Prazosin receptors adrenergic alpha 2. Medical search. Frequent questions

WB-4101 is a compound which acts as an antagonist at the α1B-adrenergic receptor. (wikipedia.org)
All effects were antagonized by the alpha 1-adrenoceptor antagonist prazosin (0.1 microM), indicating receptor-mediated effects. (aspetjournals.org)
The alpha 1-agonist methoxamine and the alpha 1-antagonist prazosin were injected into the DPT of freely moving, unanaesthetized cats. (nih.gov)
The phenylephrine studies were repeated in seven hypertensive patients during treatment with prazosin, an alpha 1 adrenergic antagonist. (ox.ac.uk)
Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. (lgmpharma.com)
These include the alpha-2 adrenergic agonists clonidine and guanfacine, the nonselective beta-adrenergic agent propranolol, and most promising prazosin, which is an alpha-1 adrenergic receptor antagonist that blocks the actions of NE on alpha-1 receptors(Petrakis, 2016). (duepapers.net)
Alpha-receptor antagonist medications potentially interfere with iris muscle dilation, resulting in difficult lens removal and possibly increasing complications. (urotoday.com)
and an angiotensin II receptor antagonist (used for blood pressure control), losartan (Cozaar). (raynauds.co.in)
The stimulating effect of NE on the TRH secretion was abolished by icv antagonist of adrenergic alpha2-receptor, yohimbine (40 nmol/L). (nel.edu)
Such effect was completely reversed both by the opioid receptor antagonist naloxone and by the unselective muscarinic receptor antagonist atropine. (researchgate.net)
Tamsulosin is an alpha-1 receptor antagonist [ 2 ]. (kratom.org)
systemic administration of the CRF1 receptor antagonist MPZP (20 mg/kg) alleviated withdrawal-induced mechanical hypersensitivity. (monossabios.com)
The CRF 1 receptor antagonist MPZP was prepared for systemic administration as described (Richardson et al. (monossabios.com)
Phentolamine is an alpha-adrenergic receptor antagonist. (empowerpharmacy.com)

It is unclear whether this is caused by structural changes in the arterial wall or by hyperresponsiveness of vascular smooth muscle to endogenous alpha adrenergic agonists. (ox.ac.uk)
This indicates that small doses of prazosin (1-2 mg) cause significant in vivo shifts in the dose-response relationship of alpha adrenergic agonists. (ox.ac.uk)
Cooling augmented contractions evoked by the alpha 2-adrenergic agonists B-HT 920 and UK 14304 but did not affect responses to the full alpha 1-adrenergic agonist phenylephrine. (johnshopkins.edu)
Therefore, cooling reduces alpha 1-adrenergic responsiveness in canine cutaneous veins, but in the case of full alpha 1-adrenergic agonists such as norepinephrine and phenylephrine the inhibitory effect of cooling is buffered by an alpha 1-adrenoceptor reserve. (johnshopkins.edu)
Specific antagonists and agonists of alpha(2)-adrenoceptors were employed for the characterization of alpha(2)-adrenoceptors involved in the autoregulation of depolarization-evoked release of norepinephrine in the pig pineal. (nel.edu)
Alpha-2 agonists often have a sedating effect and are commonly used as anesthesia enhancers in surgery, as well as in treatment of drug or alcohol dependence . (wikipedia.org)

Using the dorsal hand vein compliance technique we compared the changes in diameter of superficial veins in response to phenylephrine, an alpha 1 adrenergic receptor agonist, and to nitroglycerin, a venorelaxant, in patients with essential hypertension and in normotensive subjects. (ox.ac.uk)
However, the contractions evoked by the partial alpha 1-adrenergic agonist St 587 were virtually abolished by cooling. (johnshopkins.edu)
In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro , and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. (pharmacycode.com)
Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. (pharmacycode.com)
In contrast, a selective α-adrenergic agonist phenylephrine, elicited greater contractions both in the aged body and trigone than those in young rats. (scirp.org)
The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is able to increase analgesic effects of ibuprofen in the writhing test in mice. (nel.edu)
Kratom is an alpha-2 adrenergic receptor agonist [ 1 ]. (kratom.org)
Clonidine hydrochloride (presynaptic alpha-2-adrenoceptor agonist) was purchased from Sigma-Aldrich and dissolved in 0.9% saline and injected SC in a CH5132799 volume of 1 ml/kg body weight. (monossabios.com)
α receptor agonist causes an increase in blood pressure. (pharmacology2000.com)

Prazosin is thought to produce alpha-adrenergic blockade in a different way from the classical alpha-blockers phenoxybenzamine and phentolamine.2 The unusual side effects of prazosin, frequency of micturition and incontinence of urine, have been attributed to this alpha-blocking action.5 We now consider priapism a potential hazard of treatment with prazosin. (erowid.org)
Losartan belongs to the class of medications called angiotensin II receptor blockers . (medbroadcast.com)
Beta-blockers inhibit the action of epinephrine and norepinephrine on beta-adrenergic receptors , decreasing heart rate and cardiac output. (pharmacologymentor.com)
Alpha-blockers antagonize alpha-1 adrenergic receptors in vascular smooth muscle, causing vasodilation and reduced peripheral vascular resistance. (pharmacologymentor.com)
The "intra-operative floppy iris syndrome" cataract surgery complication has been reported in men using alpha-blockers. (urotoday.com)
The risk of complicated cataract surgery was 14.9% in patients using alpha-blockers, approximately 50% higher than those not receiving this medication (9.5%) (p=0.003). (urotoday.com)
Alpha Receptor Blockers: prozosin (Minipres) or doxazosin (Cardura). (raynauds.co.in)
Alpha-1 adrenergic blockers such as prazosin can be used to control Raynaud's vasospasms under supervision of a health care provider. (raynauds.co.in)
[ 3 ] Drugs such as angiotensin converting enzyme (ACE) inhibitors, calcium channel blockers (CCBs), angiotensin receptor blockers (ARBs), beta-blockers, and diuretics are all considered acceptable alternative therapies in patients with hypertension. (medscape.com)
Except in special conditions, vasodilators and alpha- and beta-blockers are 3rd-line drugs, which if needed should be used after consultation with a specialist. (msdmanuals.com)
For instance, non-depolarising neuromuscular blockers like d-tubocurarine, pancuronium, vecuronium, atracurium and depolarising neuromuscular blocker like suxamethonium all act on nicotinic acetylcholine receptors (nAChR) which are of ionotropic receptors. (egpat.com)
Two classes of drugs that should never be used during pregnancy are ACE inhibitors and angiotensin II receptor blockers. (cardiohow.com)
Thiazide diuretics (such as HCTZ) or calcium channel blockers are recommended first, along with the possibility of adding a second drug from the ACE inhibitor or angiotensin II receptor blocker class. (cardiohow.com)
Along with a diuretic, some calcium channel blockers, ACE inhibitors and angiotensin II receptor blockers may also be good choices. (cardiohow.com)
Beta blockers , which counter some of the effects of noradrenaline by blocking their receptors, are frequently used to treat glaucoma , migraine , and a range of cardiovascular problems. (wikipedia.org)
Alpha blockers , which counter a different set of noradrenaline effects, are used to treat several cardiovascular and psychiatric conditions. (wikipedia.org)

Cooling (from 37 to 24 degrees C) augmented contractions to norepinephrine under control conditions and after alpha 1-adrenergic blockade (prazosin) but not following alpha 2-adrenergic blockade (rauwolscine). (johnshopkins.edu)
With norepinephrine, this permits the potentiating effect of cooling on the alpha 2-adrenergic component of the response to predominate. (johnshopkins.edu)
Norepinephrine released from adrenergic nerve endings, relaxes bladder body by increasing intracellular cAMP via β-adrenergic receptors widely expressed in the bladder body, and contracts bladder base and proximal urethra via α-adrenergic receptors to prevent premature bladder emptying. (scirp.org)
[2] "Norepinephrine" is also the international nonproprietary name given to the drug . (wikipedia.org)
Regardless of how and where it is released, norepinephrine acts on target cells by binding to and activating adrenergic receptors located on the cell surface. (wikipedia.org)

Prazosin (10(-8) M) shifted the concentration-response curves to phenylephrine and UK 14,304 to the right, but did not shift the concentration-response curves to clonidine and oxymetazoline. (aspetjournals.org)
Pretreatment with chlorethylclonidine, which selectively alkylates the alpha-1B subtype, did not affect the Emax value of phenylephrine-induced contractions, but significantly shifted the curve to the right. (aspetjournals.org)
The mean dose ratio of the shift in phenylephrine ED50 (ED50 during prazosin therapy/ED50 before prazosin therapy) was 6.1. (ox.ac.uk)
Moreover, following partial irreversible blockade of the alpha 1-adrenoceptors with phenoxybenzamine, cooling also reduced the contractions evoked by phenylephrine. (johnshopkins.edu)
In order to elucidate the mechanism of functional changes in aged rat urinary bladder, we studied the influence of senescence on, 1) the α-adrenergic contractile response to phenylephrine in the urinary bladder body and trigone, 2) the muscarinic contractile response to carbachol in the body and trigone. (scirp.org)

in particular, the beta-adrenergic receptors are likely at fault. (hypothes.is)

In contrast several functional adrenergic system antagonists (clonidine prazosin propranolol) failed to alter mechanical hypersensitivity in this state. (monossabios.com)

The prazosin was stopped, and his blood pressure was controlled with propranolol, triamterene, and hydrochlorothiazide. (erowid.org)

The drug is commercially available in a racemic mixture of 2 isomers, and is pharmacologically related to doxazocin, prazosin, and terazosin. (lgmpharma.com)
Other drug interactions includeenhanced vertigo with alpha-blockingdrugs such as prazosin or terazosin;bradycardia and hypotension may beamplified with concurrent use of selectiveserotonin reuptake inhibitors andphenothiazines, or drugs that inhibitthe CYP2D6 metabolic enzyme. (pharmacytimes.com)

Alpha adrenergic blockade during prazosin therapy. (ox.ac.uk)
Metoprolol should be avoided in thepresence of sick sinus syndrome orsinus-mediated bradycardia, in severeperipheral artery disease, and duringthe final 2 trimesters of pregnancy.Beta blockade presents a challengewith concurrent bronchial diseasestates, such as asthma. (pharmacytimes.com)
People with normal or low BP would invoke compensation by the sympathetic nervous system in response to alpha blockade. (hypothes.is)

Distribution of adrenergic receptor subtypes and adrenergic receptor number are important factors in organ or cellular responses to adrenergic input. (pharmacology2000.com)

ARBs selectively block the binding of angiotensin II to its receptor, leading to vasodilation and reduced aldosterone secretion. (pharmacologymentor.com)
There is some evidence that Angiotensin II receptor antagonists (often Losartan) reduce frequency and severity of attacks, and possibly better than nifedipine. (raynauds.co.in)
Angiotensin II receptor blocker valsartan (Diovan) at the forefront of drugs for high blood pressure. (cardiohow.com)

However, unlike these drugs, tamsulosin has a higher affinity for the alpha-1A- adrenergic receptors, which are located in vascular smooth muscle. (lgmpharma.com)
The antihypertensive effect of Prazosin results from a decrease in systemic vascular resistance and the parent compound Prazosin is primarily responsible for the antihypertensive activity. (pharmacycode.com)
In tumor necrosis factor (TNF)-alpha-stimulated human aortic endothelial cells, beta-sitosterol was found to significantly inhibit vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression. (drugs.com)
α receptor dominate in the cutaneous vascular beds. (pharmacology2000.com)
Both α and β adrenergic receptor are present in skeletal muscle vascular beds. (pharmacology2000.com)

Acetylcholine released from cholinergic nerve endings, contracts the smooth muscle of bladder body via activation of muscarinic receptors to cause voiding. (scirp.org)
The muscarinic receptor-mediated contraction of smooth muscle is induced by activation of protein kinase C and by increased intracellular Ca 2+ . (scirp.org)
In order to elucidate the mechanisms of age-related changes in urinary bladder function, we studied the influence of aging on the contractile response to muscarinic and α-adrenergic stimulation, and on the binding characteristics of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB) to muscarinic cholinoceptors, in addition to histological examination in rat urinary bladder. (scirp.org)
We revealed that the muscarinic receptor-mediated response was not affected by aging, while the contractile response to α-adrenergic stimulation was significantly augmented in both bladder body and trigone. (scirp.org)
A classic stimulator of the salivationlacrimation-urination-defecation response,pilocarpine is a cholinergic drug that actsupon muscarinic receptors. (pharmacytimes.com)
All muscarinic acetylcholine receptors are G-protein coupled receptors present at various locations such as CNS, heart, many smooth muscles and exocrine glands. (egpat.com)

For example, epinephrine binds to the β2 receptor on bronchial muscle which then activates adenylyl cyclase system releasing cAMP. (egpat.com)
epinephrine and isoproterenol might be expected to be effective bronchodilators because of their activity at 2 receptors. (pharmacology2000.com)

This drug, the first of a new class of antihypertensive agents, interferes with alpha-adrenergic function at the postsynaptic level. (erowid.org)
These results show no evidence for a generalized change in alpha adrenergic responsiveness in hypertension and support the concept that increased blood pressure responses to alpha adrenergic stimulation in hypertensives are due to structural and geometric changes in the arterial wall rather than to an increased responsiveness of postsynaptic alpha adrenergic receptors. (ox.ac.uk)

It was one of the first selective antagonists developed for this receptor and was invented in 1969, but is still commonly used in research into adrenergic receptors, especially as a lead compound from which to develop more selective drugs. (wikipedia.org)
Search for selective antagonists at alpha 1-adrenoreceptors: neutral or negative antagonism? (wikipedia.org)
Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. (pharmacycode.com)

Tamsulosin, a sulfamoylphenethylamine-derivative alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH). (lgmpharma.com)
Several randomized controlled trials have found that the alpha-1 blocker prazosin is effective in reducing symptoms of posttraumatic stress disorder (PTSD) among active-duty soldiers(Roundup, 2017). (duepapers.net)
Alpha-blocker medications are the first line of therapy for men with these urinary symptoms. (urotoday.com)
To assess the frequency of cataract surgery complications arising from alpha-blocker therapy in a large patient population. (urotoday.com)
If possible, alpha blocker medications should be discontinued prior to eye surgery in older patients. (urotoday.com)
As alpha-blocker medications are the first line of therapy for men with LUTS, these reports of IFIS led the Food and Drug Administration, American Urological Association, American Academy of Ophthalmology, and American Society of Cataract and Refractive Surgery to issue statements alerting physicians and patients to potential difficulties during cataract surgery in patients using alpha-1 blocker therapy [7,8,9]. (urotoday.com)
The purpose of this study was to assess the impact of alpha-blocker therapy on complications during cataract surgery in a large patient population. (urotoday.com)
Tamsulosin is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia and ureteric stones. (kratom.org)
Tamsulosin is an alpha-adrenergic receptor blocker. (kratom.org)

In previous studies we investigated the role of beta- and alpha 2-adrenergic receptors through local microinjections of various drugs into the dorsal pontine tegmentum (DPT) of the cat. (nih.gov)
Unlike some beta-blocking drugs,metoprolol demonstrates selectiveinhibition of beta 1 adrenergic receptorsat low doses. (pharmacytimes.com)
Drugs can bind to the various protein targets among which G-protein coupled receptors (GPCR) hold their flagship. (egpat.com)
Then, can we include all drugs acting on receptors into the list? (egpat.com)
Few of the drugs act on receptor coupled with ion channels again not fall into the list. (egpat.com)
These receptors, commonly called as ionotropic receptors, are not GPCR hence all drugs acting on these should be properly differentiated. (egpat.com)
Similar is the case with many drugs acting on these receptors. (egpat.com)
For reasons that are still unclear, some Alpha-2 drugs, such as guanfacine , have also been shown to be effective in the treatment of anxiety disorders and ADHD . (wikipedia.org)

2 3 Phentolamine also has been used to treat hypertensive crisis associated with monoamine oxidase inhibitor (MAOI) therapy and in combination with papaverine to treat erectile dysfunction (ED). 1 According to ED treatment guidelines, oral phosphodiesterase type 5 (PDE5) inhibitors are considered first-line therapy. (empowerpharmacy.com)

Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)
Pharmacological characterization of alpha(2)adrenoceptors mediating this process. (nel.edu)

Existence and alpha 1-adrenergic stimulation of inositol polyphosphates in mammalian heart. (aspetjournals.org)
1,4,5-IP3 (significant at 10 microM) and both IP4 isomers (significant at 1 microM) increased after alpha-adrenoceptor stimulation, whereas 1,3,4,5,6-IP5 and IP6 remained unaffected. (aspetjournals.org)
Increased inositol polyphosphate turnover may be involved in the mechanism(s) whereby alpha 1-adrenoceptor stimulation produces an increase in myocardial force of contraction. (aspetjournals.org)
Contraction linked to 5-HT(1B/1D) receptor stimulation in the rabbit renal artery can be explained by an influx of external Ca(2+) through voltage-dependent Ca(2+) channels and sensitization of the contractile myofilaments to existing levels of Ca(2+), with no release of Ca(2+) from intracellular stores. (ox.ac.uk)

The residual contraction was abolished by the putative receptor operated channel inhibitor, SKF 96365 (2 microM). (ox.ac.uk)
Imatinib is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. (keralapharmacist.com)

When the active metabolites of kratom bind to these receptors, they cause vasoconstriction, papillary constriction, and constriction of smooth muscles in the genitourinary tract. (kratom.org)
α receptor activation causes vasoconstriction. (pharmacology2000.com)

Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. (lgmpharma.com)

Do not take 2 doses within 6 hours of one another. (medbroadcast.com)
If you miss more than 2 doses in a row, contact your doctor for instructions on restarting the medication. (medbroadcast.com)
Only at higher doses doesbeta 2 inhibition occur. (pharmacytimes.com)
If you miss 2 or more doses, contact your doctor. (pharmasave.com)

This is a combination product that contains 2 medications used to lower high blood pressure (hypertension), losartan and hydrochlorothiazide. (medbroadcast.com)

The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)
On the other hand, adrenergic activity is inhibited in this phase, leading to relax proximal urethra for voiding. (scirp.org)
The drug acts by blocking alpha-1 adrenergic receptors in the genitourinary tract's and relaxing the muscles, especially the bladder's detrusor muscles and prostatic muscles, allowing easy passage of urine through the urethra. (kratom.org)

These experiments suggest that cooling augments alpha 2-adrenergic responsiveness without affecting alpha 1-adrenergic responsiveness. (johnshopkins.edu)

The purpose of this study was to evaluate functional genetic polymorphisms of physiologic pathways related to the regulation of the cardiovascular function (alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor) and exercise muscle vasodilatation in apparently healthy men and women. (scipedia.com)
R. Nunes, L. Barroso, A. Pereira, M. Rondon, C. Negrão, J. Krieger and A. Mansur, Alpha2A-adrenergic receptor and eNOS genetic polymorphisms are associated with exercise muscle vasodilatation in apparently healthy individuals, IJC Heart & Vasculature (2016). (scipedia.com)
β receptor activation promotes vasodilatation. (pharmacology2000.com)

Since 2 receptors are activated at lower, physiological concentrations, vasodilation results. (pharmacology2000.com)

In intact arterial segments, 1 nM - 10 microM 5-HT failed to induce contraction or increase the fura-2 fluorescence ratio (in the presence of 1 microM ketanserin and prazosin to block 5-HT(2) and alpha(1)-adrenergic receptors, respectively). (ox.ac.uk)

Studies show that tamsulosin has about 12 times greater affinity for alpha-1 adrenergic receptors in the prostate than those in the aorta, which may result in a reduced incidence of adverse cardiovascular effects. (lgmpharma.com)
A study published in 2005 described a new clinical entity, the "intra-operative floppy iris syndrome" (IFIS), and suggested that this syndrome was associated with tamsulosin, a drug used widely for the treatment of lower urinary tract symptoms (LUTS) due to benign prostate enlargement [2]. (urotoday.com)
Thus, because kratom and tamsulosin have opposite effects mediated by the alpha-adrenergic receptors, they will become ineffective if combined. (kratom.org)
Kratom and tamsulosin act via alpha-adrenergic receptors. (kratom.org)

This would counteract the depressant effects of adrenergic antagonism. (hypothes.is)

The dorsal hand vein compliance technique is useful in detecting systemic effects of alpha adrenergic antagonists. (ox.ac.uk)

Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. (pharmacycode.com)

Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men. (lgmpharma.com)

Cooling and alpha 1- and alpha 2-adrenergic responses in cutaneous veins: role of receptor reserve. (johnshopkins.edu)
Experiments were designed to determine the effects of cooling on alpha 1- and alpha 2-adrenergic responses in isolated canine cutaneous veins. (johnshopkins.edu)

Prazosin (1-100 nM) did not change either the inhibitory effect of UK-14,304 or the facilitatory effect of CEC. (unesp.br)

Dose maybe titrated at 1 to 2 week intervals, up to 8 mg once daily. (nih.gov)
Because his blood pressure was not well controlled prazosin was substituted for hydrallazine at a dose of 6 mg daily and gradually increased to 20 mg daily. (erowid.org)
He was started on prazosin treatment in December 1977 at a dose of 1-5 mg daily, and this was increased gradually to 18 mg daily by the end of January. (erowid.org)
The usual recommended starting dose for this medication is 3.125 mg 2 times daily in order to allow the body to get used to it. (medbroadcast.com)
Your doctor will then increase the dose every 2 weeks until the most effective dose is reached. (medbroadcast.com)
Depending on the individual patient's urodynamics and BPH symptomatology, the dose may be titrated at 1 to 2 week intervals to 2 mg, and thereafter to 4 mg and 8 mg once daily. (sdrugs.com)
The recommended dose ranges from 1 to 2 tablets once daily of enalapril 10 mg - hydrochlorothiazide 25 mg. (mediresource.com)
Forhypertension, the extended-releasedose begins with a daily dose of 25 to100 mg, with a 400-mg daily maximum.For angina, polymorphic ventriculartachycardia, and prophylaxis of heartattack, the initial daily dose is 100 mg,with the same 400-mg daily limit.Elderly patients should initiate treatmentwith 25 to 50 mg daily as a singledose, with increases at 1-to 2-weekintervals. (pharmacytimes.com)
Many medications must be continued through the perioperative period, with the last dose taken with a sip of clear liquid up to 2 hours prior to the procedure, and resumed during recovery. (medscape.com)

CONCLUSIONS: These findings suggest that higher standing BP is a biomarker that helps identify persons with combat PTSD who are likely to benefit from prazosin. (hypothes.is)

For the chronic prophylactic administration studies the vehicle-treated rats were given repeated SC injections of 2 ml 20% HBC vehicle/kg body weight. (monossabios.com)
2011 Briefly rats were anesthetized with isoflurane (2%) and chronic intravenous catheters were placed in the jugular vein. (monossabios.com)

Priapism has been described in patients taking guanethidine, and the direct-acting vasodilator hydrallazine.3 Sexual difficulties are said to be rare with prazosin although congestion of (the) penis has been attributed to the drug in one case.4 Priapism associated with prazosin has not previously been reported. (erowid.org)
The drug mainly acts on alpha-1 adrenergic receptors. (kratom.org)

To date, a number of adrenergic agents have been tested for their efficacy in treating PTSD. (duepapers.net)

Diseases1

Chemicals and Drugs24

Antagonist14

Agonists6

Agonist9

Blockers16

Norepinephrine5

Phenylephrine5

Beta-adrenergic1

Clonidine1

Propranolol1

Terazosin2

Blockade3

Subtypes1

Angiotensin3

Vascular5

Muscarinic6

Epinephrine2

Postsynaptic2

Selective3

Blocker9

Drugs8

Inhibitors1

Characterization2

Stimulation4

Inhibitor2

Vasoconstriction2

Subtype1

Doses4

Losartan1

Urethra3

Responsiveness1

Vasodilatation3

Vasodilation1

MicroM1

Tamsulosin4

Antagonism1

Systemic1

Benign1

Relaxation1

Veins2

Inhibitory effect1

Dose9

Conclusions1

Chronic2

Drug2

Agents1