Precise somatic cells cell proliferation. Medical search. Frequent questions

Certainly, Gene ontology evaluation revealed altered manifestation of genes mixed up in regulation of mobile proliferation, apoptosis, as well as the cell routine in EGFR TKI-resistant cells. (technuc.com)
Using mRNA microarrays, genome-wide evaluation of gene manifestation profiles has generated a clear department between parental and resistant cells, with modified manifestation of genes mixed up in regulation of mobile proliferation, apoptosis as well as the cell routine in the EGFR TKI-resistant cells. (technuc.com)
A proliferation burst for bypassing apoptosis and switching the metabolic condition from oxidative to glycolytic can be necessary for cell reprogramming from fibroblasts to iPSCs [22,23]. (cancer8.info)
AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. (biomedcentral.com)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)

Non-small cell lung malignancies harboring somatic gain-of-function mutations in the epidermal development factor receptor (EGFR) tyrosine kinase domain respond well to treatment with EGFR tyrosine kinase inhibitors (TKIs) including gefitinib and erlotinib. (technuc.com)
The present study provides new insights into TERT p mutational spectrum occurring in central nervous system tumors, with the identification of new recurrent somatic gain-of-function mutations, occurring in 0.8% of glioblastoma IDH -wildtype. (biomedcentral.com)

Most studies have relied on targeted gene expression measurements of only selected HOX genes, or they have focused on AMLs with canonical somatic mutations and/or cytogenetic abnormalities. (biotech2012.org)
Mutations, amplification and deletions of the upstream regulators of AKT are among the most frequent somatic events in cancer [ 2 , 3 ]. (oncotarget.com)
This happens when DNA "processing errors," coupled with damage from external carcinogens and other factors, cause mutations that allow cells to go into reproductive overdrive, growing out of control and eventually overtaking healthy cells, bypassing the body's ability to police and repair errors and eventually crowding out the body's healthy tissue. (protomag.com)
One of the most successful recent frontiers in cancer research, powered by advances in genomic sequencing, has been to pinpoint which mutations initiate cancer and explore how each one may help tumor cells thrive. (protomag.com)
B-cell lymphomas arise from mutations affecting B-cell differentiation, particularly within germinal centers (GCs) where B-cells interact with T follicular helper cells ( 1 ). (iiarjournals.org)
It has an essential role in B-cell development, influencing the transition of memory B-cells to plasma cells, while mutations in the TBL1XR1 gene have been observed to inhibit this progression and promote lymphomagenesis ( 7 , 8 ). (iiarjournals.org)
Activating mutations upstream may also underlie some epigenetic or within the ERK1/2 cascade are events that change cell signalling. (who.int)

We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)
It is relatively well documented that transcription factors and signaling pathways are critically involved in the formation of inner ear structures and in the development of hair cells. (encyclopedia.pub)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

The precise mechanism by which Lin28B and let7 miRNA regulate mTORC1 activity in cochlear epithelial cells awaits further investigation. (encyclopedia.pub)
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)

Single-cell RNA-seq of primary AML samples and CD4 + T cells before and after their interaction uncovered transcriptional programs that correlate with AML sensitivity or resistance to CD4 + T cell killing. (bvsalud.org)
We show that AML transcriptional programs correlate with susceptibility to T cell killing. (bvsalud.org)
Accumulating evidence highlights emerging functions of RBPs in the post-transcriptional regulation of inner ear development and hair cell function. (encyclopedia.pub)
Transcriptional profiles at the HOX loci were similar between normal cells and AML samples, and involved Rabbit Polyclonal to LRP10 bidirectional transcription FK 3311 at the center of each gene cluster. (biotech2012.org)
A network of intercellular signaling, signal transduction, and transcriptional regulation underlies the precise formation of this organ, which is the connection between the hermaphrodite uterus and the outside of the nematode. (wormbook.org)
Moreover, immune infiltrations analysis showed that transcriptional levels and somatic copy number alterations (SCNA) in E2F family were significantly correlated with several immune cell recruitments, including B cells, CD8+ T cells, CD4+ T cells, neutrophils, macrophages, and dendritic cells. (fortunepublish.com)
Together, our data suggest that transcriptional regula tion of stat3 might represent a standard mechanism linking Wnt pathway overactivation to your expansion of undif ferentiated cells from the sickness state. (hdac-inhibitors.com)

The iPSC technology was pioneered by Shinya Yamanaka and Kazutoshi Takahashi in Kyoto, Japan, who together showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors could convert somatic cells into pluripotent stem cells. (wikipedia.org)
iPSCs are typically derived by introducing products of specific sets of pluripotency-associated genes, or "reprogramming factors", into a given cell type. (wikipedia.org)
Upon introduction of reprogramming factors, cells begin to form colonies that resemble pluripotent stem cells, which can be isolated based on their morphology, conditions that select for their growth, or through expression of surface markers or reporter genes. (wikipedia.org)
They hypothesized that genes important to embryonic stem cell (ESC) function might be able to induce an embryonic state in adult cells. (wikipedia.org)
Among the genes whose manifestation was significantly modified, genes whose manifestation was modified in gefitinib- Vinflunine Tartrate manufacture and erlotinib-resistant cells had been centered on. (technuc.com)
Notably, a complete of just one 1,617 genes had been identified as becoming differentially indicated in gefitinib- and erlotinib-resistant cells. (technuc.com)
Additionally, it might be used to recognize genes whose manifestation is transformed in cells Vinflunine Tartrate manufacture with obtained medication resistance by evaluating gene manifestation in drug-resistant cells compared to that in parental cells that are delicate to treatment with, for instance, EGFR TKIs. (technuc.com)
However, the majority of samples expressed a canonical set of HOXA and HOXB genes that was nearly identical to the expression signature of normal hematopoietic stem/progenitor cells (HSPCs). (biotech2012.org)
In addition, functional studies in mice demonstrated that expression of specific HOXA and HOXB genes can lead to expansion of long-term repopulating hematopoietic stem cells and a myeloproliferative phenotype (5C9). (biotech2012.org)
Mice lacking specific genes also showed deficits in the repopulating ability of hematopoietic cells in competitive transplantation experiments FK 3311 (10C13), although these phenotypes have been variable across studies (14). (biotech2012.org)
In addition, although some studies have shown that HOX genes are expressed in both AML samples and normal hematopoietic cells (25), the precise patterns of expression in normal versus malignant hematopoietic cells remains unclear. (biotech2012.org)
Cell reprogramming is normally attained by reconstitution of focus on cell TRN where innate markers are downregulated while focus on genes are triggered. (cancer8.info)
However, how these TRNs together affect the induction of target cell-specific genes and the downregulation of start cell-specific MLN8054 genes has not been well explored. (cancer8.info)
Collectively, our TF outcomes indicate the asymmetric legislation of peripheral genes by two TRNs during cell reprogramming. (cancer8.info)
The transcripts of most expressed genes, in a variety of cell types, were shown to be methylated, indicating that m6A modifications are widespread. (pharmaceuticalintelligence.com)
The expression of HIF-1 downstream genes, cancer colony formation, and Matrigel invasion of glioblastoma cells were stimulated by conditioned medium from astrocytes pre-exposed to hypoxia. (cancerindex.org)
In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
Moreover, we find that the distal NDRs are enriched specifically for binding motifs of the pluripotency and germ cell master regulators such as NANOG, SOX17, AP2γ and OCT4 in human FGCs, indicating the existence of a delicate regulatory balance between pluripotency-related genes and germ cell-specific genes in human FGCs, and the functional significance of these genes for germ cell development in vivo . (nature.com)
Materials and Methods: Digital RNA quantification (Nanostring) of previously curated 188 B-cell lymphoma specimens across four subtypes, follicular lymphoma (FL), diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), primary testicular lymphoma (PTL), and plasmablastic lymphoma (PBL), was reanalyzed with focus on TBL1XR1 and NCOR1 expression, juxtaposing them with 730 ontogenically linked genes. (iiarjournals.org)
The TBL1XR1-DDR genes connection offers insights into potential DNA repair roles, paving avenues for innovative therapies in B-cell lymphomas. (iiarjournals.org)
The function of differentially expressed E2Fs and their neighboring genes were mainly linked to P53 signaling pathway, cell cycle, and oocyte meiosis. (fortunepublish.com)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

We have investigated regulation of the origin licensing factors Cdc6, Cdt1, Mcm2 and Geminin in human somatic and germ cells. (dundee.ac.uk)
We demonstrated that the silencing of the ambra1b gene determines a reduction of primordial germ cells (PGCs), a condition that, in the zebrafish, leads to the development of all-male progeny. (biomedcentral.com)
Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. (nature.com)
However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). (nature.com)
Although the genome-wide histone modification landscapes of mouse in vivo germ cells and in vitro PGCLCs have been profiled and several germline-specific properties of epigenetic reprogramming have been revealed, the study of genome-scale chromatin states in human FGCs is still challenging, due to the scarcity of materials and technical difficulties. (nature.com)

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. (wikipedia.org)
Shinya Yamanaka was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent. (wikipedia.org)
Pluripotent stem cells hold promise in the field of regenerative medicine. (wikipedia.org)
The most well-known type of pluripotent stem cell is the embryonic stem cell. (wikipedia.org)
citation needed] Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that each individual could have their own pluripotent stem cell line. (wikipedia.org)
Induced pluripotent stem cells were first generated by Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University, Japan, in 2006. (wikipedia.org)
Unlike the first generation of iPSCs, these second generation iPSCs produced viable chimeric mice and contributed to the mouse germline, thereby achieving the 'gold standard' for pluripotent stem cells. (wikipedia.org)
For instance, the increased loss of local characteristics, such as for example mesenchymal-to-epithelial changeover (MET), are essential in the first stage from fibroblasts to induced pluripotent cells aswell as induced dopaminergic neurons [19C21]. (cancer8.info)
Controlled expansion and differentiation of pluripotent stem cells (PSCs) using reproducible, high-throughput methods could accelerate stem cell research for clinical therapies. (biomedcentral.com)
Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are potentially unlimited cell sources for cellular therapies due to the unique capacities of PSCs to self-renew indefinitely and differentiate into cells from all three germ lineages (ectoderm, mesoderm, and endoderm) [ 1 ]. (biomedcentral.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

The fibroblasts were engineered so that any cells reactivating the ESC-specific gene, Fbx15, could be isolated using antibiotic selection. (wikipedia.org)
Today's results demonstrate special gene manifestation patterns of EGFR TKI-resistant lung tumor cells using the T790M mutation. (technuc.com)
Today's study can offer crucial insights into gene manifestation profiles involved with conferring level of resistance to EGFR TKI therapy in lung cancers cells. (technuc.com)
We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)
These data provide an integrated epigenetic view of the HOX gene loci in primary AML samples, and suggest that HOX expression in most AML samples represents a normal stem cell program that is controlled by epigenetic mechanisms at specific regulatory elements. (biotech2012.org)
Initial studies of HOX gene expression in human hematopoietic cells showed that expression is largely restricted to hematopoietic stem/progenitor cells (1C4), which are uniquely capable of long-term self-renewal. (biotech2012.org)
Introduction Gene control in cells is composed of sophisticated functions accomplished by particular transcription factors (TFs) [1]. (cancer8.info)
Constitutional PV's in the tumor suppressor gene adenomatous polyposis coli (APC) result in constitutive activation of the Wnt signaling pathway through deregulation of β-catenin, causing downstream effects on proliferation and differentiation within colonic crypts. (aacrjournals.org)
The gene is preferentially expressed by immature dendritic cells and memory T cells. (cancerindex.org)
It is known to be a central component in the formation of GCs by binding and recruiting the majority of TBL1XR1/SMRT/NCOR1 complexes, a process mediated by B-cell lymphoma 6 ( BCL6 ) gene expression ( 5 ). (iiarjournals.org)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

The anchor cell induces nearby epidermal precursor cells to generate vulval cells via an epidermal growth factor (EGF) signaling pathway. (wormbook.org)
In particular, our cold seawater treatment induces the synchronization and increased proliferation and differentiation of specific spermatogonial cells. (biomedcentral.com)

The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)

Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
Similar to αβ T cells, γδ T cells also develop in embryos, and their intra-thymic development shows strict regulation and flexible plasticity [ 2 ]. (explorationpub.com)

In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
fluid apparently regulates the microenvironment of hematopoietic stem cells, where Igf signaling regulates progenitor proliferation (Orkin and Zon, 2008 and Zhang and Lodish, 2004). (inhibitorkits.com)

Therapy-resistant leukemia stem and progenitor cells (LSC) are a main cause of acute myeloid leukemia (AML) relapse. (bvsalud.org)
SIGNIFICANCE: The elimination of therapy-resistant leukemia stem and progenitor cells (LSC) remains a major challenge in the treatment of AML. (bvsalud.org)
Interestingly, Lin28B inhibits the processing of mature let7 miRNA, which functions to induce cell cycle exit in progenitor cells [ 2 ] . (encyclopedia.pub)
Studies using a zebrafish model further illustrate an important role of Lin28A in the recovery of progenitor cells. (encyclopedia.pub)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

This connection is initiated by the anchor cell, which invades between the vulF cells in a process analogous to invasive behavior of metastatic tumor cells. (wormbook.org)
Yet even while asking the question, he knew why: He, along with some other oncologists, suspected that this deadly disease might be vanquished by training the immune system to attack tumor cells. (harvard.edu)

dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)

It is also clear that pro-mitotic factors such as C-MYC/L-MYC or repression of cell cycle checkpoints, such as p53, are conduits to creating a compliant cellular state for iPSC reprogramming. (wikipedia.org)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
The phosphatidylinositol 3 kinase (PI3K)-AKT signaling cascade is a vital mediator of essential cellular activities including proliferation and survival [ 1 ]. (oncotarget.com)
Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
Cellular senescence, which is morphologically characterized by an enlarged and flattened cell shape, was first described by Hayflick [ 9 ]. (hindawi.com)
Cellular senescence refers to active cells that eventually enter a state of irreversible growth arrest. (hindawi.com)

Our experiments focused on the age-associated effects of CSF on survival and proliferation across the cortical ventricular zone. (inhibitorkits.com)
Patients in the high-risk group had worse overall survival, lower immune score and ESTIMATE score, higher TMB, higher cancer stem cell index, and higher sensitivity to conventional chemotherapeutic agents. (biomedcentral.com)

The requirements for the successful culture of organoids in vitro differ significantly from those of traditional monolayer cell cultures. (mdpi.com)
The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro. (cancerindex.org)
In vitro studies using infra-/red light have not shown any useful impact on wound healing by activating cells located in deeper skin layers such as fibroblasts or stem cells [2] . (researchgate.net)
However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
It is hard to preserve the important characteristics such as proliferation capacity and stemness of MSCs the inadequate cultivating microenvironment in vitro . (hindawi.com)

Therefore, an appreciation of constitutional and somatic events linked to these syndromes have provided a useful model for the development of risk models and preventative strategies. (aacrjournals.org)
In one study, peripheral blood mononuclear cells (PBMC) from 6 of 7 patients with EMS and other functional somatic syndromes, when incubated with peak E, produced type II (profibrotic) cytokines (compared with 3 of 24 controls). (medscape.com)

Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)

γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
immunotherapeutics being a prime example of the latter) with the potential to eliminate all cancer cells, despite their clonal heterogeneity and their surrounding microenvironment. (nih.gov)
Given that cancer cells and astrocytes in glioblastomas coexist in a hypoxic microenvironment, we examined whether astrocytes affect the adaptation of glioblastoma cells to hypoxia. (cancerindex.org)

However, because these two malignancies don't have to be reported to cancer registries, precise numbers aren't known: The cancer officially ranked as the most common in this country is breast cancer, with 270,000 new cases each year. (harvard.edu)

The innate immune system mainly comprises innate immune cells (macrophages: neutrophils, dendritic cells) and complement factors. (biomedcentral.com)
This role is fulfilled by specialized cells called dendritic cells. (biomedcentral.com)
When dendritic cells are activated by inflammatory cytokines such as LPSs and inflammatory cytokines produced by macrophages, they present fragments of pathogens digested intracellularly to T cells and induce the activation of antigen-specific T cells. (biomedcentral.com)

Tissue Organization Field Theory (TOFT) is an alternative to what is sort of the dominant paradigm in cancer biology, the Somatic Mutation Theory (SMT) . (freethoughtblogs.com)
The relationship between risk scores and tumor mutation burden (TMB), cancer stem cell index, and drug sensitivity was explored. (biomedcentral.com)

Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. (wikipedia.org)

Functional relevance of shared AML/LSC antigens is illustrated by presence of their cognizant memory T cells in patients. (bvsalud.org)
Consistent with this activity, functional analyses in mice suggest that Lin28B plays an important role in hair cell development and regeneration. (encyclopedia.pub)
Nevertheless, the black package from the reprogramming system is gradually getting uncovered and many functional events important for cell reprogramming have already been identified [18]. (cancer8.info)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)

Cancer is thought to be a multistep evolutionary process arising from a single cell, acquiring genomic alterations, which provide a fitness advantage ( 1, 2 ). (aacrjournals.org)

Conclusion: Our exploratory findings unravel the expression patterns of TBL1XR1/NCOR1 in B-cell lymphoma variants. (iiarjournals.org)

Patient-matched embryonic stem cell lines can now be derived using somatic cell nuclear transfer (SCNT). (wikipedia.org)
For the best each of our knowledge, Some is the first steel complicated for you to eliminate osteosarcoma cells by simply simultaneously curbing COX-2 and harming nuclear Genetic.Just synthetized platinum nanoparticles have already been remarkably used in medication along with medical as a result of their particular biocompatibility, conductivity, and being effortlessly functionalized along with biomolecules like aptamer. (nadph-oxidasesignaling.com)

In the cochlea of mouse embryos, it is highly expressed in prosensory cells and down-regulated at the onset of hair cell differentiation. (encyclopedia.pub)
Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
At increased doses of AG 490, we were in a position to comple tely eradicate both proliferation and progenitor marker expression in wild form embryos. (hdac-inhibitors.com)

A single cell of the somatic gonad, the anchor cell, organizes the development of the vulva from epidermal precursors as well as the physical connection of the epidermis with the uterus. (wormbook.org)
The aberrant increase in Igf2 in advanced GBM patients reinforces the hypothesis that Igf signaling has an influence on proliferation of cortical precursors. (inhibitorkits.com)

Carcinogenesis is introduced through a localized event (a spot of depolarized cells) or by random depolarization of cells in the tissue, which returns cells to their initial proliferative state. (nature.com)
This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)

It is of great significance to gain insight into the classification of γδ T cell subsets. (explorationpub.com)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)

Analysis of leukemia stem cell (LSC) chromatin changes at relapse indicated that this leukemic compartment underwent significantly less epigenetic evolution than non-LSCs, while epigenetic changes in non-LSCs reflected overall evolution of the bulk leukemia. (bvsalud.org)
Stem cells for neurologic illnesses The possibility to handle neurologic illnesses and ASD specifically with stem cell software is described with this section. (exposed-skin-care.net)
This intermediate (I)-ProSG subset translocates from the center of seminiferous tubules to the spermatogonial stem cell (SSC) 'niche' in its periphery soon after birth. (biologists.com)
Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)

In addition, Lin28B functions to enhance the regenerative competence of maturing supporting cells in the cochlea through cooperation with Follistatin, which inhibits Lin28B-induced TGF-ß signaling that can trigger proliferative quiescence [ 5 ] . (encyclopedia.pub)
Starting from a depolarized (proliferative) cell, the organism grows to a certain size, limited by the increasingly polarized state after successive proliferation events. (nature.com)
The system reaches homeostasis, with a depolarized core (proliferative cells) surrounded by a rim of polarized cells (non-proliferative in this condition). (nature.com)
T, confers a proliferative advantage to neoplastic cells. (biomedcentral.com)
The differential capacity of Igf signaling to confer a proliferative advantage to stem cells may be regulated in part by Igf's interactions with binding proteins Androgen Receptor Antagonist cell line or other secreted factors in the environment (Clemmons, 1997). (inhibitorkits.com)

The differentiation of mesenchymal stem cells (MSCs) into multiple cell lineages can be exploited as an attractive strategy for cell-based therapy and regenerative medicine [ 1 ]. (hindawi.com)

Shi D, Cheng X, Saquet A, Grifone R. RNA-Binding Proteins and Inner Ear Hair Cell. (encyclopedia.pub)
RNA-Binding Proteins and Inner Ear Hair Cell" Encyclopedia , https://encyclopedia.pub/entry/30958 (accessed December 05, 2023). (encyclopedia.pub)
LIN28 (LIN28A and LIN28B) proteins are highly conserved small cytoplasmic RNA-binding proteins (RBPs) that function as pluripotency factors, regulating the transition from self-renewal to a differentiated cell fate [ 1 ] . (encyclopedia.pub)
The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
However, STK38 the distribution of CSF resident proteins, as well as the flow of the CSF, may also influence ciliary orientation and maturing ependymal cell polarity (Mirzadeh et al. (inhibitorkits.com)
Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)

To date, RUNX2 has been involved in diverse physiological processes, including osteogenic differentiation of mesenchymal stem/stromal cells, chondrocyte hypertrophy, immunomodulation, vascular invasion and endothelial cell migration via modulating a variety of signaling cascades (e.g. (spandidos-publications.com)

European eel males treated with cold seawater (10 °C, T10) for 2 weeks showed an increase in the proliferation and differentiation of spermatogonial cells until the differentiated spermatogonial type A cell stage, and elevated testosterone and 11-ketotestosterone plasma levels. (biomedcentral.com)

Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

The enzymes in your cells have to copy six billion letters with every division," says Moritz Gerstung , a computational cancer biologist at the European Bioinformatics Institute in Cambridge, England. (protomag.com)
Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)
Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. (spandidos-publications.com)
For instance, RUNX2 is involved in the progression of various tumor types, such as osteosarcoma, renal cell carcinoma, gastric cancer and breast cancer ( 15 - 20 ). (spandidos-publications.com)
Of note, other studies have also indicated the involvement of RUNX2 in breast cancer stem cells (BCSCs) and breast cancer progression ( 22 , 23 ). (spandidos-publications.com)
Cancer cell metastasis. (ubc.ca)

Skin Cutaneous melanoma (SKCM) is a highly aggressive malignant neoplasm that develops from uncontrolled proliferation and transformation of melanocytes. (fortunepublish.com)
Molecular analysis of melanocytes and melanoma cells from mouse models: transcriptomics, bioinformatics, proteomics. (ubc.ca)

We compared the HOX expression phenotypes in these AMLs to data from normal bone marrow cells to study the HOX regulatory programs in normal and malignant hematopoiesis. (biotech2012.org)
Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)

Lin28A is required for hair cell regeneration in the mammalian cochlea, and may function in redundant processes with Lin28B [ 3 ] [ 5 ] . (encyclopedia.pub)
expression during cell reprogramming processes and contributes to the elaborate exploration of TRNs. (cancer8.info)
B-cell receptor diversification, essential for adaptive immunity, depends on processes like V(D)J recombination and somatic hypermutation ( 1 ). (iiarjournals.org)

CCL20 was secreted in a hypoxia-dependent manner from astrocytes and busted the hypoxic induction of HIF-1α in glioblastoma cells. (cancerindex.org)

Here we demonstrate that LSCs present HLA-restricted antigens that induce T-cell responses allowing for immune surveillance of AML. (bvsalud.org)

Besides, as new methods and treatment approaches for precise medicine are available, there is an urgent need for utilizing more precise and effective biomarkers to detect melanoma before distant metastasis formation and to assess the risk of relapse [12,13]. (fortunepublish.com)

Together, these antigens shared among AML and LSCs represent prime targets for T cell-based therapies with potential of eliminating residual LSCs in patients with AML. (bvsalud.org)
identify molecular markers that can meaningfully predict responses or resistance to anticancer therapies and develop algorithms that can be applied to predict responses to treatments and/or define more precise treatment modalities. (nih.gov)
New T cell therapies succeed with a narrow band of cancers. (protomag.com)

It was found that GSOs reversed GLU-induced reductions in cell viability and the LDH release rate, and rescued ROS accumulation. (sdbonline.org)

In striking contrast, we show that proliferation control during male gametogenesis is not linked to Cdc6 or Mcm2, but appears to be coordinated by the negative regulator Geminin with Cdt1 becoming rate-limiting in late prophase. (dundee.ac.uk)

Early identification of VHL is important because of the increased risk of serious complications (eg, renal cell carcinoma) to foster more effective treatment options and better prognoses. (medscape.com)

Epigenetic analysis of a subset of AML samples also identified common regions of chromatin accessibility in AML samples and normal CD34+ cells that displayed differences in methylation depending on HOX expression patterns. (biotech2012.org)
Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)
The two 2 ° precursor cells generate vulA, vulB1, vulB2, vulC and vulD cells but in mirror symmetric polar patterns: ABCD and DCBA. (wormbook.org)
The anchor cell also patterns nearby uterine cells, via the DSL ligand LAG-2 and LIN-12 , to generate the four uv1 cells that form the tight connection with the vulva. (wormbook.org)

The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)
During tumor development, stromal cells are co-opted to the tumor milieu and provide favorable conditions for the tumor. (cancerindex.org)

The DNA replication (or origin) licensing system ensures precise duplication of the genome in each cell cycle and is a powerful regulator of cell proliferation in metazoa. (dundee.ac.uk)
Here we use nucleosome occupancy and methylation sequencing method to analyze both the genome-wide chromatin accessibility and DNA methylome at a series of crucial time points during fetal germ cell development in both human and mouse. (nature.com)

But for patients with metastatic melanoma-cancers that begin in melanin-producing skin cells then spread to other parts of the body-he could offer little help. (harvard.edu)
Their prognostic roles in various cancers are established, yet their precise impact on B-cell lymphoma is elusive. (iiarjournals.org)

These unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. (wikipedia.org)
Killing-sensitive AML potently activated T cells before being killed, and upregulated ICAM1 , a key component of the immune synapse with T cells. (bvsalud.org)
Killing-sensitive, but not resistant AML activate T cells and upregulate ICAM1 that binds to LFA-1 on T cells, allowing immune synapse formation which is critical for AML elimination. (bvsalud.org)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
It is hoped that the host immune status can be accurately predicted and gradually advance γδ T cell precise individualized medicine. (explorationpub.com)
Innate immune cells are also called phagocytes because they phagocytose when they recognize foreign substances such as lipopolysaccharides (LPSs). (biomedcentral.com)
In contrast, the adaptive immune system consists primarily of T and B cells and in theory can eliminate an infinite variety of targets. (biomedcentral.com)
Although the acquired immune system functions as early as 2-4 days after encountering the pathogen, some T and B cells respond specifically to the invading microorganisms, even after the immune response has ended. (biomedcentral.com)

We motivated that PRRX1 lately, OSR1, LHX9, and TWIST2 are primary TFs in individual dermal fibroblasts, a cell most utilized being a begin cell in cell reprogramming often, and demonstrated that mutual legislation among these elements characterizes the precise TRN that safeguards the balance of fibroblasts [24]. (cancer8.info)
Furthermore, we previously determined primary monocytic MLN8054 TFs (SPI1, MNDA, CEBPA, and IRF8) and confirmed that reconstitution of monocytic TRN with the ectopic appearance of four TFs partly reprogrammed fibroblasts into monocyte-like cells [25]. (cancer8.info)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

Although a "default state" is a theoretical construct and a limit case that does not need to be instantiated, conditions that closely resemble unrestrained cell proliferation are readily obtained experimentally. (bsahely.com)

This suggests that coactivation of Lin28B and Follistatin may represent an endogenous mechanism mediating reprogramming of supporting cells for hair cell regeneration. (encyclopedia.pub)
Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive. (oncotarget.com)
however the precise understanding mechanism is not clear [ 13 - 15 ]. (hindawi.com)
This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)

dubious - discuss] In his Nobel seminar, Yamanaka cited the earlier seminal work of Harold Weintraub on the role of myoblast determination protein 1 (MyoD) in reprogramming cell fate to a muscle lineage as an important precursor to the discovery of iPSCs. (wikipedia.org)

The new treatments wouldn't have been possible without fundamental discoveries in immunology, genetics, skin cell biology, and cell signaling. (harvard.edu)

In neonatal murine cochlear organoids and explants, Lin28B antagonizes the activity of let7 miRNA and increases Akt-mTORC1 signaling to promote hair cell regeneration from immature supporting cells by inducing their de-differentiation and proliferation as well as by directly converting them into hair cells [ 3 ] . (encyclopedia.pub)
Thus, Lin28B functions in hair cell regeneration through mitotic and non-mitotic mechanisms, which are dependent on mitotic division or trans-differentiation of supporting cells into hair cells, respectively. (encyclopedia.pub)
Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)

Other lesions reported with BSS include parotid basal cell adenomas, organoid nevi, syringomas, and basal cell carcinomas. (medscape.com)
New devices have demonstrated significant results for the treatment of medical conditions, including mild-to-moderate acne vulgaris, wound healing, psoriasis, squamous cell carcinoma in situ (Bowen's disease), basal cell carcinoma, actinic keratosis, and cosmetic applications. (researchgate.net)
Basal and squamous cell carcinomas make up the vast majority, with somewhere between 1 million and 5.4 million new instances diagnosed each year. (harvard.edu)

Anatomy52

Organisms16

Diseases10

Chemicals and Drugs77

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes67

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Apoptosis5

Gain-of-function mutati2

Mutations7

Pathways4

Epithelial cells2

Transcriptional7

Genes22

Germ Cells5

Pluripotent11

Gene11

Induces2

Motility1

Regulation2

Regulates2

Progenitor cells5

Tumor cells2

Pathway2

Cellular6

Survival2

Vitro6

Syndromes2

Testicular1

Microenvironment4

Malignancies1

Dendritic cells3

Mutation2

Downstream1

Neurons1

Functional5

Alterations1

Variants1

Nuclear2

Embryos3

Precursors2

Carcinogenesis2

Subsets2

Stem cell7

Proliferative5

Lineages1

Proteins6

Physiological1

Spermatogonial1

Regenerative medicine1

Cancer7

Melanocytes2

Malignant2

Processes3

Hypoxic1

Induce1

Metastasis1

Therapies3

Viability1

Gametogenesis1

Renal cell carc1

Patterns4

Stromal cells2

Genome2

Cancers2

Immune8

Fibroblasts3

Resemble1

Mechanism4

IPSCs1

Biology1

Regeneration3

Basal3