Precursor cell differentiation gata3 transcription factor. Medical search. Frequent questions

This immunosuppressive helper T cell phenotype can be further induced by the zinc-finger transcription factor GATA3, which regulates Th2 cytokine expression [ 9 ] . (encyclopedia.pub)

Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. (nih.gov)
We have previously demonstrated that GATA-2 and GATA-3 are expressed in adipocyte precursors and control the preadipocyte-to-adipocyte transition. (harvard.edu)

Here, we have analyzed cis element regulation of the critical hematopoietic factor Gata2 , which is expressed in early precursors and repressed as GATA-1 levels rise during terminal differentiation. (prolekarniky.cz)
Although Gata2 is normally repressed in late-stage erythroblasts, the −1.8 kb mutation unexpectedly resulted in reactivated Gata2 transcription, blocked differentiation, and an aberrant lineage-specific gene expression pattern. (prolekarniky.cz)
For example, GATA-1 directly represses Gata2 transcription via displacing GATA-2 from chromatin sites at its own locus, a process termed a "GATA Switch" [6] , [7] . (prolekarniky.cz)
Sheng, G., Stern, C. Gata2 and Gata3: novel markers for early embryonic polarity and for non-neural ectoderm in the chick embryo. (arizona.edu)

Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. (nih.gov)
Thus, GATA-2 and GATA-3 regulate adipocyte differentiation through molecular control of the preadipocyte-adipocyte transition. (nih.gov)
This study aimed to explore adipogenic transcriptional dynamics before (proliferation) and after (differentiation) initial preadipocyte differentiation in ducks. (biomedcentral.com)
Exogenous oleic acid alone successfully induced duck subcutaneous preadipocyte differentiation. (biomedcentral.com)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
Finally, we manually assembled a proposed regulation network model of subcutaneous preadipocyte differentiation base on the expression data, and suggested that E2F1 may serve as an important link between the processes of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
For the first time we comprehensively analyzed the transcriptome dynamics of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)

The hallmarks of development during pregnancy are the formation of tertiary branches, which terminate in alveolar buds, and the rapid proliferation of the luminal epithelium accompanied by differentiation and commitment to the secretory alveolar lineage. (biologists.com)
We explored 36 mRNA-seq libraries in order to study transcriptome dynamics during proliferation and differentiation processes at 6 time points. (biomedcentral.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Silencing KIAA1429 suppressed cell proliferation and metastasis in vitro and in vivo. (biomedcentral.com)
The T cells also effectively terminate their activation and proliferation as a means of avoiding autoimmunity, resulting in different phenotypes that either further activate Th1 immune responses or suppress via Th2-driven responses. (encyclopedia.pub)
PD-1 is an immunoinhibitory receptor that stymies lymphocyte proliferation and cytokine secretion when bound to its membrane-bound or secreted ligands, PD-L1 or PD-L2, expressed by both immune and tumour cells [ 7 ] . (encyclopedia.pub)
ALL is a malignant clonal proliferation of lymphoid progenitor cells, most commonly of the B-cell lineage (B-ALL). (biomedcentral.com)
In adult mice, lymphopenia-induced proliferation (LIP) leads to T cell activation, memory differentiation, tissue destruction, and a loss of TCR diversity. (aai.org)
In adult lymphopenic mice, naive T cells undergo homeostatic or lymphopenia-induced proliferation (LIP) in response to the recognition of self-peptide-MHC complexes ( 1 ). (aai.org)

ILC1 and NK cell lineages diverge early in their developmental pathways and can be discriminated by their difference in dependence on transcription factors, their cytotoxicity, and their resident marker expression. (wikipedia.org)
Studies reveal that chronic exposure of T cells to TNF uncouples TCR signal transduction pathways by impairing the assembly and stability of the TCR/CD3 complex at the cell surface. (biomedcentral.com)
A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells. (biologists.com)
By computing significance with hypergeometric test based on the KEGG pathway database, upregulated DEGs highlight the pathways of T cell receptor signaling and the differentiation of T helpers. (hindawi.com)
The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. (biomedcentral.com)
Cytogenetics advances of B-ALL have led to the discovery of numerous additional genetic changes, including mutations involving key cellular pathways in lymphoid development, tumor suppression, and cell cycle regulation. (biomedcentral.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

We study ILCs development from hematopoietic precursors using mouse models. (pasteur.fr)

NK cells are cytotoxic cells, circulating in the bloodstream, killing virus-infected, and tumor cells. (wikipedia.org)
The paucity of murine models of this "luminal" tumor subtype has hindered studies of factors that promote their pathogenesis and modulate responsiveness to estrogen-directed therapeutics. (biomedcentral.com)
These tumors were distinct from mouse mammary tumor virus (MMTV)-neu tumors, and contained elevated transcripts for factors associated with luminal/alveolar expansion and differentiation, suggesting that they arose from physiologic targets of prolactin. (biomedcentral.com)
Different breast tumor subtypes have different risk factors, clinical presentation, histopathological features, outcome, and response to systemic therapies [ 3 - 8 ]. (jcancer.org)
In addition to tumor cells, there are also important stromal components in tumor niche. (biomedcentral.com)
Among the components of TME, distinct populations of innate and adaptive immune cells consist of tumor immune microenvironment (TIME). (biomedcentral.com)
Accordingly, we found that the tumor growth and metastasis driven by KIAA1429 or GATA3-AS were mediated by GATA3. (biomedcentral.com)
CD16 is indispensable for functional ADCC, as downregulation or blocking of CD16 on NK cells has been proven to diminish NK cell activity thereby promoting tumor success [39,40]. (healthweblognews.info)

GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, and defective GATA-2 and GATA-3 expression is associated with obesity. (nih.gov)
ILC1s and NK cells can also produce TNF- α, further contributing to the inflammatory response, depending on their molecule expression. (wikipedia.org)
They also have differences in phenotypic markers, including the expression of CD127 on human ILC1s, which is not present on all NK cells. (wikipedia.org)
However in utero administration of dTAG resulted in variable and lineage-specific degradation, likely reflecting diverse cell type-specific Eomes expression dynamics. (bvsalud.org)
The ability to temporally manipulate Eomes protein expression in combination with cell marking by the mCherry-reporter offers a powerful tool for dissecting Eomes-dependent functional roles in these diverse cell types in the early embryo. (bvsalud.org)
The aim of our study was to assess the effect of PACAP treatment during embryo vitrification on the developmental rate and the expression of the heparin-binding EGF-like growth factor gene (Hbegf). (bvsalud.org)
Single-cell-specific delivery of small RNAs, such as short hairpin RNA (shRNA) and small noncoding RNAs, allows us to elucidate the roles of specific upregulation of RNA expression and RNAi-mediated gene suppression in early embryo development. (bvsalud.org)
ILC1 consists of NK cells and other interferon-g producing innate lymphocytes characterized by expression of the transcription factors T-bet and/Eomes. (pasteur.fr)
We examined a panel of prolactin-induced tumors for characteristics relevant to clinical tumors: histotype, ERα/progesterone receptor (PR) expression and estrogen responsiveness, Activating Protein 1 (AP-1) components, and phosphorylation of signal transducer and activator of transcription 5 (Stat5), extracellular signal regulated kinase (ERK) 1/2 and AKT. (biomedcentral.com)
We also show that a Runx-binding enhancer in the Rorc gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression. (life-science-alliance.org)
Further, ELAVL1 expression correlating with multiple T cell proportions suggests that ELAVL1 may regulate T cell activation. (hindawi.com)
Osr1 -expressing cell clusters spatially regulate Six2 expression, which in turn induces the cap mesenchymal population. (j-organoid.org)
The interstitial stroma, another subcompartment of the metanephric nephron, is characterized by the expression of the transcription factor forkhead box D1 ( Foxd1 ). (j-organoid.org)
GATA factors are often expressed in an overlapping but reciprocal pattern, such that expression of one GATA factor increases as expression of another decreases. (prolekarniky.cz)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
Regulatory factors (RF) potentially involved in the expression differences were identified by calculating the regulatory impact factors . (biomedcentral.com)
In addition, activated T cells can express an inducible co-stimulator (iCOS), a surface receptor that is structurally and functionally similar to CD28 and enhances expression of Th2-related interleukin (IL)-10 rather than immune activating IL-2 [ 8 ] . (encyclopedia.pub)
Lentivirus-mediated overexpression of GATA3 significantly increased the number of GFAP/SOX2 double positive astrocytes and expression of pro-neural factor ASCL1, but failed to induce neurogenesis, suggesting that GATA3 is required for enhancing the neurogenic potential of primary human astrocytes and is not sufficient to induce neurogenesis alone. (frontiersin.org)

Different innate immune cells, like dendritic cells, recognize the antigens via pattern recognition receptors, such as Toll-like receptors (TLR) and NLR, and then regulate the activation of T cells [ 3 ]. (hindawi.com)
that regulate the differentiation and activation of these cells. (cdc.gov)

Characteristics allowing their differentiation from other immune cells include the regular lymphoid morphology, absence of rearranged antigen receptors found on T cells and B cells (due to the lack of the RAG gene), and phenotypic markers usually present on myeloid or dendritic cells. (wikipedia.org)
Acquired immune responses are initiated by activation of CD4 + helper T (Th) cells via recognition of antigens presented by conventional dendritic cells (cDCs). (life-science-alliance.org)
Conventional dendritic cells (cDCs) are specialized antigen-presenting cells of the immune system. (life-science-alliance.org)
and the innate immune cells contain natural killer (NK) cells and dendritic cells (DCs) (Fig. 1 ). (biomedcentral.com)
A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses. (immport.org)
As cells undergo oncogenesis, neoantigens are released and captured on major histocompatibility complex (MHC)/ human leukocyte antigen (HLA) of dendritic cells (DCs) that subsequently mature and migrate to central lymphoid organs. (encyclopedia.pub)

Crohn's disease (CD), as a systemic inflammatory disease, mainly influences the gastrointestinal tract with a wide range of contributing factors including host genetics, immune system, environmental exposures, and the gut microbiome [ 1 ]. (hindawi.com)
Among the factors associated with CD in immune system, T cells were highlighted in CD pathology because about 200 CD risk loci are involved in T cell signaling [ 4 , 5 ]. (hindawi.com)
Cancer is not a chaotic malignant cell mass, but a delicate "hostile" organ, where many other cells are recruited and domesticated to become "accomplices", thereby protecting themselves from recognition and attack by the immune system [ 1 ]. (biomedcentral.com)
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. (immport.org)
Designer T and NK cells are a modality within immunotherapy that manipulates receptor-ligand interactions to enhance cells of the immune system to destroy cancer more effectively. (encyclopedia.pub)
The other genetic variants identified are also located in or near genes thought to play an important role in the immune system: REL on chromosome 2, GATA3 on chromosome 10, and PVT1 on chromosome 8. (regenerativemedicine.net)

Our experiments analyzing homozygously tagged embryonic stem cells and embryos demonstrate that the degron-tagged Eomes protein is fully functional. (bvsalud.org)
NetworkAnalyst identified ELAV-like RNA binding protein 1 (ELAVL1) as the most crucial upregulated gene and amyloid- β precursor protein (APP) as the most crucial downregulated gene in peripheral blood of CD patients. (hindawi.com)
Estrogens are important regulators of growth and differentiation in (range, 0 -9 fmol/mg protein, median 0.7). (lu.se)
KIAA1429 induced m6A methylation on the 3′ UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA. (biomedcentral.com)
Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)
Especially significant is the removal of old damaged protein aggregates, which are detrimental to the functioning of the cell. (geresdengle.com)

ILC1s and NK cells have some phenotypic markers in common, including: NK1.1 in mice, and NK cell receptors (NCRs) such as NKp44 and NKp46 in both humans and mice. (wikipedia.org)
In mice, CD200R has been shown to distinguish NK cells from ILC1s. (wikipedia.org)
Recently, additional innate lymphocytes have been discovered named innate lymphoid cells (ILCs) in both humans and mice ( 1-8 ). (pasteur.fr)
In this study, we show that IL-7R-dependent innate lymphoid cells (ILCs) block LIP of CD8 + T cells in neonatal but not adult mice. (aai.org)
In contrast, LIP and its pathological consequences appear to be prevented in adult immunocompetent mice by several mechanisms, including regulatory T cells ( 4 ). (aai.org)
Newborn T cell-competent mice are nearly devoid of peripheral T cells ( 7 ). (aai.org)

Presently, kidney organoids contain not only nephrons and ureteric buds but also stromal cells. (j-organoid.org)
Cancer cells also recruit and alter nearby stromal cells to aid the tumour cells in avoiding immune detection and destruction [ 16 ] [ 17 ] . (encyclopedia.pub)

Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells, derived from common lymphoid progenitors (CLPs). (wikipedia.org)
In response to pathogenic tissue damage, ILCs contribute to immunity via the secretion of signalling molecules, and the regulation of both innate and adaptive immune cells. (wikipedia.org)
ILCs are primarily tissue resident cells, found in both lymphoid (immune associated), and non- lymphoid tissues, and rarely in the blood. (wikipedia.org)
The development of ILCs is initiated in response to the presence of transcription factors that are switched on due to the presence of surrounding microenvironmental factors, such as: cytokines, notch ligands, and circadian rhythm (inbuilt behavioural changes following a daily cycle). (wikipedia.org)
The classification of ILCs is therefore based on the differences in the transcription factor and cytokine profiles associated with the development and function of the different ILC subtypes. (wikipedia.org)
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. (pasteur.fr)
1. To be able to describe the role of innate lymphoid cells (ILCs) in Date of Original Release: April 2014. (cdc.gov)
Importantly, CD8 + T cell responses against a foreign Ag are not inhibited by neonatal ILCs. (aai.org)

Both cell types produce IFN-γ as their principle cytokine and require the transcription factor T-bet to do so. (wikipedia.org)
Indeed, there are now compelling data to suggest that chronic cytokine activation may contribute substantially to the phenotype and effector function of synovial T cells. (biomedcentral.com)
On the basis of these data, it is proposed that T-cell survival and effector responses are driven by antigen-independent, cytokine-dependent mechanisms, and that therapeutic strategies that seek to restore T-cell homeostasis rather than further depress T-cell function should be explored in the future. (biomedcentral.com)
This process of differentiation is characterised by a distinctive pattern of cytokine production and is important because its outcome dictates the host response to foreign pathogens such as Listeria monocytogenes infection or to parasitic infestation [ 2 ]. (biomedcentral.com)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)

Due to the production of granzymes and perforin, NK cells are considered the innate counterparts of cytotoxic CD8+ T cells, whereas ILC1s are considered the innate counterpart of T helper cells, due to the sole production of IFN-γ without cytotoxic activity. (wikipedia.org)

The luminal epithelium forms the ducts and the secretory alveoli, whereas the basal epithelium consists essentially of myoepithelial cells. (biologists.com)
Although the pathogenesis is complex, the decades of studies have illustrated that CD is caused by environmental factors that broke the mucosal barrier and increased the luminal antigens into the lamina propria [ 2 ]. (hindawi.com)

Both cells can also produce IFN-γ when the cytokines IL-15 or IL-12 are up-regulated in tissues after infection or injury, and secrete TGFβ1 in tandem with IFN-γ when stimulated. (wikipedia.org)
ILC2 secrete 'T H 2-like' cytokines under the control of the transcription factors GATA-3 and RORa. (pasteur.fr)
ILC3 includes several phenotypically distinct cells that express and require the transcription factor RORgt in order to produce notably the cytokines IL-17 and IL-22. (pasteur.fr)
The hierarchy of T-cell dysfunction from peripheral blood to inflamed joint suggests that these defects are acquired through prolonged exposure to proinflammatory cytokines such as tumour necrosis factor (TNF)-α. (biomedcentral.com)
The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. (immport.org)
These cells secrete immune inhibitory growth factors and cytokines, including vascular endothelial growth factor (VEGF), which is primarily produced by microglia, myeloid-derived suppressor cells (MDSCs) and tumour-associated macrophages (TAMs). (encyclopedia.pub)

Little is known about the underlying molecular mechanisms governing Eomes actions during the formation of these distinct progenitor cell populations. (bvsalud.org)
This paradigm proposes that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. (biomedcentral.com)
This chapter aims to explore this theme in more depth, beginning with an outline of the molecular events that dictate the differentiation of T helper (Th) cells at the outset of adaptive immune responses in regional lymph nodes. (biomedcentral.com)
There is now good evidence that there exists a coordinated programme of molecular events initiated at the outset of T-cell differentiation that leads to the generation of CD4 + Th effector cells [ 1 ]. (biomedcentral.com)
Molecular dissection of this process has been challenging as transcription factor loci are regulated by many trans -acting factors functioning through dispersed cis elements. (prolekarniky.cz)
Therefore, finding out molecular mechanisms by which reactive astrocytes can be coaxed into neurons will be of utmost importance for regenerative therapies as these astrocytes are the imminent cell types around the lesion site. (frontiersin.org)
The pathophysiological mechanisms through which enteroviral infections may favor T1D development include promoting local islet inflammation, cytolytic effects on cells and molecular mimicry [7]. (healthweblognews.info)

However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
Although adipocyte differentiation starts early in fetal stages, the increase in adipose cell number and size is maintained along early postnatal growth and later development [ 6 ]. (biomedcentral.com)

Precisely how effector T cells initiate and promote the inflammatory process in RA, however, remains far from clear. (biomedcentral.com)
Cancer stem cells (CSCs) represent a distinct group of cells within cancerous tissue that possess the ability to initiate tumorigenesis and exhibit potency, self-renewal, and drug resistance. (bmrat.org)
While epidemiological studies show a temporal correlation between enteroviral infections and appearance of anti-islet auto-antibodies (aAbs) [5], investigations using the NOD mouse model suggest that enteroviral infections may accelerate rather than initiate T1D progression, as they are effective only once autoimmune T cells have already accumulated in the islets [6]. (healthweblognews.info)

The relationship between the ILC1 and NK cell lineages still remains fuzzy due to a lack of these characteristic markers present on some NK/ILC1 cells in certain tissues, or after certain infection/inflammation events. (wikipedia.org)
Much of the remainder of the discussion focuses on the different ways in which, in the longer term, the chronic inflammatory process influences maturation, differentiation, and function of effector T cells at sites of inflammation. (biomedcentral.com)
I conclude by speculating about how our understanding of T-cell activation in chronic inflammation may influence future therapy, and discuss this in the context of the prevailing view that in a susceptible host, chronic inflammatory disease occurs through a failure of regulatory T cells to downregulate the inflammatory process. (biomedcentral.com)
Furthermore, the CD4 + T cell, including Th1, Th17, and regulatory T (Treg) cells, were associated with the severity of CD, particularly with active inflammation [ 2 ]. (hindawi.com)
As a result, there is a reduction of cellular debris clearance (autophagy), decreased the pool of stem cells, increase in inflammation and cellular senescence. (geresdengle.com)
Curcumin inhibits the powerful inflammation transcription factor NF-κB and is associated with reduced levels of inflammation. (geresdengle.com)
If inflammation (redness) is present in the cells on the Pap smear, it means that some white blood cells were seen on your Pap smear. (com.ng)

Recent studies have provided new insights into the origin, specification and fate of mammary stem and progenitor cells and into how the differentiated lineages that comprise the functional mammary gland are determined. (biologists.com)

In this context, regulatory T cells (Tregs) hold a key role in balancing immune homeostasis and mediating cutaneous wound healing. (biomedcentral.com)
The maintenance of tissue homeostasis and proper wound healing is, therefore, a critical process that can be disturbed by a plethora of external and internal factors. (biomedcentral.com)
Astrocytes bear multiple vital functions such as maintaining the ion homeostasis, contributing to the blood-brain barrier, restoring synaptic integrity, regulating immune response, and acting as neural stem cells ( Kettenmann and Ransom, 2012 ). (frontiersin.org)
This ILC-based inhibition of LIP ensures the generation of a diverse naive T cell pool in lymphopenic neonates that is mandatory for the maintenance of T cell homeostasis and immunological self-tolerance later in life. (aai.org)

Furthermore, GSEA data show that NOD-like receptor signaling-associated gene signatures are enriched and the xCell analysis indicated that most T cells are significantly decreased in the three microarray studies, which could help in understanding the role of ELAVL1 and APP in the blood of CD patients. (hindawi.com)
Specifically, the timely orchestration of pro- and anti-inflammatory responses, based on the activation and inhibition of various cell types, such as tissue-resident cells and different types of immune cells, can significantly impact wound repair [ 7 ]. (biomedcentral.com)

However, the unusual phenotype of synovial T cells, including their profound proliferative hyporesponsiveness to TCR ligation, has challenged the notion that T-cell effector responses are driven by cognate cartilage antigens in inflamed synovial joints. (biomedcentral.com)

This factor promotes the growth and branching of the ureteric bud. (j-organoid.org)
The cap mesenchyme secretes Wingless family member 11 (Wnt-11), which promotes ureteric bud differentiation. (j-organoid.org)
The covalent modification of histones to yield specific histone marks promotes either the activation or repression of transcription [3] . (prolekarniky.cz)
GATA3 promotes neural progenitor state but not neurogenesis. (frontiersin.org)

Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103 + CD11b + cDC2s and alters characteristics of CD103 − CD11b + cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt + Th17 cells and type 3 Rorγt + regulatory T cells. (life-science-alliance.org)
Regulatory T cells (Tregs) play a pivotal role in this context. (biomedcentral.com)

Spatial distribution of LTi-like cells in intestinal mucosa regulates type 3 innate immunity. (stanford.edu)

Remarkably, Clec4a4+ eosinophils were instructed by the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that imprints many gut immune cells. (stanford.edu)

Loss of tissue is then repaired in a complex process that involves tissue-resident immune, stromal, and epithelial cells, as well as infiltrating immune cells [ 2 ]. (biomedcentral.com)
http://dx.doi.org/10.1016/j.jaci.2014.02.015 epithelial cells and airway smooth muscle cells. (cdc.gov)

Hormones and growth factors play a role in these different stages of mammary development and are also implicated in breast cancer. (biologists.com)

Activating invasion and metastasis' and 'evading immune destruction' drive the differentiation of triple negative breast cancers. (jcancer.org)
Our study proposed a complex KIAA1429-GATA3 regulatory model based on m6A modification and provided insights into the epi-transcriptomic dysregulation in hepatocarcinogenesis and metastasis. (biomedcentral.com)

While transcription factors bind and recruit chromatin-modifying and remodeling proteins, the relative contribution of individual cis elements residing within clusters of cis elements to the transcriptional control of endogenous loci is incompletely understood. (prolekarniky.cz)

Nat Cell Biol. (geresdengle.com)
Front Cell Dev Biol. (geresdengle.com)

CRTH2: Chemoattractant receptor-homologous molecule expressed includes nonallergic asthma phenotypes, such as asthma on TH2 cells associated with exposure to air pollution, infection, or obesity, ILC: Innate lymphoid cell that require innate rather than adaptive immunity. (cdc.gov)
Here, the peptide neoantigen on the DCs' MHC is presented to the awaiting CD4 + or CD8 + T cell receptor (TCR) complex. (encyclopedia.pub)
Subsequently, binding of the CD28 co-stimulatory receptor to the DCs' CD80/86 receptor fully activates the cytotoxic T cells which then migrate to infiltrate the tumour and kill the cells by locally releasing perforin and granzymes [ 2 ] [ 3 ] . (encyclopedia.pub)

DCs instruct Th-cell polarization program into specific effector Th subset, which will dictate the type of immune responses. (life-science-alliance.org)
Hence, it is important to unravel how differentiation and/or activation of DC are linked with Th-cell-intrinsic mechanism that directs differentiation toward a specific effector Th subset. (life-science-alliance.org)

Resisting cell death', 'genome instability and mutation' and 'deregulating cellular energetics' refine breast cancer classification with their predictive values. (jcancer.org)

Here, we characterized the whole-genome distribution of methyl-CpG and 5-hydroxymethylcytosine (5hmC) in mouse innate lymphoid cell 3 (ILC3), ILC2 and natural killer (NK) cells. (stanford.edu)

Gata3 was previously found to be a mechanism that zebrafish brain uses to injury-dependent induction of neural progenitors. (frontiersin.org)

their evolution from distinct cell lineages. (lu.se)
An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. (immport.org)

Kidney tubuloids derived from adult stem cells offer the advantage of long-term culture and expansion, but they include only tubular structures and lack glomerular components. (j-organoid.org)
Therefore, the size of and the competition within the adult T cell pool are critical for the maintenance of immunological self-tolerance ( 5 , 6 ). (aai.org)

TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. (biomedcentral.com)
TIME primarily consists of myeloid cells, lymphocytes and some other innate immune cells. (biomedcentral.com)
These lymphocytes successfully eliminate the genetically unstable tumour cells with intrinsically high immunogenicity [ 4 ] through a series of successive stages [ 5 ] . (encyclopedia.pub)
Around 1,500 people are diagnosed each year in the UK with Hodgkin lymphoma, a type of cancer originating from white blood cells called lymphocytes. (regenerativemedicine.net)

Introduction Type 1 diabetes (T1D) is a paradigmatic example of autoimmune disease stemming from a complex interaction between genetic Olcegepant hydrochloride and environmental factors [1]. (healthweblognews.info)
While several genetic susceptibility loci have been pinpointed, the environmental factors at play remain boldly elusive. (healthweblognews.info)
Scientists suspected inherited genes were involved in these cases, as having a family history of disease increases risk, but until now they have not been able to identify any specific genetic risk factors. (regenerativemedicine.net)

Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. (j-organoid.org)
Astrocytes are abundant cell types in the vertebrate central nervous system and can act as neural stem cells in specialized niches where they constitutively generate new neurons. (frontiersin.org)
Outside the stem cell niches, however, these glial cells are not neurogenic. (frontiersin.org)

However, the results of detailed phenotypic and functional analyses of chronically activated T cells derived from inflamed joints are difficult to reconcile with traditional models of cartilage-antigen-driven inflammatory disease in patients with RA. (biomedcentral.com)
We therefore asked whether neonate-specific mechanisms prevent lymphopenia-driven T cell activation. (aai.org)

In addition, CD8 + T cell transcriptional signatures were identified as reliable prognostic biomarkers in the blood of CD patients [ 6 , 7 ]. (hindawi.com)
We identified differentially methylated regions (DMRs) and differentially hydroxymethylated regions (DHMRs) between ILC and NK cell subsets and correlated them with transcriptional signatures. (stanford.edu)

Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. (harvard.edu)
The GATA family of transcription factors plays diverse roles in multiple developmental contexts [5] . (prolekarniky.cz)

Transcriptional regulation of innate lymphoid cell fate. (pasteur.fr)
GATA factor cross-regulation represents an instructive model system for investigating the contribution of individual cis elements to the initiation and maintenance of transcriptional repression. (prolekarniky.cz)

In interaction with other non-immune cells, such immune cell subsets ensure the functionality and integrity of the skin layers [ 1 ]. (biomedcentral.com)
Strikingly, a long noncoding RNA (lncRNA) GATA3-AS, transcribed from the antisense strand of the GATA3 gene, functioned as a cis -acting element for the preferential interaction of KIAA1429 with GATA3 pre-mRNA. (biomedcentral.com)
The rapidly growing tumour alters the balance of interaction between cancer and immune cells, by outstripping its metabolic resources and shifting to glycolysis [ 15 ] . (encyclopedia.pub)

On day E10.5 of murine development, the metanephric mesenchyme secretes glial cell line-derived neurotrophic factor (GDNF). (j-organoid.org)

Anatomy33

Organisms13

Diseases1

Chemicals and Drugs110

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes72

Disciplines and Occupations1

Information Science3

Zinc-finger transcription factor1

Adipocyte precursors2

Gata24

Preadipocyte7

Proliferation9

Pathways7

Hematopoietic1

Tumor8

Expression19

Regulate2

Dendritic6

Immune system6

Protein6

Mice6

Stromal cells2

ILCs8

Cytokine5

Helper cells1

Luminal2

Cytokines6

Molecular7

Adipose2

Initiate3

Inflammation7

Progenitor cells1

Homeostasis4

Significantly2

Proliferative1

Promotes4

Regulatory T cel2

Regulates1

Eosinophils1

Epithelial2

Mammary1

Metastasis2

Proteins1

Biol2

Receptor3

Effector2

Mutation1

ILC31

Progenitors1

Lineages2

Adult2

Lymphocytes4

Genetic3

Stem3

Driven2

Transcriptional signatures2

Family of transcription factors2

Regulation2

Interaction3

Glial1