Amyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesProtein BindingProtein PrecursorsAspartic Acid EndopeptidasesAmyloid beta-PeptidesAlzheimer DiseaseMolecular Sequence DataPresenilin-1Base SequenceAmino Acid SequenceProtein Processing, Post-TranslationalEndopeptidasesBinding SitesBlood ProteinsMutationPeptide FragmentsEnzyme PrecursorsMice, TransgenicMembrane ProteinsCell LinePlaque, AmyloidBrainProtein Structure, TertiaryPresenilin-2NeuronsProtease NexinsAmyloidPresenilinsCells, CulturedCloning, MolecularDNA-Binding ProteinsKineticsTransfectionNerve Tissue ProteinsRNA, MessengerDNAProtein TransportProtein Sorting SignalsRecombinant ProteinsPromoter Regions, GeneticTranscription, GeneticRecombinant Fusion ProteinsRNA PrecursorsGene Expression RegulationTranscription FactorsNuclear ProteinsChloroplastsProteinsSequence Homology, Amino AcidMitochondriaEscherichia coliMolecular WeightOrosomucoidPeasBlotting, WesternPeptidesElectrophoresis, Polyacrylamide GelModels, BiologicalBiological TransportCricetinaeProtein BiosynthesisCarrier ProteinsAmyloidogenic ProteinsDisease Models, AnimalCHO CellsNucleic Acid ConformationMice, Inbred C57BLMutagenesis, Site-DirectedModels, MolecularCell MembraneProtein ConformationPlasmidsMembrane Transport Proteinstau ProteinsIntracellular MembranesSaccharomyces cerevisiaeHeLa CellsCell DifferentiationImmunohistochemistryRegulatory Sequences, Nucleic AcidDNA PrimersTissue DistributionDNA, ComplementaryGene ExpressionSerum AlbuminSignal TransductionChromatography, High Pressure LiquidSubstrate SpecificityTime FactorsBinding, CompetitiveHippocampusPlant ProteinsHalf-LifeNucleic Acid PrecursorsSequence AlignmentPrecipitin TestsStructure-Activity RelationshipFurinPC12 Cells