prompts oligodendrocyte precursor cell proliferation and differentiation into myelin-forming oligodendrocytes. (stanford.edu)
  • Many different cells produce TGF beta and it mediates effects on the proliferation, differentiation and function of many cell types. (thermofisher.com)
  • Promotes also differentiation and proliferation of hematopoietic cells. (joplink.net)
  • The exact cause of GCTs is not fully understood, but they are thought to be related to abnormal proliferation and differentiation of osteoclast precursors. (medicinenet.com)
  • Androgens are also key regulators of immune cell function and have a suppressive influence on differentiation, proliferation, and cytokine production. (bham.ac.uk)
  • Luvita Suryani et al, Effects of Electromagnetic Field on Proliferation, Differentiation, and Mineralization of MC3T3 Cells, Tissue Engineering Part C: Methods (2019). (medicalxpress.com)
  • Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
  • Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
  • Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors. (nature.com)
  • Prolactin also stimulates proliferation of oligodendrocyte precursor cells. (wikipedia.org)
  • Sending neural impulses quickly down a long nerve fiber requires insulation with myelin, which is formed by a cell called an oligodendrocyte that wraps itself around a neuron. (stanford.edu)
  • Compared with cells taken from non-autistic controls, neural precursors from autistic boys proliferated in atypical ways, a small study finds. (the-scientist.com)
  • Found in the cell membrane, this protein activates a signalling pathway that regulates the expression of genes that make the cell divide, grow, migrate, specialise or die. (sciencedaily.com)
  • The description of the new role of Notch, found in the fly Drosophila melanogaster , and the mechanism that regulates this function have been published in the journal Current Biology , which belongs to the Cell group. (sciencedaily.com)
  • At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)
  • cancer cell growth and spreading, it has also been proposed that GPR56 regulates cell adhesion, but this has remained untested in the nervous system. (jneurosci.org)
  • Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. (joplink.net)
  • Multiple sclerosis (MS) lesions are initiated by the infiltration of T cells to the CNS. (nature.com)
  • Demyelinating disorders, such as multiple sclerosis, attack these cells and degrade nerve transmission, especially over long distances. (stanford.edu)
  • This extracellular family of enzymes is a universal early trigger in all of the inflammatory diseases studied that hydrolyze phospholipids on the cell membrane into two key inflammatory precursors: arachidonic acid (AA) and lysophospholipids (LysoPLs). (drugdiscoverynews.com)
  • This enzyme releases arachidonic acid, the precursor of CysLTs, from the cell membranes, upon activation. (lu.se)
  • Erythroleukemia is a neoplastic proliferation of erythroid and myeloid precursors of bone marrow hematopoietic stem cells . (medscape.com)
  • In vivo work showed that the outcomes of disease (erythroid, myeloid, or both) depend on the driving oncogene and the hematopoietic target cell in which it is aberrantly expressed. (medscape.com)
  • Intrathymic development of committed progenitor (pro)-T cells from multipotent hematopoietic precursors offers an opportunity to dissect the molecular circuitry establishing cell identity in response to environmental signals. (lu.se)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
  • During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. (joplink.net)
  • Recent studies have reported that taurine causes increased proliferation of neural stem/progenitor neural cells (neural precursor cells, NPCs) obtained from embryonic and adult rodent brain. (nih.gov)
  • This transition encompasses programmed shutoff of stem/progenitor genes, upregulation of T cell specification genes, proliferation, and ultimately commitment. (lu.se)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
  • She is known for her work on neuronal and mesenchymal stem and precursor cells and how they can promote tissue repair and regeneration. (nature.com)
  • Pediatric Brain Tumor Cancer Stem Cells: Cell Cycle Dynamics, DNA Repair, and Etoposide Extrusion. (worthington-biochem.com)
  • New mRNA stem cell therapy, akin to COVID-19 vaccine tech, shows potential against chronic and acute liver diseases. (medindia.net)
  • Histopathological studies and immunohistochemical analysis of anti-müllerian hormone (AMH), mechanistic target of rapamycin (mTOR), Sirtuin1 (SIRT1), stem cell factor (SCF) studies were done. (bvsalud.org)
  • Stem cells. (bvsalud.org)
  • Undifferentiated mesenchymal stem cells are pluripotent cells that can differentiate into various phenotypes and are a source of osteogenic Cells 1,2 . (bvsalud.org)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
  • A hormone thought to make murine insulin-secreting cells proliferate in mice did not perform in replication studies. (the-scientist.com)
  • We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
  • We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
  • In vivo , the identification of macrophage phenotype is complicated since macrophages are obviously exposed to a microenvironment that is more complex respect to cell culture conditions, and they display characteristics that do not conform to the in vitro defined phenotypic categories. (hindawi.com)
  • A new study characterizes the in vitro effects of these PEMFs on the crucial osteoblast precursor cells and seeks to determine the optimal conditions that will promote bone regeneration. (medicalxpress.com)
  • Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)
  • It has important cell cycle-related functions as a growth-, differentiating- and anti-apoptotic factor. (wikipedia.org)
  • Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • The Ki-67 proliferation index and the apoptotic index using the terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling method were also evaluated. (aacrjournals.org)
  • Fate of airway epithelial cells exposed to titanium dioxide nanoparticle s: NGF regulated apoptotic death. (cdc.gov)
  • It has also been reported that unprocessed NGF precursor, proNGF, binds p75NTR preferentially over trkA, and this selective binding of proNGF to p75NTR leads to apoptotic death of cells. (cdc.gov)
  • The total cell number per blastocyst and percentage of apoptotic cells were increased and decreased in the 2 ISO-treated group, respectively. (bvsalud.org)
  • Erythroleukemia is a subtype of acute myeloid leukemia ( AML ) that is distinguished by erythroblastic proliferation. (medscape.com)
  • Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
  • 2023) Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer. (systembio.com)
  • Platelets (thrombocytes) are blood cells involved in blood clotting. (medlineplus.gov)
  • These proteins work together to turn on (activate) the JAK/STAT pathway, which promotes the proliferation of blood cells, particularly platelets and their precursor cells, megakaryocytes. (medlineplus.gov)
  • In addition, LAP can also be expressed on platelets and activated regulatory T cells. (thermofisher.com)
  • It is believed that this surface-expressed LAP is due to the binding of LAP to GARP (LRRC32), which is a transmembrane protein that is also found at high levels on platelets and activated regulatory T cells. (thermofisher.com)
  • Cancer cells depart their normal microenvironment from the primary tumor site through complicated and multistep processes disseminate and colonize distant organs [ 1 ]. (intechopen.com)
  • The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
  • In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • We isolated stromal cells from endometrial cancer patients to examine local biosynthesis of estrogens and tumor-stromal interactions. (scirp.org)
  • The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)
  • LysoPLs induce white cell activation and extravasation, induce cell activation (by lyso phosphatidylserine in particular), induce tissue damage, such as gastric ulceration, and act as growth factors (especially lyso phosphatidic acid) to induce proliferation of cancer cells and tumor metastasis. (drugdiscoverynews.com)
  • Is GCT (Giant Cell Tumor) Cancerous? (medicinenet.com)
  • Giant cell tumors (GCTs) are a type of bone tumor. (medicinenet.com)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • The JAK2 , MPL , and THPO genes provide instructions for making proteins that promote the growth and division (proliferation) of blood cells. (medlineplus.gov)
  • The proteins produced from the JAK2 , MPL , and THPO genes are part of a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from outside the cell to the cell's nucleus. (medlineplus.gov)
  • We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase ( TS ) and Survivin , in case of non-small-cell lung cancer (NSCLC). (aacrjournals.org)
  • Using RNA fluorescence in situ hybridization (FISH) measurements of genes encoding key TFs and measured bulk population dynamics, this single-cell model predicts state-switching kinetics validated by measured clonal proliferation and commitment times. (lu.se)
  • By directly stimulating the neurons with light, the researchers were able to show it was the activation of the neurons that prompted the myelin-forming cells to respond. (stanford.edu)
  • Earlier studies have shown that proliferation of endogenous neural precursor cells cannot alone compensate for the damage to neurons and axons. (medindia.net)
  • The presence of neurotransmitter receptors in microglia illustrates their functional connection to neurons and this receptor activation could cause microglial cells to perform different activation phenotypes ( Pocock and Kettenmann, 2007 ). (frontiersin.org)
  • Marco Milán's group has now discovered that the presence of Notch proteins in the cell membrane is also required to inactivate the pathway. (sciencedaily.com)
  • It is a precursor of membrane phospholipids (e.g., phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl group donor S -adenosylmethionine. (mdpi.com)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)
  • Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
  • A multitasking plasma membrane protein coordinates cell division and energy metabolism in healthy-and perhaps also cancerous- Drosophila cells. (the-scientist.com)
  • One major regulatory mechanism of GPCRs is the internalization from cell membrane upon activation. (lu.se)
  • hNPCs obtained from 3 fetal brains (14-15 weeks of gestation) were cultured and expanded as neurospheres, which contained 76.3% nestin-positive cells. (nih.gov)
  • The formation of new vessels in the hypoxic area restores blood flow, provides oxygen and nutriments to the surviving cells, and promotes the migration and engraftment of new cells. (elifesciences.org)
  • Michelle Monje is senior author of a paper that found neuronal activity causes changes in myelin, cells that insulate nerve fibers and make them more efficient.The brain is a wonderfully flexible and adaptive learning tool. (stanford.edu)
  • There have been studies that showed a correlation between experience and myelin dynamics, and studies of isolated cells in a dish suggesting a relationship between neuronal activity and myelination. (stanford.edu)
  • These cells break down and resorb bone tissue during normal bone remodeling. (medicinenet.com)
  • Can we apply strategies used by extremophiles to improve mammalian cell and tissue storage? (researchgate.net)
  • 2. Mode of carcinogenic action cell and tissue changes over time. (cdc.gov)
  • These cells differentiate into oligodendrocytes, the cells responsible for the formation of myelin coatings on axons in the central nervous system. (wikipedia.org)
  • Nerve Growth Factor (NGF) can bind to tyrosine kinase A (trkA) and with p75NTR depending the physiological state of the cell. (cdc.gov)
  • MicroRNAs (miRNAs) are small non-encoding RNAs that actively regulate biological and physiological processes, and play an important role in regulating gene expression in all cells, especially in most animal cells, including oocytes and embryos. (bvsalud.org)
  • As more with the interaction of an agent with a cell, through data become available on precursor events, and as physiological and tissuerorgan changes, resulting in our understanding improves about how chemicals tumour development. (cdc.gov)
  • EMT is an embryologically conserved genetic program by which epithelial cells down regulate intercellular tight junctions, loose polarity, express mesenchymal markers, and manifest a migratory phenotype [ 1 ]. (intechopen.com)
  • The primary human airway bronchial epithelial cells exposed to nanoparticle s elicit high levels of neurotrophins, which has a significant role in modulating the cell cycle, cell proliferations and inflammatory responses. (cdc.gov)
  • It has been shown in rats and sheep that prolactin affects lipid synthesis differentially in mammary and adipose cells. (wikipedia.org)
  • The researchers found that functional electrical stimulation can promote endogenous neural precursor cell proliferation in the brains of acute cerebral infarction rats, enhance expression of basic fibroblast growth factor and epidermal growth factor, and improve the motor function of rats. (medindia.net)
  • Recent studies revealed that nano-sized TiO2 can cause inflammatory response in airways of rats and mice, fibrosis or lung tumors in rats and DNA damage in Chinese hamster ovary (CHO) cells, Syrian hamster embryo fibroblasts and human lymphoblastoid cells. (cdc.gov)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • Hasegawa, S, Imai, M & Takahashi, N. (2023) Role of acetoacetyl-CoA synthetase in glucose uptake by HepG2 cells. (systembio.com)
  • A Non-Aggressive, Highly Efficient, Enzymatic Method for Dissociation of Human Brain-Tumors and Brain-Tissues to Viable Single-Cells. (worthington-biochem.com)
  • During the progression of NSCLC, E2F1 overexpression could produce more aggressive tumors with a high proliferation rate and chemoresistance. (aacrjournals.org)
  • The encoded protein is also known as cathepsin X and cathepsin P. This gene is ubiquitously expressed in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. (enigmadiagnostics.com)
  • Giant cell tumors (GCTs) are benign or noncancerous. (medicinenet.com)
  • Giant cell tumors (GCTs) are benign (noncancerous) tumors that most commonly occur in the bones of the arms and legs. (medicinenet.com)
  • These tumors are also called osteoblastoma or giant cell reparative granuloma. (medicinenet.com)
  • Giant cell tumors typically affect young and middle-aged adults and are more common in women than in men. (medicinenet.com)
  • Although giant cell tumors are benign, they can cause problems if they press on nearby structures or grow and weaken the bone to the point of fracture . (medicinenet.com)
  • What are the causes of giant cell tumors? (medicinenet.com)
  • Giant cell tumors (GCTs) arise from cells called osteoclast precursors. (medicinenet.com)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
  • Role of glycosphingolipid SSEA-3 and FGF2 in the stemness and lineage commitment of multilineage differentiating stress enduring (MUSE) cells. (nih.gov)
  • Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
  • Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
  • The scientists used the Drosophila wing because it is an excellent model to describe how cells behave when a certain gene is mutated and to determine and test how this mutation affects adjacent cells. (sciencedaily.com)
  • Dpp, a member of the BMP family, is a morphogen that specifies positional information in Drosophila wing precursors. (elifesciences.org)
  • An in vivo CRISPR screen of T cell infiltration in a rat model of MS now identifies the genetic modules that control this key step in the immunopathology of MS. (nature.com)
  • Directed gene transfer into specific cell lineages in vivo is an attractive approach for both modulating gene expression and correcting inherited mutations such as emphysema caused by human α1 antitrypsin (hAAT) deficiency. (jci.org)
  • Our results challenge the dogma that AMs are short lived and suggest that these differentiated cells may be a possible target cell population for in vivo gene therapy applications, including the sustained correction of hAAT deficiency. (jci.org)
  • CCD camera imaging demonstrated in vivo expression of the luciferase reporter gene, while flow cytometry of cells obtained by BAL from this mouse demonstrated expression of GFP in 33% of cells. (jci.org)
  • The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
  • PBMCs were incubated ex vivo with androgen precursors and active androgens from the classic pathway (DHEA, A4 and T) and the 11-oxygenated androgen pathway (11KA4, 11KT, 11OHA4 and 11OHT). (bham.ac.uk)
  • In order for the Notch pathway to be activated, ligand-type proteins from neighbouring cells bind to the Notch receptor. (sciencedaily.com)
  • This is the basic and "extremely simple activation system" of the Notch signalling pathway, which is based on short distance contact between cells through a ligand and a receptor. (sciencedaily.com)
  • As expected, the cells lacking Notch did not activate the pathway, but what was surprising was the observation that neighbouring cells did. (sciencedaily.com)
  • It is strange, but in the cell emitting the signal, Notch receptor captures the ligands by acting as a silencer while in the cell receiving the signal the binding of ligands with Notch allows activation of the pathway. (sciencedaily.com)
  • In other words, Notch is a kind of double agent and exerts opposing functions: repressing or activating the pathway depending on whether it is located in cells emitting or receiving the signal. (sciencedaily.com)
  • It is well established that the Notch pathway controls the development of T lymphocytes, cells of the immune response system found in blood. (sciencedaily.com)
  • Proliferation of the cancer cells was significantly increased through the steroid sulfatase pathway, which metabolizes androgens, estrone sulfate, and estradiol sulfate as its substrates. (scirp.org)
  • In a developing wing and through a technique called Clonal Analysis, the researchers manipulated groups of cells, among groups of normal cells, to remove Notch receptor expression. (sciencedaily.com)
  • The levels are (1) a core gene regulatory network (GRN) architecture from transcription factor (TF) perturbation data, (2) a stochastically controlled chromatin-state gate, and (3) a single-cell proliferation model validated by experimental clonal growth and commitment kinetic assays. (lu.se)
  • Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
  • These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
  • Several lines of evidence support the hypothesis that gonadal steroids exert effects on the development of B cells in bone marrow. (jci.org)
  • Androgens also exert effects on B cell development in bone marrow. (jci.org)
  • [ 1 ] Patients usuallly present with nonspecific signs and symptoms from the anemia, thrombocytopenia, and leukopenia resulting from the replacement of bone marrow by leukemic cells (see Presentation ). (medscape.com)
  • Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
  • Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
  • Results: Bone marrow cells were adherent since the first day of culture and were positive for osteonectin. (bvsalud.org)
  • Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)
  • The CALR gene provides instructions for making a protein with multiple functions, including ensuring the proper folding of newly formed proteins and maintaining the correct levels of stored calcium in cells. (medlineplus.gov)
  • Normal human peripheral blood cells were stimulated overnight with Human IL-2 Recombinant Protein (Product # 14-8029-81), Anti-Human CD3, and Anti-Human CD28 Functional Grade Purifieds (Product # 16-0037-81 and Product # 16-0289-81). (thermofisher.com)
  • Processing and cleavage of the precursor protein between amino acids 278 and 279 results in the formation of LAP dimers and TGF beta dimers that then non-covalently associate with each other to form the small latent TGF beta complex. (thermofisher.com)
  • This group exposed fruit flies to a standard mobile radiofrequency output, and found an increase in the production of 'heat shock protein (hsp)70'-an indication of cell stress-with no direct thermal heating effects. (buergerwelle.de)
  • An enzymatically inactive form of the protein, that is associated with the propeptide, may be involved in cancer cell invasion and proliferation. (enigmadiagnostics.com)
  • The survival test exploits the natural tendency of cells to die in culture and is therefore used to assess the neuroprotective properties of compounds. (neurofit.com)
  • Conditional knockout of α1A adrenergic receptors in OPCs suppresses spontaneous and locomotion-induced Ca 2+ increases and reduces OPC proliferation. (nature.com)
  • Physiologic levels of prolactin in males enhance luteinizing hormone-receptors in Leydig cells, resulting in testosterone secretion, which leads to spermatogenesis. (wikipedia.org)
  • Indeed, the analyses demonstrated that the Notch receptor sequesters the ligands and prevents these from connecting to the Notch receptors of adjoining cells. (sciencedaily.com)
  • The experiments showed that the absence of the receptor in the mutated cells leaves many ligands free, ready to enter into contact with Notch receptors of the non-manipulated cells. (sciencedaily.com)
  • In fact," says Milán, "it is all to do with a fine balance between ligands and receptors of the emitting and receiving cell. (sciencedaily.com)
  • The cells destined to become lymphocytes receive the appropriate signalling through Notch receptors. (sciencedaily.com)
  • The same pathways responsible for the development and growth of organisms are involved in the transformation of healthy cells into cancerous ones," says Marco Milán, so "all new data on the modulation of Notch activity, the first step in the chain, may be relevant for the design of effective therapies. (sciencedaily.com)
  • In recent years, researchers have seen clues that nerve cell activity could promote the growth of myelin insulation. (stanford.edu)
  • From the perspective of neural plasticity, Dr. Yun Xiang and co-workers from Sun Yat-sen University in China observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side. (medindia.net)
  • In aged skeletal muscle, impairments in regrowth and regeneration may be explained by a decreased responsiveness of muscle precursor cells (MPCs) to environmental cues such as growth factors. (uncg.edu)
  • Thus, the stripe of Dpp ensures that signalling remains above a pro-growth threshold, while at the same time generating a gradient that patterns cell fates. (elifesciences.org)
  • These agents inhibit cell growth and proliferation. (medscape.com)
  • As human osteosarcoma cells are a source of additional growth they did not affect osteoinduction. (bvsalud.org)
  • A prolonged macrophage lifespan, rather than precursor cell proliferation, accounted for the surprisingly sustained presence of transduced AMs. (jci.org)
  • Macrophage activation has been described as a dynamic process: the same cell may initially induce proinflammatory and cytotoxic reactions and later may take part in the resolution of inflammation and wound healing [ 9 ]. (hindawi.com)
  • Estrone is only a weak agonist of estrogen receptor but it serves as a precursor for biosynthesis of 17β-estradiol, 16α-hydroxyestrone and catechol estrogens. (helsinki.fi)
  • Local generation of active androgens from circulating androgen precursors is an essential mediator of androgen action in peripheral androgen target cells and tissues. (bham.ac.uk)
  • It was identified that alliin inhibited proliferation of gastric carcinoma cells by decreasing the cell viability but not in the normal intestinal cells. (phcog.com)
  • These cells were then stained with Fixable Viability Dye eFluor® 450 (Product # 65-0863-14), followed by surface staining with Mouse IgG1 K Isotype Control APC (Product # 17-47. (thermofisher.com)
  • The authors applied a daily controlled dose of pulsed electromagnetic radiation in varying duration to MC3T3-E1 osteoblast precursor cells and monitored cell viability and metabolic activity. (medicalxpress.com)
  • They have proinflammatory functions: they produce effector molecules (reactive oxygen and nitrogen intermediates) and inflammatory cytokines (IL-1 β , TNF α , and IL-6) and participate as inducer and effector cells in polarized Th1 responses. (hindawi.com)
  • Under stress, microglial cells are induced into the M1 type, releasing inflammatory factors and causing neuroinflammatory responses. (frontiersin.org)
  • If this new mechanism is also present in vertebrates, it should be taken into consideration when designing effective therapies against certain kinds of cancer, such as T-cell acute lymphoblastic leukaemia (T-ALL)," concludes Milán. (sciencedaily.com)
  • Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. (joplink.net)
  • Now, researchers at the Stanford University School of Medicine have demonstrated that brain plasticity also comes from another mechanism: activity-dependent changes in the cells that insulate neural fibers and make them more efficient. (stanford.edu)
  • You can't really implant an electrode in the brain to answer this question because the resulting injury changes the behavior of the cells," Monje said. (stanford.edu)
  • Modulation of tight junction structure in blood-brain barrier endothelial cells. (worthington-biochem.com)
  • Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics. (worthington-biochem.com)
  • These animal findings were later confirmed in another 'test-tube' study, this time using isolated human brain cells. (buergerwelle.de)
  • CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
  • Hence, in the present study, the influence of alliin on gastric adenocarcinoma (AGS) cells and normal intestinal cells (INT-407) would be tested for its potent antiproliferative effect and mechanism of action. (phcog.com)
  • Our experiments demonstrate that GPR56 is essential for proper morphogenesis of the rostral cerebellum and suggest that defects caused by loss of GPR56 arise from granule cell abnormalities in this region. (jneurosci.org)
  • These results support a novel hypothesis that the cerebellar defects in Gpr56 knock-outs, and potentially in human patients with GPR56 mutations, arise from the disrupted adhesion of developing granule cells to the pial BM. (jneurosci.org)
  • Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
  • Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. (scirp.org)
  • BNP treatment increased vascularisation and the number of endothelial cells in all areas of infarcted hearts. (elifesciences.org)
  • The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)
  • It is impressive to note that alliin content was high in fresh aqueous extract compared to that of dried garlic extract which concludes that the use of garlic from time immemorial is a worthy functional food in its fresh form to combat cancer cells. (phcog.com)
  • We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
  • Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. (scirp.org)
  • We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)
  • These mechanisms are often used by cancer cells to surive and spread. (lu.se)