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  • 2018
  • Postoperative Opioid Prevention Act of 2018, H.R. 5809, 115th Cong. (govtrack.us)
  • THURSDAY, May 31, 2018 (HealthDay News) -- The widespread shortages of injectable opioids and small-volume parenteral (SVP) solutions are jeopardizing patient care and placing a strain on hospital operations, according to a report published by the American Society of Health-System Pharmacists (ASHP). (mycme.com)
  • 2017
  • WEDNESDAY, Dec. 6, 2017 (HealthDay News) -- Implementation of evidence-based guidelines can reduce opioid prescribing after laparoscopic cholecystectomy, according to a research letter published online Dec. 6 in JAMA Surgery . (pri-med.com)
  • spinal cord
  • It works by stopping the normal breakup of enkephalins, natural pain-killing opioids in the spinal cord. (wikipedia.org)
  • In the spinal cord, opioids act by reducing the release of neuropeptides at presynaptic level and by hyperpolarizing the membrane of dorsal horn neurons at the post-synaptic level. (wikipedia.org)
  • The concentration of an opioid in the spinal cord is determined by the net difference between its rate of uptake and distribution in the vascular and subarachinoid spaces. (wikipedia.org)
  • Dysfunction
  • One exception is a condition called long-term postoperative cognitive dysfunction, characterized by persistent confusion lasting weeks or months, which is more common in those undergoing cardiac surgery and in the elderly. (wikipedia.org)
  • parenteral
  • In palliative care, transdermal fentanyl has a definite, but limited, role for: people already stabilized on other opioids who have persistent swallowing problems and cannot tolerate other parenteral routes such as subcutaneous administration. (wikipedia.org)
  • constipation
  • These drugs cause constipation, which is a problem after surgery even without opioid drugs, and it makes recovery more difficult. (nyheadache.com)
  • Other medical uses include suppression of diarrhea, treating opioid use disorder, reversing opioid overdose, suppressing cough, and suppressing opioid induced constipation. (wikipedia.org)
  • Opioid drugs include partial agonists, like the anti-diarrhea drug loperamide and antagonists like naloxegol for opioid-induced constipation, which do not cross the blood-brain barrier, but can displace other opioids from binding in those receptors. (wikipedia.org)
  • Less common are the gastrointestinal effects of other opioids (mostly constipation). (wikipedia.org)
  • Paracetamol
  • In treating chronic pain, opioids are an option to be tried after other less risky pain relievers have been considered, including paracetamol/acetaminophen or NSAIDs like ibuprofen or naproxen. (wikipedia.org)
  • accelerates
  • doi: 10.1016/j.peptides.2011.03.014 PMID 21453735 Bochicchio G, Charlton P, Pezzullo JC, Kosutic G, Senagore A. Ghrelin agonist TZP-101/ulimorelin accelerates gastrointestinal recovery independently of opioid use and surgery type: covariate analysis of phase 2 data. (wikipedia.org)
  • drugs
  • Because of opioid drugs' reputation for addiction and fatal overdose, most are controlled substances. (wikipedia.org)
  • The weak opioid codeine, in low doses and combined with one or more other drugs, is commonly available without a prescription. (wikipedia.org)
  • Some types of chronic pain, including the pain caused by fibromyalgia or migraine, are preferentially treated with drugs other than opioids. (wikipedia.org)
  • Other delta opioid-targeting drugs are known to cause seizures, but Trevaga hopes to avoid this with TRV250 by bypassing the β-arrestin pathway. (wikipedia.org)
  • this gives butorphanol a lower potential for abuse than other opioid drugs. (wikipedia.org)
  • Chronic
  • Chronic opioid use emerging after bariatric surgery. (springer.com)
  • In many cases opioids are a successful long-term care strategy for those with chronic cancer pain. (wikipedia.org)
  • Guidelines have suggested that the risk of opioids is likely greater than their benefits when used for most non-cancer chronic conditions including headaches, back pain, and fibromyalgia. (wikipedia.org)
  • The efficacy of using opioids to lessen chronic neuropathic pain is uncertain. (wikipedia.org)
  • Opioids are contraindicated as a first-line treatment for headache because they impair alertness, bring risk of dependence, and increase the risk that episodic headaches will become chronic. (wikipedia.org)
  • When other treatments fail or are unavailable, opioids may be appropriate for treating headache if the patient can be monitored to prevent the development of chronic headache. (wikipedia.org)
  • Trevena's pipeline currently includes a clinical stage mu-opioid biased ligand for post-operative pain, and discovery-stage programs for chronic pain, migraine, and Parkinson's disease. (wikipedia.org)
  • addiction
  • The euphoria attracts recreational use, and frequent, escalating recreational use of opioids typically results in addiction. (wikipedia.org)
  • As of 2015, increased rates of recreational use and addiction are attributed to over-prescription of opioid medications and inexpensive illicit heroin. (wikipedia.org)
  • Conversely, fears about over-prescribing, exaggerated side effects and addiction from opioids are similarly blamed for under-treatment of pain. (wikipedia.org)
  • nausea
  • Dopamine antagonists act in the brain and are used to treat nausea and vomiting associated with neoplastic disease, radiation sickness, opioids, cytotoxic drugs and general anaesthetics. (wikipedia.org)
  • Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting. (wikipedia.org)
  • codeine
  • A double-blind comparison with oral codeine for postoperative pain relief. (wikipedia.org)
  • Dextropropoxyphene is known under several synonyms, including: Alpha-d-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate [(2S,3R)-4-(Dimethylamino)-3- methyl-1,2-diphenylbutan-2-yl] propanoate (+)-1,2-Diphenyl-2-propionoxy- 3-methyl-4-di-methylaminobutane Desoxypropiophen Dextropropoxyphene, like codeine, is a weak opioid, known to cause dependency among recreational users. (wikipedia.org)
  • sedation
  • Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. (nih.gov)
  • found
  • Oxycodone is a semisynthetic opioid synthesized from thebaine, an opioid alkaloid found in the Persian poppy, and one of the many alkaloids found in the opium poppy. (wikipedia.org)
  • times
  • In addition, both propoxyphene and its metabolite norpropoxyphene have local anesthetic effects at concentrations about 10 times those necessary for opioid effects. (wikipedia.org)