As a schoolboy, Wilmut worked as a farm hand on weekends, which inspired him to study Agriculture at the University of Nottingham. (wikipedia.org)
Wilmut was raised in Coventry, a town in the historic English county of Warwickshire, and he attended the Agricultural College at the University of Nottingham. (mathisfunforum.com)
Cryopreservation2
In 1966, Wilmut spent eight weeks working in the laboratory of Christopher Polge, who is credited with developing the technique of cryopreservation in 1949. (wikipedia.org)
The following year Wilmut joined Polge's laboratory to undertake a Doctor of Philosophy degree at the University of Cambridge, from where he graduated in 1971 with a thesis on semen cryopreservation. (wikipedia.org)
19972
In 1997 Wilmut was Time magazine man of the year runner up. (wikipedia.org)
When Professor Wilmut introduced the sheep in 1997, it paved the way for potential stem cell treatments to treat conditions such as Parkinson's disease, a degenerative disease that affects more than 150,000 people in the UK. (worldtimetodays.com)
Dolly6
He is best known as the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. (wikipedia.org)
Wilmut was the leader of the research group that in 1996 first cloned a mammal, a lamb named Dolly. (wikipedia.org)
In 2008 Wilmut announced that he would abandon the technique of somatic cell nuclear transfer by which Dolly was created in favour of an alternative technique developed by Shinya Yamanaka. (wikipedia.org)
Ian Wilmut, quoted in Time Wilmut led the team that created Dolly, but in 2006 admitted his colleague Keith Campbell deserved "66 per cent" of the invention that made Dolly's birth possible, and that the statement "I did not create Dolly" was accurate. (wikipedia.org)
is a British developmental biologist who was the first to use nuclear transfer of differentiated adult cells to generate a mammalian clone, a Finn Dorset sheep named Dolly, born in 1996. (mathisfunforum.com)
Professor Sir Ian Wilmut, the scientist who led the team that cloned Dolly the sheep, has died aged 79. (worldtimetodays.com)
19441
Sir Ian Wilmut OBE FRS FMedSci FRSE (7 July 1944 - 10 September 2023) was a British embryologist and the chair of the Scottish Centre for Regenerative Medicine at the University of Edinburgh. (wikipedia.org)
Somatic cell3
It was created in a laboratory in Edinburgh in 1996 using a technique called somatic cell nuclear transfer (SCNT). (worldtimetodays.com)
Because cattle are a species widely used for nuclear transfer studies, and more laboratories have succeeded in cloning cattle than any other specie, this review will be focused on somatic cell cloning of cattle. (biomedcentral.com)
Somatic cell cloning (cloning or nuclear transfer) is a technique in which the nucleus (DNA) of a somatic cell is transferred into an enucleated metaphase-II oocyte for the generation of a new individual, genetically identical to the somatic cell donor (Figure 1 ). (biomedcentral.com)
Parkinson's2
Wilmut believed that this method holds greater potential for the treatment of degenerative conditions such as Parkinson's disease and to treat stroke and heart attack patients. (wikipedia.org)
Wilmut died from complications of Parkinson's disease on 10 September 2023, aged 79. (wikipedia.org)
Mammalian1
Cloning by nuclear transfer using mammalian somatic cells has enormous potential application. (biomedcentral.com)
Adult1
The breakthrough technique involved transferring the nucleus of an adult cell into an unfertilized egg whose own nucleus had been removed. (worldtimetodays.com)
Nucleus1
It demonstrated that genes inactivated during tissue differentiation can be completely re-activated by a process called nuclear reprogramming: the reversion of a differentiated nucleus back to a totipotent status. (biomedcentral.com)
Embryo3
Wilmut was appointed OBE in 1999 for services to embryo development and knighted in the 2008 New Year Honours. (wikipedia.org)
Wilmut was appointed Officer of the Order of the British Empire (OBE) in the 1999 Birthday Honours "for services to Embryo Development" and a Fellow of the Royal Society (FRS) in 2002. (wikipedia.org)
Although the efficiency of nuclear transfer has been dramatically improved from the initial success rate of one live clone born from 277 embryo transfers [ 1 ], none of the aforementioned efforts abolished the common problems associated with nuclear transfer. (biomedcentral.com)
Breakthroughs1
Various strategies have been used to improve the efficiency of nuclear transfer, however, significant breakthroughs are yet to happen. (biomedcentral.com)
Clone1
More than 100 nuclear transfer procedures could be required to produce one viable clone. (wikiquote.org)
Research1
Embryonic stem cell technology is still at a preliminary research stage and announcements about its potential may be premature. (edu.au)
Attempts1
Various strategies have been employed to modify donor cells and the nuclear transfer procedure in attempts to improve the efficiency of nuclear transfer. (biomedcentral.com)
Stem cells1
The unique properties of human stem cells have aroused considerable optimism about their potential as new pathways for alleviating human suffering caused by disease and injury. (edu.au)
Cells1
Given that we have an efficiency of 1% cloning for livestock species and if only one in a thousand cells are viable then around 100,000 cells would need to be transferred. (wikiquote.org)
News1
Professor Sir Peter Mathieson, principal and vice-chancellor of the University of Edinburgh, said: "We are deeply saddened by the news of the death of Professor Sir Ian Wilmut. (worldtimetodays.com)
Order1
These observations suggest that further studies on nuclear reprogramming are needed in order to understand the underlying mechanisms of reprogramming and significantly improve the ability of the differentiated somatic nuclei to be reprogrammed. (biomedcentral.com)
Produce1
They used these techniques to produce lead, copper, tin and bronze. (mathisfunforum.com)
Roslin Institute2
Professor David Hume, current Director of The Roslin Institute, welcomed guests to the event and recalled his encounter with a Dolly-savvy Brisbane taxi driver en route to his new job at Roslin, demonstrating Dolly's worldwide fame. (ed.ac.uk)
Dolly was born at the Roslin Institute on 5th July 1996, and was the first mammal to be cloned from an adult cell. (ed.ac.uk)
Dolly's3
Ian Wilmut, quoted in Time Wilmut led the team that created Dolly, but in 2006 admitted his colleague Keith Campbell deserved "66 per cent" of the invention that made Dolly's birth possible, and that the statement "I did not create Dolly" was accurate. (wikipedia.org)
His supervisory role is consistent with the post of principal investigator held by Wilmut at the time of Dolly's creation. (wikipedia.org)
I am slightly disappointed by the fact that, technically, cloning is only slightly better than it was originally," explained Professor Ian Wilmut, one of Dolly's creators who is now based at Edinburgh University. (bbc.co.uk)
Somatic7
He is best known as the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. (wikipedia.org)
In 2008 Wilmut announced that he would abandon the technique of somatic cell nuclear transfer by which Dolly was created in favour of an alternative technique developed by Shinya Yamanaka. (wikipedia.org)
It turns out that somatic cell nuclear transfer - the process used to create Dolly and her cloned peers - is just not that efficient. (bbc.co.uk)
Scientists used a technique called Somatic Cell Nuclear Transfer to clone a cell taken from the udder of an adult sheep to create Dolly, proving that specialised adult cells can give rise to a fully formed animal. (ed.ac.uk)
The technique used to produce Dolly is called somatic-cell nuclear transfer (SCNT) and involves reprogramming normal sheep cells into embryonic cells that can turn into any other specific type of cell in the body. (thelimbic.com)
The experiment was the first to demonstrate somatic cell nuclear transfer , which is the use of somatic differentiated cells in nuclear transfer rather than embryonic cells that have not differentiated. (asu.edu)
The first step to cloning these animals is a technique called Somatic Cell Nuclear Transfer (SCNT). (research-ethics.org)
Sheep1
The use of nuclear transfer in sheep in 1986 continued the development of nuclear transfer techniques and the development of Mitalipov and Tachibana's mitochondrial gene therapy. (asu.edu)
Donor3
The technique involves removing the nucleus of one cell from a donor animal and transferring it into an unfertilised egg that has had its own genetic material removed. (bbc.co.uk)
Mitalipov and Tachibana, researchers at the Oregon National Primate Research Center in Beaverton, Oregon, developed a technique to remove the nucleus of the mother and place it in a donor oocyte , or immature egg cell, with healthy mitochondria. (asu.edu)
When Gurdon transferred the intestinal cells into oocytes, the resulting tadpole was a genetic match to the intestinal cell donor tadpole. (asu.edu)
Campbell1
Wilmut and Campbell, in conjunction with Colin Tudge, published The Second Creation in 2000. (wikipedia.org)
Embryos3
Dr Robl, president of Hematech, based in South Dakota, said: "We [Hematech] do cloning on a very large scale: last year, we transferred 4,000 cloned embryos. (bbc.co.uk)
In 1975, Derek Bromhall in Oxford, England, experimented with the embryos of rabbits using Briggs and King's method of nuclear transfer. (asu.edu)
Stem cells can be obtained from embryos, but embryos are only one of many potential sources. (research-ethics.org)
Scientists3
However, while the success rate for cloning remains low, this does not mean the technology has ground to a halt: scientists still see great scientific and commercial potential. (bbc.co.uk)
When developing the technology of mitochondrial gene replacement therapy, Mitalipov, Tachibana, and their team of researchers built off of the research of other scientists, and used many of the same techniques in his own work. (asu.edu)
While most hESC scientists view the human embryo as human cells with great biological and scientific potential, there are many members of our society who hold religious beliefs that define the human embryo as equivalent to a human life. (research-ethics.org)
Cell1
This cell contains a different set of genetic instructions (resulting in an alternative pattern of gene expression) and is characterized by a reduced proliferative capacity and more restricted developmental potential than its parent. (jci.org)
Eventually1
Wilmut's father, Leonard Wilmut, was a mathematics teacher who suffered from diabetes for fifty years, which eventually caused him to become blind. (wikipedia.org)
Stem1
Each potential use of stem cells promises revolutionary advances. (jci.org)
Science1
Wilmut was an Emeritus Professor at the Scottish Centre for Regenerative Medicine at the University of Edinburgh and in 2008 was knighted in the New Year Honours for services to science. (wikipedia.org)
Time1
This suggests that the cloning technique can, after all, produce perfectly normal and viable offspring that don't grow old before their time. (thelimbic.com)
Impossible1
Researchers had thought nuclear transplantation of differentiated cells was impossible because the cells were already functioning as a certain tissue. (asu.edu)
Year2
Wilmut was appointed OBE in 1999 for services to embryo development and knighted in the 2008 New Year Honours. (wikipedia.org)
The following year Wilmut joined Polge's laboratory to undertake a Doctor of Philosophy degree at the University of Cambridge, from where he graduated in 1971 with a thesis on semen cryopreservation. (wikipedia.org)
People1
People were familiar with certain new techniques in metallurgy. (mathisfunforum.com)