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Atrial Natriuretic FactorNatriuretic Peptide, BrainNatriuretic Peptide, C-TypeNatriuretic PeptidesReceptors, Atrial Natriuretic FactorPeptidesNatriuretic AgentsPeptide FragmentsGuanylate CyclaseCyclic GMPHeart FailureBiological MarkersNatriuresisBrain ChemistryProtein PrecursorsBrain InjuriesNeprilysinNerve Tissue ProteinsPeptide LibraryBrain NeoplasmsMyocardiumPeptides, CyclicBlood PressureAmino Acid SequenceVentricular Dysfunction, LeftAntimicrobial Cationic PeptidesPredictive Value of TestsMolecular Sequence DataHemodynamicsRats, Sprague-DawleyCardiomegalyBrain MappingKidneyRNA, MessengerAdrenomedullinRadioimmunoassayTime FactorsCells, CulturedHeart AtriaPrognosisAldosteroneBrainOligopeptidesPeptide MappingROC CurveProspective StudiesEchocardiographyStroke VolumeReninRats, WistarBase SequenceHeart VentriclesCyclic GMP-Dependent Protein KinasesTroponin TDose-Response Relationship, DrugElapid VenomsBrain EdemaChromatography, High Pressure LiquidVentricular Function, LeftVentricular RemodelingDyspneaEndothelin-1Angiotensin IIHeartDogsKineticsHeart DiseasesSensitivity and SpecificityBrain IschemiaProtein BindingHypertensionCalcitonin Gene-Related PeptideSodiumRats, Inbred StrainsDiureticsGlomerular Filtration RateThiorphanDiuresisVasoactive Intestinal PeptideProteinsBrain StemDisease Models, AnimalPulmonary Wedge PressureGene Expression RegulationCardiomyopathy, DilatedGene ExpressionEchocardiography, DopplerMyocytes, CardiacReceptors, PeptideArginine VasopressinMagnetic Resonance ImagingTroponin ISignal TransductionRenin-Angiotensin SystemCell LineReceptors, Cell SurfaceBinding SitesHeart Failure, SystolicWater-Electrolyte BalanceCattle

AtrialCalcitonin gene-reReceptorsNitric oxideEndothelialSecretionInhibitoryVasodilatorVasoconstrictorEndogenousReceptor AntagonistsNPRACardiacNeuropeptideBody fluid homeostasisBradykininInsulinActionsAxisGeneHumansEstablishActivityLevelsFailureDamageEffectsTissueHeartAnimalIncreased blood pressureHighResponse

Atrial5

• Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. (wikipedia.org)
• We also investigated whether gene expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which participate in some pathological cardiac conditions, in the rat hearts is altered by aging and subsequent exercise training. (elsevierpure.com)
• NP (atrial natriuretic peptide) is released mainly in the atrial region, BNP (brain natriuretic peptide) from the ventricular region and C-natriopeptide from the cardiac endothelium. (wikilectures.eu)
• Glucocorticoid secreted fortunately there is an easy that atrial natriuretic. (edward-kim.com)
• Atrial natriuretic peptide (ANP) secreted from atrial myocytes is proven to own anti-inflammatory, anti-oxidant and immunomodulatory results. (isotope.info)

Calcitonin gene-re1

• n all organs, the nerve endings of efferent nerves also contain nonadrenergic and noncholinergic peptides, eg neuropeptide Y , VIP (vasoactive intestinal peptide), substance P, calcitonin gene-related peptide (CGRP). (wikilectures.eu)

Receptors2

• In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpectedly enhanced by pharmacological block of natriuretic peptide receptor-A (NPR-A), outlining a potential inhibitory role of endogenous natriuretic peptides in nociception mediated by P2X3 receptors. (biomedcentral.com)
• Endothelins exert their effects by binding to two distinct cell surface ET receptors, ET A and ET B . The ET B receptor (ET B R) binds the three peptide isotypes with equal affinity. (biomedcentral.com)

Nitric oxide1

• The cyclic nucleotides cAMP and cGMP participate in the main pathways regulating cardiac and vascular functions and they act as second messengers for sympathetic and parasympathetic systems, nitric oxide (NO) and natriuretic peptides (NPs). (protheragen.com)

Endothelial1

• The pathophysiological pathways have common neurohormonal links such as renin-angiotensin-aldosterone system, natriuretic peptides, oxidative stress and endothelial dysfunction. (cardiologyresearchjournal.com)

Secretion1

• enhanced secretion of adiponectin by cardiomyocytes that is stimulated by BNP (brain natriuretic peptide), disturbed metabolism of adiponectin in older patients with CVD as well as changes in multimerization of adiponectin. (czytelniamedyczna.pl)

Inhibitory1

• Because hyper-osmolality is a potent stimulus for VP and OT release, this suggests an inhibitory role for ER-β in MNCs. (jneurosci.org)

Vasodilator2

• Bradykinin is a potent vasodilator in the pulmonary and systemic circulation. (wikilectures.eu)
• It is a potent vasodilator in the systemic circulation, but leads to vasoconstriction in the pulmonary circulation. (wikilectures.eu)

Vasoconstrictor1

• Throughout the body, angiotensin II is a potent vasoconstrictor of arterioles . (wikipedia.org)

Endogenous2

• One candidate for the role of endogenous negative regulator of sensory ganglion activity is the brain natriuretic peptide (BNP). (biomedcentral.com)
• Kinins (bradykinin and lys-bradykinin) are endogenous vasodilators and natriuretic peptides known best for their ability to antagonize angiotensin-induced vasoconstriction and sodium retention. (nature.com)

Receptor Antagonists1

• This has propelled the development of several potent and selective ET-1 receptor antagonists. (biomedcentral.com)

NPRA1

• This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA). (wikipedia.org)

Cardiac2

• NOMI is precipitated by a severe reduction in mesenteric perfusion, with secondary arterial spasm from such causes as cardiac failure, septic shock, hypovolemia or the use of potent vasopressors. (rcpjournals.org)
• Laboratory markers of oncotic pressure (albumin) and cardiac dysfunction (brain natriuretic peptide [BNP]) may be abnormal, but the clinical application remains unclear. (stanfordchildrens.org)

Neuropeptide1

• Most of these peptides, with the exception of neuropeptide Y, lead to vasodilation and help regulate regional perfusion. (wikilectures.eu)

Body fluid homeostasis1

• These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. (wikipedia.org)

Bradykinin1

• Humoral factors that regulate vascular tone include renin-angiotensin-aldosterone system (RAAS), ADH , bradykinin , histamine , serotonin , thyroxine , natriuretic peptides and many others. (wikilectures.eu)

Insulin1

• It has been reported that isomer of adiponectin, HMW, has more potent metabolic, insulin sensitizing and cardioprotective effects than LMW, MMW and total adiponectin. (czytelniamedyczna.pl)

Actions1

• Adrenomedullin (AM), an ubiquitous regulatory peptide with different actions, is known to be elevated in different clinical situations, including diabetes mellitus (DM), but its potential role in the pathogenesis of diabetic vascular complications is not clear. (phoenixpeptide.com)

Axis1

• RhANP attenuates endotoxin-derived cognitive dysfunction by way of subdiaphragmatic vagus nerve-mediated intestine microbiota-brain axis. (isotope.info)

Gene1

• Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene. (wikipedia.org)

Humans1

• In humans, angiotensin-converting enzyme inhibitors, a potent class of antihypertensive agents, lower blood pressure at least partially by favoring enhanced kinin accumulation in plasma and target tissues. (nature.com)

Establish2

• The findings establish semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, as a second class of medication with proven efficacy and safety for people with HFpEF, joining two agents also proven beneficial for people with HFpEF, dapagliflozin (Farxiga) and empagliflozin (Jardiance), both from the class of sodium-glucose cotransporter 2 (SGLT2) inhibitors. (medscape.com)
• Pending direct investigation of these general mechanisms in aged tissues, this review predicts that future work will establish epigenetic rejuvenation as a potent method to delay CVD. (oaepublish.com)

Activity1

• Unlike ANP and BNP, CNP does not have direct natriuretic activity. (wikipedia.org)

Levels2

• Increased serotonergic and noradrenergic levels in the brain , similar to the effects of antidepressants. (athingnamed.com)
• For starters, exercise immediately elevates levels of norepinephrine, in certain areas of the brain. (athingnamed.com)

Failure1

• Natriuretic peptides are released from the heart during its distension in congestive failure. (wikilectures.eu)

Damage1

• Dose-finding studies in nude mice demonstrate that F10 administered i.c. using an Alzet osmotic mini-pump at doses up to 200 mg/kg administered over 7 days are well-tolerated and do not cause damage to normal brain (Fig. 2b). (alzet.com)

Effects1

• ET-1 has potent positive inotropic and chronotropic effects on heart and induces myocardial cell hypertrophy. (elsevierpure.com)

Tissue1

• It is a potent PDE9 inhibitor that characterized by high selectivity, low brain penetration, and target tissue distribution. (protheragen.com)

Heart1

• in case of hypovolemic shock perfusion of heart and brain is maintained and, conversely, reduced in muscles, skin and splanchnic. (wikilectures.eu)

Animal1

• A new generation of drugs is likely to emerge from peptides, including those found in animal venoms. (scielo.br)

Increased blood pressure1

• Angiotensin II is a potent vasoconstrictive peptide that causes blood vessels to narrow, resulting in increased blood pressure. (wikipedia.org)

High1

• A blood examination on admission revealed elevated high-sensitive troponin I (52.0 ng/mL), N-terminal pro-brain natriuretic peptide (3,193 pg/mL), D-dimer (152 ng/mL) and creatinine kinase myocardial band (196.5 U/L). ECG and blood tests were repeated 1 hour after arrival. (rcpjournals.org)

Response1

• You have a panic attack when your body's natural fight-or-flight reaction - the sudden surge of adrenaline, cortisol, and other brain chemicals you experience in response to a real threat - becomes excessive or occurs out of context. (athingnamed.com)