Porous functional cartilage on scaffolds tissue engineering. Medical search. Frequent questions

Composite scaffolds show mechanical properties of the same order of magnitude as values for native articular cartilage, as measured by compressive, tensile and shear testing. (wustl.edu)
Moreover, our findings showed that porous composite scaffolds could be engineered with initial properties that reproduce the anisotropy, viscoelasticity and tension-compression nonlinearity of native articular cartilage. (wustl.edu)
3. Browe D.C., Burdis R., Diaz Payno P., Freeman F.E., Nulty J.M., Buckley C.T., Brama P.A.J. and Kelly, D.J. Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds. (buckleylab.eu)
Another example is articular cartilage damage as a result of trauma or chronic degenerative changes. (openorthopaedicsjournal.com)
Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial. (unibas.ch)
Regenerative Potential of Tissue-Engineered Nasal Chondrocytes in Goat Articular Cartilage Defects. (unibas.ch)
It is obvious that loss of meniscus tissue leads to focal overload of articular cartilage and finally to a higher incidence of osteoarthritis [ 1 , 3 ]. (biomedcentral.com)
A recent publication titled "Co-electrospun PCL/Zein membranes as scaffolds for articular cartilage engineering" by the ETH team was featured in MDPI Bioengineering. (biotrib.eu)
The study explores the application of Zein, a corn protein widely used in food packaging and drug encapsulation industries, in the development of tissue engineering scaffolds for articular cartilage. (biotrib.eu)
Overall, this research highlights the potential of co-electrospun PCL/Zein membranes as promising scaffolds for articular cartilage engineering, showcasing their improved protein adsorption properties and reduced surface roughness. (biotrib.eu)
Ferguson, S.J. Co-Electrospun Poly(ε-Caprolactone)/Zein Articular Cartilage Scaffolds. (biotrib.eu)
Budday, S.: Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials. (uni-rostock.de)

Such scaffolds uniquely combine the potential for load-bearing immediately after implantation in vivo with biological support for cell-based tissue regeneration without requiring cultivation invitro. (wustl.edu)
In this review, biomaterial scaffolds and cell-based therapies for IVD regeneration are briefly discussed. (bjbms.org)
This has led to development of alternative tissue engineering approaches to enhance cartilage regeneration through combinations of cells (including stem cells) and three-dimensional biomaterial scaffolds. (rochester.edu)
Here, an electrodeposition strategy is reported, which enables the selective formation of TEPSs with osteoprogenitor and vascular niches in a multiphasic scaffold in combination with different human cell types for cartilage regeneration in an in vivo osteochondral defect model. (bvsalud.org)
Coculture of hMSCs with functional cells (HUVECs/HDFs) in TEPSs also effectively promoted periosteal regeneration, including osteogenic and angiogenic processes. (bvsalud.org)
The osteoarthritis cartilage histopathology assessment and histologic/histochemical grading system data indicate that the TEPSs containing hMSCs/HUVECs/HDFs exhibit superior potential for cartilage regeneration. (bvsalud.org)
Carbohydrate-based porous scaffolds are promising biomaterials to support cartilage regeneration. (umf.org.nz)
16. Buckley C.T., Hoyland J.A., Fujii K., Pandit A., Iatridis J.C. and Grad S. Critical aspects and challenges for intervertebral disc repair and regeneration - Harnessing advances in tissue engineering. (buckleylab.eu)
TE strategies typically incorporate cells, biomaterials and signals (e.g. growth factors), with the goal of developing a construct that once implanted will promote tissue regeneration. (nature.com)
One of the potential limitations associated with the use of alginate for in vivo tissue regeneration is that it is in general non-degradable by mammals, as they lack the enzymes needed to break down the polymer chains 21 . (nature.com)
Three-dimensional (3D) printed hydrogel scaffolds enhanced with ceramics have shown potential applications for cartilage regeneration, but leaving biological and mechanical properties to be desired. (desktopmetal.com)
This paper presents our study on the development of chitosan /alginate scaffolds with nano hydroxyapatite (nHA) by combining 3D printing and impregnating techniques, forming a hybrid, yet novel, structure of scaffolds for potential cartilage regeneration. (desktopmetal.com)
The main limitation seems to be the capacity for tracheal tissue regeneration. (ersjournals.com)
She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
Subsequent regenerative dental procedures include the development of guided tissue or bone regeneration (GTR, GBR) procedures and distraction osteogenesis 2 the application of platelet rich plasma (PRP) for bone augmentation 17 . (bvsalud.org)
Grafting with autogenous bone, guided bone regeneration (GBR), distraction osteogenesis, and tissue engineering have been developed to perform intraoral bone augmentation in dentistry. (allenpress.com)
They are responsible for several biological activities involving tissue morphogenesis, regeneration, healing, and cell differentiation processes. (allenpress.com)
2019) 3D printing approaches for cardiac tissue engineering and role of immune modulation in tissue regeneration. (aimspress.com)

Tissue engineering in conjunction with biomaterials holds promise for generating cartilage substitutes that withstand stress in joints. (bru.ac.th)
The scaffolds have several empirical advantages over man-made biomaterials (synthetic or biological) the most important of which is their content of native growth factors (e.g. cartilage-derived morphogenetic proteins or CDMPs) and native extracellular matrix molecules that provide crucial signals to regulate the differentiation of the MSCs into functional hyaline cartilage. (rochester.edu)
Current research in tissue engineering is geared towards elucidating the appropriate compositional elements (biomaterials, biomolecules and cell sources) as well as methods of assembly. (biomedcentral.com)
The Biomaterials Lab at Rice printed a scaffold with custom mixtures of a polymer for the former and a ceramic for the latter with imbedded pores that would allow the patient's own cells and blood vessels to infiltrate the implant, eventually allowing it to become part of the natural bone and cartilage. (innovationtoronto.com)
For this, a promising approach is extrusion-based three-dimensional (3D) printing technique to deliver cells, biomaterials, and growth factors within a scaffold to the injured site. (desktopmetal.com)
Chen F, Liu X. Advancing biomaterials of human origin for tissue engineering. (scielo.br)
30) C Li, L Ouyang, JPK Armstrong* & MM Stevens* "Advances in the fabrication of biomaterials for gradient tissue engineering" Trends in Biotechnology (2021). (thearmstronggroup.co.uk)

To address these limitations, we recently developed novel porous scaffolds derived from freeze-dried cartilage allograft tissue and demonstrated that these scaffolds can be efficiently seeded with stromal mesenchymal stem cells (MSCs) for cartilage tissue engineering. (rochester.edu)

32) JPK Armstrong,* E Pchelintseva, S Treumuth, C Campanella, C Meinert, TJ Klein, DW Hutmacher, BW Drinkwater & MM Stevens* "Tissue engineering cartilage with deep zone cytoarchitecture by high-resolution acoustic cell patterning" Advanced Healthcare Materials (2022). (thearmstronggroup.co.uk)
M. Nadra, W. Niu, M. Kurisawa , D. Rousson M. SpectorPlatelet-Rich Plasma Lysate-Incorporating Gelatin Hydrogel as a Scaffold for Bone Reconstruction, Bioengineering 9, 513 (2022). (labby.jp)

Gioffré, Michela (2013) Biodegradable systems for the development of functional materials , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
These osteoconductive three dimensional constructs seeded with MSCs are highly porous, biodegradable and biomechanically stable scaffolds which do not evoke an immunogenic host cell response. (openorthopaedicsjournal.com)
These scaffolds should be biocompatible, biodegradable and porous and support the normal proliferation and functioning of the cells seeded on to it (Gnanaprakasam Thankam et al. (docksci.com)

Preliminary in vitro tests indicated that the scaffolds are suitable for cartilage tissue engineering, and that their potential applications can be extended to cartilage-bone interface tissue engineering. (unibo.it)
Preliminary in vitro tests show good osteoblast response in terms of proliferation and adhesion on all the scaffolds. (unibo.it)
Stem cell behaviour can also be controlled in vitro by manipulating the elasticity of both porous and non-porous materials, yet translation to therapeutic processes in vivo remains elusive. (nature.com)
During the last years tissue engineering based treatment concepts and cell therapeutics showed promising results in vitro . (biomedcentral.com)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
In vitro cell adhesion assay was performed to study the adherent ability of rabbit BMSCs on functional β-TCP scaffolds. (biomedcentral.com)
Her research interests include the preparation and design of materials and scaffolds for in vitro and in vivo fundamental studies, and a further focus is the provision of useful tools to assess mechanisms that govern cell behavior in regenerative medicine. (ibecbarcelona.eu)

Gross image of the cartilage-derived scaffold and a magnified SEM image showing the porosity of the scaffold. (rochester.edu)
The gradient nature of cartilage-into-bone and its porosity have made it difficult to reproduce in the lab, but Rice scientists led by bioengineer Antonios Mikos and graduate student Sean Bittner have used 3D printing to fabricate what they believe will eventually be a suitable material for implantation. (innovationtoronto.com)
Three groups of scaffolds with increasing levels of porosity, and pore sizes of 490 ± 10 μm, were fabricated and evaluated for compressive properties. (springer.com)
Results indicate that this technique allows the fabrication of scaffolds with high amount of interconnectivity and controllability of porosity, pore size, and mechanical properties, the advantage that other methods lack. (springer.com)
Previous research has primarily focused on the effect of parameters associated with scaffold design (e.g., scaffold porosity) and specific scaffold printing processes (e.g., printing pressure). (desktopmetal.com)

Bone grafting is a common procedure in orthopaedic surgery and the implantation of autologous bone grafts supplying osteoinductive growth factors, osteogenic cells, and a structural scaffold, has become the gold standard for the surgical treatment of bone defects caused by trauma, tumor, infection or congenital abnormalities. (biomedcentral.com)
Because of their capacity for ex vivo proliferation and differentiation they provide a good source of osteoprogenitor cells within custom-shaped scaffolds for implantable autologous bone tissue thus allowing the generation of a large transplantable cell population from a small biopsy [ 5 - 11 ]. (biomedcentral.com)
and 5) autologous tissue composite. (ersjournals.com)
Currently, an autologous tissue composite, with or without a tracheal allograft, is the only long-term working solution for every aetiology, despite its technical complexity and setbacks. (ersjournals.com)

This significantly impacted the development of tissue engineering in various medical fields, including regenerative techniques for intervertebral disc (IVD) degeneration (IDD). (bjbms.org)
This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
Recent advances in regenerative medicine place us in a unique position to improve the quality of engineered tissue. (biomedcentral.com)
Combining biomimetic regenerative medicine strategies will allow us to improve tissue-engineered auricular cartilage with respect to biochemical composition and functionality, as well as microstructural organization and overall shape. (biomedcentral.com)
Due to recent advances in regenerative medicine and additive manufacturing we are entering into an age where we have the potential to replace 'like with like', by improving the quality of engineered tissue with respect to biochemical composition and functionality, as well as microstructural organization and overall shape. (biomedcentral.com)
We will use the lessons learnt from auricular cartilage tissue engineering to illustrate how combining additive manufacturing and regenerative medicine for tissue-engineering purposes can be used to create functional and durable tissue with potential to shift the paradigm in reconstructive surgery. (biomedcentral.com)
Cartilage heals very poorly, owing to the lack of intrinsic regenerative capacity of the chondrocytes and its poor vascular supply. (openorthopaedicsjournal.com)
In: Encyclopedia of Tissue Engineering and Regenerative Medicine, 1. (unibas.ch)
Researchers have looked to cartilage tissue engineering to address the lack of cartilage regenerative capability related to cartilage disease/trauma. (desktopmetal.com)
The low endogenous regenerative capacity of the heart,added tothe prevalence of cardiovascular diseases, triggered the advent ofcardiac tissue engineering in the last decades. (ibecbarcelona.eu)
Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. (bvsalud.org)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
One novel approach to restore tooth structure is based on regenerative endodontic procedures by application of tissue engineering. (bvsalud.org)
The purpose of this article is to review the biological principles of tissue engineering and the hurdles that must be overcome to develop regenerative endodontic procedures. (bvsalud.org)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
Journal of tissue engineering and regenerative medicine 14 (11), S. 1630-1640. (uni-rostock.de)

Tissue engineering seeks to repair or regenerate tissues through combinations of implanted cells, biomaterial scaffolds and biologically active molecules. (wustl.edu)

Manufacture of complex heart tissues: technological advancements and future directions[J]. AIMS Bioengineering, 2021, 8(1): 73-92. (aimspress.com)
Post-doctoral Research Engineer at the Bioengineering group (GEBI) of the Earth and Life Institute (ELI), Univerité Catholique de Louvain, Louvain-la-Neuve, Belgium. (imperial.ac.uk)

Inspired by flexible biological tissues, researchers incorporate carbon-based, polymeric, ceramic and/or metallic nanomaterials to give these hydrogels superior characteristics like optical properties and stimulus-sensitivity which can potentially be very helpful to medical (especially drug delivery and stem cell engineering) and mechanical fields. (wikipedia.org)
The platelets act as cross-links to modify molecular functions to enable the hydrogels to have superior elasticity and toughness that resembles closely that of biological tissue. (wikipedia.org)
The porous network of clay particles enable nanocomposite hydrogels to swell in the presence of water. (wikipedia.org)
Nanocomposite hydrogels that are enforced with carbon-based nanomaterials are mechanically tough and electrically conducive, which make them suitable for use in biomedicine, tissue engineering, drug delivery, biosensing, etc. (wikipedia.org)
The electrical conducting property of these hydrogels allow them to mimic the characteristic of nerve, muscle, and cardiac tissues. (wikipedia.org)
However, even though these nanocomposite hydrogels demonstrate some functions of human tissue in lab environments, more research is needed to ensure their utility as tissue replacement. (wikipedia.org)
Nanocomposite hydrogels incorporated with polymeric nanoparticles are tailored for drug delivery and tissue engineering. (wikipedia.org)
Affinity-controlled capture and release of engineered monoclonal antibodies by macroporous dextran hydrogels using coiled-coil interactions. (polymtl.ca)
8. Carroll, S.F., Buckley, C.T., Kelly, D.J. Measuring and modelling oxygen transport and consumption in 3D hydrogels containing chondrocytes and stem cells of different tissue origins. (buckleylab.eu)
PEG-penetrated chitosan-alginate co-polysaccharide-based partially and fully cross-linked hydrogels as ECM mimic for tissue engineering applications. (docksci.com)
PIAC-P hydrogels were superior to certain aspects due to the availability of free functional groups than PIAC-F where most of these groups were utilized for cross-linking. (docksci.com)
The biological evaluations confirmed the healthy being and 3D growth of fibroblasts on the porous networks of both the hydrogels. (docksci.com)
We next explored if spatially modulating the stiffness of 3D bioprinted hydrogels could be used to direct MSC fate inside printed tissues. (nature.com)
However, the fabrication of cell-laden patches with porous structure remains challenging due to the limitations of currently available hydrogels and existing processing techniques. (desktopmetal.com)
Research in 2019 about chitosan was in relation to nanoparticles (995), hydrogels (369) and scaffolds (236). (gmp-chitosan.com)
3D printing of electrically conductive hydrogels for tissue engineering and biosensors - A review. (uni-rostock.de)
Ionically and Enzymatically Dual Cross-Linked Oxidized Alginate Gelatin Hydrogels with Tunable Stiffness and Degradation Behavior for Tissue Engineering. (uni-rostock.de)
Alginate-based hydrogels show the same complex mechanical behavior as brain tissue. (uni-rostock.de)
Computational study on electromechanics of electroactive hydrogels for cartilage-tissue repair. (uni-rostock.de)

Newer techniques using tissue engineering to regenerate musculoskeletal tissue by using biomimetic materials are now being studied. (openorthopaedicsjournal.com)
Sun W, Starly B, Darling A, Gomez C (2004) Application to biomimetic modeling and design of tissue scaffolds. (springer.com)
The myocardial nicheplays a critical role in directing the function and fate of cardiomyocytes;therefore, engineering a biomimetic scaffold holds excellent promise.We produced an electroconductive cardiac patch of bacterial nanocellulose(BC) with polypyrrole nanoparticles (Ppy NPs) to mimic the naturalmyocardial microenvironment. (ibecbarcelona.eu)

Introduction The cells in a tissue are held together by colloidal extracellular matrix (ECM), which is gel like in consistency. (docksci.com)
The significantly different biomechanical properties of the artificial scaffolds highlight the necessity of cellular ingrowth and formation of extracellular matrix to gain viscoelastic properties. (biomedcentral.com)
Development of new methods of scaffold fabrication that closely mimic the structure and function of the extracellular matrix (ECM) is one of the main issues in tissue engineering. (springer.com)
Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)
8 nm).Ppy NPs effectively augment the conductivity, surface roughness, andthickness of BC composites despite reducing scaffolds' transparency.BC-Ppy composites were flexible (up to 10 mM Ppy), maintained theirintricate 3D extracellular matrix-like mesh structure in all Ppy concentrationstested, and displayed electrical conductivities in the range of nativecardiac tissue. (ibecbarcelona.eu)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)

Development and Characterization of Functional Polylactic Acid/Chitosan Porous Scaffolds for Bone Tissue Engineering. (polymtl.ca)
Fang Z, Starly B, Sun W (2005) Computer-aided characterization for effective mechanical properties of porous tissue scaffolds. (springer.com)
Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization. (uni-rostock.de)

To date, however, stem cell-based tissue engineering remains far from clinical utility due in part to challenges associated with control of cell differentiation in vivo. (rochester.edu)
Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. (nature.com)
Stem cell therapy is an exciting and upcoming branch of tissue engineering with application in the field of orthopaedics. (openorthopaedicsjournal.com)
Nevertheless, stem cell based tissue engineering in orthopaedics shows a promising future. (openorthopaedicsjournal.com)
Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that modulation of alginate bioink mechanical properties represents a promising strategy to spatially regulate MSC fate within bioprinted tissues. (nature.com)
Tissue-engineered microtissue is an effective strategy for stem cell culture and therapy in nerve tissue engineering. (biomedcentral.com)
Functional β-tricalcium phosphate (β-TCP) scaffolds modified by DPIYALSWSGMA (DPI) peptide, a bone marrow-derived mesenchymal stem cell (BMSC) affinity peptide, were constructed using an adsorption/freeze-drying strategy. (biomedcentral.com)
Zhou X, Castro NJ, Zhu W, Cui H, Aliabouzar M, Sarkar K, Zhang LG 2016 "Improved bone marrow mesenchymal stem cell osteogenesis in 3D bioprinted tissue scaffolds with low intensity pulsed ultrasound stimulation," Nature Scientific Report , 6, 32876. (sarkarkausik.com)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
The latest technological advances in stem cell biology and mechanical engineering provide new opportunities for cardiac tissue engineering, enabling the production of highly efficient differentiated cells and the manufacture of high-resolution complex cardiac tissues. (aimspress.com)
In this review, we summarize the progress of stem cell technology in 3D bioprinting of heart tissue and the latest technological breakthroughs. (aimspress.com)
Stem cell scaffold bioprocessing. (imperial.ac.uk)

Finally, 3D porous gelatin scaffolds, enriched with calcium phosphate, were prepared with the freeze-drying method. (unibo.it)
Rabiee SM, Moztarzadeh F, Kenari HS, Solati-Hashjin M (2007) Preparation and properties of a porous calcium phosphate bone graft substitute. (springer.com)

In the current study, novel polyethylene glycol interpenetrated cross-linked hydrogel scaffold based on a co-polysaccharide (PIAC) synthesized from two marine heteropolysaccharides, alginate and chitosan, was designed. (docksci.com)
Morphology of bulk PMMA scaffolds and PMMA scaffolds with chitosan/β-TCP composite coating were studied using scanning electron microscopy (SEM). (springer.com)
Furthermore, chitosan/β-TCP composite coating improves the interaction between osteoblast-like cells and the polymeric scaffolds and accelerates the rate of cell proliferation. (springer.com)
First, we incorporated nHA into chitosan scaffold printing and studied the printability by examining the difference between the printed scaffolds and their designs. (desktopmetal.com)
This paper evaluates the printability of chitosan scaffolds for a cartilage tissue engineering, with a focus on identifying the influence of drying technique implemented before crosslinking on the improvement of chitosan printability. (desktopmetal.com)

Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)

Such a scaffold can be made from synthetic and natural molecules or a combination of both, which can be effectively used for the ex vivo engineering of various organ parts. (docksci.com)

The first tissue-engineered, ear-shaped appendages made from bovine chondrocytes and biocompatible scaffolds by the Vacanti group were prone to deformation when xenografted onto immune-compromised mice, highlighting the lack of long-term stability [ 6 ]. (biomedcentral.com)

Here we present a microscale 3D weaving technique to generate anisotropic 3D woven structures as the basis for novel composite scaffolds that are consolidated with a chondrocyte-hydrogel mixture into cartilage tissue constructs. (wustl.edu)
[ 1 ] In addition to providing a physical barrier to pathogenic organisms, skin functions as an active immune organ with distinctive antigenic properties that play a significant role with particular regard to composite tissue allotransplantation. (medscape.com)

This PhD work was aimed to design, develop, and characterize gelatin-based scaffolds, for the repair of defects in the muscle-skeletal system. (unibo.it)
Despite the abundance of surgical treatment options, current standards of care for cartilage defects repair have many complications that limit long-term benefits. (rochester.edu)
This method aims to regenerate rather than repair skeletal tissue defects. (openorthopaedicsjournal.com)
The association of scaffolds to repair extensive bone defects can contribute to their evolution and morphophysiological recomposition. (scielo.br)

A successful method was developed to prepare gelatin nanofibrous scaffolds electrospun from acetic acid/water solution and stabilized with a non-toxic crosslinking agent, genipin, able to preserve their original morphology after exposure to water. (unibo.it)
Moreover, the co-electrospinning technique was used to prepare nanofibrous scaffolds at variable content of gelatin and polylactic acid. (unibo.it)

Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
Our results highlight the remarkablepotential use of BC-Ppy scaffolds as a cardiac patch in tissue regenerativetherapies. (ibecbarcelona.eu)

A novel foaming technique to develop functional open-cell polylactic acid scaffolds for bone tissue engineering. (polymtl.ca)

Scientists at Rice University and the University of Maryland reported their first success at engineering scaffolds that replicate the physical characteristics of osteochondral tissue - basically, hard bone beneath a compressible layer of cartilage that appears as the smooth surface on the ends of long bones. (innovationtoronto.com)

The repair process begins with the formation of the clot, accompanied by an inflammatory process with proliferation of granulation tissue. (scielo.br)

20) C Li, L Ouyang, IJ Pence, AC Moore, Y Lin, CW Winter, JPK Armstrong* & MM Stevens* "Buoyancy-driven gradients for biomaterial fabrication and tissue engineering" Advanced Materials 1900291 (2019). (thearmstronggroup.co.uk)

A limitation of current TE strategies is their relatively poor spatial control of the distribution of cells, matrix components and bioactive cues within the engineered construct 1 . (nature.com)
Fu Q, Saiz E, Rahaman MN, Tomsia AP (2011) Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. (springer.com)
Seitz, H.: 3D Printing of Piezoelectric and Bioactive Barium Titanate-Bioactive Glass Scaffolds for Bone Tissue Engineering. (uni-rostock.de)

Abstract The emerging strategy of tissue engineering for the management of end-stage organ failure and associated complications mainly relies on ECM mimicking scaffolds for neo-tissue genesis. (docksci.com)

A major challenge of tissue substitution is creating a functional framework to support cartilage tissue formation. (bru.ac.th)
The results suggest that PVA/CMC scaffolding material can be tailored in terms of its physical and swelling properties to potentially support cartilage formation. (bru.ac.th)

The goal of this study was to investigate how CMC incorporation and crosslinking density might affect scaffold pore formation, swelling behaviors, mechanical properties, and potential use for engineered cartilage. (bru.ac.th)
The rapid restoration of tissue biomechanical function remains an important challenge, emphasizing the need to replicate structural and mechanical properties using novel scaffold designs. (wustl.edu)

The future trend of grafts for ACL reconstruction might not be same as we see today because of on going research like tissue engineering. (asianarthroscopy.com)
Initial studies indicate an immense potential for cell based strategies to enhance current orthopaedic approaches in skeletal tissue reconstruction. (openorthopaedicsjournal.com)
Tissue-engineered ear cartilage scaffold based on three-dimensional (3D) bioprinting technology presents a new strategy for ear reconstruction in individuals with microtia. (desktopmetal.com)
Melek LN. Tissue engineering in oral and maxillofacial reconstruction. (scielo.br)

Advances in manufacturing techniques, material processing and development, surface functionalization, drug delivery systems and cell incorporation furthered the development of tissue engineering therapies. (bjbms.org)

The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. (mdpi.com)
The ECM component of the tissues forms an insoluble scaffold, which determines the shape and dimension of the organs (Cox and Erler 2011). (docksci.com)
Tissue engineering (TE) is a promising strategy for replacing, repairing or regenerating damaged tissues and organs. (nature.com)
Engineering Small-Scale and Scaffold-Based Bone Organs via Endochondral Ossification Using Adult Progenitor Cells. (unibas.ch)

The initial study is a proof-of-concept to see if printed structures can mimic the gradual transition from smooth, compressible cartilage to hard bone at the end of long bones. (innovationtoronto.com)
The present hydrogel can form an ECM mimic and can form a potent candidate for various tissue engineering applications. (docksci.com)

Tissue-engineered periosteum substitutes (TEPSs) incorporating hierarchical architecture with osteoprogenitor and vascular niches are drawing much attention as a promising tool to support functional cells in defined zones and nourish the cortical bone. (bvsalud.org)
1997). So the need of ECM substitutes that hold the cells until the rejuvenation of host tissue, post-disease stages, is highly demanding. (docksci.com)
2013). Incorporation of physiochemical, biological and mechanical cues along with these scaffolds improves the quality and durability of the ECM substitutes. (docksci.com)
are used to develop new bone substitutes that restore, improve or prevent the deterioration of compromised tissue function [ 8 8. (scielo.br)
Langer and Vacanti 19 defined tissue engineering as an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. (bvsalud.org)

Current tissue-engineered auricular constructs implanted into immune-competent animal models have been observed to undergo inflammation, fibrosis, foreign body reaction, calcification and degradation. (biomedcentral.com)

By controlling the interactions between nanoparticles and polymer chains, a range of physical, chemical, and biological properties can be engineered. (wikipedia.org)

Jost passed away on June 2016, but his legacy lives on through the countless researchers, engineers, and practitioners who have been influenced by his work. (biotrib.eu)

The information acquired on the effect of crosslinking in different conditions was utilized to optimize the preparation procedure of electrospun and freeze-dried scaffolds. (unibo.it)

Biocompatibility and introduction to biology": Biomedical Engineering, Politecnico di Milano, sede distaccata presso San Raffaele, Segrate Mi, Italy) from 1994-1997. (unitn.it)

Immobilizing Enzyme Biocatalysts onto Porous Polymer Monoliths Prepared from Cocontinuous Polymer Blends. (polymtl.ca)

In this work, gelatin based scaffolds were prepared following three different strategies: films were prepared through the solvent casting method, electrospinning technique was applied for the preparation of porous mats, and 3D porous scaffolds were prepared through freeze-drying. (unibo.it)
In this study, porous scaffold materials based on polyvinyl alcohol (PVA) and gelatin (Gel) were successfully fabricated and characterized. (mdpi.com)

Mikos said the collaboration is a great early success for the Center for Engineering Complex Tissues (CECT), a National Institutes of Health center at Maryland, Rice and the Wake Forest School of Medicine developing bioprinting tools to address basic scientific questions and translate new knowledge into clinical practice. (innovationtoronto.com)
21) L Ouyang, JPK Armstrong, M Salmeron-Sanchez & MM Stevens "Assembling living building blocks to engineer complex tissues" Advanced Functional Materials 1909009 (2020). (thearmstronggroup.co.uk)

An ECM substitute should act as a scaffold to carry the cells until a functional tissue is reestablished (Finosh and Jayabalan 2012). (docksci.com)

The addition of CMC modulates the pore architecture and increases the swelling ratio of scaffolds. (bru.ac.th)

Loss of meniscal tissue is correlated with early osteoarthritis but few data exist regarding detailed biomechanical properties (e.g. viscoelastic behavior) of menisci in different species commonly used as animal models. (biomedcentral.com)
For future research the use of ovine meniscus would be desirable showing the highest biomechanical similarities to human meniscus tissue. (biomedcentral.com)
Especially, studies about the biomechanical properties of theses polyurethane scaffolds at time of implantation are missing. (biomedcentral.com)

17) JPK Armstrong & MM Stevens "Emerging technologies for tissue engineering: from gene editing to personalized medicine" Tissue Engineering Part A 25, 9-10 (2019). (thearmstronggroup.co.uk)

Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)

This paper presents the development of a natural bioink from chicken eggwhite and sodium alginate for bioprinting cell-laden patches to be used in endothelialized tissue engineering applications. (desktopmetal.com)
22) L Ouyang, JPK Armstrong, Q Chen, Y Lin & MM Stevens "Void-free 3D bioprinting for in-situ endothelialization and microfluidic perfusion" Advanced Functional Materials 1908349 (2020). (thearmstronggroup.co.uk)

The purpose of the current study was to biomechanically characterize bovine, ovine, and porcine menisci (each n = 6, midpart of the medial meniscus) and compare their properties to that of normal and degenerated human menisci (n = 6) and two commercially available artificial scaffolds (each n = 3). (biomedcentral.com)
Through co-electrospinning, the team successfully reduced protein adsorption by half compared to scaffolds made solely of bovine serum albumin and equine synovial fluid. (biotrib.eu)

Scaffold Composition Determines the Angiogenic Outcome of Cell-Based Vascular Endothelial Growth Factor Expression by Modulating Its Microenvironmental Distribution. (unibas.ch)

Anatomy62

Organisms5

Diseases10

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes35

Disciplines and Occupations12

Technology, Industry, Agriculture37

Information Science3

Articular cartilage12

Regeneration18

Biomaterials7

Seeded with stroma1

20222

Biodegradable3

Vitro7

Porosity5

Autologous4

Regenerative16

Biomaterial scaffolds1

Bioengineering2

Hydrogels19

Biomimetic3

Extracellular6

Characterization3

Stem cell12

Calcium phosphate2

Chitosan5

Differentiation1

Vivo1

Chondrocytes1

Composite2

Defects4

Nanofibrous scaffolds2

Cardiac2

Polylactic acid1

Osteochondral tissue1

Proliferation1

Fabrication1

Bioactive3

Abstract1

Support cartilage2

Mechanical properties2

Reconstruction4

Advances1

Organs4

Mimic2

Substitutes5

Constructs1

Nanoparticles1

20161

Electrospun1

Biomedical Engineering1

Polymer Blends1

Gelatin2

Complex Tissues2

Substitute1

Pore1

Biomechanical3

20191

Bone marrow1

Bioprinting2

Bovine2

Composition1