• www.sbes.vt.edu ), have developed a process for controlling the motion of cellulose-producing Acetobacter xylinum bacteria, guiding them to produce structures that the researchers hope will one day be able to support cartilage, bone tissue, and other biomaterials. (mddionline.com)
  • Karageorgiou V and Kaplan D. "Porosity of 3D biomaterials scaffolds and osteogenesis. (stryker.com)
  • Tissue engineers use biomaterials for a variety of applications from drug delivery to supporting the regeneration of damaged or lost tissues to creating in vitro disease models. (leica-microsystems.com)
  • Characterizing scaffold morphology and porosity through imaging is crucial to the fabrication of modular biomaterials. (leica-microsystems.com)
  • Mollie Smoak's research focuses on the synthesis, processing, and evaluation of new biomaterials for use as scaffolds to support the regeneration of musculoskeletal tissues [2] . (leica-microsystems.com)
  • Our tissue engineering research focuses on repairing diseased or damaged tissues, incorporating the areas of biomaterials, stem cells, computer modelling and molecular biology. (edu.au)
  • Tissue engineering and regenerative medicine can provide a novel treatment regime based on the use of synthetic biomaterials, which may be constructed into three-dimensional implants and combined with biologics (such as cells and/or bioactive molecules). (edu.au)
  • Biomaterials have been widely utilized in a variety of biomedical applications, such as tissue engineering, regenerative medicine, biosensors and medical implants, due to their inherent physical and chemical properties including biocompatibility, tunable mechanical properties and biodegradability, and hierarchical internal structures. (programmaster.org)
  • Additive manufacturing, based on layer-by-layer fabrication mechanism, possesses critical advantages in fabrication of 3D structures of biomaterials for various biomedical applications, including complex geometries, heterogeneity, porosities, and incorporation of different growth factors. (programmaster.org)
  • The symposium shall focus on the recent advances in the biomaterials for 3D printing of scaffolds and tissues. (programmaster.org)
  • In this work, the goal was to combine the useful biomaterial properties of both chitosan and silica to design biocomposite organic/inorganic biomaterials for bone tissue engineering applications. (iyte.edu.tr)
  • The development of new biomaterials for tissue engineering provides a scientific basis for the creation of scaffolds that could provide appropriate regeneration and tissue repair 14 . (bvsalud.org)
  • The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
  • Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
  • Particularly for bone defect regeneration, the complex coupling of biological mechanisms to the scaffolds' properties has led to a widespread trial-and-error approach. (kit.edu)
  • Here, we consider two complementary approaches: first, an efficient macroscopic optimization routine based on a simple one-dimensional time-dependent model for bone regeneration in the presence of a bioresorbable polymer scaffold is developed. (kit.edu)
  • The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold and regenerated bone system over the regeneration time, so that the propensity for mechanical failure is minimized. (kit.edu)
  • Our work aims to develop optimal tissue engineered constructs for the repair and regeneration of different types of musculoskeletal tissues, including bone, cartilage and tendon. (edu.au)
  • Recently bone tissue engineering studies have focused on the development of 3D scaffolds that can organize the tissue regeneration in natural way with appropriate porosity and reinforced the structure. (iyte.edu.tr)
  • Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. (hindawi.com)
  • One of the most attractive subjects in tissue engineering is the development of a scaffold, a three-dimensional porous solid structure that plays a key role in assisting tissue regeneration [ 1 ]. (hindawi.com)
  • Its degradation rate should match the rate of new tissue regeneration in order to maintain the structural integrity and to provide a smooth transition of the load transfer from the scaffold to the tissue [ 3 ]. (hindawi.com)
  • Biodegradability can be imparted into polymers through molecular design with a controlled rate in concert with tissue regeneration [ 18 - 21 ]. (hindawi.com)
  • The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)
  • The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
  • The tissues that used to be discarded may now serve as a basis for scientific research and clinical use in tissue regeneration and treatment of many diseases 23 . (bvsalud.org)
  • In recent years, tissue engineering has evolved considerably, due to the problems in the biomedical area concerning tissue regeneration therapies. (bvsalud.org)
  • Moreover, sterilization strategies of scaffold are a crucial step for its application in tissue regeneration, however, the sterilization process have to maintain the structural and biochemical properties of the scaffold. (bvsalud.org)
  • Previous in vitro and small animal (murine) in vivo studies highlighted a porous hydroxyapatite/poly (DL-lactic acid) composite scaffold in combination with skeletal stem cells (SSCs) as a potential bone graft substitute candidate. (port.ac.uk)
  • Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. (elsevierpure.com)
  • We created double-layered porous scaffolds composed of synthetic biodegradable polymers by combining freeze-drying and porogen leaching techniques to create tissue- engineered articular cartilage. (elsevierpure.com)
  • Designing heterogeneous porous tissue scaffolds for additive manufacturing processes. (sabanciuniv.edu)
  • Functionally heterogeneous porous scaffold design for tissue engineering. (sabanciuniv.edu)
  • Modeling of variational gradient porous architecture with multi-directional filament deposition in 3D scaffolds. (sabanciuniv.edu)
  • Spatially multi-functional porous tissue scaffold. (sabanciuniv.edu)
  • Polymers have been widely chosen as tissue scaffolding material having a good combination of biodegradability, biocompatibility, and porous structure. (hindawi.com)
  • With further optimization in topologically ordered porosity design exploiting material property and fabrication technique, porous biodegradable metals could be the potential materials for making hard tissue scaffolds. (hindawi.com)
  • Ideally, a scaffold must be porous, bioactive, and biodegradable and possess adequate mechanical properties suited to the biological site. (hindawi.com)
  • Zhang and Ma have developed [ 25 ] a highly porous biodegradable polymer/apatite composite scaffold (95% porosity) through a thermally induced phase separation technique, which resulted in significant improvement in mechanical properties compared to polymer-only scaffold. (hindawi.com)
  • These scaffolds should be biocompatible, biodegradable and porous and support the normal proliferation and functioning of the cells seeded on to it (Gnanaprakasam Thankam et al. (docksci.com)
  • A parallel in vitro analysis of ovine SSC seeded scaffolds was also performed. (port.ac.uk)
  • Organ-on-a-chip (OOC) devices offer new approaches for metabolic disease modeling and drug discovery by providing biologically relevant models of tissues and organs in vitro with a high degree of control over experimental variables for high-content screening applications. (ibecbarcelona.eu)
  • In traditional tissue engineering, tissues are grown in-vitro prior to insertion in the body, and thus a scaffold is needed to support and guide the cells during growth. (uwo.ca)
  • In vitro biomineralization on scaffolds was determined by Von Kossa and Alizarin red staining. (iyte.edu.tr)
  • For instance, PLA could be combined with PGA to form poly(lactic- co -glycolic acid) (PLGA), which has degradation rate tailored with the tissue healing period and has been shown to support osteoblast cells attachment and growth in vitro and in vivo [ 22 - 24 ]. (hindawi.com)
  • MSCs have great therapeutic potential in tissue engineering, they can be expanded in vitro, and combined with scaffolds they can be inserted into wounds to promote healing and tissue replacement. (bvsalud.org)
  • Useful scaffold geometries should have high porosity (60-80%) with small (100-500 μm) interconnected pores. (utexas.edu)
  • Moreover, the high porosity achieved with CMC cryogels allowed us to create specific range pseudoislets. (ibecbarcelona.eu)
  • In the current study, we have made-up various compositions of silk fibroin (SF) scaffolds incorporated with hydroxyapatite (HAp) and Ce-doped ZnO nanoparticles through the freeze gelation method. (lancs.ac.uk)
  • The hardening process, associated to the conversion of a-tricalcium phosphate to hydroxyapatite was drastically accelerated by the hydrothermal treatments, reducing the time for complete reaction from 7¿days to 30 minutes, while preserving the scaffold architectural integrity and retaining the nanostructured features. (upc.edu)
  • The present work introduces a new method to harden biomimetic hydroxyapatite 3D-plotted scaffolds which avoids high-temperature sintering. (upc.edu)
  • and ii) it retains the nanostructured character of biomimetic hydroxyapatite and allows controlling the porosity from the nano- to the macroscale. (upc.edu)
  • The scaffold patterns are then mineralized with a biocompatible ceramic (hydroxyapatite). (utexas.edu)
  • However, hydrogel scaffolds have several limitations, such as weak mechanical property and a lack of bioactive property. (mdpi.com)
  • However, the bacteria's mechanical properties could not be controlled beyond thin, flexible layers because cellulose scaffolds produced using Acetobacter xylinum bacteria lacked the stiffness required to support healing bone or cartilage. (mddionline.com)
  • The composite scaffolds were characterized by using FT-IR and micro-CT techniques while mechanical stability was determined through the mechanical testing machine. (lancs.ac.uk)
  • Tissue exhibits unique mechanical, biochemical and structural properties, with discrete and continuous changes in cellular and extracellular composition that defines intricate channels, chambers and interfaces. (edu.au)
  • Here, we use cryogelation technology to develop a more resemblance scaffold with the mechanical and physical properties needed to engineer pancreatic tissue. (ibecbarcelona.eu)
  • The post-printing properties and microstructures are of great importance to the biomaterial functionality, such as mechanical properties, physical properties including swelling and degradation properties, pore size and porosity. (programmaster.org)
  • Nanoparticles and scaffolds were characterized regarding morphology, chemical and mineral composition, porosity and mechanical properties. (maastrichtuniversity.nl)
  • Scaffolds 50HA/50β-TCP featured superior interconnectivity and mechanical properties. (maastrichtuniversity.nl)
  • Three-dimensional layers, formed by the proposed tool-path plan, vary the pore size and the porosity based on the biological and mechanical requirements. (psu.edu)
  • The effects of silica type and loading on the mechanical, morphological, chemical, surface properties, wettability and biocompatibility of composite scaffolds were investigated and characterized by using SEM, AFM, contact angle analysis, swelling study, protein adsorption assay, biodegradation and biomineralization tests. (iyte.edu.tr)
  • Alginate-based hydrogels show the same complex mechanical behavior as brain tissue. (uni-rostock.de)
  • Metals that can degrade in physiological environment, namely, biodegradable metals, are proposed as potential materials for hard tissue scaffolding where biodegradable polymers are often considered as having poor mechanical properties. (hindawi.com)
  • Biodegradable metal scaffolds have showed interesting mechanical property that was close to that of human bone with tailored degradation behaviour. (hindawi.com)
  • Finally, as a mechanical support, a scaffold must possess adequate mechanical stability to withstand both the implantation procedure and the mechanical forces that are typically experienced at the scaffold-tissue interface and does not collapse during patient's normal activities [ 3 ]. (hindawi.com)
  • In more detail, the lectures of the proposed course will cover topics concerning the key challenges of contemporary tissue engineering strategies, which result from (at least) two competing requirements: (i) the tissue engineering scaffolds must exhibit a sufficient mechanical competence, i.e. stiffness and strength comparable to natural bone. (esbiomech.org)
  • 2013). Incorporation of physiochemical, biological and mechanical cues along with these scaffolds improves the quality and durability of the ECM substitutes. (docksci.com)
  • Biocompatible and easily manipulated, this biopolymer is suitable for tissue engineering. (mddionline.com)
  • Directly fabricating scaffolds through AM methods is limited because of the relatively few biocompatible materials available for processing in AM machines. (utexas.edu)
  • The result is a biocompatible ceramic scaffold composed of hollow tubes, which may promote attachment of endothelial cells and vascularization [1]. (utexas.edu)
  • We aimed to fabricate biocompatible 3D-scaffolds featuring macro- and microporous calcium phosphates with high pore interconnection. (maastrichtuniversity.nl)
  • in the HA pure scaffolds was negative for cell viability and proliferation, while in the 50HA/50β-TCP composite scaffolds it resulted more biocompatible. (maastrichtuniversity.nl)
  • Moreover, the histological response showed that the scaffolds are biocompatible and those sterilized by GR showed a more severe inflammatory response, accompanied with the presence of giant foreign body cells. (bvsalud.org)
  • A computational reaction–diffusion model for biosynthesis and linking of cartilage extracellular matrix in cell-seeded scaffolds with varying porosity. (ncsu.edu)
  • Nanofibrous scaffolds are considered promising since they mimic the extracellular matrix, have a high surface area-to-volume ratio, and possess excellent porosity and pore interconnectivity. (uwo.ca)
  • A biodegradable scaffold allows the replacement of biological tissues via physiological extracellular components without leaving toxic degradation products. (hindawi.com)
  • In natural tissues, the extracellular matrix composition, cell density and physiological properties are often non-homogeneous. (ibecbarcelona.eu)
  • Introduction The cells in a tissue are held together by colloidal extracellular matrix (ECM), which is gel like in consistency. (docksci.com)
  • In this article, we report on the preparation and cell culture performance of a novel fibrous matrix that has an interbonded fiber architecture, excellent pore interconnectivity, and controlled pore size and porosity. (edu.au)
  • The average pore size and porosity of the fibrous matrices were controlled by the fiber/template ratio. (edu.au)
  • Both cell lines grew successfully in the matrices, but they showed different preferences in pore size and porosity. (edu.au)
  • Biodegradable polymers have been widely used and accepted as the most suitable materials for scaffolds due to their degradability, biocompatibility, and ease of processability [ 9 - 11 ]. (hindawi.com)
  • The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
  • Pseudoislets formed within CMC-scaffolds showed cell viability for up to 7 d and a better response to glucose over conventional monolayer cultures. (ibecbarcelona.eu)
  • Biodegradable polymers degrade through hydrolysis process and are gradually absorbed by the human body thus allowing the supported tissue to gradually recover its functionality [ 8 , 17 ]. (hindawi.com)
  • The aim of the present study was designed to analyze the effects of different sterilization techniques, i.e. ethylene oxide (ETO), gamma radiation (GR) and hydrogen peroxide- based plasma (H2O2) in biodegradable PLA scaffolds, and to determine the best sterilization technique to render a sterile product with minimal degradation and deformation, and good tissue response. (bvsalud.org)
  • The cell-derived scaffold could provide a favorable environment for cartilage cells to maintain their characteristics while synthesizing cartilage in the scaffold structure in vivo," notes study author Dr. Byoung-Hyun Min. (medicalxpress.com)
  • Such a scaffold can be made from synthetic and natural molecules or a combination of both, which can be effectively used for the ex vivo engineering of various organ parts. (docksci.com)
  • In conclusion, the results show that among sterilization techniques used in the preset study, the best results were observed with H2O2 sterilization, since it did not significantly modify the surface structure of the PLA fibers and their in vivo response did not cause an unfavorable tissue reaction. (bvsalud.org)
  • Three different scaffold architectures were analysed. (upc.edu)
  • In this work different scaffold strut sizes (0.3 - 0.5 mm) have been fabricated using two different plaster powders (zp102 and zp130) with variations in shell saturation levels, part print position, and part print orientation. (utexas.edu)
  • Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization. (uni-rostock.de)
  • Design and characterization of advanced micro- and nano-fiber reinforced hydrogels for 3D bioprinting of anisotropic tissues. (polito.it)
  • Currently, work has been focused on the synthesis and physicochemical characterization of poly lactic acid scaffolds, a synthetic polyester that has been extensively study for its excellent biocompatibility and biodegradability. (bvsalud.org)
  • Computational study on electromechanics of electroactive hydrogels for cartilage-tissue repair. (uni-rostock.de)
  • A new study examines the use of tissue-engineered scaffolding made of cartilage cells, which have a limited ability to heal naturally, to replace defective cartilage tissue. (medicalxpress.com)
  • Cartilage cells are extracted and seeded to the scaffold which is implanted into the body, where new cartilage tissue is grown along the structure. (medicalxpress.com)
  • A variety of applications are possible for the engineering of cartilage tissue as the shape and porosity can be altered to suit the type of tissue required. (medicalxpress.com)
  • The worldwide shortage of donor organs and drawbacks of surgical methods have created significant challenges in repairing and replacing diseased or damaged tissues and organs. (edu.au)
  • We aim to gain a better understanding of the relationship between T cell functions and their physical microenvironment by 3D printing hydrogels as a model for the soft tissues and organs in our bodies. (edu.au)
  • The course will gather experts from the fields of applied mechanics, biology, and chemistry, in order to give, in an unprecedented transdisciplinary fashion (normally, applied mechanicians are rather missing in the topic, than coordinating a joint educational effort), the cutting-edge view on what the up-to-date ingredients of tissue engineering for load-carrying organs are. (esbiomech.org)
  • The ECM component of the tissues forms an insoluble scaffold, which determines the shape and dimension of the organs (Cox and Erler 2011). (docksci.com)
  • Tissue engineering is the science that combines the principles of biology and engineering techniques in order to obtain biological substitutes for regenerating, replacing, modifying, repairing or restoring the function of organs and tissues. (bvsalud.org)
  • Biomimetic and hydrothermally treated scaffolds supported the adhesion and proliferation of rat mesenchymal stem cells, indicating a good suitability for bone tissue engineering applications. (upc.edu)
  • WST-1 cytotoxicity, cell proliferation with rezasurin and alkaline phosphatase activity assays were performed to determine biological activity of the composite scaffolds. (iyte.edu.tr)
  • Sufficient porosity is needed to accommodate cell proliferation and differentiation, which will eventually enhance tissue formation [ 2 , 3 ]. (hindawi.com)
  • The porosity of composite scaffolds was found to be in the range of 50%-66% with an appreciable degradation rate. (lancs.ac.uk)
  • These novel composite scaffolds present promising candidates for craniofacial defects reconstruction. (lancs.ac.uk)
  • Wet chitosan-silica composite scaffolds exhibited higher compression moduli compared to pure chitosan scaffold in 67.3- 81.4kPa and 78.1 to 107.6kPa range respectively. (iyte.edu.tr)
  • Average pore size range of chitosandiatomite and chitosan-POSS composite scaffolds was obtained as 15-180μm and 220- 300μm, respectively. (iyte.edu.tr)
  • Therefore, these composite scaffolds could be used for bone tissue engineering applications. (iyte.edu.tr)
  • 26 ] has shown that osteoblast survival and growth were significantly enhanced in the PLLA/HA composite scaffolds compared to the plain PLLA scaffolds. (hindawi.com)
  • Previously it was shown that the behavior of scaffold geometries can be well simulated with Finite Element Modeling (FEM) however the prediction of actual strength and stiffness values are dependent on dimensional accuracy. (utexas.edu)
  • Ionically and Enzymatically Dual Cross-Linked Oxidized Alginate Gelatin Hydrogels with Tunable Stiffness and Degradation Behavior for Tissue Engineering. (uni-rostock.de)
  • Mechanically, the major challenge is to achieve adequate initial strength and stiffness and to maintain them during the stage of healing or neotissues generation throughout the scaffold degradation process [ 3 , 7 , 8 ]. (hindawi.com)
  • Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. (mdpi.com)
  • Traditionally-used hydrogel encapsulation methods do not accomplish all the requisites for pancreatic tissue engineering, as its poor nutrient and oxygen diffusion induces cell death. (ibecbarcelona.eu)
  • In the current study, novel polyethylene glycol interpenetrated cross-linked hydrogel scaffold based on a co-polysaccharide (PIAC) synthesized from two marine heteropolysaccharides, alginate and chitosan, was designed. (docksci.com)
  • The present hydrogel can form an ECM mimic and can form a potent candidate for various tissue engineering applications. (docksci.com)
  • In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
  • Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
  • Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
  • The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)
  • Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)
  • For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)
  • Stem cells are classified into two main: embryonic stem cells, which are found in the embryos and adult stem cells, found in adult tissues. (bvsalud.org)
  • Adult stem cells are found in differentiated tissues and are able to generate specialized cells in some types of tissues (Multipotent Stem Cells). (bvsalud.org)
  • Second, we consider a periodic microstructure optimization problem for scaffold architectures based on a domain-splitting. (kit.edu)
  • A 0.004 mm mineral coating was found on the ABS patterns that featured a strut offset of 0.3 mm, which is in the range of appropriate pore size for bone tissue engineering [2]. (utexas.edu)
  • Natural polymer-based composites have been focused with more attention than synthetic polymer composites for bone tissue engineering applications because of their biocompatibility and biodegradability. (iyte.edu.tr)
  • To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)
  • Tissue engineering. (edu.au)
  • Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. (mdpi.com)
  • Loh QL and Choong C. "Three-dimensional scaffolds for tissue-engineering applications: Role of porosity and pore size. (stryker.com)
  • Tissue Engineering Part B 19 (2013): 485-502. (stryker.com)
  • Karande TS, Kaufmann JM, and Agrawal CM. "Chapter 3: Functions and Requirements of Synthetic Scaffolds in Tissue Engineering. (stryker.com)
  • Nanotechnology and Regenerative Engineering: The Scaffold, Second Edition. (stryker.com)
  • Scaffold architecture can be tailored to specific tissue engineering applications. (leica-microsystems.com)
  • Widefield microscopy can reach its limits when used for tissue engineering due to the thickness and optical characteristics of the tissue. (leica-microsystems.com)
  • Tissue engineering develops materials that mimic biological tissues [1] . (leica-microsystems.com)
  • 3D printing (3DP) is a widely investigated scaffold manufacturing process for Tissue Engineering (TE). (utexas.edu)
  • Additive manufacturing (AM) is a rapidly emerging technology that has the potential to produce personalized scaffolds for tissue engineering applications with unprecedented control of structural and func- tional design. (kit.edu)
  • What is tissue engineering? (edu.au)
  • This pressing need has led to the rise of 'tissue engineering and regenerative medicine', a multidisclinary field which aims to induce the body's natural regenerative abilities and produce functional substitutes of biological tissue for clinical use. (edu.au)
  • The fundamental concept combines various tissue engineering elements, most often a scaffold as a supporting matrix in combination with living cells and/or bioactive molecules, to form a tissue engineering construct that repairs or regenerates the diseased or damaged tissue or organ. (edu.au)
  • Applications of research outcomes will have significant impact on the field of advanced nanobiomaterials for tissue engineering, target drug delivery, imaging contrast for MRI and CT scan and therapy. (edu.au)
  • Tissue engineering deals with creating tissues, using patient-derived cells, in order to restore, maintain or improve existing tissue function. (uwo.ca)
  • Presented at the 15th Annual North Carolina Tissue Engineering and Regenerative Medicine Society Conference, Winston-Salem, NC. (ncsu.edu)
  • Journal of tissue engineering and regenerative medicine 14 (11), S. 1630-1640. (uni-rostock.de)
  • 3D printing of electrically conductive hydrogels for tissue engineering and biosensors - A review. (uni-rostock.de)
  • Design of microfiber-reinforced bioinks for the engineering of aligned tissues. (polito.it)
  • Design and development of click-chemistry based electroconductive hydrogels for cardiac tissue engineering. (polito.it)
  • Dual-porosity PCL scaffolds for skeletal muscle tissue engineering. (polito.it)
  • PEGDA-Gelatin/PEDOT:PSS hydrogels as electroconductive bioinks for cardiac tissue engineering. (polito.it)
  • Here we describe a model system, in which the distribution of cells throughout tissue engineering scaffolds after perfusion seeding can be influenced by the pore architecture of the scaffold. (ibecbarcelona.eu)
  • Ellen Arruda of the University of Michigan in Ann Arbor says she is "intrigued by the implications for gel applications, such as the design of scaffolds for tissue engineering. (aps.org)
  • The shrinkage of cartilage that occurs frequently in other tissue engineering methods, and often renders the replacement tissue wrongly-sized for implantation, did not occur in the study. (medicalxpress.com)
  • Tissue engineering is the use of cells and bio-chemical substances, in combination with engineering and materials methods, in order to restore, maintain, or improve the functioning of biological tissue. (esbiomech.org)
  • The material scientific and cell biological technologies used in contemporary tissue engineering have reached breathtaking sophistication. (esbiomech.org)
  • On the contrary, the current design process of tissue engineering (TE) scaffolds is still a pure trial and error approach. (esbiomech.org)
  • PEG-penetrated chitosan-alginate co-polysaccharide-based partially and fully cross-linked hydrogels as ECM mimic for tissue engineering applications. (docksci.com)
  • Abstract The emerging strategy of tissue engineering for the management of end-stage organ failure and associated complications mainly relies on ECM mimicking scaffolds for neo-tissue genesis. (docksci.com)
  • Tissue engineering holds great promise for the advancement of cardiovascular surgery as well as other medical fields. (medscape.com)
  • The results allow for better dimensional specification for scaffold geometry fabrication by defining the process parameters in 3DP that may be used further in scaffold accuracy optimization. (utexas.edu)
  • Unlike traditional stochastic scaffold fabrication techniques, additive manufacturing (AM) can be used to create tissue-specific three-dimensional scaffolds with controlled porosity and pore geometry. (utexas.edu)
  • Specifically, the authors investigate the use of Fused Deposition Modeling to fabricate scaffold patterns of varied pore size and geometry. (utexas.edu)
  • In fact, it is very complicated (if not impossible), even with tremendous input gained from sophisticated experimental work, to guess suitable combinations of the key design parameters (chemical composition, porosity, microstructural geometry, distribution of signalling factors and biological cells), which reflect a highly complex system of mutually coupled phenomena. (esbiomech.org)
  • This relates to the topic of bioresorbable scaffolds enabling internal growth of new tissue. (esbiomech.org)
  • The ECM integrates molecular signals that synchronize the specific function of the tissues on responding to the physiological demands. (docksci.com)
  • El objetivo del presente estudio fue analizar los efectos de diferentes técnicas de esterilización como óxido de etileno (ETO), radiación gamma (GR) y plasma a base de peróxido de hidrógeno (H2O2) en andamios biodegradables de PLA, y determinar la mejor técnica de esterilización con mínima degradación y deformación, así como una respuesta tisular favorable. (bvsalud.org)
  • The goal was to study the fiber morphology and pore characteristics of the scaffold. (leica-microsystems.com)
  • Analysis of surface morphology showed that ETO and GR modified the PLA scaffolds without any change in its chemical composition. (bvsalud.org)
  • To mitigate this, shape or topology optimization can be a useful tool to design a scaffold architecture that matches the desired design targets, albeit at high computational cost. (kit.edu)
  • The aim of the current study was to scale up the bone cell-scaffold construct to large animals and examine the potential for repair of a critical-sized defect via an ovine model. (port.ac.uk)
  • It is also desirable for a scaffold to have high interconnectivities between pores for uniform cell seeding and distribution, and for the nutrients and metabolites exchange at the cell/scaffold construct [ 4 - 6 ]. (hindawi.com)
  • Much research focuses on increasing the porosity and pore interconnectivity of ceramic scaffolds to increase osteoconductivity, cell migration and cell-cell interaction. (maastrichtuniversity.nl)
  • Functionally gradient tissue scaffold design and deposition path planning for bio-additive processes. (sabanciuniv.edu)
  • Such an interbonded fibrous matrix may be useful for developing new fiber-based 3D tissue scaffolds for various cell culture applications. (edu.au)
  • Scaffolds with total porosity of 71%-87%, pores in the range of 280-550 µm and connectivity density up to 43 mm-3 were obtained. (maastrichtuniversity.nl)
  • The material provides a scaffold for human tissue to grab onto and grow into, due to biological trabecular porosity similar to that found in the body," said Dr Ahneez Ahmed. (additive3dasia.com)